| An initial rigorous analysis for detected virus sequences in blood samples with reduced LVEF detected no significant correlation. Analysis of paramyxovirus (A) orthomyxovirus (B) or total combined paramyxovirus and orthomyxovirus (C) sequences detected no significant correlation on simple regression analysis.

| An initial rigorous analysis for detected virus sequences in blood samples with reduced LVEF detected no significant correlation. Analysis of paramyxovirus (A) orthomyxovirus (B) or total combined paramyxovirus and orthomyxovirus (C) sequences detected no significant correlation on simple regression analysis.

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Background Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown. Objective An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function. Methods Hi...

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Context 1
... sequence detection was read blinded by four investigators (ST, SS-C, AV, AL). No significant correlations were detected for measured LVEF post chemotherapy; r = 0.177 for paramyxovirus (p = 0.4961, Figure 3A), and r = 0.208 for orthomyxovirus (p = 0.4229, Figure 3B). Screening for LVEF and a combined analysis of paramyxovirus and orthomyxovirus virus sequences detected a minimal, but again non-significant, increase in the correlation with reductions in LVEF reported on 2D echo post chemotherapy (r = 0.233, p = 0.3732, Figure 3C). ...
Context 2
... sequence detection was read blinded by four investigators (ST, SS-C, AV, AL). No significant correlations were detected for measured LVEF post chemotherapy; r = 0.177 for paramyxovirus (p = 0.4961, Figure 3A), and r = 0.208 for orthomyxovirus (p = 0.4229, Figure 3B). Screening for LVEF and a combined analysis of paramyxovirus and orthomyxovirus virus sequences detected a minimal, but again non-significant, increase in the correlation with reductions in LVEF reported on 2D echo post chemotherapy (r = 0.233, p = 0.3732, Figure 3C). ...
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... significant correlations were detected for measured LVEF post chemotherapy; r = 0.177 for paramyxovirus (p = 0.4961, Figure 3A), and r = 0.208 for orthomyxovirus (p = 0.4229, Figure 3B). Screening for LVEF and a combined analysis of paramyxovirus and orthomyxovirus virus sequences detected a minimal, but again non-significant, increase in the correlation with reductions in LVEF reported on 2D echo post chemotherapy (r = 0.233, p = 0.3732, Figure 3C). This would suggest that RNA virus gene signatures are detectable at low levels in blood samples FIGURE 2 | RNA virus sequence reads detected in blood samples demonstrated no significant association for orthomyxovirus (A), paramyxovius (B) nor retrovirus (C) with bortezomib or with dexamethasone for detected paramyxovirus reads (D). ...
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... was an unbiased screen for the detection of RNA virus sequences in venous blood samples in cancer patients receiving chemotherapy. On the initial more rigorous analysis, both paramyxovirus and orthomyxovirus sequences were detectable, but had no clear correlation with changes in LVEF (Figure 3). The orthomyxovius Influenza A has a wellknown association with viral myocarditis, but demonstrated similar correlations with LVEF measured prior to, or after, chemotherapy (6-9). ...