Spray Drying

Spray Drying

  • Jeffrey G. Tait added an answer:
    Does anyone know of an aerosol device able to spray small quantities of liquid nano-microlitres?
    We would like to apply small quantities of liquid as an aerosol to specific objects.
    Jeffrey Tait · imec Belgium
    Along with Emanuele, our group uses ultrasonic spray coating for a multitude of materials and solvent systems. Another option you may consider if the Aerosol Jet system from Optomec. These operate with either ultrasonic atomization or pneumatic, and print lines on the order of 10um wide with a precise deposition control system for the volumes you are looking at.
  • Jeffrey G. Tait added an answer:
    Can anyone shed some light on how to go about doing a co-current spray dryer design to manufacture detergents?
    The spray dryer is using a pressure nozzle.
    Jeffrey Tait · imec Belgium
    Depending on your design requirements, and if you are considering ultrasonic atomization, I have successfully used concurrently pumped nozzles from Sono-tek. With some design alterations it is possible to control the exact solution meeting point within the horn, or at the nozzle tip. I have used these nozzles for spraying a variety of different surface tension and viscosity inks in the field of organic photovoltaics.
  • Closed account added an answer:
    Which is best to use, Tween 20 and Tween 80?
    I'm wondering if its possible to use Tween 20/80 as a carrier/solubilizer to dissolve a hydrophobic substance. So far, I tried heating either Tween to around 70C, and it manage to dissolve my hydrophobic substances. But when I remove it from the heat plate, it starts to turn into like white solid like ghee, which I guess happens because of the decrease in temperature to the cloud point? Anyway, I'm trying to understand the differences in both Tween. I read somewhere that tween 20 is better to emulsify small amounts of lighter oils; whereas Tween 80 to emulsify larger amounts of heavier oil. Then I check the HLB value (wikipedia) in which: 12 to 15: detergent 12 to 16: O/W (oil in water) emulsifier 16 to 20: solubiliser or hydrotrope Tween 20 (16.7) seems like a better choice as it can act as a solubiliser or O/W emulsifier compare to Tween 80. But then other sources said tween 80 is better to emulsify larger amount of heavier oil?Which sounds like its better to solubilised my hydrophobic substances. Erm. Do correct me if I'm wrong. Appreciated.
    In order to use either tween 20 or 80 y have to look for pH of te midium each one works in different situation pH, type of oil, amount of olis.......etc
  • Elias Baghdan asked a question:
    What is the best fluorophore for the labeling of a spray dried chitosan?
    In my lab work, I dissolve Chitosan in 1% acetic acid to be applied in spray drying. For the characterization of the spray dried product (Chitosan Acetate), I need to label the chitosan with suitable fluorophore. That means this fluorophore should work in acidic medium and is convenient for spray drying application.
  • Steva Levic added an answer:
    What is the most suitable solution for bacterial cell release after spray drying immobilization?
    I am working with alginate and chitosan immobilization of bacterial cells. I am experiencing some difficulties in the assessment of the process yield, in what concerns to determining the viable number of cells after spray drying. I am now resuspending the spray dried product in NaCl 0,85% and make successive dilutions for spreading. However, after 24h, few cells have been released.
    Steva Levic · University of Belgrade
    1. Alginate should be soluble even in water (without NaCl). But in this case NaCl is necessary for bacterial cell osmotic stability. 2. Chitosan is soluble in diluted acids (HCl or acetic acid). 3. Do you see any visual changes in your suspension upon addition to NaCl solution? Are particles completely disintegrated. If not, try with magnetic stirrer to break particles. 4. Are you used proven protocol for spray drying of bacterial cells? Conditions during spray drying are critical for cells viability.
  • Olivia Ho added an answer:
    Anyone an expert on Antioxidant Assay (ABTS)?
    I'm a total newbie on antioxidant assay. Trying to determine antioxidant activity of an encapsulated polyphenolic compound So I was looking at some journals for ABTS Assay procedures, and got quite confused as below: 1)http://download.springer.com/static/pdf/786/art%253A10.1007%252Fs00217-013-1982-1.pdf?auth66=1392101239_329b5b3a9126a53a8de31a092af2cfd2&ext=.pdf & http://staff.science.nus.edu.sg/~scilooe/srp2002/sci_paper/Biochem/research_paper/Tan%20Tze%20Guan1.pdf 2) http://www.ifrj.upm.edu.my/18%20(04)%202011/(32)IFRJ-2011-023.pdf This is the confusion part for me: For (1), 7mM ABTS solution mixed with K2S2O8 solution. In that mixture, the concentration of K2S2O8 is 2.45mM. Whereas for (2) equal amount of 7mM ABTS solution is mixed 2.45mM K2S2O8 solution. Doesnt that mean the final concentration of K2S2O8 in that mixture is 1.225mM. Is (2) correct. Are they trying to get final concentration of 1.225mM. Or am I reading it incorrectly?
    Olivia Ho · Monash University (Malaysia)
    Wait Im confuse,the 2 papers that you attached. 1 said mix with 2.45 mM K2S2O8 whereas 1 said mix with K2S2O8 inwhich the final concentration of K2S2O8 in that mixture is 2.45 mM
  • Olivia Ho added an answer:
    Newbie here: How to determine Encapsulation Efficiency of an encapsulated hydrophobic antioxidant
    I am thinking of encapsulating a hydrophobic antioxidant (lets call it A) using a spray dryer. Since it is hydrophobic, i was thinking of dissolving A with a vegetable oil, maltodextrin as a wall material and gum arabic as surfactants in water. This emulsion is then spray dried. However, I am not too sure how to determine encapsulation efficiency. Any advice? *sadly i do not process a spray dryer capable of handling solvent.
    Olivia Ho · Monash University (Malaysia)
    Hi Robin Joshi, thanks for answering. Besides using HPLC and GC, are there any other ways?
  • Oleg Gusev added an answer:
    What is the main difference between gram-negative and gram-positive bacteria in relation to desiccation tolerance?
    I would like to make a comparison between gram-negative and gram-positive bacteria in relation to desiccation tolerance.
    Oleg Gusev · Kazan (Volga Region) Federal University
    Oh, interesting, is the Mn(II) story is taking place in the taxa other than Deinococcus ?
  • Stephen Warren added an answer:
    Has anyone (else) used dry-spraying of a nitric acid solution to obtain gas-phase nitric acid?
    We used it for generating the highly adsorptive nitric acid vapor as an alternative for the permeation tube (discussed by Karl Cammann in these topics). It is briefly described in Artefacts in the sampling of nitrate studied in the “INTERCOMP” campaigns of EUROTRAC-AEROSOL M. Schaap et al Atmospheric Environment. 12/2004; 38(38):6487-6496
    Stephen Warren · Marlow
    Harry - I was director of the environment lab for the UK water authorities from 1980 -1987. Acid rain was a minor problem for them and we avoided it because it was a crowded field already. in 1982 I was asked to chair a government committee because the state electric power company was at war with the state-funded environment laboratories. My job was to keep the peace while we produced a report. I was a neutral with a background that meant I could pick up the science as we went along. We finished in 1984 and I left the subject then but had learned a lot and not all to do with acid rain! I left the water research centre in 1992 after the govt privatised the water authorities and spent the next 18 years working as a consultant in former communist countries, on EU, WB, or nationally funded projects.
  • Katerina Simkova added an answer:
    Unstable spray in spray drying - can anyone help?
    Can someone please share some thoughts on why do I get an unstable spray in spray drying? The spray is pulsating (looks like it is spitting). It does not matter what kind of solvent/solution/suspension/emulsion I am feeding, the result is always the same. The system is Büchi P-290.
    Katerina Simkova · University of Applied Sciences and Arts Northwestern Switzerland
    Hello Alen, so we had our spray dryer checked last week and it seems that it helped (but I didn't try so far anything else than water). We had problem with the most inner part of the nozzle and with the cap that you put on as first when you assemle the whole nozzle. Thus the nozzle's inner part was not symetrically positioned in the cap where it comes into conntact with the atomizing gas. Regards, Katerina
  • Michele Bonus added an answer:
    Is mannitol soluble in acetone?
    I have checked online and of course I found information that it is soluble. But dissolving mannitol in distilled water and injecting it into a beaker containing acetone produced precipitates of mannitol. So please is mannitol really soluble in acetone?
    Michele Bonus · Heinrich-Heine-Universität Düsseldorf
    You're welcome!

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