Stefano Veraldi

Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, Lombardy, Italy

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Publications (183)322.84 Total impact

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    ABSTRACT: We present a case of onychomycosis caused by Trichosporon mucoides in a man with diabetes. The infection was characterized by a brown-black pigmentation of the nail plates and subungual hyperkeratosis of the first three toes of both feet. Onychogryphosis was also visible at the 3rd left toe. Direct microscopic examinations revealed wide and septate hyphae, and spores. Three cultures on Sabouraud-gentamicin-chloramphenicol 2 agar and chromID candida agar produced in white, creamy and smooth colonies, that were judged as morphologically typical for T. mucoides. Microscopic examinations of the colonies showed artroconidia and blastoconidia. Urease test was positive. Sugar assimilation test on yeast nitrogen base agar showed assimilation of galactitol, sorbitol and arabinitol. Maldi-Tof mass spectometry study confirmed the diagnosis of T. mucoides infection. The patient was treated with topical urea and oral itraconazole. Three months later, a mild improvement was observed. The patient was subsequently lost to follow up.
    International Journal of Infectious Diseases 11/2015; DOI:10.1016/j.ijid.2015.11.011 · 1.86 Impact Factor
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    ABSTRACT: Tinea imbricata is a chronic superficial mycosis caused by Trichophyton concentricum. It is characterized by widespread, annular, concentric, squamous lesions. Tinea imbricata is endemic in three geographical areas: Southwest Pacific, Southeast Asia, and Central and South America. Tinea imbricata in travelers returning from endemic areas is exceptionally rare. We report a case of tinea imbricata in an Italian child who acquired the infection during a trip to Solomon Islands. Three cultures were positive for T. concentricum. The patient was successfully treated with griseofulvin and terbinafine cream.
    Mycopathologia 08/2015; 180(5-6). DOI:10.1007/s11046-015-9930-1 · 1.53 Impact Factor
  • S Veraldi · G Nazzaro ·

    Clinical and Experimental Dermatology 07/2015; DOI:10.1111/ced.12738 · 1.09 Impact Factor
  • S. Veraldi · F. Vaira · G. Nazzaro ·
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    ABSTRACT: Clopidogrel is an adenosine diphosphate receptor antagonist used for the prevention of vascular events in patients with atherothrombotic diseases manifested by recent myocardial infarction, ischemic stroke or peripheral arterial disease. Diarrhoea, rash and pruritus are rather common side effects of clopidogrel. Other side effects include epistaxis, nausea, abdominal pain, vomiting, gastritis, gastric and duodenal ulcer. Thrombocytopenia is the most common laboratory abnormality. Leucopenia and neutropenia are rare. We report three cases of purpuric herpes zoster in patients in therapy with clopidogrel. To our knowledge, only one case of haemorrhagic herpes zoster has been published in a patient in therapy with this drug. Copyright © 2015 Elsevier B.V. All rights reserved.
    Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology 06/2015; 69. DOI:10.1016/j.jcv.2015.05.028 · 3.02 Impact Factor
  • Stefano Veraldi · Michela Brena · Mauro Barbareschi ·
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    ABSTRACT: Acne is a chronic inflammatory disease for which a long-lasting therapy, very often with topical drugs, is necessary. Despite the fact that several topical antiacne drugs (in particular, tretinoin, benzoyl peroxide, clindamycin and erythromycin) are used for many years, often on broad skin surfaces and for long periods of time, their potential for contact sensitization is low. Their potential for phototoxic and photoallergic reactions is also low. Much more frequent is irritant contact dermatitis caused by some of these drugs, in particular, retinoids and benzoyl peroxide, for which the short contact therapy has been recently suggested.
    Expert Review of Clinical Pharmacology 05/2015; 8(4):1-5. DOI:10.1586/17512433.2015.1046839 · 2.18 Impact Factor
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    ABSTRACT: Unlabelled: Background. Thus far, the role of fungi in superinfection of chronic leg ulcers has been poorly studied. Many articles are based on either a small number of patients or single cases. Furthermore, the study conclusions are conflicting. Objective: The objective of this study was to evaluate the percentage of mycotic superinfections and their clinical importance in chronic leg ulcers. Methods: A group of 149 consecutive patients without diabetes was subjected to mycologic examination of the ulcers. Two specimens were obtained from each ulcer. Results: Mycologic examinations were positive in 11 patients (7.4%). Candida albicans was the most frequently isolated species (7 patients), followed by C. parapsilosis (2 patients), C. krusei (1 patient), C. parapsilosis and C. lipolytica (1 patient). Neither dermatophytes nor molds were isolated. No particular features characterized the clinical appearance of ulcers superinfected by fungi, and no clinical improvement of ulcers with mycotic superinfections was observed with oral antimycotic therapy. Conclusion: Based on the results of this study, mycologic examinations may be considered unnecessary in patients without diabetes who suffer with chronic leg ulcers. .
    Wounds: a compendium of clinical research and practice 05/2015; 20(9):250-3. · 0.54 Impact Factor
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    ABSTRACT: A fixed combination of 0.1% hydroxypinacolone retinoate (synthetic esther of 9-cis-retinoic acid), 1% retinol in glycospheres and 2% papain in glycospheres in aqueous gel has been recently introduced into the Italian market in order to reduce the incidence and severity of irritant contact dermatitis caused by topical retinoids, without compromising their efficacy. Primary objectives of this sponsor-free, pilot, open, multicenter study were to evaluate the efficacy and tolerability of this gel in patients with comedonal-papular, mild to moderate acne of the face. Ninety-eight Caucasian patients (28 males and 70 females), with an age ranging from 15 to 40 years, were treated with the gel once daily for 12 weeks. Acne severity and treatment efficacy were evaluated by means of the Global Acne Grading System (GAGS) and lesions count. Ninety-four patients were considered evaluable. A 41% mean reduction in the GAGS score was observed; a 40.8% mean reduction of total lesions was recorded; 15.3% of patients experienced mild to moderate local side effects (dryness, peeling, erythema, burning). No patients stopped the treatment because of these side effects. This study, based on a high number of evaluable patients, demonstrates that this fixed combination is an effective and safe option for the treatment of comedonal-papular, mild to moderate acne of the face. A controlled clinical study is necessary to confirm these data.
    Giornale Italiano di Dermatologia e Venereologia 04/2015; 150(2):143-7. · 0.68 Impact Factor
  • S Veraldi · F Vaira · D D Raia · M Barbareschi ·

    Giornale Italiano di Dermatologia e Venereologia 03/2015; · 0.68 Impact Factor
  • S Veraldi · G Nazzaro · S M Serini ·
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    ABSTRACT: We present two cases of crusted scabies who were successfully treated with acitretin. Case 1. An 83-year-old woman was admitted to our Department because of a crusted dermatitis. The patient stated that she was in therapy with metoprolol and levodopa/benserazide for essential arterial hypertension and Parkinson's disease. The patient also stated that the dermatitis had appeared approximately six months earlier. It was diagnosed at other centres as allergic contact dermatitis and unsuccessfully treated with topical and oral corticosteroids, and oral anti-histamines. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 03/2015; 173(3). DOI:10.1111/bjd.13780 · 4.28 Impact Factor
  • B Hube · R Hay · J Brasch · S Veraldi · M Schaller ·
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    ABSTRACT: Dermatomycosis is characterized by both superficial and subcutaneous infections of keratinous tissues and mucous membranes caused by a variety of fungal agents, the two most common classes being dermatophytes and yeasts. Overall, the stepwise process of host infection is similar among the main dermatomycotic species; however, the species-specific ability to elicit a host reaction upon infection is distinct. Yeasts such as Candida albicans elicit a relatively low level of host tissue damage and inflammation during pathogenic infection, while dermatophytes may induce a higher level of tissue damage and inflammatory reaction. Both pathogens can, however, manipulate the host's immune response, ensuring survival and prolonging chronic infection. One common element of most dermatomycotic infections is the disease burden caused by inflammation and associated signs and symptoms, such as erythema, burning and pruritus. There is a strong clinical rationale for the addition of a topical corticosteroid agent to an effective antimycotic therapy, especially in patients who present with inflammatory dermatomycoses (e.g., tinea inguinalis). In this review, we aim to compare the pathogenesis of common dermatomycotic species, including Candida yeasts (Candida albicans), dermatophytes (Trichophyton, Epidermophyton or Microsporum species), and other pathogenic yeasts (Malassezia), with a special focus on unique species-specific aspects of the respective infection processes, the interaction between essential aspects of pathogenic infection, the different roles of the host inflammatory response, and the clinical consequences of the infection-related tissue damage and inflammation. We hope that a broader understanding of the various mechanisms of dermatomycoses may contribute to more effective management of affected patients. Copyright © 2015. Published by Elsevier Masson SAS.
    Journal de Mycologie Médicale/Journal of Medical Mycology 02/2015; 25(1). DOI:10.1016/j.mycmed.2014.11.002 · 0.57 Impact Factor
  • D D Raia · M Barbareschi · S Veraldi ·
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    ABSTRACT: We report a case of severe Citrobacter koseri folliculitis of the face in a boy with acne. A 15-year-old boy affected by acne was admitted because of a rash located on the face. Dermatological examination revealed two large plaques, with numerous pustules, eschars and crusts, located bilaterally and symmetrically on the cheeks. Three bacteriological examinations were positive for C. koseri. The patient was successfully treated with i.m. ceftriaxone. C. koseri is a Gram-negative, aerobic, mobile, nonsporulating bacillus belonging to the Enterobacteriaceae family. It can cause meningitis, central nervous system abscess and sepsis, almost exclusively in infants and immunocompromised hosts. Respiratory tract and urinary infections have been reported in elderly people. Furthermore, rare cases of skin infections have been described.
    Infection 01/2015; 43(5). DOI:10.1007/s15010-015-0734-5 · 2.62 Impact Factor
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    ABSTRACT: Introduction: Tungiasis is an infestation caused by the penetration in the skin of the gravid female of the flea Tunga penetrans (T. penetrans). The current epidemiological situation of tungiasis in Eastern Africa is poorly known. We present the results of a cross-sectional study on tungiasis which was carried out in Qameyu (Northern Tanzania). Methodology: Sixty-two schoolchildren with suspected cases of tungiasis were examined. Location, number, morphology and symptoms associated with T. penetrans infestation were recorded for each patient. Results: A total of 62 schoolchildren (38 males and 24 females), with ages ranging from 6 to 14 years, were examined. Sixty children were infested by T. penetrans. A total of 865 lesions were observed: 170 lesions were vital and 695 were non-vital. The first and the fifth toes were especially involved. The highest number of lesions observed in a single patient was more than 55 lesions. Pain was reported by 42 children, itching by 39 and difficult walking by 28. One child presented with fever which was considered to be caused by superinfected tungiasis. Complications were nail dystrophy (48 patients), deformity of the fingers or toes (12 patients), scarring (4 patients) and nail loss (4 patients). Thirteen children needed oral antibiotic therapy because of bacterial superinfections. Conclusions: Tungiasis is a public health concern in this region of Tanzania and it is associated with high morbidity. Improvement in housing hygiene, confining domestic animals and increasing the knowledge of the disease via health education are measures that should be taken to control the disease.
    The Journal of Infection in Developing Countries 11/2014; 8(11):1456-60. DOI:10.3855/jidc.4324 · 1.14 Impact Factor
  • Gianluca Nazzaro · Marco Rovaris · Stefano Veraldi ·

    JAMA Dermatology 11/2014; 150(11):1204. DOI:10.1001/jamadermatol.2014.1015 · 4.43 Impact Factor
  • F Dall'Oglio · A Tedeschi · G Fabbrocini · S Veraldi · M Picardo · G Micali ·
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    ABSTRACT: Aim: The aim of this review was to evaluate, by a thorough revision of the literature, the true efficacy of currently available topic and systemic cosmetic acne agents. Methods: The efficacy of currently available cosmetic acne agents has been retrospectively evaluated via thorough revision of the literature on matched electronic databases (PubMed). All retrieved studies, either randomized clinical trials or clinical trials, controlled or uncontrolled were considered. Results: Scientific evidence suggests that most cosmetic products for acne may enhance the clinical outcome. Cleansers should be indicated to all acne patients; those containing benzoyl peroxide or azelaic/salicylic acid/triclosan show the best efficacy profile. Sebum-controlling agents containing nicotinamide or zinc acetate may minimize excessive sebum production. Cosmetics with antimicrobial and anti-inflammatory substances such as, respectively, ethyl lactate or phytosphingosine and nicotinamide or resveratrol, may speed acne recovery. Topical corneolytics, including retinaldehyde/glycolic acid or lactic acid, induce a comedolytic effect and may also facilitate skin absorption of topical drugs. Finally, the use of specific moisturizers should be strongly recommended in all acne patients. Conclusion: Cosmetics, if correctly prescribed, may improve the performance of the therapy, whereas wrong procedures and/or inadequate cosmetics may worsen acne. Cosmetological recommendations may allow clinicians to make informed decisions about the role of various cosmetics and to indentify the appropriate indications and precautions. The choice of the most effective product should take into consideration the ongoing pharmacological therapy and acne type/severity as well.
    Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 10/2014; 150(1). · 0.86 Impact Factor
  • S Veraldi · E Cuka · C Francia · M C Persico ·

    Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 10/2014; 149(5):627-8. · 0.86 Impact Factor
  • Stefano Veraldi · Ermira Cuka · Gianluca Nazzaro ·
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    ABSTRACT: Background: There is no established therapy of choice for Mycobacterium marinum skin infections; clarithromycin monotherapy was used in some anecdotical cases at changeable daily doses and length. Objective: To evaluate the efficacy and safety of pulsed clarithromycin monotherapy. Methods: 29 patients with a clinical diagnosis of sporotrichoid fish tank granuloma were admitted from 2002 to 2013. In 14 patients, the clinical diagnosis was confirmed by history, histopathology and bacteriological examinations. All patients were treated with clarithromycin (500 mg/day for 10 consecutive days/month for 5 months). Results: In 12 out of 14 patients (85.7%) complete clinical remission was recorded. Two patients showed partial remission after 3 months of therapy, but they were lost to follow-up and were therefore not considered evaluable. Conclusion: Our study suggests that pulsed clarithromycin monotherapy is effective and safe in sporotrichoid M. marinum skin infections. © 2014 S. Karger AG, Basel.
    Dermatology 09/2014; 229(2):83-87. DOI:10.1159/000362199 · 1.57 Impact Factor
  • S Benardon · S Ramoni · V Boneschi · M Cusini · S Veraldi ·

    Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 08/2014; 149(4):477-8. · 0.86 Impact Factor
  • Article: "Dumbo' ear
    F Vaira · G Nazzaro · F Pesapane · S Veraldi ·

    Clinical and Experimental Dermatology 07/2014; 39(5):667-8. DOI:10.1111/ced.12383 · 1.09 Impact Factor
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    ABSTRACT: Abstract Thirty-seven adult Caucasian patients (9 males and 28 females), with erythemato-telangiectatic rosacea accompanied by stinging and burning sensation, were treated with a cream containing 5% potassium azeloyl diglycinate and 1% hydroxypropyl chitosan. All patients were previously treated at other centers with topical azelaic acid and/or metronidazole. The cream was applied twice daily for 12 weeks. Objective of the study was the evaluation of the soothing effect of the cream: stinging and burning sensation were measured by means of a 4-point scale (0=absent; 1=mild; 2=moderate and 3=severe). All patients were clinically evaluated every 4 weeks. Thirty out of 37patients (81.1%) were considered evaluable. Before the beginning of the study, the total score of stinging and burning sensation was 66 (mean: 2.2 points/patient); at the end of the study, it was 37 points (-29) (mean: 1.2 points/patient), with a reduction of 56.1%. No side effects were reported or observed. This study shows that the fixed combination potassium azeloyl diglycinate - hydroxypropyl chitosan is effective in reducing stinging and burning sensation in patients with erythemato-telangiectatic rosacea.
    Journal of Dermatological Treatment 05/2014; 26(2):1-10. DOI:10.3109/09546634.2014.921275 · 1.67 Impact Factor
  • Source
    Stefano Veraldi · Paolo Pontini · Gianluca Nazzaro ·
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    ABSTRACT: Abstract is missing (Short Communication).
    Acta Dermato-Venereologica 05/2014; 95(2). DOI:10.2340/00015555-1887 · 3.03 Impact Factor

Publication Stats

1k Citations
322.84 Total Impact Points


  • 2012-2015
    • Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
      • Dermatology
      Milano, Lombardy, Italy
  • 1988-2015
    • University of Milan
      • • Department of Pathophysiology and Transplantation
      • • Department of Anesthesia, Intensive Care and Dermatologic Sciences
      • • Istituto di Scienze Dermatologiche
      Milano, Lombardy, Italy