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ABSTRACT: Fenpropathrin, a synthetic pyrethroid widely used as an insecticide, is known to affect locomotion and memory in mammals. It is possible that exposure to pyrethroids may occur in an elderly population where transient ischemic attacks are a higher risk for occurrence with consequent changes in memory and control of movement. Thus, the aim of this study was to determine whether bilateral clamping of carotid arteries (BCCA), a model for ischemia, together with fenpropathrin affected memory in tests such as the passive avoidance task and fresh spatial memory in a Y-maze, as well as movement activity and movement coordination on a rotarod in mice. BCCA together with fenpropathrin significantly reduced latency in a passive avoidance task compared to controls. There were no significant differences among the groups with respect to the Y-maze, movement activity, or movement coordination. In conclusion, fenpropathrin needs to be used with caution in the presence of an elderly population at risk for ischemia, as there appears to be evidence of some memory loss in mice.
Journal of Toxicology and Environmental Health Part A 01/2010; 73(17-18):1166-72. · 1.83 Impact Factor
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ABSTRACT: The aim of the study was to examine the effects of simultaneous acute exposure to cadmium (Cd) and in the presence of streptozotozin (STZ) on the central nervous system (CNS) memory processes in mice subjected to transient brain ischemia. In order to obtain transient brain ischemia, operative occlusion of common carotid arteries for 30 min was performed. Cadmium chloride was administered intraperitoneally (ip) after the surgery at a single dose of 0.1 LD(50) (LD(50) = 14 mg/kg). Disturbances in glucose metabolism in the brain tissue were induced by bilateral intracerebral administration of STZ, a drug that inhibits the function of a neuronal insulin receptor. Long-term memory was evaluated by means of a step-through passive avoidance task. Spatial working memory expressed as spontaneous alternations was tested in the Y-maze test. Coexposure to brain oligemia and STZ on the CNS produced significant impairment of long-term memory processes in mice. An additional exposure to Cd exacerbated the deficits of these processes. These results indicate that brain oligemia, Cd, and altered glucose metabolism may aggravate adverse effects on memory.
Journal of Toxicology and Environmental Health Part A 01/2010; 73(17-18):1159-65. · 1.83 Impact Factor
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ABSTRACT: Zearalenone is a mycotoxin compound produced mainly by Fusarium species of fungi which is present in cereals cultivated all over the world. The aim of the research was to examine the toxic influence of different doses of zearalenone on liver cells through estimating mycotoxin influence on markers evaluation of biochemical liver damage. The research was carried out on male Wistar rats. The rats were divided into 9 groups of 10 animals each. Group A was orally given 8% ethyl alcohol. Group B, C, D, E was orally given once a day for 10 days a zearalenone alcohol solution properly in dose of 50, 100, 200, 500 microg/kg b.w. Single doses of zearalenone was given to the animals from groups X, Y, Z and W. Control group W - 8% ethyl alcohol, group X dose 1 mg/kg b.w., group Y dose 2 mg/kg b.w., group Z dose 3 mg/kg b.w. For the research, blood was taken from hearts. The blood was centrifuged and the plasma analyzed using spectrophotometric methods: aspartate and alanine aminotransferase, alkaline phosphatase and complete bilirubin. The results of the experiment show that liver cells are exposed to zearalenone activity increased liver aminotransferases (ALT and AST) in blood plasma. Rise of liver aminotransferase level (ALT and AST) in animal's blood plasma after giving zearalenone may confirm the hepatotoxic influence of this mycotoxin. Short-lasting zearalenone influence does not cause changes in the liver aminotransferases.
Annals of agricultural and environmental medicine: AAEM 07/2009; 16(1):31-5. · 2.31 Impact Factor
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ABSTRACT: Cigarette smoking is a well known independent risk factor for a more severe course of Crohn's disease, but individual factors determining this impact are poorly known and it is not evident if smoking cessation is associated with an improvement in the disease activity. The aim of our study was to assess the factors determining the harmful impact of smoking in individuals with Crohn's disease. A total of 148 consecutive patients with Crohn's disease and Crohn's disease activity index < 200 were enrolled in a prospective 12-18 month study. Patients were classified into three groups as: current smokers, former smokers, and nonsmokers. Body mass index, alcohol consumption, oral contraceptive use and blood lipid levels were also recorded. The main outcome measure was the rate of fare-up. We observed the flare-up developement in 38% current smokers, versus 21% non-smokers and 26% former smokers. The relative risk of flare-up adjusted for confounding factors was 1.37 (1.09 +/- 1.96) in current smokers. Obesity, dyslipidaemia, and alcohol consumption had no significant effect. Current smoking, particularly heavy smoking, significantly increases the risk of flare-up in Crohn's disease patients. Former smokers have a risk similar to that of non-smokers.
Przegla̧d lekarski 01/2009; 66(10):567-70.
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ABSTRACT: Approximately 10 mln of Poles smoke 15-20 cigarettes per day. In total Poles smoke 4,5 billions of packaging each year. Nicotine is not only major threat to humans' health but smoking is also one of the most common elements of any healthy life style. The aim of the work was to analyze factors which influence nicotine addiction as well as to evaluate motivation among patients to stop smoking. The study was conducted among patients hospitalized in the period between January 2006 and December 2007 in SPSK 4 in Lublin. Participation in studies was freewill and anonymous and choice of respondents random. In order to collect necessary information questionnaire was created. First part includes questions as regards age, gender, place of residence, marital status, education and economic situation. Second part includes the right questionnaire which is Fageström and Schneider test. Questionnaire was filled by 2346 patients who were chosen randomly. 36.23% of patients admitted smoking. 79.05% of patients are slightly addicted to nicotine, whereas 20.95% are in medium or in higher group of addiction. Analysis of willingness to give up smoking proved that 56% of respondents want to give up smoking. On the base of performer research we can conclude that: patients, who based on the results of Fageström's test, qualified into high level addiction are at increased risk of developing nicotine-related diseases and healthy behavior as well as nonsmoking should be promoted among patients.
Przegla̧d lekarski 02/2008; 65(10):609-11.
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ABSTRACT: The study covered 160 patients - 80 females and 80 males, hospitalised due to arterial and venous vessels disorders. The objective of the study was an attempt to evaluate selected behaviours, such as tobacco smoking, consumption of alcohol and coffee among people with diseases of peripheral vessels. The research tool was a questionnaire form. Participation in the study was voluntary and patients were selected at random. The study showed that 60% of respondents suffered from peripheral vessels disorders, 67.5% of females had venous vessels disorders, and 87.5% of males - arterial vessels disorders. In the total population examined 69.38% of respondents consumed alcohol, 47.5% were current smokers, and 56.88% consumed coffee. The style of life of the people examined may result in the development of peripheral vessel disorders.
Przegla̧d lekarski 02/2005; 62(10):989-91.
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ABSTRACT: Studies of self-reported psychosomatic health among non-smokers and current smokers were conducted among students aged 19-20 by means of a standardised questionnaire form concerning people actively and passively smoking. The analysis covered the number and type of cigarettes, time of exposure to tobacco smoke, as well as health effects in active and passive smokers. Tobacco smokers constituted 22% of the total number of the population examined, whereas passive smokers - 78%. Females constituted 56.3% of current smokers, and 78.7% of those passively exposed to tobacco smoke. The majority of respondents experienced health effects. Considering self-reported psycho-somatic health, 82.8% of respondents who were passive smokers mentioned irritation by tobacco smoke, the majority of them suffered headaches and burning sensation of the eyes. As many as 96.1% of non-smokers considered smoking as harmful for health. Health effects reported by current smokers concerned headaches, dyspnea, dry cough and general malaise (depression, low mood, anxiety). 70% of the respondents would like to discontinue cigarettes smoking.
Przegla̧d lekarski 02/2005; 62(10):1099-101.
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ABSTRACT: The research, carried out among young people of selected groups from different environments estimated the occurrence of addictions, the degree of danger of nicotine addiction, alcoholism and pharmacomania. A questionnaire of the interview standardized into smokers and non-smokers was used among students. Evaluation of addiction to alcohol, drugs and nicotine among young people treated at the Toxicology Ward was done on the basis of clinical material of toxemias. Addiction to psychoactive substances among students amounts to on average of 30%. Most of the smokers would like to drop the habit. Frequency of addictions among young people hospitalized in the clinic is much higher in comparison with the group occupationally passive or working, especially in big cities. Acute toxemias among addicts, especially in the group of alcohols, drugs and psychotropic drugs were quite serious. Toxic coma accompanying toxemia is a danger to health and life.
Przegla̧d lekarski 02/2004; 61 Suppl 3:25-7.
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ABSTRACT: An artificially created working environment, conditioned by technological processes, puts people in circumstances unparalleled in the place of living. Working conditions exert an influence on the employee's health, thus affecting health status of the whole society. Risks occurring on the working stands may result from the presence of physical, chemical and biological agents. Their vicinity devastates the harmony of man's co-operation with the environment, activates defence mechanisms and enforces an introduction of protection systems. The target of this research was to estimate a sugar factory employees' exposure to the detrimental agents occurring in their place of work. The research was conducted in one of Lublin sugar factories and it involved an estimation of working conditions via a measurement of such physical agent parameters as microclimate, dust density, noise volume, light intensity and exposure to carbon oxide. The results of sanitary-epidemic services' inquiry into the issue were also included here. The estimation of the joint influence of the microclimatic elements in the working environment was made with the measures of temperature, humidity and air circulation were taken into account. The WBGT factor ranged from 18.80 degrees to 31.73 degrees and frequently stayed out of the limits of the thermal comfort. The measuring of the dust density showed an exceeding of the binding quotas on single working stands only. The highest weight average was 17 mg/m3. A comparison of these results with the findings of the previous years surveys shows a constant decrease in dust density. The most considerable bias from the binding quotas was noted while measuring noise level. The noise volume on some stands reached from 98 dB to 109 dB, which, taking into account the eight-hour working day, gave an average exposure level within the boundaries of 82 dB to 98 dB. Conclusions: 1. The presence of detrimental agents in working environment should lead to permanent monitoring of risks. 2. It is purposeful to undertake various preventive actions in order to minimalise effects to the employees.
Przegla̧d lekarski 02/2004; 61 Suppl 3:43-4.
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ABSTRACT: Chronic kidneys' failure as well as hemodialysis operations lead to disorders of many organs' and system's functions. We can observe a decrease in the immunulogical system's efficiency, which consequently causes the decrease in a human body's defence abilities. The dialysed patients are subject to a frequent contact with medical equipment and they require numerous examinations. All these factors, including the dialysis itself, increase the risk of occurrence of various types of infections, both bacterial and viral ones. The aim of the work was to try to define the kind and frequency of infectious diseases occurring among the dialysed patients. In order to conduct the research, the questionnaire among 50 patients in the centre of dialysis of the hospital in Chełm was made. Among the examined group, the most frequently occurring infectious diseases were infections of the ureter, bronchitis, flu and ear infection. Among 30% of the examined, inflammatory and thrombotic changes within a dialysis drainage tube occurred. 22% of the examined are the carriers of HBV. Among 36%, however, the antibodies of HCV were detected. Conclusions: 1. The hemodialysed patients make up a group that is at increased risk of infectious diseases. 2. The infection of B and C type is the exceptional problem among the hemodialysed patients. 3. The frequency of infectious diseases occurrence increases along with age and length of dialysotherapy. 4. Education of the patients about how to prevent infections brings measurable effects in the form of the decreasing number of morbidity cases.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):351-5.
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ABSTRACT: The aim of the study was to examine quantitative fluorine content in tooth tissues with the decay process, tissues of teeth without decay and tissues with diseases different than those of decay origin. It has been found that in the examined teeth decay process the average fluorine content in hard tissues amounted to 235.6 ppm of fluorine and it was lower than in healthy teeth (304.8 ppm) extracted for orthodontic or periodontological reasons, whereas the highest fluorine content--383.5 ppm--was found in teeth with diseases of non-decay etiology. Analyzing particular teeth groups depending on the age of the patients, it was observed that the fluorine level is higher in the teeth received from younger patients, especially in the group of healthy teeth and teeth with wedge defects. Susceptibility of tooth enamel to dissolution was estimated by the CRT test with the use of discs impregnated with crystal violet (hexamethylene-4 hydrochloride of fuchsin) with the range of colour change from yellow and green to violet and blue at ph 0.1-1.5. The lengthening of the time of reaction in this test testified to lower acid sensitivity of tissues and at the same time to harder demineralization of enamel, e.g. in the process of decay. Longer time of reaction was observed in teeth with higher indicated fluorine content.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):317-20.
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ABSTRACT: Allergic diseases have become recently an accretive medical as well as social problem, mainly in highly developed countries. Frequently they occur in the infancy and early childhood. In this analysis an attempt has been made to evaluate the occurrence of the allergic illnesses among 3-5 years old children living in the urban and rural environment. The research carried out has showed no significant differences in the occurrence of allergic diseases among children from cities and from rural areas.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):321-4.
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ABSTRACT: The usage of psychoactive substances can be related to a vast percentage of teenage population. Smoking cigarettes, drinking alcohol or taking drugs during the stage of growth and development can lead to detrimental health effect and, frequently, to serious addictions. The aim of this paper was the evaluation of the spreading frequency of mentioned habits among the high school students. The precise analysis of causes of these pathological phenomena, as well as elaboration and actual usage of broad-scale educational and prophylactic programs seem indispensable.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):402-5.
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ABSTRACT: The research has been carried out on the chosen work stands of various strenuousness level in metallurgical industry. Microclimate conditions were estimated, together with noise exposure, dust density and the exposure to the chosen chemical agents, among others carbon monoxide, nitric oxides, manganese and iron. The analysis of the resulting figures showed exceeding of the binding quotas of Wet Bulb Globe Temperature (WBGT) indicator for some stands, leading sometimes to thermal discomfort. The exposure to noise exceeded NDN coefficient for equal sound levels. Dust density on the stands did not exceed binding quotas. The concentration of chemical agents did not exceed the norms, except for single exceeding of manganese, and does not constitute toxicity hazard.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(2):416-20.
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ABSTRACT: The aim of the research was to evaluate the frequency of occurrence of obesity and body mass deficits among the children of grammar schools in Lublin. The research included 1,096 children (549 girls and 547 boys) at the age of 14 and 15. The measurements of height and weight of the examined children were taken and BMI - index of related to age standards presented in centile charts elaborated by the Institute of Mother and Child in Warsaw. The research showed that the average values of height, weight and BMI index of the examined children were between centile 25 and 75. Obesity features were observed with 4.9% of all the examined children (5.5% of girls and 4.4% of boys). Body mass deficits were observed with 5.5% of the examined children (6% of girls and 4.9% of boys). Incorrectness of physical development parameters are more often observed with 15-year-olds and more often in the group of girls than in that of boys. Obesity was observed with 4.9% of girls and 2.2% of boys at the age of 14 and with 6% of girls and 5.9% of boys at the age of 15. Features of body mass deficit were observed with 7.7% of girls and 5.3% of boys at the age of 14 and with 4.6% of girls and 4.4% of boys at the age of 15.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):325-9.
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ABSTRACT: The research was conducted in the selected vehicle industry plant. Work conditions were assessed on the assembly line by measuring chemical and physical factors. Exposure to noise in the investigated plant exceeded the values of permissible standards. The pollution on the posts did not exceed the standards except singular concentrations. While assessing the values of chemical factors concentration, no toxicological danger was revealed in the investigated population. The work conditions of the investigated plant did not create the danger of professional diseases.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):330-4.
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ABSTRACT: The research into the state of health of the examined rural population in the macroregion of Lublin was done in the years 1999-2002. The research included both sexes at the age of 31 to 61 and above, with special regard to circulatory heart diseases. The highest sick rate caused by circulatory system diseases was observed in the age group of 61 and above. The prevailing group of circulatory system diseases was hypertension disease followed by coronary disease. The sick rate was higher in women.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(1):335-8.
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ABSTRACT: Magnesium plays very important metabolic and regulatory roles in the animal organism. On this element tissues' concentration may have an influence other factors, such as sex hormones and vitamin E. The aim of our paper was to determine the influence of various testosterone doses given to male rats and various estradiol doses given to female rats on tissue magnesium concentration. Moreover, we analysed the influence of vitamin E applied with sex hormones on magnesium concentration in the tested groups of male and female rats. Testosterone was given to male rats at the doses of 0.01 mg kg(-1) of b.w. and 0.1 mg kg(-1) of b.w. Estradiol was given to female rats at the doses of 0.01 mg kg(-1) of b.w. and 0.1 mg kg(-1) of b.w. Some groups of animals additionally received vitamin E at the dose of 100 mg kg(-1) of b.w. The experiment was conducted for two weeks and next the brain, liver, kidneys and heart were taken for analysis. Tissue magnesium concentration was studied. We showed that sex hormones (estradiol in females, testosterone in males) influenced magnesium concentration reduction in the tested tissues. This decrease depended on the dose of applied hormone and only insignificantly on its kind. It was showed that simultaneously applied vitamin E diminished the effect of sex hormones action on magnesium concentration in the tested tissues.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(2):114-8.
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ABSTRACT: Ascorbic acid concentration in a living body undergoes alterations continually. The changes in homeostasis of this important antioxidant may be induced by the effect of sex hormones for example. Based on this, the aim of our work was to estimate the influence of sex hormones administration and vitamin E supplementation on tissue ascorbic acid concentration in female and male rats. It has been showed that estrogen administration to females resulted in vitamin C loss, while testosterone administration to males elevated this level in all the tested tissues. However, the supplementation of vitamin E during sex hormones administration had beneficial effects on the tissue ascorbic acid concentration.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(2):134-9.
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ABSTRACT: Good eating habit is an essential part of a healthy lifestyle. It helps prevent civilisation diseases. The BMI and eating plan analysis are useful in individual's nutritional assessment. The aim of the study was to assess nutritional status and eating habits in young adults. An average BMI was 23.63 kg/ m2 in the interviewed men, and 20.6 kg/m2 in women. Caloric value of the daily eating plans was average: in men 2943 kcal, in women 2272 kcal. Four people were on diets, but none of BMI over 25 kg/m2. There were no people suffering from food allergies nor gastrointestinal diseases. Only one male did sports (weight-lifting) regularly. The majority of the students ate at lunchtime at the university cafeteria or prepared meals themselves. The eating plans varied very much: the majority was based on the Eating Guide Pyramid and consisted of three balanced meals during the day-time; there were also single cases where students stuck to eating high-calorie meals at night-time mostly.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 02/2004; 59(2):437-40.
