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Marco Bettoni
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ABSTRACT: Exercise echocardiography is performed with transthoracic echocardiography recorded during ergometry in order to detect and evaluate coronary heart disease. In experienced hands this technique is safe, comfortable and easy to perform. It is mainly indicated for patients with intermediate probability of coronary disease. Performances are identical to myocardial scintigraphy or cardiac MRI with significant less costs.
Revue médicale suisse 04/2007; 3(102):660-3.
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ABSTRACT: This study retrospectively determined the prognostic variables of blood pressure by 24-hour ambulatory blood pressure measurement in relation to onset of atrial fibrillation in treated patients who had essential hypertension and analyzed the class effect of antihypertensive management on the nonoccurrence of this supraventricular arrhythmia.
The American Journal of Cardiology 01/2005; 94(12):1566-9. · 3.37 Impact Factor
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ABSTRACT: The prognostic value of dobutamine echocardiography (DOBU-ECHO) in patients with intermediate coronary lesions has not been described in the literature. The aim of this study was to determine the prognostic value of DOBU-ECHO in patients presenting with coronary lesions smaller than 50% at angiography. Ninety-four consecutive patients were analyzed and followed-up for 64 +/- 7 months (range: 12 to 75 months). All patients presented with coronary lesions between >or= 30% and < 50% of the luminal diameter of at least one major epicardial vessel. The patient population was divided into two groups: Those with a positive DOBU-ECHO (n = 23) and those with a negative DOBU-ECHO (n = 71). The number of coronary lesions did not differ between the two groups. The patients with a positive DOBU-ECHO result were more likely than those in the negative group to have a family history of coronary artery disease or suffer from hypertension or a dyslipidemia. During the follow-up period, 13 cardiac events occurred (1 cardiac death, 5 myocardial infarctions, 2 unstable anginas, and 5 myocardial revascularizations), 11 (47.8%) of which occurred in patients with positive DOBU-ECHO. The annual incidence for a cardiac event was 7.9% per year in the positive DOBU-ECHO group and 0.5% per year in the negative DOBU-ECHO group (P < 0.001). This incidence remained significant for spontaneous cardiac events, such as cardiac death, myocardial infarction, and unstable angina (5.8% per year vs 0.2% per year; P < 0.001). CONCLUSIONS: In patients with angiographically confirmed intermediate coronary lesions, a positive DOBU-ECHO is an additional risk factor for the onset of a cardiac event, whereas a negative DOBU-ECHO can be used to define patients with a low cardiac risk.
Echocardiography 10/2002; 19(7 Pt 1):549-53. · 1.24 Impact Factor
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ABSTRACT: Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients.
Holter tapes from 77 unselected consecutive patients (63 men and 14 women aged 58+/-12 years) with PAF were analyzed. A total of 147 episodes of sustained AF (>30 minutes) were recorded and submitted to time-domain and frequency-domain heart rate variability analyses; 6 periods were studied using repeated measures ANOVA: the 24-hour period, the hour preceding PAF, and the 20 minutes before PAF divided into four 5-minute periods. In the time-domain analyses, a linear decrease in mean RR interval from 925+/-16 to 906+/-16 ms (P<0.0002) was observed before the onset of PAF, together with a significant increase in the standard deviation of NN intervals from 65+/-4 to 70+/-4 ms (P<0.02). In the frequency-domain analyses, a significant increase in high-frequency (HF, HF-NU) components was observed before PAF (P<0.001 and P<0.0001, respectively), together with a progressive decrease in low-frequency components (LF, LF-NU) (P<0.0001 and P<0.004, respectively). The low/high frequency ratio showed a linear increase until 10 minutes before PAF, followed by a sharp decrease immediately before PAF, suggesting a primary increase in adrenergic tone followed by a marked modulation toward vagal predominance. No difference was observed in these heart rate variability changes between patients with "lone" PAF and patients with structural heart disease.
The occurrence of PAF greatly depends on variations of the autonomic tone, with a primary increase in adrenergic tone followed by an abrupt shift toward vagal predominance.
Circulation 07/2002; 105(23):2753-9. · 14.74 Impact Factor
