- Jose Gros added an answer:What is the difference between pPNET and embryonal neuroblastoma?
The good prognosis of those rare cases with pPNET and embryonal neuroblastomas
elucidates questions concerning the tumor's biological behaviour and role of different
factors affecting cell differentiation, tumour growth and dissemination.
According to D A casciato, editor, and M C Territo, associate editor, 2012, 'Manual of Clinical Oncology, 7th edition', page 881:
Small Blue Cell tumors in children may be:
*Synovial cell Sarcoma
To distinguish among them, markers are: CK, EMA, CD99, S100, NET, WT1, and Muscular Markers (Desmin, MSA, MyoD1, myogenin) are of help
Small Blue Cell tumors in Adults are:
*Carcinoma *Carcinoma, Small Cell
*Carcinoma, Merkel Cell
*Desmoplastic Small Cell Tumor
*Synovial Sarcoma *Lymphoma
To discriminate, they propose: CK, EMA, CD99, S100, NET, CD45, Des, and other specific for some of the individual tumor types citedFollowing
- Jason Peter Ross added an answer:Embryology: Do the 3 lineages give rise to layers in colon with 3 distinct patterns of ancestral somatic mutations?
Is this really what happens? If so, the three lineages would give rise to layers in organs such as the colon with three distinct patterns of ancestral somatic mutations. Alternately, organs could be created by pluripotent stem cells that locally create the layers of tissue observed. In such a case local elements of layers would to some extent share a genetic pattern of somatic mutations.
A number of years back, some of my lab members published a paper on the very clear distinction in RNA expression patterns across the colon proximal-distal axis. http://physiolgenomics.physiology.org/content/33/1/50Following
- Joseph Carroll added an answer:Is there any neurological or embryological influence in the Foveal Development in Down SyndromeThere has been no study which talks about any relation of the development of the eye in Down Syndrome and any neurological involvement in the sameHttp://www.ncbi.nlm.nih.gov/pubmed/22612356Following