- Gamal Abdul Hamid added an answer:What is the difference between pPNET and embryonal neuroblastoma?
The good prognosis of those rare cases with pPNET and embryonal neuroblastomas
elucidates questions concerning the tumor's biological behaviour and role of different
factors affecting cell differentiation, tumour growth and dissemination.
Primitive neuroectodermal tumor (PNET) is a small round cell malignancy of presumedly primitive, neuroectodermal tissue or pluripotential, migratory neural crest cells arising from the soft tissue or bone, predominantly in older children and adults. The term, “PNET” includes malignant small round cell tumors of the thoracopulmonary region (Askin's tumor), extraskeletal Ewing's sarcoma, peripheral neuroblastoma, and peripheral neuroepithelioma.
Neuroblastoma is the most common extracranial solid tumor of infancy. It is an embryonal malignancy of the sympathetic nervous system arising from neuroblasts (pluripotent sympathetic cells). In the developing embryo, these cells invaginate, migrate along the neuraxis, and populate the sympathetic ganglia, adrenal medulla, and other sitesFollowing
- Jason Peter Ross added an answer:Embryology: Do the 3 lineages give rise to layers in colon with 3 distinct patterns of ancestral somatic mutations?
Is this really what happens? If so, the three lineages would give rise to layers in organs such as the colon with three distinct patterns of ancestral somatic mutations. Alternately, organs could be created by pluripotent stem cells that locally create the layers of tissue observed. In such a case local elements of layers would to some extent share a genetic pattern of somatic mutations.
A number of years back, some of my lab members published a paper on the very clear distinction in RNA expression patterns across the colon proximal-distal axis. http://physiolgenomics.physiology.org/content/33/1/50Following
- Joseph Carroll added an answer:Is there any neurological or embryological influence in the Foveal Development in Down SyndromeThere has been no study which talks about any relation of the development of the eye in Down Syndrome and any neurological involvement in the sameHttp://www.ncbi.nlm.nih.gov/pubmed/22612356Following