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ABSTRACT: We describe the case of a 75-year-old woman with an iatrogenic fistula between a left internal mammary artery graft to the left anterior descending coronary artery and the left subclavian vein that developed after implantation of a dual-chamber pacemaker.
Europace 08/2008; 10(7):890-1. · 1.98 Impact Factor
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ABSTRACT: We developed an experimental model in sheep femora to evaluate the process of cortical allograft incorporation.
Twenty-four sheep were divided into four groups according to the various treatments of cortical allografts as follows: fresh, frozen, autoclaved, and frozen with perforation. Periodical radiographic and histological evaluations were performed for each group.
Perforated frozen allograft proved to be superior radiographically in the first stage to fresh, frozen, and autoclaved forms. Revascularization was demonstrated by both Spalteholz's technique and histological examination. Histological analysis also showed creeping substitution, from the host bone to the allograft, which increased the reabsorption to facilitate new bone penetration, including endochondral ossification at the host-graft interface.
We believe that endochondral ossification is probably a biological event occurring routinely during the bone healing process and that the processes of incorporation of variously treated cortical allografts differ only at the early phase of implantation.
Archives of Orthopaedic and Trauma Surgery 07/2004; 124(5):320-5. · 1.37 Impact Factor
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ABSTRACT: Preservation methods have enabled bone banks to furnish cortical bone grafts to orthopaedic surgeons. However, cortical bone preserved by freezing and autoclaving, may be weakened by these treatments. To test this hypothesis we compared the ultimate tensile strength of freshly harvested sheep femora with that of femora which were frozen at -20 degrees C for 60 days, or autoclaved at 134 degrees C for 8 min. We measured the collagen and mineral contents (calcium, phosphorus, magnesium) and hydroxyproline of the specimens and tested for changes induced by preservation. Mechanical three point tests showed that frozen femora were significantly stronger than either fresh or autoclaved femora (p<0.05). Frozen specimens also had the highest phosphorus level, indicating these measures are related to strength. Cortical bone is not significantly weakened by autoclaving or freezing. This result does not imply that preserved grafts are clinically interchangeable with fresh grafts, rather, it suggests that future studies should focus on post surgical issues, such as the rate of remodeling and integration, which may be sensitive to preservation technique.
Biomaterials 07/2002; 23(12):2615-9. · 7.40 Impact Factor
