- Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

(A) Hind paw withdrawal threshold of C57BI/6 J male mice after incision procedure and vehicle/drug (50 μl Popliteal Block) treatment, n = 8. (B) Basso Motor Scale (BMS) of C57BI/6 J male mice after incision procedure and vehicle/drug (50 μl Popliteal Block) treatment, n = 8. Data represented as mean ± S.E.M and analyzed by repeated measures two-way ANOVA followed by Sidak post-hoc test (*** represents p < 0.001, ** represent p < 0.01, * represents p < 0.05 in all cases vs vehicle treatment, # represents p < 0.05 and ### represents p < 0.001 vs bupivacaine treatment, n = 8.).