Lupus and rna

Hi, I am not so familiar with the medical health part of that disease more with the biological part, but I think people would need to take immunsuppressive medicine all over the entire life since the molecular background behind that disease (e.g. mutations) can not get reverted to original stage (healthy stage). The mutation can not get cured.

@Nicole Forster, i mean (odapus) people with lupus usually called in indonesia, can cure as before the lupus active in their body, because the mutation is hard to cure.....is it?...

Sure we can help you as long as the list is not containing 50 papers ;-)

to Mr vladimir teif, thank you for the advice, i have do some search in google, but most journal should be purchased first, and i dont have any account yet...so i cant access it, can you help me???

I agree with Vladimir, that we can help you sending you papers in case you do not have access to. What do you mean by your question, if "people with lupus, can cure 100%, like before?"

are people with lupus, can cure 100%, like before............?

alrigth, thanks for the explanation, i have searched in google and pub med, but some good journal, it must has an account to acsess, and i haven't account yet, so i can't acsess it.....do you have more journal related with lupus that you can share to me....?///

Maybe I did not explain that well enough. The mutation in the FasLigand is just an observation people received when they check the mouse model therefore. It is just one example what might happen. I have no idea if there is a specific factor/virus leading to that mutation. Furthermore, I even do not think it is just one specific mutation in that protein, I guess there might be several different once observed leading to the same effect. Why do you not search in google and pubmed for that? These are so overall questions from which I am not quite sure if there will be JUST ONE specific answer for. I have no idea about the EBV function in SLE.

ok thanks for the explanation, but a still have a question : so, what factor that cause the mutation happened?...and what about the virus for example (EBV), epstein barr virus, is it has some role in the mutation,......???

Hi! The disease "Systemic Lupus Erythematosus" is not related with ONE specific gene. There are several functions of different proteins involved in that protein. The classical model is a mutation of the FasLigand which is involved in apoptosis and therefore leading to failed apoptosis of self-reactive cells. On the other hand, epigenetic regulation and genes regulated via the p300 acetyltransferase activity are involved in that phenotype (see Forster et al., Journal of immunology 2007). You can read the introduction of that paper as well as a couple of review articles showing that it is a very complex disease and not just occuring due to one gene mutation etc. I hope that helps. If you would have more specific questions I can try to answer them.