Myota Miura

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Publications (2)4.99 Total impact

  • Article: Protective effects of Polygalae root in experimental TNBS-induced colitis in mice.
    Tie Hong, Guang Bi Jin, Gen Yoshino, Myota Miura, Yoko Maeda, Shigefumi Cho, Jong Chol Cyong
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    ABSTRACT: In this study, the protective effect of Polygalae root was evaluated in a murine model of experimental colitis by intrarectal injection with 2,4,6-trinitrobenzene sulfonic acid (TNBS). Polygalae root, given orally at 2, 4 g/kg body weight of herbs once a day consecutively for 9 days, could recover the lost body weight and decrease the gross rectal bleeding. Polygalae root also reduced the degree of inflammation and improved significantly the histological changes such as infiltration by polymorphonuclear leukocytes and multiple erosive lesions. Furthermore, the cytokine production of intraepithelial lymphocytes was analyzed. The results showed that IFN-gamma was increased, but IL-4 was decreased in TNBS-induced colitis, when those were compared with the sham controls. But the administration of Polygalae root to TNBS-induced colitis mice showed lower production of IFN-gamma and higher production of IL-4 than the TNBS-induced colitis. These results suggest that the protective effects of Polygalae root against the TNBS colitis may be associated with the regulation of cytokine production of intraepithelial lymphocytes.
    Journal of Ethnopharmacology 04/2002; 79(3):341-6. · 3.01 Impact Factor
  • Article: The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.
    Shigefumi Cho, Tie Hong, Guang-Bi Jin, Gen Yoshino, Myota Miura, Yoshihiro Aikawa, Fumiko Yasuno, Jong-Chol Cyong
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    ABSTRACT: The combination therapy of a Kampo formula and an analgesic-antipyretic agent is often used for the common cold in Japan. We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress. The combination therapy of Ephedra herb and Loxoprofen caused gastric mucosal lesions and loss of body weight. It is considered that this combination therapy should be avoided because of its adverse effects.
    The American Journal of Chinese Medicine 02/2002; 30(4):571-7. · 1.98 Impact Factor
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