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![Amino acid sequence homology of mouse, human, and bovine SLO3. Conserved regions are highlighted in blue. Sequence alignment performed using Jalview Version 2 [39-41].](publication/371388246/figure/fig1/AS:11431281166434854@1686241832303/Amino-acid-sequence-homology-of-mouse-human-and-bovine-SLO3-Conserved-regions-are.png)
Amino acid sequence homology of mouse, human, and bovine SLO3. Conserved regions are highlighted in blue. Sequence alignment performed using Jalview Version 2 [39-41].
Source publication
Sperm cells must undergo a complex maturation process after ejaculation to be able to fertilize an egg. One component of this maturation is hyperpolarization of the membrane potential to a more negative value. The ion channel responsible for this hyperpolarization, SLO3, was first cloned in 1998, and since then much progress has been made to determ...
Context in source publication
Context 1
... as is the case with many reproductionrelated genes, SLO3 has evolved rapidly. SLO3 shows only 60% protein sequence identity between mouse, human, and bovine (Figure 1), whereas the SLO1 protein sequence is 90% identical across the same species [48]. Moreover, SLO3 has accumulated species-specific features, which we will discuss later in this review. ...
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