- prof V.S Muralidharan added an answer:How to measure authorship?How select order of authors in case where one person designs experiment (aim, goals, materials and methods), order chemicals/kits, select statistical tests to perform and prepare manuscript while the other run assays and statistical analysis. Is there a quantitative method/model to show what is the value of selecting kit versus running experiment with this kit?
The supervisor is paid for the job--The student pays tuition fess to the university every semester-- Train the student to write in English in his own words - then sit with him and help -let him see what you want - at least two papers help him ; Now the student knows you and he will include your name automatically; now it is up to you to acceptFollowing
- Maria Susana Ciruzzi added an answer:Can Physicians practice common crime, when they do not obey Lex Artis procedure and Ethics, or is this only malpractice ?
Physicians most of the time take risk and plead innocence when something goes wrong during a medical act, in criminal discipline they say they have a "dolus bonus", is that truth ? Never a physicians will practice a crime during a procedure. How we can explain the great amount of deaths by iatrogenic diseases and medical errors ?
I think that Law is never going to get at the same pace as Medicine.......and that's a good thing, in my own point of view. I always tell my students that Medicine is like a Ferrari, and Law is a bike........The duty of law is to provide a common ground that assures the most important principles that a society thinks are so relevant that MUST be protected by law (eg: human rights). But Law -understood as formal law, the one approved by Congress- is not called to regulate medical knowlodge and scientific development, these issues should be regulated by protocols and ethical norms, "material laws". Law has to go along the path with Medicine, guaranteeing the conditions for doctors to exercise Medicine and to gain scientific knowledge, stand by its side, but never impose what Medicine is called to decide in science, applying scientific principles.Following
- Alok Arya added an answer:When is an ethical clarification needed in research experiments?
I've submitted a research article that deals with new biomarkers, and is based on samples received from cancer patients. The patients didn't give the blood for this project, however they consented to use the samples for research purposes. The journal asked me an ethical clarification, because I'm working with human material. Can anyone help me with this? If there is any document for exception of ethical clarifications please send it to me.
I am sure you must have been able to resolve the situation.
For future, it is always advisable to submit your research proposal (involving human subjects/specimens) to your IRB/IEC and seek their opinion in written document. The IRB/IEC must have mentioned in their SOPs about their review procedures.
All the best.Following
- Brendan P Minogue added an answer:How do we best address the moral issues about medical rationing?Given the various kinds of health care problems we face as a result of an aging and growing population, is it possible to address medical rationing concerns without, at some point, necessarily reducing such considerations to economic (i.e. basic supply and demand) questions? That is, given the reality that we live on a finite planet with finite resources, must basic economic considerations always be present when we make decisions that directly affect human life and human well-being within the context of our health care systems?
John Rawls' Theory of Justice is a masterpiece of liberal theory regarding distribution and there are literally hundreds of articles about his theory. Start there! Relative to bioethics Beauchamp and Childdress' Bioethics is a great text for getting you up to speed on this big issue. A more conservative approach can be found in Englehardt's Foundations of Bioethics. These three will give you a great sense of how large the problem is .
Most hospital emergency rooms deal with this on a triage basis and tend toward taking care of seriously ill patients on a "first come first served basis" This is basically a lottery approach to distribution but looks really bad if you do not adequately fund the ER or if your patient population is so large and so ill that the concept of "minimally decent" becomes totally unworkable.
Try to narrow your focus to a question like "how do you define minimally decent funding for an ER" in a poor part of a city. You will find that defining "minimally decent" is brutally difficult.
Try taking a look at a technological approach to distribution. In this arena you eliminate the human providers and replace them with data gatherers connected to IBM's Watson. Watson can diagnose better than most docs and he can monitor ongoing care better than most nurses and he can manage millions of patients at one time. It feels a little inhumane but inhumane care is better than no care and subsequent death. This might meet our budget requirements.
- Julian Cockbain added an answer:How simple or complex is it to remove introns to create cDNA?After reading the Supreme Court's decision on the Myriad case, I am wondering how easily cDNA can be made patentable.
OK, the Supreme Court said native DNA was unpatentable under 35 USC 101, but that cDNA was. Simple as that. Except that Prometheus v Mayo hinted that subject matter that was obvious over the unpatentable product of nature might also be unpatentable, e.g. cDNA. The story is not yet closed. The attorneys for AMP missed the boat.Following
- Tod Clark added an answer:Does signing a consent form in clinical trials guarantee achievement of research ethics?In other words, are clinical trials ethical? Bio-availability studies depend on humans, and some people agree to participate in such studies for money. How ethical is it to conduct such studies?
That IC exists is no guarentee of the morality or ethical basis for a medical. while a signed document may prove later to identify that the studiers informed the studiees of the possible risks involved in such a study, informed consent only enages the debate at a minimal level.
There are other deeper considerations of morality to embrace. Is the study necessary at all? What are the anticipated outcomes, Are we using humanity in the service of science in a way that degrades or enhances that humanity? These are not easy questions to answer. As the religious and ethical voice for the organization in which i work, I ask and am asked these same questions. While the circumstances fram the answer - the main issue remains Is ethical science and oxymoron in this age of increasing pressure to use science for less than legitimate purposes.Following
- Risa Mandell added an answer:Experimental animal models in scientific research: ethical problems and predictability?Are animal models still needed in biomedical research to understand normal and abnormal function, from gene to phenotype, and to provide a basis for preventive or therapeutic intervention in human diseases?
http://www.ncbi.nlm.nih.gov/pubmed/19519367Please view the website, pcrm.org for their section on replacing animals in research, http://www.pcrm.org/research/.Following
- M. Chaitanya Varma added an answer:What are the unique features of nanomedicine compared to other nanotechnology-based application?Nanomedicine is one of the many applications of nanotechnology for monitoring or treating physiological conditions using nano-scale designed devices, particles, materials, drug delivery systems etc. Since nanomedicine implies dealing with how these tools and devices interact with complex biological systems, one could anticipate there are many issues to consider during their design, manufacturing, and delivery.
I would like to hear your opinion about this and have some input on why nanomedicine can be considered unique.magnetic nanoparticles like iron oxide are best suited for targeted drug delivery since they can be monitored and can be controlled with the help of MRI or by applying magnetic field. when the iron oxide particle reaches the targeted site, by applying ac magnetic field the drug can be released.
for enhancing the contrast at tumor or some other region, one can use semiconducting nanoparticles (quantum dots) and get more details.
like wise there are so many applications and these will increase once scientists understand about how to fully control the properties of the materials at nanoscaleFollowing
- Filippo Salustri added an answer:Scientific experiments: solving peripheral mysteries or a search for dogmatic validation of the scientist’s beliefs?Scientists are responsible for solving and understanding physical mysteries.
The scientific method outlines the steps in scientific inquiry where the meeting of reality and scientific vision occur at the level of the experiment. The solving of physical puzzles requires experiments for obtaining proof from the physical world and as validation of the scientist’s hypothesis. Results from scientific experiments orient scientific understanding into the direction of current dogmas or novel perceptions. This brings up interesting questions:
Are most scientists really interested in searching for the truth when conducting experiments or validating what they believe to be true? How does the competitiveness of science interfere with this process?
What does a scientist do when an experiment confers results that differ from the dogma they have been taught or are trying to establish?Following
- Fahmi Khan added an answer:Is it necessary to have consent when conducting a retrospective study? If yes, from whom?From ethical point of view, Is it necessary to have consent when conducting a retrospective study?Thanks Mohamed and CarlosFollowing
- Francesca Cansani added an answer:Is there really a 'Wisdom of Repugnance?'In 1997, former chairman of the President's council on bioethics, advanced the idea that “in crucial cases…repugnance is the emotional expression of deep wisdom, beyond reason’s power to fully articulate…” (The New Republic).
I suspect that few ethicists working today take this position at face value. Still, there do appear to be tangible concepts that are commonly defended on the basis of intuition alone - human dignity is one such example.
Do those who would reject any role for emotion and intuition in moral judgment throw the metaphorical baby out with the repugnant bathwater (cf. Jones, The depths of disgust, Nature, 2007)?Following
- Dick Sobsey added an answer:Where can we set the ethical limits for genetic manipulation of human embryos?There is ethical dilemma toward genetic manipulation of human embryo for correction of genetic disorder and replacement of unwanted gene and defects. When and where can we set-off the limits?X-linked disorders make a strong case for replacing one or a small group of genes. In some cases a single-gene defect means passing on a problem to 50% of offspring, with females having a 50-50 chance of being carriers and males having a 50-50 chance of having a devastating disability. Without this technology women carried these disorders must roll the dice for their future babies, simply forgo having children, or risk repeated pregnancies that end in abortion if the defect is found. So in these cases, it is difficult to argue that replacing a single defective gene would be unethical. The problem is that if this technology is allowed, it might be used for a much broader group of less compelling cases. However, most technologies can be used for unethical purposes and it is difficult to deny legitimate uses simply because there is a potential for misuse.Following
- Ziad O. Abu-Faraj added an answer:What do you think the benefits or drawbacks of integrated circuits in babies are?http://bit.ly/1fn0LYj
Doctors predict that in 5-10 years, babies will be tattooed with integrated circuits that push medical data to the cloud.There is no doubt Chandra that progressive thought and act should prevail, but the ethical challenges are getting more and more difficult and the research community should be ready for it.Following
- Ivo Van Hilvoorde added an answer:Is there any way of analysing class room discussion on bioethical issues? Is there any research technique such as 'ethical discourse analysis'?These bioethical issues raise diverse opinions as well as arguments that need to be analysed from an ethical perspective so that right kind of decision making ensues.And these as well
- Marco Huesch added an answer:Cost and availability of cytostatic drugs?In Indonesia some generic drugs on the essential drugs list of both WHO and Indonesia should be available, but in practice they are not and have to be procured by unusual routes. Does anybody have any experience with similar situations in other countries?
The last few years, 6-mercaptopurine as well as Methotrexate were sometimes unavailable, causing interruption of maintenance treatment for children with leukemia. It has been proven that such interruptions cause increased relapse rates. What can and should we do about this situation?My personal view is that stockouts of generic drugs are unfortunately to be expected, and happen in the US (http://www.nytimes.com/2012/02/11/health/policy/supply-of-methotrexate-a-cancer-drug-may-run-out-soon.html?_r=2&) as well as Indonesia.
Original manufacturer firm exit upon brand expiration and generic firm entry can reduce supply capacity, low profit margins in the eventual generic production & distribution business are insufficient to sustain adequately stocked supply chains and inventories (and sometimes inadequate to sustain good manufacturing practices), and longer supply chains are also common.
This is, as always, reducible to a trade-off between greater investment pre-expiry versus less post-expiry, between more expensive, more restricted but more reliable access before versus after expiry, and ultimately between welfare gains among the current generation of patients benefiting from generics versus welfare losses among future generations from lower innovation in the present.
Practical solutions for Indonesia might be to think about some investments by Indonesia in home-grown generic manufacturing, a regional cooperative to share capacity and overcome local stockouts, having the government look at purchasing excess EU stock (or US http://www.goodrx.com/methotrexate) perhaps under foreign aid programs, or using charitable foundations to fund this very worthwhile and affordable investment in a sick child's future...Following
- Dhastagir Sheriff added an answer:Does a sperm donor have a moral duty to pay for the subsistence of the resulting children by virtue of being their "biological father"?The British newspaper "The Guardian" reported a couple of weeks ago (27 October 2012) that a gay man who several years ago had donated his sperm to a lesbian couple was now held accountable and told to pay up for the two children that he helped to be conceived. Apparently, if he did the same today, he would not be liable. What happened is that the lesbian couple separated. The children now live with one of them, presumably the biological mother, and the other visits them from time to time, but does not support them financially. In that situation, the mother sued the sperm donor, and he was sentenced to pay. Now, the question is of course whether that is morally justied. Never mind what the law says, can we really believe that he is morally responsible for the children, in the sense that he has a moral duty to contribute to their subsistence?
At first glance, this seems to be case of gross ingratitude. The donor was friends with the two women. They wanted to have children and asked the man for help. That's what he did. He did them a favour. As a friend. It was never intended that he have any part in bringing up the children or contributing financially. The only thing that was expected of him, as a gift to his friends, was to hand over some of his sperm.
However, not everyone sees it this way, as the letters of Guardian readers prove that were published a week after the original article. One reader wrote: "They are his biological children. He helped bring them into the world. He has a duty to cover their costs. He should have been less cavalier with his sperm." Another commented: "This isn't a question of gay rights, it's a question of responsibility for another human being / is a donor really any different to a man who has a one-night stand, which ends in pregnancy (wanted or not)? To reduce the conception of a child to 'doing someone a favour' is an appallingly cavalier attitude. Of course he should pay for the upkeep of his children. If he wasn't prepared to, he should have done us all a favour and kept his sperm to himself." Not much sympathy here.
So the question is whether biological fatherhood really is morally so important that it makes the biological father responsible for any children that may result from the use of his sperm, independent of the circumstances. In this particular case, of course, the donor was aware that his sperm was to be used to conceive a child, but he also had an agreement with the mother that he would have no further obligations, that his only contribution would be the donation of his sperm. Does this agreement count for nothing because biological fatherhood overrides all other considerations? But why should biology be seen as having such paramount importance? Underlying the comments by those Guardian readers also seems to be the intuition that sperm is not the kind of thing that we should be allowed to sell or give away. It is not a commodity. But again, why exactly is it not? Is it because, as Monty Python put it, "every sperm is sacred"?Following
- Bill Johnson added an answer:Is there any ethical algorithm for abortion?In your country or globally?I must confess my ignorance here. I am not at all aware of how it would be possible to have an "ethical algorithm". Are you using the process aspect of algorithms (which is similar to that of a flow chart) to speak by way of analogy here? Are you seeking an ethical flow of reasoning, comparable to the flow of an algorithm, by which to determine whether or not an abortion is or isn't ethical?Following
- Closed account added an answer:It is possible to consider the "after birth abortion" as A. Giubilini and F. Minerva wrote about two months ago? What kind of bioethics is that?In the attached file I send my opinion on abortion in general. If you want to discuss I can replayThere is not much, we two could discuss. As you wrote, the attached file bears your opinion. What is there to discuss? My opinion - an absolute respect of human life- is different from yours, and neither of us will give up or change our opinions, since we have made them after long searching of what we find is truth.Following
- Elizabeth Amisi added an answer:Non-treatment of skin cancer for severely mentally ill man with delusionsI am an emergency medical guardian/attorney.
The challenge is the tendency to try to "cure death" among some medical professionals. The resultant pain to the patient and their reaction to it, i.e. pulling out a breathing tube, should be taken into account in the treatment plan. Thoughts?Following
- Ulf-Dietrich Reips added an answer:The Association of Internet Research just published a new ethics guidelines document. What is missing, what is questionable?The doc is at http://aoir.org/documents/ethics-guide/. The guideline seems to draw mostly on US-based literature and approaches and practices common within Northern America and thus may need an extension. Please also write whether you believe the document will hold for needs and practices in your field, especially if you work outside communication.Marcin, can you give an example where European ethics guidelines have a different perspective?Following
- Adrianne John R Galang added an answer:Modafinil research with healthy volunteers?I would like to do some research with a design similar to this: http://www.ncbi.nlm.nih.gov/pubmed/22820554
What would be the best strategy of pursuing this in a sound, bio-ethical manner in a developing country like the Philippines? I am aware I would need to collaborate with a psychiatrist, but beyond that are there other hurdles that I might need to consider? Would the cost be prohibitive for a modest research budget?Thanks for all the valuable procedural and methodological advice. To give you some context regarding my question, my research on creativity is actually pointing me towards the hypothesis that there might be a functional trade-off to the cognitive enhancements delivered by drugs like Modafinil. Please see my attached mini-proposal for just a bit more background.Following
- Pablo Arango R. added an answer:What kind of bioethics is more appropriate in developing countries?What kind of Bioethics is more appropriate for resolving moral conflicts related to public health in Latin America and other developing countries? Bioethics of protection or intervention?Regarding the question of what is the difference between bioethics of developed and developing countries I think that bioethics is only one, change the problems that are studied. Bioethics should have some basic principles such as respect for life, respect for human dignity, solidarity, respect for the body, beneficence, autonomy, along with other principles such as responsibility. What changes? That in a developed country do not steal kidneys, if they do in poor countries. That human subjects research is do with extreme caution in developed countries and in poor countries are use people as "guinea pigs". In all places bioethics can provide guidance on how is the best to act according with the principles.
Pablo Arango MD, PhDFollowing
- Marin Gillis added an answer:Sponsoring distance learning education.Is anyone aware of any organizations that one may apply to for help sponsoring distance learning education in bioethics?Creighton UniversityFollowing
A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care.