Alterations of fecal bacterial microbiota profile. a Venn diagram intuitively presents the number of the common and exclusive OTUs between the CRC and the HC group calculated through R software. b The boxplot of Shannon index shows the difference in OTU diversity between the CRC and the HC group (p = 0.0054). c The boxplot of Simpson index shows the difference in OTU diversity between the CRC and the HC group (p = 0.0074). d PCoA using Bray–Curtis of beta diversity in CRC and HC groups. CRC, colorectal cancer; HC, healthy controls

Alterations of fecal bacterial microbiota profile. a Venn diagram intuitively presents the number of the common and exclusive OTUs between the CRC and the HC group calculated through R software. b The boxplot of Shannon index shows the difference in OTU diversity between the CRC and the HC group (p = 0.0054). c The boxplot of Simpson index shows the difference in OTU diversity between the CRC and the HC group (p = 0.0074). d PCoA using Bray–Curtis of beta diversity in CRC and HC groups. CRC, colorectal cancer; HC, healthy controls

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Studies of both, microbiota and target therapy associated with gene mutations in colorectal cancer, (CRC) have attracted increasing attention. However, only a few of them analyzed the combined effects on CRC. we analyzed differences in intestinal microbiota of 44 colorectal cancer patients and 20 healthy controls (HC) using 16S rRNA gene sequencing...