C Sirlin

Publications (6)18.33 Total impact

• Article: Transmetalation of Aryl Units from Gold(I) to Cobalt(III): A Clean Route to the Synthesis of Anion Cobaltoreceptors

  M. Robitzer, I. Bouamaieed, C Sirlin, P.A. Chase, G. van Koten, M. Pfeffer
  Organometallics 04/2013; · 3.96 Impact Factor
• Article: Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture

  P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin, M. Pfeffer
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  ABSTRACT: The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis.
  Letters in Drug Design &amp Discovery 12/2007; 5(1):1-6. · 0.87 Impact Factor
• Article: Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

  C Gaiddon, P Jeannequin, P Bischoff, M Pfeffer, C Sirlin, J P Loeffler
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  ABSTRACT: The metallic compound cisplatin has been used for many years to treat various human cancers. Here, we describe the cytostatic and cytotoxic properties of a new class of organometallic compounds that contain a ruthenium (II) atom covalently linked to carbon and nitrogen atoms. We found that several ruthenium-derived compounds (RDCs) led to G1 arrest and induced apoptosis in tumor cell lines derived from glioblastomas, neuroblastomas, and lymphoid tumors at least as efficiently as cisplatin. We further analyzed the signaling pathways underlying these effects, and we showed that both RDCs and cisplatin induced p53 and p73 protein levels but with different intensities and kinetics. This accumulation of p53 and p73 proteins correlated with an increase in p21 and Bax expression, two p53 target genes linked to cell growth arrest and apoptosis. However, in contrast to cisplatin-induced apoptosis, overexpression of DeltaNp73, a p53 and p73 dominant-negative isoform, only partly reduced RDC-induced apoptosis, suggesting p53-dependent and p53-independent modes of action. This observation was further confirmed by the ability of RDC to induce apoptosis in p53-/- cells. Altogether, this study highlights key cellular and molecular features of RDCs and suggests that further development of this new class of compounds may contribute to improve future chemotherapeutic protocols.
  Journal of Pharmacology and Experimental Therapeutics 01/2006; 315(3):1403-11. · 3.83 Impact Factor
• Article: Palladium-mediated intramolecular C-N bond formation involving allyl substituted pyridines. Application to a novel strategy for the synthesis of the skeleton of berberinium derivatives

  J Chengebroyen, M Linke, M Robitzer, C Sirlin, M Pfeffer
  Journal of Organometallic Chemistry 01/2003; 687(2):313-321. · 2.38 Impact Factor
• Source

  Available from: Vincent Ritleng

  Article: Optically active ortho-metalated half-sandwich ruthenium complexes: solid-state NMR as a convenient tool to analyze mixtures of diastereomers.

  V Ritleng, P Bertani, M Pfeffer, C Sirlin, J Hirschinger
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  ABSTRACT: Bulk solid samples of various ratios of the cyclometalated arene ruthenium diastereomers (S)Ru- and (R)Ru-[(eta(6)-C6H6)Ru(C6H4-2-(R)-CH(Me)NMe2)PMe2Ph](+)PF6(-) (3a/3b), of which the configurational stability at the metal center has been established by classical solution techniques, have been analyzed by the 13C cross-polarization magic angle spinning (CP-MAS) and 31P MAS NMR. The spectra obtained allowed us to detect both isomers and to estimate their respective proportions by 31P spectra. This technique was applied to a bulk solid sample of the diastereomers (S)Ru- and (R)Ru-[(eta(6)-C6H6)Ru(C6H4-2-(R)-CH(Me)NMe2)NCMe](+)PF6(-) (1a/1b), which were shown to be configurationally labile by classical solution experiments. Detection of isomer 1a only in the resulting 13C CP-MAS NMR spectrum demonstrated that there has been epimerization of 1b to 1a during crystallization, thus confirming the configurational lability at the metal center.
  Inorganic Chemistry 10/2001; 40(20):5117-22. · 4.60 Impact Factor
• Article: Palladium-assisted intramolecular formation of n-heterocycles by sp2 N nucleophilic attack on η3-allyl-Pd complexes generated by allene insertion into σ PdC bond

  J. Chengebroyen, M. Pfeffer, C. Sirlin
  Tetrahedron Letters 37(40):7263-7266. · 2.68 Impact Factor