S Veraldi

Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, Lombardy, Italy

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Publications (170)319.32 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A fixed combination of 0.1% hydroxypinacolone retinoate (synthetic esther of 9-cis-retinoic acid), 1% retinol in glycospheres and 2% papain in glycospheres in aqueous gel has been recently introduced into the Italian market in order to reduce the incidence and severity of irritant contact dermatitis caused by topical retinoids, without compromising their efficacy. Primary objectives of this sponsor-free, pilot, open, multicenter study were to evaluate the efficacy and tolerability of this gel in patients with comedonal-papular, mild to moderate acne of the face. Ninety-eight Caucasian patients (28 males and 70 females), with an age ranging from 15 to 40 years, were treated with the gel once daily for 12 weeks. Acne severity and treatment efficacy were evaluated by means of the Global Acne Grading System (GAGS) and lesions count. Ninety-four patients were considered evaluable. A 41% mean reduction in the GAGS score was observed; a 40.8% mean reduction of total lesions was recorded; 15.3% of patients experienced mild to moderate local side effects (dryness, peeling, erythema, burning). No patients stopped the treatment because of these side effects. This study, based on a high number of evaluable patients, demonstrates that this fixed combination is an effective and safe option for the treatment of comedonal-papular, mild to moderate acne of the face. A controlled clinical study is necessary to confirm these data.
    Giornale Italiano di Dermatologia e Venereologia 04/2015; 150(2):143-7. · 0.49 Impact Factor
  • Giornale Italiano di Dermatologia e Venereologia 03/2015; · 0.49 Impact Factor
  • S Veraldi, G Nazzaro, S M Serini
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    ABSTRACT: We present two cases of crusted scabies who were successfully treated with acitretin. Case 1. An 83-year-old woman was admitted to our Department because of a crusted dermatitis. The patient stated that she was in therapy with metoprolol and levodopa/benserazide for essential arterial hypertension and Parkinson's disease. The patient also stated that the dermatitis had appeared approximately six months earlier. It was diagnosed at other centres as allergic contact dermatitis and unsuccessfully treated with topical and oral corticosteroids, and oral anti-histamines. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 03/2015; DOI:10.1111/bjd.13780 · 4.10 Impact Factor
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    ABSTRACT: Dermatomycosis is characterized by both superficial and subcutaneous infections of keratinous tissues and mucous membranes caused by a variety of fungal agents, the two most common classes being dermatophytes and yeasts. Overall, the stepwise process of host infection is similar among the main dermatomycotic species; however, the species-specific ability to elicit a host reaction upon infection is distinct. Yeasts such as Candida albicans elicit a relatively low level of host tissue damage and inflammation during pathogenic infection, while dermatophytes may induce a higher level of tissue damage and inflammatory reaction. Both pathogens can, however, manipulate the host's immune response, ensuring survival and prolonging chronic infection. One common element of most dermatomycotic infections is the disease burden caused by inflammation and associated signs and symptoms, such as erythema, burning and pruritus. There is a strong clinical rationale for the addition of a topical corticosteroid agent to an effective antimycotic therapy, especially in patients who present with inflammatory dermatomycoses (e.g., tinea inguinalis). In this review, we aim to compare the pathogenesis of common dermatomycotic species, including Candida yeasts (Candida albicans), dermatophytes (Trichophyton, Epidermophyton or Microsporum species), and other pathogenic yeasts (Malassezia), with a special focus on unique species-specific aspects of the respective infection processes, the interaction between essential aspects of pathogenic infection, the different roles of the host inflammatory response, and the clinical consequences of the infection-related tissue damage and inflammation. We hope that a broader understanding of the various mechanisms of dermatomycoses may contribute to more effective management of affected patients. Copyright © 2015. Published by Elsevier Masson SAS.
    Journal de Mycologie Médicale/Journal of Medical Mycology 02/2015; 25(1). DOI:10.1016/j.mycmed.2014.11.002 · 0.40 Impact Factor
  • D D Raia, M Barbareschi, S Veraldi
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    ABSTRACT: We report a case of severe Citrobacter koseri folliculitis of the face in a boy with acne. A 15-year-old boy affected by acne was admitted because of a rash located on the face. Dermatological examination revealed two large plaques, with numerous pustules, eschars and crusts, located bilaterally and symmetrically on the cheeks. Three bacteriological examinations were positive for C. koseri. The patient was successfully treated with i.m. ceftriaxone. C. koseri is a Gram-negative, aerobic, mobile, nonsporulating bacillus belonging to the Enterobacteriaceae family. It can cause meningitis, central nervous system abscess and sepsis, almost exclusively in infants and immunocompromised hosts. Respiratory tract and urinary infections have been reported in elderly people. Furthermore, rare cases of skin infections have been described.
    Infection 01/2015; DOI:10.1007/s15010-015-0734-5 · 2.86 Impact Factor
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    ABSTRACT: Tungiasis is an infestation caused by the penetration in the skin of the gravid female of the flea Tunga penetrans (T. penetrans). The current epidemiological situation of tungiasis in Eastern Africa is poorly known. We present the results of a cross-sectional study on tungiasis which was carried out in Qameyu (Northern Tanzania).
    The Journal of Infection in Developing Countries 11/2014; 8(11):1456-60. DOI:10.3855/jidc.4324 · 1.27 Impact Factor
  • Gianluca Nazzaro, Marco Rovaris, Stefano Veraldi
    JAMA Dermatology 11/2014; 150(11):1204. DOI:10.1001/jamadermatol.2014.1015 · 4.30 Impact Factor
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    ABSTRACT: The aim of this review was to evaluate, by a thorough revision of the literature, the true efficacy of currently available topic and systemic cosmetic acne agents will be suggested.
    Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 10/2014; · 0.86 Impact Factor
  • Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 10/2014; 149(5):627-8. · 0.86 Impact Factor
  • Stefano Veraldi, Ermira Cuka, Gianluca Nazzaro
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    ABSTRACT: Background: There is no established therapy of choice for Mycobacterium marinum skin infections; clarithromycin monotherapy was used in some anecdotical cases at changeable daily doses and length. Objective: To evaluate the efficacy and safety of pulsed clarithromycin monotherapy. Methods: 29 patients with a clinical diagnosis of sporotrichoid fish tank granuloma were admitted from 2002 to 2013. In 14 patients, the clinical diagnosis was confirmed by history, histopathology and bacteriological examinations. All patients were treated with clarithromycin (500 mg/day for 10 consecutive days/month for 5 months). Results: In 12 out of 14 patients (85.7%) complete clinical remission was recorded. Two patients showed partial remission after 3 months of therapy, but they were lost to follow-up and were therefore not considered evaluable. Conclusion: Our study suggests that pulsed clarithromycin monotherapy is effective and safe in sporotrichoid M. marinum skin infections. © 2014 S. Karger AG, Basel.
    Dermatology 09/2014; 229(2):83-87. DOI:10.1159/000362199 · 1.69 Impact Factor
  • Article: "Dumbo' ear
    Clinical and Experimental Dermatology 07/2014; 39(5):667-8. DOI:10.1111/ced.12383 · 1.23 Impact Factor
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    ABSTRACT: Abstract Thirty-seven adult Caucasian patients (9 males and 28 females), with erythemato-telangiectatic rosacea accompanied by stinging and burning sensation, were treated with a cream containing 5% potassium azeloyl diglycinate and 1% hydroxypropyl chitosan. All patients were previously treated at other centers with topical azelaic acid and/or metronidazole. The cream was applied twice daily for 12 weeks. Objective of the study was the evaluation of the soothing effect of the cream: stinging and burning sensation were measured by means of a 4-point scale (0=absent; 1=mild; 2=moderate and 3=severe). All patients were clinically evaluated every 4 weeks. Thirty out of 37patients (81.1%) were considered evaluable. Before the beginning of the study, the total score of stinging and burning sensation was 66 (mean: 2.2 points/patient); at the end of the study, it was 37 points (-29) (mean: 1.2 points/patient), with a reduction of 56.1%. No side effects were reported or observed. This study shows that the fixed combination potassium azeloyl diglycinate - hydroxypropyl chitosan is effective in reducing stinging and burning sensation in patients with erythemato-telangiectatic rosacea.
    Journal of Dermatological Treatment 05/2014; DOI:10.3109/09546634.2014.921275 · 1.76 Impact Factor
  • Stefano Veraldi, Paolo Pontini, Gianluca Nazzaro
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    ABSTRACT: Abstract is missing (Short Communication).
    Acta Dermato-Venereologica 05/2014; 95(2). DOI:10.2340/00015555-1887 · 4.24 Impact Factor
  • S Veraldi, G Nazzaro, E Cuka
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    ABSTRACT: We report a case of Staphylococcus aureus infection of the feet that appeared after a "fish pedicure" (immersion of the feet in a tank with the fish Garra rufa, that nibbles off dead skin). Clinical picture was characterized by maceration, purulent discharge, scales, crusts, itching and burning sensation. Bacteriological examinations were positive for Staphylococcus aureus. Mycological examinations were negative. The patient was successfully treated with ciprofloxacin. Only one case of skin foot infection after fish pedicure was reported so far. Fish pedicure can be a potentially dangerous procedure in immunocompromised or diabetic patients.
    Infection 04/2014; 42(5). DOI:10.1007/s15010-014-0622-4 · 2.86 Impact Factor
  • 04/2014; 150(4):411. DOI:10.1001/jamadermatol.2013.9675
  • Stefano Veraldi, Ermira Cuka, Francesca Gaiani
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    ABSTRACT: Centipedes are arthropods belonging to the class Chilopoda. Approximately 3000 species have been described. Centipedes are found more commonly in tropical and subtropical countries. Centipedes possess venomous fangs. The Scolopendra represent the best-known genus of centipede. We describe two cases of severe skin reactions caused by Scolopendra subspinipes bites. Both patients were bitten on the hand. The clinical picture was characterized by severe erythematous edema. In addition, one patient presented with a blister. Both patients complained of severe pain. Laboratory examinations showed leukocytosis and an increase in erythrocyte sedimentation rate (ESR). Complete remission was achieved within two weeks by means of paracetamol and oral prednisone. Western dermatologists should be aware of the possibility of severe skin reactions caused by centipede bites.
    International journal of dermatology 02/2014; 53(7). DOI:10.1111/ijd.12434 · 1.23 Impact Factor
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    ABSTRACT: Cordylobia sp. is a fly belonging to the Calliphoridae family. Three species of Cordylobia are known: C. anthropophaga, C. rodhaini and C. ruandae. The C. rodhaini Gedoelst 1909 lives in Sub-Saharan Africa, especially in rain forest areas. Usual hosts are rodents and antelopes. Humans are accidentally infested. Myiasis caused by C. rodhaini has been very rarely reported in the literature. We present three cases of C. rodhaini myiasis acquired in Ethiopia and Uganda.
    The Journal of Infection in Developing Countries 02/2014; 8(2):249-51. DOI:10.3855/jidc.3825 · 1.27 Impact Factor
  • S Veraldi, G Nazzaro, F Vaira, E Cuka
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    ABSTRACT: We report two cases of orf (ecthyma contagiosum) acquired during religious practices. In the first patient, a 34-year-old Muslim man from Tunisia, orf occurred on the left hand after the patient had handled lamb meat during the "Feast of Sacrifice." In the second patient, a 57-year-old Jewish man, orf was acquired after the "kosherization" of lamb meat and occurred on a finger of the left hand. As approximately 350,000 Muslims reside in the metropolitan area of Milan (Italy), it is possible that in the next future cases of orf acquired after religious practices will occur more often.
    Infection 02/2014; 42(4). DOI:10.1007/s15010-014-0591-7 · 2.86 Impact Factor
  • Fabrizio Vaira, Gianluca Nazzaro, Stefano Veraldi
    02/2014; 150(2):176. DOI:10.1001/jamadermatol.2013.9197
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    ABSTRACT: Tungiasis is an infestation caused by penetration in the skin of the gravid female of the flea Tunga penetrans (T. penetrans) Linnaeus 1758 (Insecta, Siphonaptera: Tungidae) (1). T. penetrans is endemic in Central and South America, Sub-Saharan Africa and Central Asia. It is uncommon in returning travellers (1): in a study on 269 patients presenting to a tropical disease unit in Paris, 6% were affected by tungiasis (2). We describe two cases of imported tungiasis with severe Staphylococcus aureus superinfection.
    Acta Dermato-Venereologica 12/2013; 94(4). DOI:10.2340/00015555-1689 · 4.24 Impact Factor

Publication Stats

939 Citations
319.32 Total Impact Points

Institutions

  • 2011–2015
    • Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
      • Dermatology
      Milano, Lombardy, Italy
  • 1988–2015
    • University of Milan
      • • Department of Pathophysiology and Transplantation
      • • Department of Anesthesia, Intensive Care and Dermatologic Sciences
      • • Istituto di Scienze Dermatologiche
      Milano, Lombardy, Italy
  • 1993
    • Istituto Nazionale Tumori "Fondazione Pascale"
      Napoli, Campania, Italy