Toshihiro Horiguchi

Publications (24)8.46 Total impact

• Article: [Study on discrepancy in perceptions of parents and teachers regarding children with developmental disorders].

  Chieko Akiyama, Kaori Kon, Toshihiro Horiguchi
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  ABSTRACT: Behavioral problems in children with developmental disorders might be recognized differently by parents and teachers. To assess this hypothesis, the same checklist created by authors was fulfilled by both parents and teachers of the same 45 children with developmental disorders. Most parents agreed that their children had problems on attention, while many teachers reported that these children had problems on hyperactivity and interpersonal communication. Acknowledging this discrepancy on the perception between parents and teachers is expected to be useful information for physicians to diagnose and support children with developmental disorders.
  No to hattatsu. Brain and development 07/2008; 40(4):284-8.
• Article: [Evaluation of preclinical onset in patients with the childhood form of cerebral adrenoleukodystrophy--usefulness of visual cognitive function and evoked potential tests].

  Wakana Furushima, Masumi Inagaki, Atsuko Gunji, Makiko Kaga, Hiroko Yamazaki, Toshihiro Horiguchi
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  ABSTRACT: We examined both visual evoked potential (VEP) and neuropsychological tests in 18 patients with X-linked adrenoleukodystrophy (ALD). Patients consisted of 10 boys with apparent lesions in the posterior white matter on MR imaging, 3 with lesions in the frontal white matter area and 5 that were neurologically asymptomatic with no apparent brain MRI abnormalities. Almost all patients with posterior WM lesion showed patterns of lower PIQ than VIQ on WISC-III and lower scores on scales for simultaneous processing than for sequential processing on Kaufman Assesment Battery for Children (K-ABC). Four of 5 asymptomatic patients showed PIQ/VIQ patterns similar to those in the posterior group. Patients with a difference more than 13 between PIQ and VIQ also showed poor results on Frostig developmental test of visual perception (DTVP). There was a prolongation of the peak latency of P100 on flash VEP in many patients with posterior whitematter lesions, however, asymptomatic patients did not show any abnormality of P100 latency but there was an increased amplitude of N75-P100 on flash and pattern reversal stimuli VEP. One patient with abnormally high VEP (31.4 microV; + 3.6 SD) gradually improved to the normal range (11.4 microV; 0SD) after hematopoietic stem cell transplantation. These cognitive and neurophysiological examinations could be useful in the detection of preclinical onset of childhood ALD before the appearance of MRI lesions on MRI.
  No to hattatsu. Brain and development 07/2008; 40(4):301-6.
• Article: [Assessment of parental perception of relevant symptoms in children with developmental disorders].

  Chieko Akiyama, Toshihiro Horiguchi
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  ABSTRACT: We assessed parental perception of relevant symptoms in children with developmental disorders (concern, anxiety and worries regarding to the development of their child) and examined the circumstances leading to consultations with physicians. We analyzed answers from 53 parents who were grouped according to the diagnoses of their children. Developmental disorders were perceived by the parents and the parents immediately consulted physicians at the time of their child's birth in the case of children with Down syndrome, when their child was around 1-1.5 years old in children with pervasive developmental disorders, and when their child was around 3 years old in children with mental retardation. Both worries and the use of consultations by the parents of 1.5-year olds were similar to those of the parents of 2-year olds. Specialists need to recognize that parental perception of developmental disorders and the use of consultations differs according to the diagnosis. To provide continuous support to the families of children with developmental disorders, public medical examination of infants and collaborations between medical, educational and other social organizations must be organized to meet the needs.
  No to hattatsu. Brain and development 08/2007; 39(4):268-73.
• Article: [Self-assessment of facility-based supports for persons with intellectual disabilities and children with motional disabilities].

  Toshihiro Horiguchi
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  ABSTRACT: To improve the support provided at facilities for persons with intellectual disabilities and children with motional disabilities, the author designed a questionnaire to be used for self-appraisal by the personnel of the relevant facilities. Twenty-one facilities participated; these facilities indicated that they needed to improve grievance procedures, the protection of privacy, staff training and collaborations with physicians, though they judged themselves to be able to respond appropriately to requests from individual users. Facilities for children answered that they supplied satisfactory supports, though other facilities such as workshops and community homes did not put regulations on staffs' abuse in statutory form. Grievance procedures and discussion with users are necessary to supply support based on needs of individual users.
  No to hattatsu. Brain and development 06/2007; 39(3):193-7.
• Article: [Assessment of families' need of social life support for persons with intellectual disabilities and physical handicaps].

  Toshihiro Horiguchi
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  ABSTRACT: To study the need for community support for the users of facilities for people with intellectual disabilities and physical handicaps, the author surveyed facility users' families using a mail-in questionnaire. The International Classification of Functioning, Disabilities and Health (ICF) guidelines were used to describe each user. Younger users were found to achieve the best ICF levels of social participation, while rehabilitation facilities and workshops attracted a larger number of adults with fixed participation whose performance level was equivalent to their capacity. In the latter group, the users' families requested accommodation at a group home and the continuous use of the facilities. Among the respondents, a demand for medical support was common, regardless of the type of facilities being used. To support self-decision and the full participation of users, the supervisors of facilities must coordinate their own needs with those of users and their families and provide improved medical support.
  No to hattatsu. Brain and development 08/2006; 38(4):271-6.
• Article: [Assessment of chromosome and gene analysis for the diagnosis of the fragile X syndrome in Japan: annual incidence].

  Toshihiro Horiguchi, Makiko Kaga, Masumi Inagaki
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  ABSTRACT: We assessed the utilization of diagnostic analyses for fragile X syndrome by a mail-in questionnaire on 1) the number of patients analyzed and diagnosed with the syndrome in the past year, 2) types of diagnostic analyses used, 3) clinical features that made physicians to decide analyses, 4) purpose of analyses, and 5) informed consent for analyses. Facilities for the mentally handicapped, as well as hospitals and physicians specialized in genetics, completed our questionnaire. Among 101 responders, total of 543 cases underwent analyses. Nine cases (including 3 cases over 20 years old) were finally diagnosed in a year. The rate of positive findings was 0.6% for chromosomal analyses, and 8% for gene analyses. Physicians dicided to make analyses based on clinical features such as mental retardation, characteristic face, and autistic features, in order to find the cause (s) of the subjects' condition. For gene analyses, more than a half of physicians obtained a form of informed consent. Specialists should have interest in this syndrome because the analyses identified new adult cases. Establishment of a guideline for diagnosis of this syndrome requires gene analyses based on evidence and informed consent.
  No to hattatsu. Brain and development 08/2005; 37(4):301-6.
• Article: ["Early" diagnosis and "early" intervention in children with mental retardation--when is early enough to diagnose them?].

  Makiko Kaga, Masumi Inagaki, Kyoko Tanaka, Toshihiro Horiguchi
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  ABSTRACT: Patients with mental retardation (MR) cannot always be diagnosed accurately by physicians who are specialized in child neurology and/or developmental disorders at their first visit to the clinic. Precise examination such as psychological tests and chromosomal analysis are often necessary to diagnose them. Some patients with autistic disorders without MR often are misdiagnosed as having MR. Patients with mild to moderate MR are sometimes diagnosed late in their late teens or twenties. Timely diagnosis and timely/continuous intervention is more important than early diagnosis and early intervention for the mentally retarded.
  No to hattatsu. Brain and development 04/2005; 37(2):139-44.
• Article: [Japanese physicians'attitude for utilization of social support services for persons with intellectual disabilities].

  Toshihiro Horiguchi, Masumi Inagaki, Makiko Kaga
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  ABSTRACT: We assessed physicians'attitude for the utilization of social (medical, educational, and financial) support services for persons with intellectual disabilities supplied by the Japanese government. A total of 113 physicians specializing in pediatric neurology answered our mail-in questionnaire. Medical care benefits for psychiatric outpatients and short-time stay were the most common services utilized. Whereas most physicians used various public support services regardless of their experience and affiliations, the selection of services by an individual physician correlated with the number and state of patients they usually cared. Physicians were less familiar with the services regarding residential or community care and advocacy. Knowledge of the specialists on each service will enrich assistance appropriate to the life styles of each patient with intellectual disabilities.
  No to hattatsu. Brain and development 10/2004; 36(5):365-71.
• Article: Human auditory evoked mismatch field amplitudes vary as a function of vowel duration in healthy first-language speakers.

  Mayako Inouchi, Mikio Kubota, Katsuya Ohta, Yasuhiro Shirahama, Atsuko Takashima, Toshihiro Horiguchi, Eisuke Matsushima
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  ABSTRACT: Previous auditory studies demonstrated that vowel shortening elicited a more prominent mismatch component than its lengthening in event-related potentials (ERP) and magnetoencephalography (MEG). Based on these findings, the current study investigated whether the magnetic mismatch field (MMF) component would be generated by vowel shortening of various degrees to determine a neuronal response threshold of pre-attentive deviation detection. Behavioral pre-test data revealed that while listening to Japanese short-duration (100%: reference), long-duration (180%), and other in-between duration-synthesized types, healthy native speakers of Japanese failed to clearly categorize 140-124% durations as either short or long words, while categorizing 108-116% durations as short words and 148-172% durations as long. Following these results, MEG responses were recorded with a whole-head 148-channel magnetometer, as subjects listened to 100% standard and five deviant durations (124, 132, 140, 148, 180%). MEG results showed that the above-32% duration decrements (180-->100%, 148-->100%) elicited a more prominent MMF than the others, the MMF amplitudes increasing linearly to the degree of duration deviance, and that neuronal responses correlated with behavioral word-categorization accuracy.
  Neuroscience Letters 09/2004; 366(3):342-6. · 2.11 Impact Factor
• Source

  Available from: Mikio Kubota

  Dataset: Human auditory evoked mismatch field amplitudes vary as a function of vowel duration in healthy first-language speakers

  Mayako Inouchi, Mikio Kubota, Katsuya Ohta, Yasuhiro Shirahama, Atsuko Takashima, Toshihiro Horiguchi, Eisuke Matsushima
  [show abstract] [hide abstract]
  ABSTRACT: Previous auditory studies demonstrated that vowel shortening elicited a more prominent mismatch component than its lengthening in event-related potentials (ERP) and magnetoencephalography (MEG). Based on these findings, the current study investigated whether the magnetic mismatch field (MMF) component would be generated by vowel shortening of various degrees to determine a neuronal response threshold of pre-attentive deviation detection. Behavioral pre-test data revealed that while listening to Japanese short-duration (100%: refer-ence), long-duration (180%), and other in-between duration-synthesized types, healthy native speakers of Japanese failed to clearly categorize 140–124% durations as either short or long words, while categorizing 108–116% durations as short words and 148–172% durations as long. Following these results, MEG responses were recorded with a whole-head 148-channel magnetometer, as subjects listened to 100% stan-dard and five deviant durations (124, 132, 140, 148, 180%). MEG results showed that the above-32% duration decrements (180→100%, 148→100%) elicited a more prominent MMF than the others, the MMF amplitudes increasing linearly to the degree of duration deviance, and that neuronal responses correlated with behavioral word-categorization accuracy.
• Article: [Abnormal findings of dichotic listening test in patients with childhood adrenoleukodystrophy].

  Seiko Shirane, Masumi Inagaki, Toshihiro Horiguchi, Masako Nakamura, Kyoko Sasaki, Makiko Kaga
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  ABSTRACT: Ten Japanese boys with childhood-onset adrenoleukoqdystrophy (ALD) were evaluated with dichotic listening test (DLT). Six cases showed abnormal findings especially of laterality index (L.I.) calculated from the score of each ear. Some of them showed no abnormal findings with other auditory examinations containing auditory brainstem responses (ABR). One patient showed abnormal L.I. of DLT at an early stage. The abnormality of laterality index was similar to the so-called "strong left-ear suppression" in patients who underwent callosotomy. Although all of these six patients had a high signal lesion at the splenium of the corpus callosum in a T3-weighted MRI sequence, it was difficult to evaluate the width of demyelinated area. DLT could detect the early damage of connecting fibers mediating inter-hemispheric transfer of auditory information, and might be a useful method for evaluating the cerebral function of auditory processing in patients with childhood ALD.
  No to hattatsu. Brain and development 08/2004; 36(4):311-7.
• Article: [Guidelines for medical examination of children with mental retardation in pediatric clinics which are specialized for developmental disorders--recommendation based on the current selection and usefulness of diagnostic examinations for children with mental retardation and/or pervasive developmental disorder].

  Kyoko Tanaka, Toshihiro Horiguchi, Masumi Inagaki, Makiko Kaga
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  ABSTRACT: We assessed the present status of choice and usefulness of medical examinations of children with mental retardation (MR) and/or pervasive developmental disorder (PDD). Children with severe MR received more examinations than those with mild MR. Many abnormal findings were demonstrated by MRI in cases of severe MR. Cases of PDD without MR rarely showed abnormal results. Cases of PDD with MR underwent fewer examinations, but showed more abnormal results. We presented guidelines regarding medical examinations for children with MR in pediatric clinics which are specialized for developmental disorders, including psychological tests, hearing tests, EEG, genetic tests and neuroimaging. Physicians should select appropriate medical examinations based on evidence. The goal of testing is to provide useful information concerning medical treatment, therapeutic rearing, and education, and to support patients and their families in cooperation with relevant facilities.
  No to hattatsu. Brain and development 06/2004; 36(3):224-9.
• Article: [Assessment of social networks between developmental physicians and welfare facilities/specialists for children with intellectual disabilities in Japan].

  Masumi Inagaki, Toshihiro Horiguchi, Makiko Kaga
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  ABSTRACT: The social networks between Japanese child neurologists and welfare facilities/specialists for children with mental retardation (MR) were assessed. A total of 113 physicians answered our mail-in questionnaire. Most of the doctors had various connections with nursery homes for children with MR or severe motor and intellectual disabilities (SMID) and with public health centers, and often collaborated with teachers of schools and kindergartens. On the other hand, most physicians had little relation with residential and vocational facilities for adults with MR, and with specialists in residential or community care. There was a statistical correlation between the number of facilities or collaborated specialists and the number of persons seen by each physician; however, the physicians' experience and affiliations had no relation. In view of 'social participation', physicians who usually see children with developmental disorders can play an important role in decision making of their life-style with their families.
  No to hattatsu. Brain and development 06/2004; 36(3):241-7.
• Article: [Assessment of the selection and usefulness of diagnostic examinations for children with mental retardation].

  Kyoko Tanaka, Toshihiro Horiguchi, Masumi Inagaki, Makiko Kaga
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  ABSTRACT: We retrospectively investigated medical records of 196 patients suspected of having mental retardation at their initial visits. The objective of the study was to clarify the current choice of medical examinations and to assess their usefulness. Frequently selected examinations included 1. neuroimaging, neurophysiology and other central nervous system examinations, 2. psychological examinations and 3. blood tests. The former two demonstrated abnormal results very frequently. Genetic examinations rarely showed abnormal results. On the contrary, chromosomal analysis was often useful for diagnosing diseases that are difficult to be made only by clinical symptoms. Physicians should provide patients and their families with information about medical examinations currently available and useful.
  No to hattatsu. Brain and development 10/2003; 35(5):373-9.
• Article: [Assessment of chromosome and gene analysis for the diagnosis of the fragile X syndrome in Japan--estimated prevalence rate in various facilities].

  Toshihiro Horiguchi, Makiko Kaga, Masumi Inagaki
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  ABSTRACT: We assessed the present status of chromosome and gene analyses utilized in Japan for the diagnosis of fragile X syndrome. Nursery facilities for the mentally handicapped and hospitals completed a mail-in-questionnaire including information on the number of patients diagnosed with the syndrome, the types of diagnostic analyses used, and the need for such analyses. Among 517 responders, ninety-five (18.4%, more frequently in hospitals) reportedly conducted chromosome or gene analyses, which established the diagnosis of fragile X syndrome in 56 patients, accounting for 2.2% of patients who underwent the analyses, and 0.13% of the patients included in this study. Each responder's experience with chromosome or gene analyses were related to his/her demand for them. Some facilities that had not utilized these analyses requested information on them as well as access to them. A larger number of specialists interested in diagnostic screening are essential to establish a diagnosis system of fragile X syndrome.
  No to hattatsu. Brain and development 08/2003; 35(4):297-303.
• Article: Neuropsychological developmental change in a case with Noonan syndrome: longitudinal assessment.

  Toshihiro Horiguchi, Kazuhide Takeshita
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  ABSTRACT: The authors describe the neuropsychological development of a 10-year-old boy with Noonan syndrome. The subject's IQ showed normal intelligence, although there was a discrepancy between verbal and performance IQs. Visual perception was delayed, with clumsiness and inattention affecting his performance. Both visual perception and hyperactivity improved with the subject's general development, but his inattention seemed to increase after the age of 9. The behavioral features and cognitive profile of our case resembled those of attention-deficit/hyperactivity disorder. We recommend that clinicians should evaluate cautiously the specific profile of cognitive development in Noonan syndrome with particular focus on controlling the patient's inattention.
  Brain and Development 07/2003; 25(4):291-3. · 2.12 Impact Factor
• Article: An MEG study of P300 activity during a color discrimination task 2: source localization study.

  Toshihiro Horiguchi, Katsuya Ohta, Toru Nishikawa
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  ABSTRACT: In this study, we described developmental changes in an event-related magnetic source of P300 activity during a visual oddball paradigm using magnetoencephalography. The maximum and minimum points of each peak of target P300 activity were scattered in a more anterior temporal area in children than in adults. The single dipole source analysis successfully estimated a dipole in the vicinity of the thalamus and the cingulate gyrus in adults. The location differed in children, although the dipole had overall greater moment in children than in adults. Our findings suggest that the thalamus plays an important role in generating P300 activity specific to color discrimination processing, and that in children the source is not consistent during development.
  Brain and Development 07/2003; 25(4):241-4. · 2.12 Impact Factor
• Article: An assessment of the mental health of physicians specializing in the field of child neurology.

  Toshihiro Horiguchi, Makiko Kaga, Masumi Inagaki, Akira Uno, Robert Lasky, Kurt Hecox
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  ABSTRACT: We assessed physicians working in the field of child neurology with the aim of improving the physicians' mental health. Our questionnaire included a burnout inventory and a general health questionnaire. We analyzed 29 responses from physicians in a variety of countries obtained through the Internet. According to their responses, 8 (27.5%) of the respondents had attained a burnout status, and 27 respondents (93.1%) had neurotic conditions. We found a greater percentage of physicians in poor mental health than we had found previously in assessments made in Japan. However, the respondents in the present survey had more positive styles for coping with stress. The length of time working as a physician affected respondents in Japan and internationally, whereas nationality or working environment (workplace, night shifts, and so on) did not. Consultants or mentors on work and assertive stress coping would be effective.
  Journal of Pediatric Nursing 03/2003; 18(1):70-4.
• Article: [Multiple personality disorder(dissociative identity disorder)].

  Toshihiro Horiguchi
  Ryōikibetsu shōkōgun shirīzu. 02/2003;
• Article: [Intermittent explosive disorder].

  Toshihiro Horiguchi
  Ryōikibetsu shōkōgun shirīzu. 02/2003;