Figure 5 - uploaded by Carlos Humberto Andrade-Moraes
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Absolute bilateral cell number (A and C) and density (B and D) for neuronal, non-neuronal, and total cells in the grey (A and B)
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... of the absolute number of neurons showed significant differences among groups ( Fig. 5A and Supplementary Table 7). Using Tukey's multiple test, a significant reduction of 29% was found in the demented-patients with Alzheimer's disease (8.38 billion) when compared with controls (11.8 billion), and 25% when compared with the asymptomatic subjects with Alzheimer's disease (11.12 billion), but no difference when asymp- ...
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... subjects (19.4 billion), and a similar increase when compared with asymptomatic patients with Alzheimer's disease (19.2 billion). However, no signifi- cant difference was found when control and asymptomatic subjects with Alzheimer's disease were compared. For non-neuronal cell dens- ity, one-way ANOVA showed a significant difference among groups (Fig. 5B). When compared with control subjects (34.04 million/g), a significant increase of 51% was found in the demented patients with Alzheimer's disease (51.49 million/g) and of 35% when compared with the asymptomatic subjects with Alzheimer's subjects (38.19 mil- lion/g). However, no significant difference was found between asymptomatic ...
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... for mass, ANOVA revealed a significant difference of neuronal density in the cerebral cortex among groups (Fig. 5B). Post hoc analysis showed a significant reduction of 26% in demented patients with Alzheimer's disease (15.24 million/g) when compared with control subjects (20.7 million/g) and $31% when compared with the asymptomatic subjects with Alzheimer's disease (22.12 million/g), but no difference when asymptomatic Alzheimer's disease and ...
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... showed no significant difference in the absolute neuronal composition and neuronal density of total subcortical white matter between control, asymptomatic subjects with Alzheimer's disease, and demented patients with Alzheimer's disease. The proportion of neurons was low and similar in all groups ( Fig. 5C and ...
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Citations
... ). Au-delà des pertes synaptiques, il faut également préciser que les DTA sont aussi caractérisées par des pertes neuronales qui joueraient un rôle central dans l'apparition des déficits cognitifs. En effet, si l'étendue de l'amyloïdopathie ou de la tauopathie ne permet pas de différencier les individus asymptomatiques des patients, la présence d'une perte neuronale serait spécifique des individus souffrant de symptômes cognitifs(Andrade-Moraes et al. 2013). ...
Mild Cognitive Impairments (MCI) often precedes Alzheimer’s disease (AD) and is characterized by the loss of entorhinal neurons leading to a hippocampal disconnection. However, MCI patients also revert to normal cognition, suggesting compensatory mechanisms that alter the disease progression. This compensation may be impaired in patients bearing the APOE4 allele that are more prone to MCI, present less cognitive reversion and faster transition to AD.This work in mice, demonstrated that the sprouting of cholinergic fibers compensates entorhinal lesions through the reduction of the related hippocampal hyperactivity. As in APOE4 mice the cholinergic sprouting was altered in association with cognitive impairments, such impaired synaptic compensation may contribute to the faster cognitive decline of these patients. Therefore, supporting or mimicking the cholinergic control on hippocampal hyperactivity may represent a promising alternative therapeutic strategy for APOE4-carriers.
With black hole explosion under incredibly high temperatures leading to cosmic information billions of years ago, all matters had been in gaseous phase. With temperature dropping, under atomic attractive forces, adjacent atoms which made up gases attracted each other and formed a variety of big, small or tiny gaseous lumps. With the temperature persistently dropping, the tiny gaseous lump became colder and contracted and got smaller and turned into one in liquid state and subsequently in solid state according to the principle of expanding when heated and contracting when cooled in general cases. Gradually it developed and formed a human- or animal-like fetus or a plant-like seed. If it had the same compositions as a human, cow or sunflower, the human, the cow or the sunflower formed. Similar cases happened to other humans, animals and plants. Humans neither evolved from apes nor shared a common ancestor with apes.
