Ruben Miguel Ayzin Rosoky

Publications (2)3.1 Total impact

• Article: Prevalence of metabolic syndrome in patients with intermittent claudication and its correlation with the segment of arterial obstruction.

  Antonio Eduardo Zerati, Nelson Wolosker, Ruben Miguel Ayzin Rosoky, Glauco Fernandes Saes, Luciana Ragazzo, Pedro Puech-Leão
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  ABSTRACT: The metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. Intermittent claudication reflects the presence of peripheral arterial disease (PAD). The aim of this study is to determine the prevalence of the MetS in claudicants and its correlation with age, gender, localization of arterial obstruction, and symptomatic coronary disease. Patients (n = 170) with intermittent claudication were studied. The mean age was 65 years (33-89). Metabolic syndrome was diagnosed in 98 patients (57.6%). The mean age of patients with MetS was 63.5 years compared with 67.0 years for patients without MetS (P = .027). Considering patients aged ≥65 years, MetS was present in 46 (48.9%) individuals and in 52 (68.4%) patients younger than 65 years (P = .011). Metabolic syndrome must be actively searched for in claudicant patients.
  Angiology 11/2010; 61(8):784-8. · 1.51 Impact Factor
• Source

  Available from: Magnus Gidlund

  Article: Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease.

  Ruben Miguel Ayzin Rosoky, Nelson Wolosker, Michel Nasser, Antonio Eduardo Zerati, Magnus Gidlund, Pedro Puech-Leão
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  ABSTRACT: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease. Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test. There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations. Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
  Clinics (São Paulo, Brazil) 04/2010; 65(4):383-7. · 1.59 Impact Factor