Tanya Mitra

Publications (2)8.3 Total impact

• Source

  Available from: Juan Carlos Martínez Castrillo

  Article: The nondeclaration of nonmotor symptoms of Parkinson's disease to health care professionals: an international study using the nonmotor symptoms questionnaire.

  K Ray Chaudhuri, Cristina Prieto-Jurcynska, Yogini Naidu, Tanya Mitra, Belen Frades-Payo, Susanne Tluk, Anne Ruessmann, Per Odin, Graeme Macphee, Fabrizio Stocchi, William Ondo, Kapil Sethi, Anthony H V Schapira, Juan Carlos Martinez Castrillo, Pablo Martinez-Martin
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  ABSTRACT: The nonmotor symptoms (NMS) of Parkinson's disease (PD) are less well recognised and can be more troublesome to patients and carers than classical motor features. NMS are frequently missed during routine consultations and such under-recognition may have implications on quality of care given that many NMS are treatable. To determine the proportion of patients not declaring NMS to healthcare professional (HCP) as assessed by self completion of the NMS questionnaire (NMSQuest), a validated, self-completing questionnaire with 30 items. Multicentre international study. The data was collected from PD patients across all age groups and stages attending outpatient clinics in specialist and care of the elderly settings. 242 patients recruited and undeclared NMS ranged from 31.8% (diplopia) to 65.2% (delusions). The most frequently nondeclared symptoms were delusions, daytime sleepiness, intense and vivid dreams, and dizziness. In many, appropriate treatments for undeclared NMS were started only after these were recognised following completion of NMSQuest. NMS of PD are frequently undeclared at routine hospital consultation and may be related to the fact that patients often do not link these symptoms with PD or may be too embarrassed to discuss these. Use of NMSQuest allows patients to flag symptoms which may be otherwise undeclared and remain untreated when potential treatments exist.
  Movement Disorders 04/2010; 25(6):704-9. · 4.51 Impact Factor
• Article: Sleep dysfunction and role of dysautonomia in Parkinson's disease.

  Tanya Mitra, K Ray Chaudhuri
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  ABSTRACT: Altered sleep is a common non motor symptom in Parkinson's disease. Sleep dysfunction has been reported to occur in 60-90% of all PD patients, having a detrimental impact on quality of life and increasing disability. alpha-Synuclein deposits in the lower brainstem affecting autonomic and sleep regions have been identified in the pathophysiology. The resultant non motor symptoms such as REM sleep behaviour disorder (RBD) can precede the motor symptoms by years. RBD is violent, enacted dreams that expose the patient or their sleeping partner to night-time injuries. Excessive daytime sleepiness, sometimes with a narcolepsy-like phenotype, is a common occurrence in PD, owing to lesions in the arousal systems of the brain. Restless legs syndrome and sleep disordered breathing can all affect daytime alertness of PD patients. Autonomic deregulation can also negatively affect sleep patterns, by adding to night-time wakening and disrupting sleep.
  Parkinsonism & Related Disorders 12/2009; 15 Suppl 3:S93-5. · 3.80 Impact Factor