Shake the dichloromethane with colorless drierite (calcium sulfate), scintered glass filter and store over heat-dried molecular sieves. This concept for drying solvents can be found in volume 1 ofShake the dichloromethane with colorless drierite (calcium sulfate), scintered glass filter and store over heat-dried molecular sieves. This concept for drying solvents can be found in volume 1 of Fieser and Fieser.

CAN/ PYRIDINE system is the best.

HI Joerg! I am glad u think like me! Even I thought of McMurry Coupling. And i tried to perform it! but the hemithioacetal broke off as u expected! so i adjusted the synthetic starategy such thatHI Joerg! I am glad u think like me! Even I thought of McMurry Coupling. And i tried to perform it! but the hemithioacetal broke off as u expected! so i adjusted the synthetic starategy such that this hemthioacetal doesnt show up when i needed to perform this step! and it worked but gave me a dimer of the compound on left ( having dimerization from the cyclopentanone's carbonyl group). I will try to work it out some how ( coz i just dont give up)! ok then thanks anywayz! see yaar later! bye!

Check out Prof. Patrick Walsh's (Univ of Pennsylvania) research on 1,1-alkenylboronate esters published in JACS. Check for two papers, one on generation of 1,alkenyl-1,1-heterobimetallics by HongmeiCheck out Prof. Patrick Walsh's (Univ of Pennsylvania) research on 1,1-alkenylboronate esters published in JACS. Check for two papers, one on generation of 1,alkenyl-1,1-heterobimetallics by Hongmei Li and the other on its application, in which I am the first author (check my publication in JACS). Also might be helpful to check out Prof. Gary Molander's research on trifluoroborates (Univ of Pennsylvania).

Thank you both of you :-) Have a nice day ~

I agree with Hans on n butanol acetic acid and water even in ratio of 4:1:3 works excellently well for many compounds separation. regards dr kurani

Hi, There are many, both those in which the nitro group is attached to an aliphatic C and some in which it is attached to a phenyl ring, AND all in the same molecule as the lactone (five-memberedHi, There are many, both those in which the nitro group is attached to an aliphatic C and some in which it is attached to a phenyl ring, AND all in the same molecule as the lactone (five-membered only searched). In no case was Zn used to reduce the nitro group, Fe once (#608), SnCl2 once (#1143), and R3SiH once (#734. The rest (at least those which listed the reducing agent) were all catalytic hydrogenation. See the attached list. Bill

Try to oxidize the phosphorous atom with H2O2. Just dissolve in an organic solvent and wash 3 times with 10% H2O2 aqeous solution. Should change the Rf of the Binap. Works good with PPh3, but ofTry to oxidize the phosphorous atom with H2O2. Just dissolve in an organic solvent and wash 3 times with 10% H2O2 aqeous solution. Should change the Rf of the Binap. Works good with PPh3, but of course your compound should not be sensitive to hydrogen peroxide. Good Luck!

First treat with NaOH and than oxidise with OsO4 or after NaOH it react with halogen atom & than oxidise With KMnO4.

The strenuous catalyst such as AlCl3 is not suitable for acylation of heterocyles due to their reactivity. you can use TiCl4, SnCl4, FeCl3, TFA this interns depends on the nature of the substituentThe strenuous catalyst such as AlCl3 is not suitable for acylation of heterocyles due to their reactivity. you can use TiCl4, SnCl4, FeCl3, TFA this interns depends on the nature of the substituent located in 1,2,3 positions.

Hi............you just use exact 2 equiv dimethyl sulfate in excess k2co3 in dry acetone........and see what happens

POCl3 based dehydration could be carried out in Pyridine - try and see.

Hi, This might work: Bill A novel method for the regeneration of alcohols from toluenesulphonates using CeCl3.7H2O-NaI system By Reddy, G. Sudhakar et al From Synthetic Communications, 30(21),Hi, This might work: Bill A novel method for the regeneration of alcohols from toluenesulphonates using CeCl3.7H2O-NaI system By Reddy, G. Sudhakar et al From Synthetic Communications, 30(21), 3829-3832; 2000 General/Typical Procedure: In a typical reaction, 2.7 mmol, of the substrate (entry 4,table 1), and CeCl3.7H2O (1.2grns, 3.2 mmol) in acetonitrile(8 ml) was treated with NaI (0.48 gms,3.2 mmol) and was refluxed until the tlc indicated that no starting materials remained. The reaction was quenched with 1 M HCl and the solvent was removed in vacuum. The crude material was dissolved in dichloromethane, washed with water and dried over Na2SO4. Upon solvent removal the crude was purified by column chromatography. The structure of the naphthol thus obtained was confirmed from the 1H NMR , IR and Mass spectral analysis by comparing with the authentic samples. Table-1, Entry 7: yield 90%.

Thank you . I will try out and see the results