Kiichiro Danno

Publications (12)26.76 Total impact

• Article: A case of acne fulminans in a patient with ulcerative colitis successfully treated with prednisolone and diaminodiphenylsulfone: a literature review of acne fulminans, rosacea fulminans and neutrophilic dermatoses occurring in the setting of inflammatory bowel disease.

  Makiko Wakabayashi, Noriki Fujimoto, Toshiaki Uenishi, Kiichiro Danno, Toshihiro Tanaka
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  ABSTRACT: A 19-year-old Japanese man had been treated for ulcerative colitis for 2 years. He was admitted to our hospital with nodulocystic inflammatory papules and pustules on his face and chest, high-grade fever, arthralgia and general malaise. A biopsy specimen from a pustule showed prominent infiltration of neutrophils in the epidermis and dermis, particularly around hair follicles. We made a diagnosis of acne fulminans. The systemic administration of prednisolone at 30 mg daily for 1 week immediately improved his skin lesions and other symptoms; however, during tapering of prednisolone at 20 mg daily, skin lesions flared up. The addition of oral diaminodiphenylsulfone improved the skin lesions. Although there have been a few reports of acne fulminans associated with Crohn's disease, this is the first case report of acne fulminans in a patient with ulcerative colitis. It is noteworthy that the addition of diaminodiphenylsulfone was effective for treating the relapse of acne fulminans in this case.
  Dermatology 04/2011; 222(3):231-5. · 2.05 Impact Factor
• Article: Photochemotherapy combined with tacalcitol occlusive dressing in the treatment of wide-spread psoriasis vulgaris.

  Norikazu Fujii, Kiichiro Danno, Toshihiro Tanaka
  The Journal of Dermatology 08/2010; 37(8):743-6. · 1.49 Impact Factor
• Article: Photosensitivity with eosinophilia due to ambroxol and UVB.

  Noriki Fujimoto, Kiichiro Danno, Makiko Wakabayashi, Toshiaki Uenishi, Toshihiro Tanaka
  Contact Dermatitis 03/2009; 60(2):110-3. · 3.51 Impact Factor
• Article: Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis.

  Toshiro Sugimoto, Mariko Soumura, Kiichiro Danno, Kenzo Kaji, Miki Kondo, Kunio Hirata, Jun Nakazawa, Takashi Uzu, Yoshihiko Nishio, Atsunori Kashiwagi
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  ABSTRACT: We have encountered a 68-year-old Japanese woman with limited cutaneous systemic sclerosis who developed de novo onset of accelerated hypertension and renal dysfunction; thus we diagnosed scleroderma renal crisis. Anticentromere antibody alone was identified, and not anti-DNA topoisomerase I antibody, anti-RNA polymerase antibodies, anti-Th/To antibodies, or antiribonucleoprotein antibodies, even with use of immunoprecipitation assay. She was successfully treated with angiotensin-converting enzyme inhibitor. This case, scleroderma renal crisis with detection of anticentromere antibody, is thought to be extremely uncommon.
  Modern Rheumatology 02/2006; 16(5):309-11. · 1.58 Impact Factor
• Article: Atopic dermatitis-like pruritic skin inflammation caused by feeding a special diet to HR-1 hairless mice.

  Masanori Fujii, Junko Tomozawa, Nobuaki Mizutani, Takeshi Nabe, Kiichiro Danno, Shigekatsu Kohno
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  ABSTRACT: Dry skin/barrier dysfunction is considered to be one of the characteristic features of atopic dermatitis (AD). When HR-1 hairless mice are fed a special diet, HR-AD, dry red skin is induced. We examined whether HR-AD-fed mouse could be used as a model for AD by showing itch-associated scratching behaviour and by analysing the immunological change. HR-1 mice were fed HR-AD from 4 weeks old. HR-AD-fed mice showed severe dry skin symptoms accompanied by a decrease in dermal water content and an increase in transepidermal water loss and prolonged scratching bout duration on day 14 or 28. These symptoms became gradually worse until day 56. Marked epidermal hyperplasia and slight increase in CD4+ cells in the skin were observed from day 28. In contrast, increases in circulating T cells and serum immunoglobulin E were seen from day 41. Other skin-infiltrating inflammatory cells, such as eosinophils and mast cells, were increased on day 56 but not on day 28. Though daily oral treatment with dexamethasone reduced the increased numbers of these cells, it did not affect the dry skin symptoms or the prolonged scratching episodes. In contrast, the development of dry skin was inhibited by feeding with 10% normal diet-containing HR-AD. The skin barrier dysfunction in HR-AD-fed mice is closely associated with the development of AD-like pruritus. Changes in the immunological parameters observed may be the consequence of skin barrier dysfunction. Our findings suggest that HR-AD-fed mouse could be used as a dry skin-based experimental model for AD.
  Experimental Dermatology 07/2005; 14(6):460-8. · 3.54 Impact Factor
• Article: Treatment of acquired perforating dermatosis with narrowband ultraviolet B.

  Shuichi Ohe, Kiichiro Danno, Hiroko Sasaki, Taiki Isei, Hiroyuki Okamoto, Takeshi Horio
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  ABSTRACT: Acquired perforating dermatosis is difficult to treat. We describe effective therapy of acquired perforating dermatosis with narrowband UVB in 5 patients. Phototherapy was given 2 or 3 times weekly. The dose was started at 400 mJ/cm(2) and increased to a maximum of 1500 mJ/cm(2). All lesions disappeared completely after 10 to 15 exposures without adverse effects. Two patients with diabetes mellitus but without chronic renal failure experienced no recurrence until 5 and 10 months after stopping the phototherapy. One patient undergoing hemodialysis for chronic renal failure experienced a recurrence of pruritus and small papules after 1 month. Two patients undergoing hemodialysis showed no recurrence during narrowband UVB maintenance therapy until 7 and 8 months.
  Journal of the American Academy of Dermatology 07/2004; 50(6):892-4. · 3.99 Impact Factor
• Article: Delayed type allergic itch-associated response induced by toluene-2,4-diisocyanate in hairless mice.

  Kazuhiro Fuchibe, Takeshi Nabe, Masanori Fujii, Nobuaki Mizutani, Kiichiro Danno, Akihide Koda, Shigekatsu Kohno
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  ABSTRACT: To develop an allergic dermatitis model showing persistent scratching in mice, toluene-2,4-diisocyanate (TDI) was repeatedly painted onto the skin of hairless HR-1 mice, and induction of itch-associated scratching behavior was observed. When HR-1 mice were epicutaneously sensitized with 1% TDI and then challenged by repeated painting the cervicodorsal skin with 0.1% TDI once every 10 days until the 10th challenge, delayed type scratching responses peaked at 1 - 2 days after challenge. TDI at 0.1% hardly induced scratching in non-sensitized HR-1 mice. The delayed scratching response was influenced by neither an H(1) nor 5-HT(1/2) receptor antagonist. On the other hand, intradermal injection of histamine and serotonin induced frequent scratching in HR-1 mice. In conclusion, repeated application of TDI can induce delayed type allergic scratching. Although HR-1 mice are high responders to both histamine and serotonin, induction of the delayed response depends on neither of these chemical mediators. This delayed response may be useful in analyzing the mechanisms of allergic pruritus.
  Journal of Pharmacological Sciences 10/2003; 93(1):47-54. · 2.08 Impact Factor
• Article: Erythema gyratum repens responding to cetirizine hydrochloride.

  Fumi Miyagawa, Kiichiro Danno, Masami Uehara
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  ABSTRACT: We report a case of erythema gyratum repens (EGR) in a 59-year-old man with inoperable pancreatic cancer and liver metastasis. The patient had a widespread erythema with concentric marginal band spreading in waves over the trunk and extremities. Numerous vesicles were seen on the margin of the erythema. The skin lesions were severely pruritic, and his peripheral blood showed marked eosinophilia. He also had palmoplantar hyperkeratosis. A biopsy specimen of the erythema disclosed spongiosis, microvesicles filled with eosinophils, infiltration of eosinophils into the epidermis, and a perivascular infiltrate in the dermis. The skin lesions and pruritus cleared quickly after the administration of cetirizine hydrochloride.
  The Journal of Dermatology 12/2002; 29(11):731-4. · 1.49 Impact Factor
• Article: Sun exposure is an aggravating factor responsible for the recalcitrant facial erythema in adult patients with atopic dermatitis.

  Hideki Deguchi, Kiichiro Danno, Hisashi Sugiura, Masami Uehara
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  ABSTRACT: In Japan, a considerable number of adult patients with atopic dermatitis suffer from recalcitrant facial erythema that resists common treatment with topical corticosteroids and antihistamines. Our purpose was to investigate the potential role of sun exposure in the aggravation of these facial lesions. The history of photoaggravation was taken from 74 adult patients with atopic dermatitis who suffered from recalcitrant facial erythema. Repeated UVB and UVA phototests were performed in 36 patients. Surface markers of infiltrating cells in UVB-provoked lesions were characterized immunohistochemically. Forty-one of 74 patients experienced an exacerbation of the facial lesions after sun exposure. UVB testing revealed an abnormal, papular response in 14 of 36 patients. All of the 14 patients complained of clinical aggravation after sun exposure. No abnormal reactions were observed at UVA testing. In UVB-provoked lesions, CD4+ cells were predominant to CD8+ cells. Exposure to UVB radiation may be responsible for the recalcitrant facial erythema in at least some of the patients with atopic dermatitis.
  Dermatology 02/2002; 204(1):23-8. · 2.05 Impact Factor
• Article: Near‐infrared irradiation stimulates cutaneous wound repair:laboratory experiments on possible mechanisms

  Kiichiro Danno, Noriko Mori, Ken-ichi Toda, Takashi Kobayashi, Atsushi Utani
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  ABSTRACT: Background/Aims: Several physical agents such as low-energy lasers have been used in the treatment of chronic skin ulcers. This study was performed to investigate potential effects of a newly-developed, specific near-infrared light source on wound repair.Methods: Cultured human keratinocytes, endothelial cells and fibroblasts were exposed to the light, and the production of transforming growth factor (TGF)-β1 and matrix metalloproteinase (MMP)-2 was examined by enzyme immunoassay, zymography and reverse transcription polymerase chain reaction. Incisional wounds were created in ICR and db/db diabetic mice and the effect of irradiation on wound closure was followed photographically.Results: The TGF-β1 and MMP-2 content of the medium of cultured cells was significantly elevated after irradiation. The amount of MMP-2 mRNA extracted from irradiated fibroblasts was also upregulated. Negative results in thermal controls suggested that the action of the light was athermic in nature. In animal models, the rate of wound closure was significantly accelerated by repeated exposures.Conclusion: Near-infrared irradiation potentially enhances the wound healing process, presumably by its biostimulatory effects.
  Photodermatology Photoimmunology and Photomedicine 11/2001; 17(6):261 - 265. · 1.30 Impact Factor
• Article: Sulphhydryl and disulphide stainings of subepidermal hyaline bodies

  KIICHIRO DANNO, TAKESHI HORIO
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  ABSTRACT: The localization of sulphhydryl (-SH) groups and disulphide (-S-S-) bonds in subepidermal hyaline bodies was examined using histochemical techniques with the specific fluorescent thiol reagent (DACM). In lichen planus, hyaline bodies showed -S-S- but not -SH staining, suggesting that cross-linking of -SH groups occurs here and favouring their derivation from epidermal cells. In lupus erythematosus and dermatomyositis, there were not only -S-S- positive hyaline bodies, considered of epidermal origin, but also -S-S- negative ones. The latter may consist of dermal components, since no dermal components are stainable with DACM. DACM staining therefore seems to be of help in determining the origin of hyaline bodies.
  British Journal of Dermatology 03/1981; 104(4):437 - 442. · 3.67 Impact Factor
• Article: Ultraviolet-B Radiation Suppresses Mast Cell Degranulation Induced by Compound 48/80

  Kiichiro Danno, Ken-ichi Toda, Takeshi Horio