Kuei-Hua Lin

National Tsing Hua University, Hsinchu, Taiwan, Taiwan

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Publications (4)5.79 Total impact

  • Kuei-Hua Lin, Tieh-Chi Chu, Fu-Ken Liu
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    ABSTRACT: We describe a rapid, simple, and highly efficient capillary electrophoresis (CE)-based method for the analysis of nanoparticles (NPs). In this study, we used the reversed electrode polarity stacking mode (REPSM) of CE to assess the feasibility of enhancing the detection of Au NPs and Au/Ag NPs, optimizing parameters such as the length of time for which the REPSM was applied, the concentrations of the buffer and the sodium dodecylsulfate (SDS) surfactant, and the pH. Under the optimized on-line enhancement conditions [buffer: SDS (40 mM) and 3-cyclohexylamino-1-propanesulfonic acid (CAPS; 10 mM) at pH 10.0; applied voltage: 20 kV; REPSM applied for 24s], the detection limits of the Au NPs and Au/Ag NPs increased by ca. 30- and 140-fold, respectively. In addition, when the NPs were subjected to on-line enhancement and separation by CE using diode array detection (DAD), this approach allowed chemical characterization of the NP species. Our results suggest that such CE analyses will be useful for accelerating the rates of fabrication and characterization of future nanomaterials.
    Journal of Chromatography A 09/2007; 1161(1-2):314-21. · 4.61 Impact Factor
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    ABSTRACT: This investigation attempts to solve the problem of the lack of skin-sparing effect in electron radiation therapy and to increase the tolerance of skin to radiation using the grid technique. Electron grid therapy involves the mounting of a Cerrobend grid in the electron cone. Film dosimetry was employed to measure the relative surface dose and the percentage depth dose profile of electron grid portals. Various grid hole diameters (d = 0.45, 1.0, 1.5 cm) and grid hole spacings (s = 0.4, 0.2 cm) were considered for electron beams from 6 to 14 MeV. Experimental results indicate that the electron grid technique can reduce the relative surface dose in electron radiation therapy. Degradations of the relative surface dose depend on the percentage of open area in the grid portal. A proper grid design allows the surface dose to be reduced and the range of nonhomogeneous doses to be limited to a depth at which the target volume can receive a homogeneous dose. The grid technique can lower the surface dose in electron radiation therapy.
    Applied Radiation and Isotopes 04/2002; 56(3):477-84. · 1.18 Impact Factor
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Publication Stats

18 Citations
5.79 Total Impact Points

Institutions

  • 2002–2007
    • National Tsing Hua University
      • • Department of Biomedical Engineering and Environmental Sciences
      • • Department of Nuclear Science
      Hsinchu, Taiwan, Taiwan