Clinical Embryology

Clinical Embryology

  • Andrey Borodach added an answer:
    Are amnioblasts the progenitor cells for the mesothelial lining?

    The mesothelial cells line the abdominal, pleural, and pericardial cavities are thought of as being the mesenchymal origin [for example, Moore KL & Persaud TVN. The Developing Human. Clinically Oriented Embryology, 8th ed, Sauders, 2006; Histology for Pathologists, 3d ed (Mills S.E. ed.), Lippincott, Williams & Wilkins, 2007; etc].

    However, during the embryonic development, the cells lining the amnion cavity are continuous with those covering the forming abdominal cavity from the very beginning of the histogenesis to app. the 10-11th weeks. What is known about the immunohistochemical similarity, if any, of the ameloblasts and the mesothelial cysts? 

    Andrey Borodach · Novosibirsk State Medical University

    May I suggest to look at the picture here below? (from Langman's Medical Embryology, 12th ed, , 2012, p.79).

  • Joe Graymer added an answer:
    What is the difference between pPNET and embryonal neuroblastoma?

    The good prognosis of those rare cases with pPNET and embryonal neuroblastomas

    elucidates questions concerning the tumor's biological behaviour and role of different 

    factors affecting cell differentiation, tumour growth and dissemination. 

    Joe Graymer · NYAS

    According to D A casciato, editor, and M C Territo, associate editor, 2012, 'Manual of Clinical Oncology, 7th edition', page 881:

    Small Blue Cell tumors in children may be:

    *Neuroblastoma,  

    *PNET/Ewing Sarcoma  

     *Rhabdomyosarcoma 

     *Synovial cell Sarcoma

     *Wilm's Tumor

    To distinguish among them, markers are: CK, EMA, CD99, S100, NET, WT1, and Muscular Markers (Desmin, MSA, MyoD1, myogenin) are of help

    Small Blue Cell tumors in Adults are:

    *Carcinoma                                                                                                                         *Carcinoma, Small Cell  

    *Carcinoma, Merkel Cell    

    *Desmoplastic Small Cell Tumor                                                                                  

    *Synovial Sarcoma                                                                                                        *Lymphoma  

     * Melanoma

     To discriminate, they propose: CK, EMA, CD99, S100, NET, CD45, Des, and other specific for some of the individual tumor types cited

  • Jason Peter Ross added an answer:
    Embryology: Do the 3 lineages give rise to layers in colon with 3 distinct patterns of ancestral somatic mutations?

    Is this really what happens? If so, the three lineages would give rise to layers in organs such as the colon with three distinct patterns of ancestral somatic mutations. Alternately, organs could be created by pluripotent stem cells that locally create the layers of tissue observed. In such a case local elements of layers would to some extent share a genetic pattern of somatic mutations.

    Jason Peter Ross · The Commonwealth Scientific and Industrial Research Organisation

    A number of years back, some of my lab members published a paper on the very clear distinction in RNA expression patterns across the colon proximal-distal axis. http://physiolgenomics.physiology.org/content/33/1/50

  • Joseph Carroll added an answer:
    Is there any neurological or embryological influence in the Foveal Development in Down Syndrome
    There has been no study which talks about any relation of the development of the eye in Down Syndrome and any neurological involvement in the same
    Joseph Carroll · Medical College of Wisconsin
    Http://www.ncbi.nlm.nih.gov/pubmed/22612356

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