ABSTRACT: Topical hemostatic agents play an important role in both common and specialized dermatologic procedures. These agents can be classified based on their mechanism of action and include physical or mechanical agents, caustic agents, biologic physical agents, and physiologic agents. Some agents induce protein coagulation and precipitation resulting in occlusion of small cutaneous vessels, while others take advantage of latter stages in the coagulation cascade, activating biologic responses to bleeding. Traditional and newer topical hemostatic agents are discussed in this review, and the benefits and costs of each agent will be provided.
Dermatologic Surgery 05/2008; 34(4):431-45. · 1.80 Impact Factor
American family physician 12/2007; 76(10):1533-4. · 1.70 Impact Factor
ABSTRACT: Isotretinoin has been proven to be an effective treatment for acne vulgaris. The enclosed package insert with isotretinoin suggests weekly/biweekly laboratory testing (hepatic functions and lipid analysis) but fails to recommend the needed action levels for abnormalities.
We provide a statistical analysis of a retrospective study of 141 individuals' course of therapy on isotretinoin and their laboratory blood analysis results.
Very few statistically significant elevations in liver enzymes or lipid profiles occurred. More importantly, in only 1 case did these elevations warrant the discontinuation of therapy.
The data presented here support the conclusion that limited blood testing should be performed for most patients and that more complete blood testing be done only for those patients with a significant response in liver enzymes, cholesterol or triglycerides. A set of guidelines is proposed for the practicing physician to interpret blood test results.
Dermatology 02/2002; 204(3):232-5. · 2.05 Impact Factor
Dermatologic Surgery 02/2002; 28(1):103-4. · 1.80 Impact Factor