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Analysis of samples by scanning electron microscopy. (a) Formulation 1 indicates the ingredients for this novel formulation of ACM by direct compression. (b) Formulation 2 indicates the ingredients for the old traditional formulation of the ACM by wet granulation, and (c) indicates a side-by-side comparison of the structural morphologies of MCC with RMAS particles showing morphological similarity.
Source publication
The conventional approach in the tablet formulation of acetaminophen (ACM) suggests the use of five or more different excipients in a wet granulation tableting process. The use of many excipients in tablet formulation may negatively create excipient-excipient interactions, excipient-drug interactions, exaggerated product side effects, and high drug...
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