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3 Antihypertensive drugs and their contraindications 

3 Antihypertensive drugs and their contraindications 

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Technical Report
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The National Heart Foundation of Australia has updated the Guide to management of hypertension 2008: assessing and managing raised blood pressure in adults (updated December 2010). Main recommendations • For patients at low absolute cardiovascular disease risk with persistent blood pressure (BP)≥160/100mmHg, start antihypertensive therapy. • The de...

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... High blood pressure and elevated fasting total cholesterol levels, low-density lipoprotein cholesterol and triglycerides, and low levels of high-density lipoprotein cholesterol are biomarkers of increased risk of cardiovascular disease [63]. Several studies have investigated the effect of diets containing LKF on these cardiovascular disease risk biomarkers. ...
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... A study found that the expression of the EHBP1 protein was downregulated in cells overexpressing PCSK9. This revealed the existence of the EHBP1 accompanying pathway linked to lipid metabolism (Gabb et al., 2016). Moreover, SNPs of the rs2710642 and rs10496099 in the EHBP1 were correlated with low-density lipoprotein cholesterol (LDL-C) (Giagtzoglou et al., 2013) and atherosclerosis (Golan et al., 2019), respectively. ...
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The associations among the EH domain-binding protein 1 (EHBP1), tubulin beta class I (TUBB), and WW domain-containing oxidoreductase (WWOX) single nucleotide polymorphisms (SNPs) and coronary artery disease (CAD) and ischemic stroke (IS) are not yet understood. This study aimed to detect the associations of these SNPs, gene-gene and gene-environment interactions and CAD and IS in the Guangxi Han population. A total of 1853 unrelated subjects were recruited into normal control (n = 638), CAD (n = 622), and IS (n = 593) groups. Related genotypes were determined by high-throughput sequencing. The genotypic and minor allelic frequencies of rs2278075 were different between the CAD and control groups, and those of rs2710642, rs3130685, and rs2278075 were also different between the IS and control groups. The rs2278075T allele, rs3130685-rs2222896-rs2278075, rs3130685-rs2222896-diabetes, rs3130685-rs2222896-drinking, and haplotype rs2710642A-rs10496099C-diabetes interactions were associated with increased risk, while G-T-G-C-G-A and G-T-T-T-G-T-drinking were associated with reduced risk of CAD. The rs2278075T and rs2710642G alleles, rs2710642G-rs10496099C haplotype, rs3130685-rs2278075-rs2222896, and rs2710642-rs2278075-hypertension interactions aggravated the association with IS, whereas the rs3130685T allele, rs2710642A-rs10496099C haplotype and the interactions of H1 (s2710642A-rs10496099C)-H2 (rs2710642G-rs10496099C)-drinking and I1 (A-C-G-C-A-A)-I3 (A-C-G-T-A-A)-I4 (A-C-G-T-G-A)-I5 (G-T-G-C-G-A) diminished the association with IS. Carrying WWOX rs2278075T was strongly associated with CAD or IS, while EHBP1 rs2710642 and TUBB rs3130685 might alter the association of IS by modifying the serum lipid profile. This study demonstrates that the EHBP1, TUBB, and WWOX SNPs, gene-gene and gene-environment interactions are associated with the risk of CAD and IS in the Guangxi Han population.
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Courses Health Communication, Science Communication, Interpersonal Communication. Objective This activity prepares students to explain jargon effectively when communicating with individuals who have low health literacy by utilizing clear communication strategies.
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ABSTRAKHipertensi merupakan penyebab kematian nomor satu di dunia setiap tahun. Tingginya angka kematian penderita hipertensi di Indonesia merupakan pertanda bahwa masyarakat masih belum memahami pentingnya kepatuhan dalam melakukan pengobatan dan perubahan gaya hidup (life style). Tujuan kegiatan pengabdian ini adalah sebagai upaya mempersiapkan ners fresh graduate yang merupakan tenaga kesehatan sehingga mampu mendampingi pasien hipertensi dalam merencanakan perubahan gaya hidup menjadi lebih sehat. Kegiatan pendampingan untuk ners fresh graduate dilaksanakan melalui Whatsaap dan google meet. Tahap persiapan berkoordinasi dengan 2 orang ners fresh graduate dan menentukan siapa yang akan menjadi peserta kegiatan. Tahapan pelaksanaan adalah menyusun skenario reschedule lifestyle card dan memberikan pendampingan dalam penyusunan reschedule lifestyle. Hari pertama hingga hari ketiga tim memberikan pendampingan, peserta mengidentifikasi gaya hidup penderita hipertensi dalam 1 minggu terakhir dan berdasarkan hasil identifikasi mengembangkan pola hidup yang lebih sehat. Melalui kegiatan pendampingan ini didapatkan hasil kemampuan ners fresh graduate dalam penyusunan reschedule lifestyle pasien hipertensi meningkat. Kata Kunci : hipertensi; reschedule; lifestyle ABSTRACTHypertension is the number one cause of death in the world every year. The high mortality rate for hypertension sufferers in Indonesia is a sign that society still does not understand the essence of taking medication and changing lifestyle. The purpose of this service activity is to prepare new graduates who are health workers so that they can assist hypertensive patients in planning lifestyle changes to be healthier. Mentoring activities for new graduates are carried out through Whatsaap and google meet. The preparation stage coordinates with 2 new graduates and determines who will be participants in the activity. The stages of implementation are compiling a lifestyle card rescheduling scenario and assisting in preparing a lifestyle to reschedule. From the first day to the third day the team assisted, participants who lived the lifestyle of hypertensive sufferers within 1 week and based on the results of the examination developed a healthier lifestyle. Through this mentoring activity, the results of the ability of fresh graduate nurses in preparing hypertension patient lifestyle rescheduling have increased Keywords: hypertension; reschedule; lifestyle