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‘Indian Madder’ (Rubia cordifolia L.) has wide range of pharmacological properties. In the present study, an attempt was made to identify the pharmacognostic features of various parts of R. cordifolia to differentiate it from adulterants. The organoleptic characters, proximate analysis, physio-chemical behavior of powders were recorded. The stomata...
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Rubia cordifolia Linn (Rubiaceae) is a climbing perennial herbal plant, which is widely distributed in China and India. Its root and rhizome, Rubiae Radix et Rhizoma (called Qiancao in China and Indian madder in India), is a well known phytomedicine used for hematemesis, epistaxis, flooding, spotting, traumatic bleeding, amenorrhea caused by obstru...
Citations
... In the Indian states of Mahabaleswar, Amboli, and Maharastra, R. cordifolia is widely distributed at high elevations. [109,110] In India, this medication is used to treat amenorrhoea, dropsy, paralysis, menstrual discomfort, urinary system disorders, Shi Feng Bi (rheumatism), and jaundice. [111,112] In China, a formula known as "Er-Xie-Ting granule" is likewise mostly composed of R. cordifolia and is used to treat acute infantile diarrhoea. ...
... [17] Rubia cordifolia extracts from the various parts of the plant are shown to have several pharmacological benefits including acne and wound treatment, anti-diuretic, anti-ulcer, cardiac disorders and various anti-inflammatory conditions. [18,19] R. cordifolia is commonly used mostly by the Maasai, Kuria and Kisii communities in Kenya for the treatment of malaria and other diseases. [20] This study aimed to investigate the anti-plasmodial efficacy of extracts from the aerial parts of Rubia cordifolia against P. falciparum chloroquine sensitive and resistant strains and qualitative phytochemical composition. ...
... Its dried samples are sold in the market under the name "Manjith". R. cordifolia is very common at high altitudes, Mahabaleswar, Amboli and Maharastra state in India (Adwankar et al., 1980;Siril, 2013). This drug is used to treat Shi Feng Bi (rheumatism), menstrual pain, urinary system diseases, dropsy, paralysis, amenorrhea and jaundice in India (Tripathi et al., 1993;Adams et al., 2009). ...
Rubia cordifolia (family: Rubiaceae) L (R. cordifolia) is a perennial botanical drug climbing vine. As the main part of the traditional Chinese medicine, the rhizome has a long history. A great number of literary studies have reported that it can be used for the improvement of blood circulation, hemostasis, activation of collaterals, etc. When it comes to the wide application of R. cordifolia in traditional medicine, we systematically review its traditional uses, phytochemistry and pharmacological effects. Literatures were systematically searched using several scientific databases, including China National Knowledge Infrastructure (CNKI), Baidu Scholar, PubMed, Web of Science, and other professional websites. Kew Botanical Garden and the iPlant were used for obtaining the scientific names and plant images of R. cordifolia. In addition, other information was also gathered from books including traditional Chinese herbal medicine, the Chinese Pharmacopoeia, and Chinese Materia Medica. So far, many prescriptions containing R. cordifolia have been widely used in the clinical treatment of abnormal uterine bleeding, primary dysmenorrhea and other gynecological diseases, allergic purpura, renal hemorrhage and other diseases. The phytochemistry studies have reported that more than 100 compounds are found in R. cordifolia, such as bicyclic peptides, terpenes, polysaccharides, trace elements, flavonoids, and quinones. Among them, quinones and peptides are the types of components with the highest contents in R. cordifolia. The modern pharmacological studies have revealed that R. cordifolia and its derived components have anti-tumor, anti-oxidative, anti-platelet aggregation, and anti-inflammatory effects. However, most studies are preclinical. The pharmacological mechanism of R. cordifolia has not been thoroughly studied. In addition, there are few pharmacokinetic and toxicity studies of R. cordifolia, therefore the clinical safety data for R. cordifolia is lacking. To sum up, this review for the first time summarizes a systemic and integrated traditional uses, chemical compositions, pharmacological actions and clinical applications of R. cordifolia, which provides the novel and full-scale insight for the drug development, medicinal value, and application of R. cordifolia in the future.
... These pigments are often responsible for the pigmentation of colored heartwood and bark of many economically valuable plants. In intact powdered form, it exhibits different shades of colors (Priya andSiril, 2013, Samatha andVasudevan 1996, Mishra et al.,) and an array of different colored dyes was also derived (Patel and Patel, 2016) (Teuscher and Lindequist, 1994). In fungi, it is represented in Aspergillus, Penicillium, and Trichoderma species (Betina et al., 1986). ...
Background: The world is demanding an increased commercial requirement of various secondary metabolites
to cure numerous ailments. Anthraquinones (AQs), is one among them, responsible for the pigmentation of
heartwood and bark of many economically valuable plants. It is a natural red dye having an outstanding curative
application, used from time immemorial.
Main body of the abstract: AQs have been identified from various plants, animals and even from microbes. In
addition to their use in various pharmacopoeias, it is used in the textile industry, cosmetics, food etc. AQs always
been a fascinating molecule for chemists to synthesize and access diversely substituted derivatives as therapeutic
agents. Its curative efficiency is well utilized in the treatment of various modern diseases and even to Covid 19.
Moreover, the AQs exhibit a unique anticancer activity in various cell lines.
Short conclusion: The present work overviews the various effective uses of AQs and highlight its importance in
cancer therapy
... On the other hand, phenolic compounds were detected when the color of the mixture switches to dark blue or blue-green by mixing four drops of ferric chloride in methanolic solution with 0.5 mL of the extract [42]. Then, anthraquinones were detected by using the Bornträger reaction [43,44], 0.5 mL of the aqueous solution was mixed with 1 mL of benzene. After decantation, 0.5 mL of ammoniac 25% was added, the turn to red of the solution indicates the presence of anthraquinones. ...
Background
Madagascar shelters over 14,000 plant species, of which 90% are endemic. Some of the plants are very important for the socio-cultural and economic potential. Tampolo forest, located in the northeastern part of Madagascar, is one of the remnant littoral forests hinged on by the adjacent local communities for their daily livelihood. However, it has considerably shrunk due to anthropogenic activities forming forest patches. Thus, documenting the useful plants in and around the forest is important for understanding the ethnobotany in this area. Methods: In this study we (1) collected and identified useful plants utilized by local communities. Voucher specimens were collected following the information given by interviewees, (2) recorded the collection activities and the consumption methods through semi-structured interviews of the local inhabitants, and (3) performed a phytochemical screening to identify the active compounds and the potential healing metabolites of the medicinal plants. Results: A total of 65 people between 25 and 75 years old were interviewed. Surveys recorded 123 species used as timber, food, or medicine. Among them, 92 were forest species and 31 were ruderal species. Medicinal plants were mostly used to cure stomach ailments (71%), fever (33.3%), and fatigue (25%) with leaves (68%) being the most used plant part. Phytochemical analyses of 20 endemic medicinal species showed the presence of compounds that could be responsible for the therapeutic effects of the plants. Conclusions: Tampolo forest proves to be an important littoral forest highly utilized by the adjacent local communities due to the presence of a high number of useful plants which are mostly endemic to the region. Hence, our investigation assessed the importance of these species in the locality and this can be used for further study on ecology, conservation, and valorization of these species.
... On the other hand, phenolic compounds were detected when the color of the mixture switches to dark blue or blue-green by mixing four drops of ferric chloride in methanolic solution with 0.5 ml of the extract [42]. Then, Anthraquinones were detected by using the Bornträger reaction [43,44], a 0.5 ml of the aqueous solution was mixed with 1 ml of benzene. After decantation, 0.5 ml of ammoniac 25% was added, the turn to red of the solution indicates the presence of Anthraquinones. ...
Background
Madagascar shelters over 14,000 plant species out of which 90% are endemic to the region. Some of the plants are very important for the socio-cultural and economic potential. Tampolo forest is one of the remnant littoral forests hinged on by the adjacent local communities for their daily livelihood. However, it has considerably shrunk due to anthropogenic activities forming forest patches. Thus, documenting the useful plants in and around the forest is important for understanding the ethnobotany in this area.
Methods
In this study, we 1) collected and identified useful plants utilized by local communities. Voucher specimens were collected following the information given by interviewees. 2) recorded the collection activities and the consumption methods through semi-structured interviews of the local inhabitants. 3) did a phytochemical screening to identify the active compounds and the potential healing metabolites of the medicinal plants.
Results
A total of 65 people between 25 to 75 years old were interviewed. Surveys recorded 123 species used as timber, food or medicine. Among them, 92 were forest species and 31 were ruderal species. Medicinal plants were mostly used to cure diarrhea, stomachache, and fever with leaves being the most used plant part. Phytochemical analyses of 20 endemic medicinal species showed the presence of compounds that could be responsible for the therapeutic effects of the plants.
Conclusions
Tampolo forest proves to be an important littoral forest highly utilized by the adjacent local communities due to the presence of high number of useful plants which are mostly endemic to the region. Hence, our investigation assessed the importance of these species in the locality and this can be used for further study on ecology, conservation and valorization of these species.
... The decoction of the roots are effective against jaundice, paralytic affections, amenorrhea, menstrual cycle irregularities, kidney stones and urinary troubles. [25] R. cordifolia is proved to be active against a number of cancer cell lines such as P388, L1210, L5178Y, 1316 melanoma, sarcoma-180, and Lewig lung cancer. [26] Chemical analysis showed the presence of bicyclic pepides such as RA-XIV, RA-XVI that exhibits the anti-cancer property. ...
... More intensive colour was notice in leaf sample compare to root and stem indicating profound amount of alkaloid in the leaf tissue. [6] who performed phytochemical screening of the powdered plant parts of R. cordifolia. Contrasting results were reported for alkaloids, steroids, tannin, flavonoids and phenols, in leaf, stem and root extracts. ...
... It was positive in all solvents except aqueous extract. These results were in agreement withDevi & Siril (2013) ...
Neanotis montholonii (Hook F.) W.H. Lewis belongs to family Rubiaceae. Neanotis genus has been represented by ca. 10 species in Maharashtra state. The morphological, anatomical and phytochemical characteristics are pivotal in diagnostics taxa at taxonomic level. In the present investigation an attempt has been made to identify alkaloids, saponins and tannin by using histochemical tests of root, stem and leaf. The organoleptic character and stomatal index (23/mm2 area) were also recorded that aid in identification. Phytochemical study revealed the presence of active ingredients like alkaloids, flavonoids, glycosides, anthroquinones, amino acids, protein, saponins, steroids and tannins in all the parts those were subjected for analysis except starch that was absent in root. Among all four solvents viz. chloroform, ethanol, acetone and aqueous extract, ethanol showed positive tests in all plant parts. Histochemical and phytochemical information reveled in the present study can be used for developing standard parameters for the proper authentication of raw materials of pharmaceutical importance. The literature review reported that this study is the first of its kind in the Neanotis montholonii which is endemic to Maharashatra.
... The root has some peculiar characteristics includes sweet, acrid, bitter and astringent with following medicinal values such as antidysenteric, antipyretic, analgesic, antiinflammatory, antiseptic, constipating, diuretic, anodyne, galactopurifier, and rejuvenating tonic. Based on the above said properties the GS extract has been used to treat variety of ailments in the modern pharmacopeia [12][13][14] . ...
Diabetes mellitus is a dreadful disease caused by the increase in hepatic glucose production and impaired insulin action. The usage of herbal based medicine has been increasing tremendously in both developing and developed countries over the last three decades. The present study aims to provide a comprehensive review of antidiabetic activity of following medicinal plants like Gymnema sylvestris, Rubia cardifolia, Bilberry, Green Tea, Salacia reticulate, Berberis aristata, Pterocarpus marsupium, Fenugreek, Ashwagandha, Bitter melon. The efficiency of these medicinal plants may regulate the diabetic metabolic abnormalities. This work would help researchers to choose potential herbal for diabetic treatment
... Deoda et al. [20], evaluated the pharmacognostic, phytochemical and pharmacological properties of Rubia cordifolia, another plant component of septilin. Priya and Siril [71], also studied the pharmacognostical and phytochemical characters of Rubia cordifolia and further they reviewed the different medicinal properties of Rubia cordifolia in the treatment of various ailments. [41], suggested that Rubia cordifolia can be used as an adjuvant with chemotherapeutic drugs since, in their study it showed the reduction in the renal damage induced by chemotherapeutic drug cisplatin. ...
Septilin (Spt) is a polyherbal drug formulation from Himalaya Drug Company, consisting of extracts from different medicinal plants and minerals. In the traditional system of medicine, septilin is being used as immunomodulatory, antioxidant and anti-inflammatory agent. In the present study, the protective effects of septilin against the genotoxicity of cyclophosphamide (CP) a widely used alkylating anticancer drug was evaluated by using in vivo micronucleus (MN) and sperm shape abnormality assays in Swiss albino mice. CP administered intraperitoneally at a dose of 50mg/kg b.w. was used as positive mutagen. Different doses of septilin viz., 125, 250 and 500mg/kg b.w. was orally administered for 5 consecutive days. CP was administered intraperitoneally on 5th day. MN and sperm preparations were made after 24hrs and 35days respectively. CP induced significant MN in both bone marrow and peripheral blood cells and also a high frequency of abnormal sperms. In septilin supplemented animals, no significant induction of MN and abnormal sperms was recorded. In septilin supplemented groups, a dose dependent significant decrease in CP induced clastogenicity was observed. Thus the current in vivo study revealed the antigenotoxic effects of septilin against CP induced damage, in both somatic and germ cells of Swiss albino mice.
