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Assessment of the discrimination and calibration abilities of the constructed nomogram using ROC curves and calibration curves. (A), (B) The ROC curves for predicting 6-,12-,18-,24-, and 36-month OS of C-SCLC patients in the training cohort and validation cohort based on the nomogram, (C), (D) The calibration curves for predicting 6-,12-,18-,24-, and 36-month OS of C-SCLC patients in the training cohort and validation cohort based on the nomogram. ROC, receiver operating characteristic curve; C-SCLC, combined small cell lung cancer.
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Introduction:
Combined small cell lung cancer (C-SCLC) represents a rare subtype of all small cell lung cancer cases, with limited studies investigated its prognostic factors. The aim of this study was to construct a novel nomogram to predict the overall survival (OS) of patients with C-SCLC.
Methods:
In this retrospective study, a total of 588...
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Citations
... Therefore, accurately identifying and selecting the BM high-risk population who may benefit from PCI is very important. However, previously established nomogram models all focused on predicting OS in SCLC patients with all stages or extensive stages [20][21][22][23]. In the study conducted by Li et al., the multivariate analysis suggested that increasing age, male sex, and higher T stage were independent risk factors for BM in SCLC patients at presentation, and those patients with BM showed inferior survival to those without BM. ...
Objective
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Methods
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Results
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Conclusion
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Objective
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Methods
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Results
The multivariate analysis revealed that age, sex, histologic type, TNM staging, tumor grade, surgery, radiation, and tumor size were independent prognostic factors of TETs, and a nomogram was developed to predict the OS of these patients based on these variables. The time-dependent ROC curves displayed that the nomogram yielded excellent performance in predicting the 12-, 36- and 60-month OS of these patients. Calibration curves presented satisfying consistencies between the actual and predicted OS. DCA illustrated that the nomogram will bring significant net clinical benefits to these patients compared to the classic TNM staging system. The estimated NRI and IDI showed that the nomogram could significantly increase the predictive ability of 12-, 36- and 60-month OS compared to the classic TNM staging system. Consistent findings were discovered in the internal and external validation cohorts.
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Background:
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Method:
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Result:
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BACKGROUND
Small cell lung cancer (SCLC) is a lung malignancy with a poor prognosis and metastases at the time of diagnosis. There is limited experience using positron emission tomography/computed tomography (PET/CT) for SCLC diagnosis, staging, and follow-up.
OBJECTIVE
Investigate the survival effect of primary tumor standardized uptake value max (SUVmax), SUV mean, metabolic tumor volume (MTV), total lesion glucose (TLG), bone marrow SUV (BM), and bone marrow to liver ratio (BLR) in SCLC.
DESIGN
Retrospective
SETTING
Single center in Turkey
PATIENTS AND METHODS
Patients who were cyto/histologically diagnosed with SCLC and had PET/CT simultaneous with the diagnosis were included in the study.
MAIN OUTCOME MEASURES
The effect of PET/CT parameters on overall survival (OS) and progression-free survival (PFS).
SAMPLE SIZE
304
RESULTS
The 5-year OS median value was 14.62 months, and the 5-year PFS was 13.01 months. In Kaplan-Meier analysis, SUVmax, MTV, and TLG were statistically significant variables in OS ( P =.03; P <.001; P <.001, respectively). MTV and TLG were significant in PFS ( P <.001; P =.0003, respectively). In the multivariate analysis, MTV was an independent PET/CT parameter associated with OS ( P =.003), stage of disease ( P =.012), SUVmax ( P =.003), MTV ( P =.016), and TLG ( P =.005) were significant variables in PFS.
CONCLUSION
In our study, MTV was an independent parameter that can be used to predict survival in SCLC. Considering the effect of MTV, a metabolic PET/CT parameter on survival, it can be recommended for clinical use as a standard measure of evaluation in PET/CT reports, just like SUVmax.
LIMITATIONS
The first limitation was the single-center and retrospective design of the study. Due to the retrospective design of the study, weight loss, performance status, and smoking history could not be obtained from every patient. Second, inaccurate registration of PET and CT images due to patient respiratory movements may affect measurements.
Background:
The role of adjuvant therapy in completely resected primary tumors that have both components of non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) ("combined small-cell lung cancer") is poorly understood. We sought to determine the potential benefits of adjuvant chemotherapy in patients who undergo complete resection for early-stage combined SCLC.
Methods:
Overall survival of patients with pathologic T1-2N0M0 combined SCLC who underwent complete resection in the National Cancer Database from 2004-2017, stratified by adjuvant chemotherapy versus surgery alone, was evaluated using multivariable Cox proportional hazards modeling and propensity score-matched analysis. Patients treated with induction therapy and those who died within 90 days of surgery were excluded from analysis.
Results:
Of 630 patients who had pT1-2N0M0 combined SCLC during the study period, 297 patients (47%) underwent complete R0 resection. Adjuvant chemotherapy was administered to 63% of patients (n=188), and 37% of patients underwent surgery alone (n=109). In unadjusted analysis, the 5-year overall survival was 61.6% (95% CI: 50.8-70.7) for patients who underwent surgery alone and 66.4% (95% CI: 58.4-73.3) for patients who underwent adjuvant chemotherapy. In multivariable and propensity score-matched analysis, there were no significant differences in overall survival between adjuvant chemotherapy and surgery alone (adjusted hazard ratio 1.16; 95% CI: 0.73-1.84). These findings were consistent when limited to healthier patients who have at most one major co-morbidity or patients who underwent lobectomies.
Conclusions:
In this national analysis, patients with pT1-2N0M0 combined SCLC treated with surgical resection alone have similar outcomes to those who undergo adjuvant chemotherapy.
