A plateform for people who work in this specific area of cancer biology

• salman farooq

  Are there any tumor markers for brain tumors

  In our hospital set up we come across a lot of brain tumors and to investigate the lesions we go for invasive procedures. I'm in search of literature on brain tumor markers

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    Pawel Buczkowicz replied

    If you're asking about diagnostic markers then the only one for brain tumours is the absence of INI1 on IHC, which gives the diagnosis of ATRT. There are also obviously combinations of differentIf you're asking about diagnostic markers then the only one for brain tumours is the absence of INI1 on IHC, which gives the diagnosis of ATRT. There are also obviously combinations of different IHC stains and pathology which are used for brain tumour diagnosis and grading but there is some grey areas here. INI1 is the only one that is "bulletproof".

    Apr 11, 2012
• Maninder Kaur

  Is there any signalling pathway of PRMT5 in brain primary tumor?

  miR-92b is over expressed in brain primary tumor, and i found that PRMT5 is upregulated in brain primary tumor. The target gene is PRMT5 .

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    Santoso Cornain replied

    PRMT5 has been studied in its role in tumor growth promotion; related to its suppressive effect on transcription of tumor suppressor genes, Rb family, ST7 and nonmetastasing nm23 protein arginine .PRMT5 has been studied in its role in tumor growth promotion; related to its suppressive effect on transcription of tumor suppressor genes, Rb family, ST7 and nonmetastasing nm23 protein arginine . The overexpression in brain tumor might be accompanied by reduced expression of the functional tumor suppressor proteins.

    Mar 21, 2012
• Manoranjan Santra

  Is there any therapy for brain tumor- glioblastoma?

  Hi: I am working on gene therapy for glioblastoma brain tumor and stroke. I am using a glioblastoma suppression gene-doublecortin which induces neuronal differentiation of glioblastoma stem cells,Hi: I am working on gene therapy for glioblastoma brain tumor and stroke. I am using a glioblastoma suppression gene-doublecortin which induces neuronal differentiation of glioblastoma stem cells, achieve remission of glioblastoma xenografts in nude (nu/nu) rats and prolong animal survival.

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    Bernhard Biersack replied

    That's a very interesting method, Dr. Santra. Is your method also suitable to treat Temozolomide-resistant brain tumors? I think it would induce differentiation of non-cancerous neural stem cells,That's a very interesting method, Dr. Santra. Is your method also suitable to treat Temozolomide-resistant brain tumors? I think it would induce differentiation of non-cancerous neural stem cells, too. That might be interesting concerning the repair of damaged parts of the brain.

    Feb 24, 2012
• B.Thamarai Chelvi

  How is research carried out in brain medical image segmentation ,

  Features extraction for brain tumor and other diseas

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    B.Thamarai Chelvi replied

    Nowadays all are concentrating on tumor is there any interesting problem related to brain image segmentation ,give me ideas in this regard please

    Dec 16, 2011
• Gian Paolo Andreoletti

  Resistance to temozolomide in xenograft models of glioblastoma multiforme

  Http://www.jci.org/articles/view/59334
• Gian Paolo Andreoletti

  Significant association of Human Cytomegalovirus with Glioblastoma Multiforme http://jvi.asm.org/content/early/2011/11/09/JVI.06097-11.abstract
• Gian Paolo Andreoletti

  New cancer-killing virus for glioblastoma?

  Http://www.nature.com/mt/journal/vaop/ncurrent/full/mt2011208a.html
• Kalaiselvi Thiruvenkadam

  Hi, anyone is working in MRI brain tumor segmentation?

  Brain tumor modeling may be used to test the proposed methods.

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    Luca Shindler replied

    2352x1728 @ 8-bit at 30 fps of fluid mechanics experiments. We use local threshold, dynamic threshold and feature extraction methods. what are you looking for?

    Nov 3, 2011
• Kalaiselvi Thiruvenkadam

  How to get MRI brain tumor image set?

  We are developing methods for brain tumor detection. We need more MRI volumes to test our results. Any flexible centre or linkages?

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    Kalaiselvi Thiruvenkadam replied

    Thank you Dr. Can I have your mail-id for further discussion?

    Nov 1, 2011
• Jon Moulton

  LeFave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L. Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas. The EMBO Journal. 2011;[Epub ahead ofLeFave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L. Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas. The EMBO Journal. 2011;[Epub ahead of print 13 September] doi:10.1038/emboj.2011.259 Alternative splicing protecting glioblastoma cells from apoptosis; experimental manipulation of splicing though blocking splice junctions of a splice regulatory protein, knocking down its function. An interesting chain of events: altering splicing of one gene in order to alter the splicing of others.

  http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2011259a.html
• Vikas Vats

  Magnetic Cell sorting markers for Brain tumor stem cells

  Dear all, i am looking some specific markers for brain tumor stem cells. As i know CD 133 is the marker for the same but i m looking other marker. if anybody suggest me any other method forDear all, i am looking some specific markers for brain tumor stem cells. As i know CD 133 is the marker for the same but i m looking other marker. if anybody suggest me any other method for isolation the same....

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    Vikas Vats replied

    Hi Joachim Thanks for comments. but i read CD 15 also the marker of cancer stem cells, but i found only few study...

    May 24, 2011
• Mamuka Khvedelidze

  New Brain Tumor Vaccine to Be Tested in Humans

  Winston-Salem, NC – December 1, 2010 – For patients with low-grade gliomas, or slow growing brain tumors, a shot in the arm might soon lead to a new treatment therapy. A groundbreaking, first inWinston-Salem, NC – December 1, 2010 – For patients with low-grade gliomas, or slow growing brain tumors, a shot in the arm might soon lead to a new treatment therapy. A groundbreaking, first in humans vaccine will be tested in an early phase clinical trial that will soon begin at Wake Forest University Baptist Medical Center. Eighteen patients will be the first in the world to receive it. The vaccine was developed by UP’s Hideho Okada, M.D., Ph.D., the third side of this scientific triangle, and is based in part on Debinski’s discoveries. Okada’s expertise lies in immunological therapy and gene therapy for brain tumors. Okada has a long track record of inventive research in the field of tumor vaccines. Shaw and Okada are co-principal investigators for the study. Okada was the first to identify and fully characterize cytotoxic T-lymphocyte (CTL) epitopes in glioma-associated antigens, enabling him to develop novel vaccines. CTLs are the warriors that the immune system uses to fight infections and cancer.

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