P Chérin

Université de Rouen, Mont-Saint-Aignan, Upper Normandy, France

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Publications (239)377.16 Total impact

  • La Revue de Médecine Interne 06/2014; 35:A155-A156. · 0.90 Impact Factor
  • P. Cherin
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    ABSTRACT: Dietary excess of saturated fats and cholesterol accounts for the most common cause of moderate LDL-C elevation, a major and independent predictor of cardiovascular disease-related morbidity and mortality. Among various treatments including diet and pharmacologic therapy affecting various pathways of cholesterol absorption and metabolism, statins are the currently available and most powerful LDL-C lowering agents leading to an effective cardiovascular mortality and morbidity decrease. Statins use is safe but muscular intolerance, a common related-disorder, is a difficult challenge to manage.
    NPG Neurologie - Psychiatrie - Gériatrie 01/2013;
  • P. Cherin
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    ABSTRACT: Myopathies in the elderly are relatively frequent and regularly underestimated. The clinical manifestations suggestive of a myopathy are somewhat unspecific: myalgia, weakness, fatigue or intolerance during effort and the problem is linking them to ageing. Certain genetic myopathies only appear in adulthood, sometimes after the fifth decade. But the great majority of myopathies in the elderly are of acquired origin: dysimmune (notably inclusion body myositis), endocrine (thyroiditis) and above all toxic or iatrogenic first of all due to two myotoxic drugs: corticoids and hypercholesterol lowering drugs (mainly statins). It is necessary, when confronted with any persistent myalgia or muscular fatigability, to request muscular enzymes and an electromyography before referring the patient to a specialized department.
    NPG Neurologie - Psychiatrie - Gériatrie 01/2013;
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    ABSTRACT: OBJECTIVES: To: 1) assess the outcome of interstitial lung disease (ILD) in anti-Jo1 patients with antisynthetase syndrome (ASS); 2) determine predictive variables of ILD deterioration in these patients; and 3) compare features of anti-Jo1 patients with and without ILD. METHODS: Ninety-nine anti-Jo1 patients were identified by medical records search in 4 medical centers. All these patients had undergone pulmonary function tests (PFT) and high resolution computed tomography (HRCT)-scan. RESULTS: Sixty six patients (72.5%) had ILD. Patients could be divided into 3 groups according to their presenting lung manifestations: acute onset of lung disease (n=12), progressive onset of lung signs (n=35) and asymptomatic patients exhibiting abnormalities consistent with ILD on PFT and HRCT-scan (n=19). Sixteen patients had resolution of ILD; 39 and 11 experienced improvement and deterioration of ILD, respectively. ILD led to decreased functional status, as 29.8% of patients exhibited a marked reduction of activities due to ILD and 13.6% had respiratory insufficiency requiring O(2) therapy; 5 of 6 patients died, due to ILD complications. Predictive parameters of ILD deterioration were: HRCT-scan pattern of usual interstitial pneumonia, respiratory muscle involvement and age ?55 years. Furthermore, anti-Jo1 patients with ILD, compared with those without, more frequently exhibited mechanic's hands and lower CK levels. CONCLUSION: Our findings confirm that ILD is a frequent complication in anti-Jo1 patients, resulting in high morbidity. We suggest that patients with predictive factors of ILD deterioration may require more aggressive therapy. Finally, anti-Jo1 patients with ILD, compared with those without, may exhibit a particular clinical phenotype. © 2012 by the American College of Rheumatology.
    Arthritis care & research. 11/2012;
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    ABSTRACT: Pesticides constitute a very heterogeneous group of chemical substances adapted to the wrestling against plants and unwanted animals: weed-killers, fungicides, insecticides, acaricides, nématicides and rodenticides mainly. These phytosanitary products possess all a toxicity, of variable intensity, for the human. The acute toxicity of pesticides results from a misuse, from an accidental use of pesticides (accidents in the home) or from an often very serious voluntary poisoning. Organophosphate pesticides and carbamates are at the origin of the cases of poisonings by the most frequent pesticides. The exposure is essentially made by cutaneo-mucous and respiratory way, oral exposure would concern more the general population by accidental or deliberate ingestion of pesticides. According to the World Health Organization (WHO), there is every year in the world one million grave poisonings by pesticides, at the origin of approximately 220,000 deaths a year.
    Medecine et Longevite 06/2012; 4(2):68–74.
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    ABSTRACT: The problems of environment became a major concern of our societies, in particular the risk bound to the exposure in pesticides. France remains a big consumer of pesticides: third world user and first consumer in Europe. These pesticides are used in 90% by the agriculture. The presence and the obstinacy of these phytosanitary products (and or of their residues) in our grounds, groundwaters, food cycle, and finally for a certain number, in our plates, worry a big part of the scientific community. And the proofs of their harmfulness for the human health, difficult to bring to light because of the complexity of the problem, begin to accumulate.
    Medecine et Longevite 06/2012; 4(2):59–67.
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    ABSTRACT: The risks for the health of pesticides are the object of numerous debates. If the data remain controversial at the adult with the exception of lymphomas, associations are found more frequently in the cancers of the child, in particular brain tumours, leukaemia and nephroblatomes. In brain tumours, an association is frequently evoked during a professional exhibition (exposure) of the relatives (parents) at the time of the pregnancy. Diverse consequences of pesticides on the reproduction were evoked: infertility, fœtal death, prematurity, hypotrophia, congenital malformations; but the studies suffer certain ways. Pesticides can interfere with hormones (endocrine disruptors), growth factors or neurotransmitters. The study of the neurological appearances in connection with the use of pesticides seems to be established. In particular, the link between the use of pesticides and the arisen of a Parkinson's disease appears at present as likely, in view of the numerous realized works.
    Medecine et Longevite 06/2012; 4(2):75–92.
  • C. de Jaeger, P. Cherin
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    ABSTRACT: Within the vascular wall, endothelial cells, vascular smooth muscle cells and fibroblasts are surrounded by a complex and structured network of secreted macromolecules and proteins, the extracellular matrix. The extracellular matrix provides a structural framework essential for the functional properties of tissues. In each tissue, the three-dimensional organisation of the extracellular matrix molecules – elastin, collagens, proteoglycans and structural glycoproteins – synthesized during development and growth is optimal for these functions. Reciprocal interactions between matrix and cells are essential to growth, development and remodeling. In adult tissues, proteases are constitutively expressed but have a very low activity and the turnover of elastic and collagen fibers is very low. During ageing, the interaction of environmental factors (glucose, lipids, calcium…) and modifications of the biosynthesis and degradation processes lead to modifications of extracellular matrix homeostasis and consequently to alterations of tissue functionality. The extracellular matrix of old large elastic arteries undergoes several modifications. The elastic lamellae are fragmented or degraded and calcify, whereas more rigid proteins, such as collagen, accumulate and cause fibrosis. These alterations are associated with the stiffening of arteries, which results in the development of isolated systolic hypertension.
    Medecine et Longevite 03/2012; 4(1):41–53.
  • C. de Jaeger, P. Cherin
    Medecine et Longevite 12/2011;
  • La Revue de Médecine Interne 12/2011; 32:S259. · 0.90 Impact Factor
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    ABSTRACT: The aims of this present study were to: 1) assess the characteristics of hematological malignancies in polymyositis/polymyositis (PM/DM) patients; and 2) determine predictive variables of hematological malignancies in PM/DM patients. We retrospectively reviewed the medical records of 32 patients (14 PM, 18 DM) associated with hematological malignancies. In our 32 PM/DM patients, hematological malignancy was concurrently identified (18.8%) or occurred during the course of PM/DM (31.2%); although, PM/DM more often preceded hematological malignancy onset (50%). We observed that the types of hematological malignancies varied, consisting of: B-cell lymphoma (n=20), T-cell lymphoma (n=4), Hodgkin's disease (n=2), multiple myeloma (n=1), myelodysplastic syndrome without excess of blasts (n=3), hairy cell (n=1) and acute lymphocytic leukemia (n=1). In 21 patients of our 32 patients with PM/DM-associated hematological malignancy (65.6% of cases), PM/DM paralleled the course of hematological malignancy. Finally, we observed that patients with PM/DM-associated hematological malignancies had a poor prognosis, the survival status ranging from 96.9%, 78.1% and 51.4% at 1, 3 and 5years, respectively. Interestingly, we found that patients with hematological malignancies, compared with those without were older and more frequently had DM; on the other hand, these patients less commonly exhibited: joint involvement (p=0.017), interstitial lung disease (p=0.06) and anti-Jo1 antibody (p=0.001). Taken together, our study underscores that the association between PM/DM and hematological malignancy, especially lymphoma, should not be ignored. Our findings also suggest that antisynthetase syndrome may be a protective factor of hematological malignancy in PM/DM patients.
    Autoimmunity reviews 10/2011; 11(9):615-20. · 6.37 Impact Factor
  • P. Cherin, C. de Jaeger
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    ABSTRACT: Low back pain is one of the most frequent pathologies in industrial nations. Low back pain is considered to be chronic if it has been present for longer than 3 months. Low back pain constitutes the second cause of consultation and the third cause of request of incapacity. The treatment and the prevention of low back pain represent major stakes in public health. The chronic low back pain comes along with a physical deconditioning, and frequently with a progressive desocialisation. The chronic low back pain constitutes a multidimensional syndrome, containing a strong psychosocial constituent. So, numerous risk factors of passage in the chronicity were highlighted, whose most important are work and psychosocial factors. Treatment for chronic low back pain may last from a few weeks to several months, and usually takes a multimodality approach, in which several different therapies (drug, physical, interventional, complementary, psychological) are used in combination with one another. The indications of the surgery in chronic low back pain remain limited.
    Medecine et Longevite 09/2011; 3(3):137–149.
  • Source
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    ABSTRACT: This study was undertaken to assess the characteristics and outcome of interstitial lung disease (ILD) in polymyositis/dermatomyositis (PM/DM) and to determine variables predictive of ILD deterioration in PM/DM. Among 348 consecutive patients with PM/DM, 107 patients with ILD were identified by medical records search in 4 medical centers. All patients underwent pulmonary function tests (PFTs) and pulmonary high-resolution computed tomography (HRCT) scan. ILD onset preceded PM/DM clinical manifestations in 20 patients, was identified concurrently with PM/DM in 69 patients, and occurred after PM/DM onset in 18 patients. Patients with ILD could be divided into 3 groups according to their presenting lung manifestations: patients with acute lung disease (n = 20), patients with progressive-course lung signs (n = 55), and asymptomatic patients with abnormalities consistent with ILD evident on PFTs and HRCT scan (n = 32). We observed that 32.7% of the patients had resolution of pulmonary disorders, whereas 15.9% experienced ILD deterioration. Factors that predicted a poor ILD prognosis were older age, symptomatic ILD, lower values of vital capacity and diffusing capacity for carbon monoxide, a pattern of usual interstitial pneumonia on HRCT scan and lung biopsy, and steroid-refractory ILD. The mortality rate was higher in patients with ILD deterioration than in those without ILD deterioration (47.1% versus 3.3%). Our findings indicate that ILD results in high morbidity in PM/DM. Our findings also suggest that more aggressive therapy may be required in PM/DM patients presenting with factors predictive of poor ILD outcome.
    Arthritis & Rheumatology 06/2011; 63(11):3439-47. · 7.48 Impact Factor
  • La Revue de Médecine Interne 06/2011; 32. · 0.90 Impact Factor
  • La Revue de Médecine Interne 06/2011; 32. · 0.90 Impact Factor
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    ABSTRACT: Fabry disease (FD) is an X-linked lysosomal storage disorder due to α-galactosidase A deficiency. It is associated with a broad range of clinical symptoms, resulting in frequent misdiagnosis and diagnostic delay, which may impact on patient outcomes. This retrospective observational study of 58 FD patients referred to 10 internal medicine departments in France aimed to review differential diagnoses received prior to diagnosis and examines diagnostic delay. The average age at the time of diagnosis was 27.6 years (range: 10-60) and 42.2 years (range: 9-77) among the 23 males and 35 females analyzed, respectively. Most common symptoms that led to FD diagnosis were family history of FD (12 males and 27 females), followed by pain in extremities (10 males and 5 females), and angiokeratoma (8 males and 4 females). Eighteen patients had received alternative diagnoses prior to FD diagnosis, including a female patient with four previous diagnoses. Four case reports are presented, which illustrate the diagnostic 'odyssey' and delayed diagnosis often experienced by patients. Clinicians should consider a diagnosis of FD when presented with a wide range of symptoms, thus helping to shorten the diagnostic delay and facilitating early therapy with enzyme replacement therapy to improve patient outcomes.
    Clinical Genetics 05/2011; 81(6):571-7. · 4.25 Impact Factor
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    ABSTRACT: Gaucher disease type 1 (GD1), results in a range of skeletal complications including osteopenia, osteoporosis, and osteonecrosis, but there is little published information regarding vertebral fractures. Findings from this observational study indicated that the prevalence of vertebral fractures in a cohort of adult French GD1 patients is approximately 15%. The aim of the study was to assess the prevalence and characteristics of vertebral fractures in a cohort of adult patients with GD1. This study was performed in adult patients with GD1 based on a detailed and complete clinical examination. For all patients for whom vertebral fractures were reported, a specific questionnaire was sent to physicians, and imaging data were collected, when available, for centralized analysis. Data were collected from a total of 105 adult GD1 patients. Bone complications were reported in 85% of patients, among whom vertebral fractures were diagnosed in 16 (15%); seven women and nine men (mean age, 45 years). We observed five patients with multiple vertebral fractures and one patient in whom the T3 vertebra was fractured. Most of these patients did not report fracture-related back pain. The prevalence of vertebral fractures in this cohort of adult patients with GD1 was 15%. Greater awareness of the natural history of vertebral fractures in GD1, and rigorous monitoring of bone fragility and spine involvement in affected patients, should allow earlier detection and initiation of treatment tailored toward improving bone status.
    Osteoporosis International 04/2011; 22(4):1255-61. · 4.04 Impact Factor
  • P. Cherin
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    ABSTRACT: Sarcopenia or age-related loss of muscle mass is observed in older adult subjects. Based on accepted definition of sarcopenia (skeletal muscle mass lesser than 2 standard deviations below the mean for young healthy adults measured by dual-photon absorptiometry), prevalence of sarcopenia is estimated to 27 to 59 % of women and 30 to 45 % of men. Sarcopenia is responsible of falls and associated with functional impairment and subsequent physical disability. Sarcopenia is hypothesized to result from various mechanisms, including physical activity, nutritionnal status, mitochondrial dysfunction, immunologic and hormonal changes occurring with age. For example, low levels of insulin-like growth factor-1 in men predict loss of fat-free mass. Endurance and resistance exercise remain the best prevention treatment of sarcopenia. Nutritional or creatine supplementation and hormone therapy including oral testosterone do not show significant interest in sarcopenia. Camptocormia, a postural disorder by malfunction of spinal extensor muscles, is related to multiples aetiologies (neurological, myopathies…). Treatment is primarily causative.
    Combustion and Flame - COMBUST FLAME. 01/2011; 11(62):70-75.
  • P. Cherin
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    ABSTRACT: Fibromyalgia is a complex medical disorder characterized by chronic widespread pain and allodynia, a heightened and painful response to pressure, without etiology. Fibromyalgia is considered a controversial diagnosis, due to lacking scientific consensus to its cause. The most widely accepted set of classification criteria for research purposes was elaborated in 1990 by the Multicenter Criteria Committee of the American College of Rheumatology. Fibromyalgia is estimated to affect 1 to 3 % of the population, with a female to male incidence ratio of approximately 8:1. There is strong evidence that severe stress and post-traumatic disorders are associated and may be the cause of fibromyalgia.
    Medecine et Longevite 01/2011; 3(1):3-14.
  • P. Cherin
    Environmental Research - ENVIRON RES. 01/2011; 3(1):1-2.

Publication Stats

1k Citations
377.16 Total Impact Points

Institutions

  • 2012
    • Université de Rouen
      Mont-Saint-Aignan, Upper Normandy, France
  • 2011
    • Hôpital Bichat - Claude-Bernard (Hôpitaux Universitaires Paris Nord Val de Seine)
      • Service de Médecine Interne
      Paris, Ile-de-France, France
  • 1993–2011
    • Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
      • Service de Médecine Interne 1
      Lutetia Parisorum, Île-de-France, France
  • 2010
    • Hôpital Saint-Antoine (Hôpitaux Universitaires Est Parisien)
      • Service de Médecine Interne
      Paris, Ile-de-France, France
  • 2002–2010
    • Centre Hospitalier Universitaire Rouen
      • Service d'Urologie
      Rouen, Upper Normandy, France
  • 1997–2001
    • Université Paris-Est Créteil Val de Marne - Université Paris 12
      • Faculty of medicine
      Créteil, Île-de-France, France
  • 1991–1994
    • Hôpital Antoine-Béclère – Hôpitaux universitaires Paris-Sud
      Clamart, Île-de-France, France