Cezary Kowalski

Publications (4)7.43 Total impact

• Source

  Available from: Mario Giorgi

  Article: Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study.

  Mario Giorgi, Giuseppe Saccomanni, Beata Lebkowska-Wieruszewska, Cezary Kowalski
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  ABSTRACT: The study evaluated the pharmacokinetics of tramadol and its major metabolites O-desmethyltramadol (M1), N-desmethyltramadol (M2) and N-O didesmethyltramadol (M5) following a single oral administration of a sustained release (SR) 100mg tablet to dogs. Plasma tramadol concentration was greater than the limit of quantification (LOQ) in three dogs, M1 was quantified only in one dog while M2 and M5 were quantified in all of the dogs. The median values of C(max) (maximum plasma concentration), T(max) (time to maximum plasma concentration) and T(1/2) (half-life) for tramadol were 0.04 (0.17-0.02)mirog mL(-1), 3 (4-2) and 1.88 (2.211-1.435)h, respectively. M5 showed median values of C(max), T(max) and T(1/2) of 0.1 (0.19-0.09)microg mL(-1), 2 (3-1) and 4.230 (6.583-1.847)h, respectively. M2 showed median values of C(max), T(max) and T(1/2) of 0.22 (0.330-0.080)microg mL(-1), 4 (7-3) and 4.487 (6.395-1.563)h, respectively. The findings suggest that the SR formulation of tramadol may not have suitable pharmacokinetic characteristics to be administered once-a-day as an effective and safe treatment for pain in the dog.
  The Veterinary Journal 03/2008; 180(2):253-5. · 2.24 Impact Factor
• Source

  Available from: Małgorzata Pomorska-Mól

  Article: Total antioxidant potential measurement using improved fluorometric assay

  Cezary Kowalski, Małgorzata Pomorska, Bronisław K Głód, Anna Konior
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  ABSTRACT: Total Antioxidant Potential (TAP) frequently better describes the antioxidant properties of the complex biological samples (such as herbal extracts or blood plasma) than concentrations of all individual antioxidants in the sample. In the paper improved fluorometric assays of the TAP measurements have been described. These tests adopt thermolabile diazocompound [2,2’-diazobis (2-amidinopropane) dihydrochloride – AAPH] generating peroxyl radical, Fenton reaction produced hydroxyl radicals and SIN-1 (3-morpholino-sydnonimine) generating peroxynitrite. These radicals oxidize the analyzed samples and so called „detector”. Sample competes with the reaction between detector and radical; therefore, it delays this reaction. Results are calculated from the delay time during which antioxidants are consumed. Assays related to different radicals are described and compared.
  A N N A L E S U N IV E R S I T A T I S MA R IA E C U R I E - S K Ł O D OWS K A L U B L IN – P O L O N IA Sectio DD. 01/2006; LXI, 6:55-59.
• Article: Lipophilicity of a series of 1,2-benzisothiazol-3(2H)-ones determined by reversed-phase thin-layer chromatography.

  Tomasz Sławik, Cezary Kowalski
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  ABSTRACT: The lipophilicity (R(Mo)) and specific hydrophobic surface area of seven 1,2-benzisothiazol-3(2H)-ones have been determined by reversed-phase TLC and the effect of different mobile-phase modifiers (acetone, acetonitrile, methanol) on the retention has been studied. The linear correlations between the volume fraction of the organic solvent and the R(M) values over a limited range were established for each solute with high values of correlation coefficients (>0.99). The influence of solvent pH on R(M) values was investigated.
  Journal of Chromatography 04/2002; 952(1-2):295-9. · 4.53 Impact Factor
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  Available from: content-manager.pl

  Article: Determination of oxytetracycline in biological matrix.

  Cezary Kowalski, Małgorzata Pomorska, Beata Lebkowska, Tomasz Sławik
  Acta poloniae pharmaceutica 64(3):277-80. · 0.66 Impact Factor