Muhammet Güven

Publications of Muhammet Güven

• Incidence, risk factors and mortality of nosocomial pneumonia in intensive care units: a prospective study.

  Authors: Emine Alp, Muhammet Güven, Orhan Yildiz, Bilgehan Aygen, Andreas Voss, Mehmet Doganay

  Annals of clinical microbiology and antimicrobials. 09/2004; 3:17.

  To determine the frequency, risk factors and mortality of nosocomial pneumonia a prospective study was conducted in the intensive care units. In the study period, 2402 patients were included. TheTo determine the frequency, risk factors and mortality of nosocomial pneumonia a prospective study was conducted in the intensive care units. In the study period, 2402 patients were included. The nosocomial pneumonia was defined according to the Centers for Disease Control Criteria. Overall, 163 (6.8%) of the patients developed nosocomial pneumonia and 75.5% (n = 123) of all patients with nosocomial pneumonia were ventilator-associated pneumonia. 163 patients who were admitted to the intensive care unit during the same period but had no bacteriologic or histologic evidence of pneumonia were used as a control group. The APACHE II score, coma, hypoalbuminemia, mechanical ventilation, tracheotomy, presence of nasogastric tube were found as independent risk factors. Crude and attributable mortality were 65% and 52.6%, respectively. The mortality rate was five times greater in the cases (OR: 5.2; CI 95%: 3.2-8.3). The mean length of stay in the intensive care unit and hospital in the cases were longer than controls (p < 0.0001). Patients requiring mechanical ventilation have a high frequency of nosocomial pneumonia.

• The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning.

  Authors: Muhammet Güven, Murat Sungur, Bülent Eser

  Human & experimental toxicology. 08/2004; 23(7):365-8.

  OBJECTIVE: To describe the role of plasmapheresis in management of organophosphate poisonings. DESIGN: Case report. SETTING: A medical intensive care unit of a medical faculty. PATIENT: A patientOBJECTIVE: To describe the role of plasmapheresis in management of organophosphate poisonings. DESIGN: Case report. SETTING: A medical intensive care unit of a medical faculty. PATIENT: A patient with organophosphate poisoning whose cholinesterase levels continuously decline and then increase up to a normal level after plasmapheresis is performed for his sepsis. INTERVENTIONS: Plasmapheresis with fresh frozen plasma. MEASUREMENTS AND MAIN RESULTS: Baseline plasma cholinesterase (ChE) level was 4001 IU/L (normal values: 4000-10000 IU/L). Aspiration pneumonia was developed on day 3, and sepsis occurred on day 5. During this period, ChE levels gradually decreased. On day 5, plasmapheresis was performed for sepsis. Interestingly, plasma ChE levels increased from 2101 IU/L to 6144 IU/L after plasmapheresis. Atropine and pralidoxime were stopped, and a high level of ChE continued during hospitalization. The patient was successfully weaned from mechanical ventilation 3 days after plasmapheresis. CONCLUSION: Plasma exchange therapy may be considered for patients with organophosphate poisoning unresponsive to atropine and pralidoxime.

• The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning.

  Authors: Muhammet Güven, Murat Sungur, Bülent Eser, Ismail Sari, Fevzi Altuntaş

  Journal of toxicology. Clinical toxicology. 02/2004; 42(5):617-23.

  OBJECTIVE: The aim of this study is to determine the effects of fresh frozen plasma, as a source of cholinesterase, on butyrylcholinesterase (BuChE; plasma or pseudo cholinesterase) levels andOBJECTIVE: The aim of this study is to determine the effects of fresh frozen plasma, as a source of cholinesterase, on butyrylcholinesterase (BuChE; plasma or pseudo cholinesterase) levels and outcomes in patients with organophosphate poisoning. MATERIALS AND METHODS: This prospective study was performed at the Department of Intensive Care of Erciyes University Medical School. Over 2 yrs, patients admitted to the ICU for OP poisoning were entered into the study. OP poisoning was diagnosed on the basis of history and BuChE levels. All patients received atropine. Fresh frozen plasma was given to 12 patients. The study was approved by the Ethical Committee, and verbal informed consent was obtained. RESULTS: Thirty-three patients were included in the study. BuChE levels measured at admission and the pralidoxime and atropine doses administered were not different between groups (p>0.05). Although intermediate syndrome developed in 28.6% of patients receiving pralidoxime, there were no intermediate syndrome cases in patients receiving plasma prior to developing intermediate syndrome. The mortality rates were 14.3% in the pralidoxime group and 0% in the plasma+atropine+pralidoxime group. Two patients received plasma after developing the intermediate syndrome, and one patient who received only atropine died. BuChE levels of fresh frozen plasma were 4069.5 +/- 565.1 IU/L. Every two bags of plasma provided an increase in BuChE levels of approximately 461.7 +/- 142.1 IU/L. CONCLUSION: Fresh frozen plasma therapy increases BuChE levels in patients with organophosphate poisonings. The administration of plasma may also prevent the development of intermediate syndrome and related mortality. Plasma (fresh frozen or freshly prepared) therapy may be used as an alternative or adjunctive treatment method in patients with organophosphate pesticide poisoning, especially in cases not given pralidoxime. Further randomized controlled and animal studies are required to infer a definitive result.

• [Cranial MR imaging findings of carbon monoxide poisoning in asymptomatic patients in the chronic stage]

  Authors: Abdulhakim Coşkun, Ali Yikilmaz, Muhammet Güven, Füsun Erdoğan

  Tanısal ve girişimsel radyoloji : Tıbbi Görüntüleme ve Girişimsel Radyoloji Derneği yayın organı. 07/2003; 9(2):146-51.

  PURPOSE: To describe MR imaging findings of the chronic stage of carbon monoxide poisoning in asymptomatic patients. MATERIALS AND METHODS: Clinical data of 34 patients, who had been admitted to ourPURPOSE: To describe MR imaging findings of the chronic stage of carbon monoxide poisoning in asymptomatic patients. MATERIALS AND METHODS: Clinical data of 34 patients, who had been admitted to our hospital for carbon monoxide poisoning were reviewed and invited for control evaluation. Of the patients who accepted, ten who had no symptoms and neurological sequelae in the physical examination were included in the study. All patients had been in coma on initial admittance and had awakened after normobaric 100% oxygen therapy 1-10 years ago. Their ages were between 22-57 years (mean, 36.2 years). All patients were examined with cranial MR imaging. RESULTS: The most common finding was bilateral symmetric hyperintensity of the white matter more evident in the centrum semiovale with relative sparing of temporal lobes and anterior parts of frontal lobes on T2-weighted and FLAIR images in all patients. Subcortical U-fibers were intact in all patients. Cerebral cortical atrophy of variable degrees was seen in eight patients, mild atrophy of cerebellar hemispheres in seven patients, and vermian atrophy in nine patients. Corpus callosum was atrophic in two patients. Bilateral globus pallidus lesions were seen in three patients as hypointense on T1-weighted and hyperintense on T2-weighted and FLAIR images. CONCLUSION: Cerebral changes may be present in patients with severe CO poisoning even when the patient becomes asymptomatic. Knowledge of these findings would be helpful when evaluating these patients for follow-up or for other reasons.

• Physiological-dose steroid therapy in sepsis [ISRCTN36253388].

  Authors: Orhan Yildiz, Mehmet Doganay, Bilgehan Aygen, Muhammet Güven, Fahrettin Keleştimur, Ahmet Tutuû

  Critical care (London, England). 07/2002; 6(3):251-9.

  INTRODUCTION: The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological doseINTRODUCTION: The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patients with sepsis. METHODS: Basal cortisol level and corticotropin stimulation test were performed within 24 hours in all patients. One group (20 patients) received standard therapy for sepsis and physiological-dose steroid therapy for 10 days; the other group (20 patients) received only standard therapy for sepsis. Basal cortisol level was measured on the 14th day in patients who recovered. The outcome of sepsis was compared. RESULTS: Only Sequential Organ Failure Assessment (SOFA) score was found related to mortality, independent from other factors in multivariate analysis. No significant difference was found between the changes in the percentage of SOFA scores of the steroid therapy group and the standard therapy group in survivors, nor between the groups in basal and peak cortisol levels, cortisol response to corticotropin test and mortality. The mortality rates among patients with occult adrenal insufficiencies were 40% in the steroid therapy group and 55.6% in the standard therapy group. DISCUSSION: There was a trend towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy. In the advancing process from sepsis to septic shock, adrenal insufficiency was not frequent as supposed. There was a trend (that did not reach significance) towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy.