Naomi Montague

Publications (7)21.62 Total impact

• Source

  Available from: Patricia L. Blackwelder

  Article: Platelet satellitism and dual surface immunoglobulin light-chain expression in circulating splenic marginal zone lymphoma cells.

  Naomi Montague, Patricia Blackwelder, Husain Alsayegh, Roberto Ochoa, Ximena Vial, Gerald E Byrne
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  ABSTRACT: Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid-anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
  Annals of diagnostic pathology 08/2011;
• Article: Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics.

  Xin Qing, Nora Sun, Samuel W French, Changjun Yue, Naomi Montague, Izidore S Lossos
  American Journal of Clinical Pathology 06/2011; 135(6):977-8; author reply 978-9. · 2.60 Impact Factor
• Article: Extraoral plasmablastic lymphoma with intravascular component and MYC translocation.

  Jennifer Chapman-Fredricks, Naomi Montague, Ikechukwu Akunyili, Offiong Ikpatt
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  ABSTRACT: Plasmablastic lymphoma (PBL) is an uncommon, clinically aggressive, Epstein-Barr virus-driven B-cell lymphoma that was initially described in tumors of relatively young human immunodeficiency virus-positive men. Subsequent to initial reports, the clinical and pathological spectrum of this disease has been expanded such that, now, PBL is recognized to be a heterogeneous disease entity. Plasmablastic lymphoma has been seen in clinical settings outside those initially reported and has been shown to demonstrate a variety of morphologic patterns. We describe a case of extraoral PBL in an human immunodeficiency virus-infected patient with a computed tomography-identified heterogeneously enhancing mass in the stomach. Histologically, a prominent intravascular component was identified. Fluorescent in situ hybridization analysis for MYC/IGH (immunoglobulin heavy chain) rearrangement t(8;14) identified fusion signals, confirming the presence of MYC rearrangement. The presence of a prominent intravascular in our case is unique. To our knowledge, these findings have not been observed in the previous reports of PBL. The observation of this vascular component supports the heterogeneity of PBL and may be an indicator of tumor aggressiveness. We were able to demonstrate the MYC/IGH rearrangement in our case of PBL. The interplay between Epstein-Barr virus and this MYC rearrangement may be similar to what is observed in Burkitt lymphoma, another clinically aggressive non-Hodgkin lymphoma.
  Annals of diagnostic pathology 01/2011; 16(1):48-53.
• Article: Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics.

  Damien Hansra, Naomi Montague, Alexandra Stefanovic, Ikechukwu Akunyili, Arash Harzand, Yasodha Natkunam, Margarita de la Ossa, Gerald E Byrne, Izidore S Lossos
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  ABSTRACT: Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
  American Journal of Clinical Pathology 11/2010; 134(5):710-9. · 2.60 Impact Factor
• Article: Massive splenomegaly and extramedullary hematopoiesis in chronic idiopathic myelofibrosis.

  Naomi Montague, Margarita De La Ossa
  Blood 10/2010; 116(14):2410. · 9.90 Impact Factor
• Article: F-18 FDG PET/CT in the assessment of recurrent anaplastic T-cell lymphoma of the external auditory canal.

  Osama Gomaa, Aldo N Serafini, Elizabeth Franzmann, Muaiad Kittaneh, Naomi Montague, Dimitrios Kalkanis
  Clinical nuclear medicine 08/2010; 35(8):592-4. · 3.92 Impact Factor
• Article: Central nervous system manifestations of marginal zone B-cell lymphoma.

  Soley Bayraktar, Alexandra Stefanovic, Naomi Montague, Janet Davis, Timothy Murray, Izidore S Lossos
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  ABSTRACT: Primary or secondary central nervous system (CNS) involvement by marginal zone B-cell lymphoma (MZBCL) is rare. A retrospective analysis of patients was done with MZBCL involving the CNS, diagnosed and treated at our institution between 2004 and 2010. We identified 10 MZBCL patients with primary (six) or secondary (four) CNS involvement. Five patients presented with primary dural lymphoma and were treated with surgical resection, whole-brain radiation, or systemic chemotherapy. Only one patient had CNS relapse 5 years later. A single patient with primary intraocular lymphoma achieved clinical remission with ocular radiotherapy and systemic chemotherapy. Four patients had ocular MZBCL within 5 years of the initial diagnosis of primary ocular adnexal MZBCL and primary splenic MZBCL. There was no evidence of local recurrence in all but one who developed systemic relapse after 3 years of follow-up. Primary or secondary CNS involvement by MZBCL display indolent clinical behavior and have a generally favorable prognosis, underlining the importance of their differentiation from aggressive lymphomas that more commonly involve the CNS.
  Annals of Hematology 05/2010; 89(10):1003-9. · 2.62 Impact Factor