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S-H Ko,
H-S Kwon,
J-M Yu,
S-H Baik,
I-B Park,
J-H Lee,
K-S Ko,
J-H Noh,
D-S Kim,
C-H Kim,
J-O Mok,
T-S Park, H-S Son,
B-Y Cha
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ABSTRACT: This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy.
An open, randomized, comparative study was conducted. Subjects with painful symmetric neuropathy in the lower limbs and mean pain-intensity score > or = 4 on a numeric rating scale were eligible. Subjects were randomized to receive either tramadol (37.5 mg)/acetaminophen (325 mg) or gabapentin (300 mg) for 6 weeks. After 2 weeks of the titration period (1200 mg/day for gabapentin and three tablets/day for T/A), the doses were maintained if the pain was relieved. The primary efficacy outcome was a reduction in pain intensity. Secondary measures evaluated a pain relief scale, a Brief Pain Inventory, a 36-item Short Form Health Survey, average pain intensity and sleep disturbance.
One hundred and sixty-three subjects (T/A 79; gabapentin 84) were included. At the final visit, the mean doses were 1575 mg/day for gabapentin and 4.22 tablets/day for T/A. Both groups were similar in terms of baseline pain intensity (mean intensity: T/A 6.7 +/- 1.6; gabapentin 6.3 +/- 1.6, P = 0.168). At the final visit, the mean reductions in pain intensity were similar in both groups (T/A -3.1 +/- 2.0; gabapentin -2.7 +/- 2.1, P = 0.744). Both groups had similar improvements in every Short Form Health Survey category and Brief Pain Inventory subcategory, and in the mean pain relief scores.
This study suggests that the T/A combination treatment is as effective as gabapentin in the treatment of painful diabetic neuropathy in patients with Type 2 diabetes.
Diabetic Medicine 09/2010; 27(9):1033-40. · 2.90 Impact Factor
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ABSTRACT: To estimate true Brix and alcoholic strength of must and wines without distillation, a novel approach using a refractometer and a hydrometer was developed. Initial Brix (I.B.), apparent refractometer Brix (A.R.), and apparent hydrometer Brix (A.H.) of must were measured by refractometer and hydrometer, respectively. Alcohol content (A) was determined with a hydrometer after distillation and true Brix (T.B.) was measured in distilled wines using a refractometer. Strong proportional correlations among A.R., A.H., T.B., and A in sugar solutions containing varying alcohol concentrations were observed in preliminary experiments. Similar proportional relationships among the parameters were also observed in must, which is a far more complex system than the sugar solution. To estimate T.B. and A of must during alcoholic fermentation, a total of 6 planar equations were empirically derived from the relationships among the experimental parameters. The empirical equations were then tested to estimate T.B. and A in 17 wine products, and resulted in good estimations of both quality factors. This novel approach was rapid, easy, and practical for use in routine analyses or for monitoring quality of must during fermentation and final wine products in a winery and/or laboratory.
Journal of Food Science 04/2009; 74(2):C106-11. · 1.66 Impact Factor
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ABSTRACT: To highly isolate inherent parasitic capacitance (C<sub>PD</sub>) of photodiode, second-order passive LC-ladder network is exploited. And to enhance the bandwidth, various techniques, such as capacitive degeneration, inductive peaking, active feedback, and negative impedance compensation, are applied. In this paper, a 1.2-V 10-Gb/s optical receiver is designed in 0.13-mum CMOS technology. The proposed optical receiver achieves ~8.2-GHz of bandwidth for 0.25-pF of C<sub>PD</sub> and ~6.9-GHz of bandwidth for 1-pF of C<sub>PD</sub> for 10-Gb/s operation.
Advanced Communication Technology, 2009. ICACT 2009. 11th International Conference on; 03/2009
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J C Lee,
J Chung,
Y R Rho,
K M Lim,
J C Kim,
J Y Park,
D W Lee,
H Choi,
S M Lee,
D S Choi, [......],
C Y Park,
S K Park, H S Son,
C M Hwang,
H K Kim,
K Sun,
Y M Yoon,
K K Lee,
Y S Won,
B G Min
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ABSTRACT: Therapeutic Artificial Organs (TAO) are extracorporeal life-saving devices that are used to bridge patients from emergency to surgery and recovery. This paper details the research on TAOs in Korea along with their development as the clinical devices. In the heart and lung area, the artificial heart system (AnyHeart) and the pulsatile heart-lung machine (T-PLS) have been developed. The T-PLS has been used in 400 patients. In the renal replacement area, the portable hemofiltration machine (C-PAK) and its applications in home renal treatment are currently being tested through animal experiments. The multiple applications of the biomaterials, the electromechanical system designs and their control, the telecommunication technology and medical technology have been combined in the research and development of life-saving artificial organs for critically ill patients.
International Journal of Applied Electromagnetics and Mechanics 01/2008; 27:205-214. · 0.12 Impact Factor
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ABSTRACT: The effects of ultraviolet (UV) intensity and wavelength on triclosan (TCS) photodegradation kinetic, efficiency, mechanisms and pathway were studied. The TCS photodegradation followed the pseudo-first order kinetic model at all UV intensities examined at the wavelengths of 254 and 365 nm and the photodegradation rate increased with increasing UV intensity. TCS photodegradation efficiencies of 90 to 98% and 79 to 90% were obtained at the wavelengths of 254 and 365 nm, respectively. TCS was degraded mainly by photon induced hydroxyl radicals while the direct photon reaction with TCS played a subordinate role. Chlorophenol, dichlorophenol and phenol were the intermediates detected in all experiments conducted. Dibenzodichloro-p-dioxin and dibenzo-p-dioxin were observed as the intermediates only at lower UV intensities investigated at the wavelength of 365 nm. Based on these intermediates, a complete TCS photolysis pathway was proposed for the first time.
Water Science & Technology 02/2007; 55(1-2):209-16. · 1.12 Impact Factor
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ABSTRACT: This study was undertaken to examine the photocatalytic degradation of explosives hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) with a circular photocatalytic reactor, using a UV lamp as a light source and TiO2 as a photocatalyst. The effects of various parameters, such as the RDX or HMX concentration, the amount of TiO, and the initial pH, on the photocatalytic degradation rates of explosives were examined. In the presence of both UV light and TiO2 RDX and HMX were more effectively degraded than with either UV or TiO2 alone. The degradation rates were found to obey pseudo-first-order kinetics represented by the Langmuir-Hinshelwood model. Increases in the RDX and HMX degradation rates were obtained with decreasing initial concentrations of the explosives. The RDX and HMX degradation rates were higher at pH 7 than at either pH 3 or pH 11. A dose of approximately 0.7 g l(-1) of TiO2 degraded HMX more rapidly than did higher or lower TiO2 doses. RDX (20 mg l(-1)) photocatalysis resulted in an approximately 20% decrease in TOC, and HMX (5 mg l(-1)) photocatalysis resulted in a 60%, decrease in TOC within 150 minutes. A trace amount of formate was produced as an intermediate that was further mineralized by RDX or HMX photocatalysis. The nitrogen byproducts from the photocatalysis of RDX and HMX were mainly NO3- with NO2-, and NH4+. The total nitrogen recovery was about 60% from RDX (20 mg l(-1)), and 70% from HMX (5 mg l(-1)), respectively. Finally, a mechanism for RDX/HMX photocatalysis was proposed, along with supporting qualitative and quantitative evidence.
Environmental Technology 03/2006; 27(2):219-32. · 1.41 Impact Factor
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ABSTRACT: In sudden cardiac arrest, the effective maintenance of coronary artery blood flow is of paramount importance for myocardial preservation as well as cardiac recovery and patient survival. The purpose of this study was to directly compare the effects of pulsatile versus non-pulsatile circulation to coronary artery flow and myocardial preservation in a cardiac arrest condition.
A cardiopulmonary bypass circuit was constructed in a ventricular fibrillation model using fourteen Yorkshire swine weighing 25-35 kg each. The animals were randomly assigned to group I (n=7, non-pulsatile centrifugal pump) or group II (n=7, pulsatile T-PLS pump). Extracorporeal circulation was maintained for two hours at a pump flow of 2 L/min. The left anterior descending coronary artery flow was measured with an ultrasonic coronary artery flow measurement system at baseline (before bypass) and at every 20 minutes after bypass. Serologic parameters were collected simultaneously at baseline, 1 hour, and 2 hours after bypass in the systemic arterial and coronary sinus venous blood. The Mann-Whitney U test of STATISTICA 6.0 was used to determine intergroup significances using a p value of <0.05.
The resistance index of the coronary artery was lower in group II and the difference was significant at 40 min, 80 min, 100 min and 120 min (p<0.05). The mean velocity of the coronary artery was higher in group II throughout the study, and the difference was significant from 20 min after starting the pump (p<0.05). The coronary artery blood flow was higher in group II throughout the study, and the difference was significant from 40 min to 120 min (p<0.05) except at 80 min. Serologic parameters showed no differences between the groups at 1 hour and 2 hours after bypass in the systemic and coronary sinus blood (p=NS).
In the cardiac arrest condition, pulsatile extracorporeal circulation provides more blood flow, higher flow velocity and less resistance to coronary artery than non-pulsatile circulation.
The International journal of artificial organs 06/2005; 28(6):609-16. · 1.86 Impact Factor
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S-H Ko,
H-S Kwon,
S-H Suh,
J-H Yang,
S-R Kim,
Y-B Ahn,
K-H Song,
S-J Yoo, H-S Son,
B-Y Cha,
K-W Lee,
H-Y Son,
S-K Kang,
C G Park,
J-K Park,
K-H Yoon
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ABSTRACT: This study was performed to investigate the effect of dexamethasone on the expansion and transdifferentiation of transplanted neonatal pancreas cell clusters (NPCCs) in vivo.
Porcine NPCCs were generated from 1 to 3-day-old neonatal pigs. After transplantation (Tx) of 4000 islet equivalents (IEqs) of NPCCs beneath the renal subcapsular space of normoglycemic nude mice, dexamethasone (Dx, 1 mg/kg) or vehicles were injected daily. Intraperitoneal glucose tolerance testing (ip-GTT) was performed at 4 weeks (n = 4) and 10 weeks (n = 7) after Tx. After harvesting the grafts, total graft and beta-cell graft mass were determined by morphometric analysis.
Although the mean value of AUCg was elevated in the Dx-treated group at 10 weeks after Tx, the glucose levels of all the animals by ip-GTT were within the normal range. At 10 weeks after Tx, the relative volume, absolute mass of beta-cells in the graft, and total graft mass were significantly lower in the Dx-treated group (relative volume of beta-cells: 22.0% versus 35.3%, P < 0.05; beta-cells mass: 1.0 +/- 1.2 mg versus 2.2 +/- 5.6 mg, P < 0.05, total graft mass: 4.4 +/- 5.4 mg versus 6.3 +/- 1.3 mg, P < 0.05, Dx-treated versus control), but there was no difference at 4 weeks. Morphologically prominent cystic structures were observed in the Dx group at 10 weeks.
Our results suggest that dexamethasone suppresses the expansion and transdifferentiation of transplanted porcine NPCCs into beta-cells in normal nude mice.
Diabetes Research and Clinical Practice 12/2004; 66 Suppl 1:S97-S101. · 2.75 Impact Factor
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B.G. Min,
J. Chung,
K.W. Nam,
Y.R. Rho,
J.C. Lee,
J.J. Lee,
J.W. Park,
S.W. Choe,
C.Y. Park,
S.K. Park, H.S. Son,
H.K. Kim,
J. Choi,
C.M. Hwang,
Y.S. Won,
K. Sun
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ABSTRACT: The mechanical circulatory support system using moving-actuator mechanisms were developed by Seoul National University and Korea University. AnyHeart is a fully implanted pulsatile bi-ventricular assist device, and T-PLS is a pulsatile flow versatile extracorporeal life support system. Through lots of in-vitro and in-vivo experiments, the developed mechanical systems are faced to produce on commercial scale. This paper describes the recent progress of two mechanical circulatory support systems, AnyHeart and T-PLS.
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE; 10/2004
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ABSTRACT: The Moving Actuator type artificial heart(AnyHeart) as well as many other artificial hearts uses a motor as its power source. For controllability of control parameters such as pump rate, pump output, blood pressure profile and flow form, the precise motor speed control is important. However, because the implantable device has limited carrying capacity of hardware components in size and number, applying diverse motor control methods are not possible. In addition, the existing PI (Proportional-Integral) motor controller does not show satisfactory performance. A new controller that is sufficiently robust for the changes of load and physical system parameters has been designed and tested. The robust speed controller is based on the sliding mode control method that is applicable to a system of which the ranges of uncertainty in physical parameters are known. In a mock circulation system test, the actual speed showed good tracking characteristics in respect to the reference speed. Fast follow-up characteristics were also observed under high afterload and speed conditions. The speed error, current and power consumption were reduced by about 40%. The proposed control technique overcomes the limitations of the PI controller, and makes important improvements in both performance and stability.
The International journal of artificial organs 10/2004; 27(9):787-95. · 1.86 Impact Factor
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ABSTRACT: A multifunctional, Korean-made artificial heart (AnyHeart) was developed, and prior to its clinical application, a cadaver-fitting study was performed. The study proposed to determine the optimal cannulation approach, implantation technique and route of the cannula to minimize the organ compression of AnyHeart. The anatomical feasibility and a variety of surgical techniques were evaluated using ten preserved, human cadavers. Implanting AnyHeart with ease is possible using various approaches, including a median sternotomy, and a right or left lateral thoracotomy. The lateral thoracotomy approach is shown to be safe and reproducible, especially in patients who have already undergone an operation that used a median sternotomy. The results of this study will guide improvements in the designs of cannulae and AnyHeart for future clinical applications.
The International journal of artificial organs 07/2004; 27(6):495-500. · 1.86 Impact Factor
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S H Ko,
S H Suh,
B J Kim,
Y B Ahn,
K H Song,
S J Yoo, H S Son,
B Y Cha,
K W Lee,
H Y Son,
S K Kang,
S Bonner-Weir,
G C Weir,
K H Yoon,
C G Park
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ABSTRACT: The expression of the intermediate filament (IF) vimentin, usually considered a marker of mesenchymal cells, has been observed in the epithelial cells during embryogenesis, carcinogenesis, and dedifferentiation, suggesting that it might be useful as a marker of proliferating precursor cells in the pancreas.
Rat pancreata at E18 and at different time points after partial pancreatectomy (Px) and human and neonatal pig pancreatic tissue sections and monolayer cultured pancreatic duct cells were observed. All tissues were simultaneously immunostained with pancytokeratin and vimentin antibodies. In costained duct cells, PDX-1 or PCNA expression was also analyzed using confocal microscope images.
In the rat embryonic pancreas at E18, all epithelial cells that formed ductlike structures expressed both cytokeratin and vimentin IF, whereas no duct cells costained for IF in the adult rat or neonatal pig pancreas. Such costaining reappeared in the following order: common pancreatic duct, main ducts, foci of regeneration and then disappeared completely at 30 days after Px. In humans, costaining was found in only 1 diabetic patient's pancreatic section, which was accompanied by massive duct cell proliferation. In monolayer culture, most of the duct cells of human and neonatal pigs coexpressed both IF proteins. Only a few costained duct cells also expressed PDX-1, and most of those cells were also stained with PCNA in rat embryonic pancreas and regenerating foci after partial Px.
Vimentin IF expression might be a useful marker for pancreatic precursor cells and could be used to investigate the concept of the dedifferentiation of fully matured duct cells during the process of the beta-cell neogenesis.
Pancreas 04/2004; 28(2):121-8. · 2.39 Impact Factor
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B G Min,
J Chung,
K W Nam,
Y R Rho,
J C Lee,
J J Lee,
J W Park,
S W Choe,
C Y Park,
S K Park, H S Son,
H K Kim,
J Choi,
C M Hwang,
Y S Won,
K Sun
[show abstract]
[hide abstract]
ABSTRACT: The mechanical circulatory support system using moving-actuator mechanisms were developed by Seoul National University and Korea University. AnyHeart is a fully implanted pulsatile bi-ventricular assist device, and T-PLS is a pulsatile flow versatile extracorporeal life support system. Through lots of in-vitro and in-vivo experiments, the developed mechanical systems are faced to produce on commercial scale. This paper describes the recent progress of two mechanical circulatory support systems, AnyHeart and T-PLS.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 02/2004; 5:3765-8.
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Y R Rho,
H Choi,
J C Lee,
S W Choi,
Y M Chung,
H S Lee,
C M Hwang,
S S Ahn,
R Y Lee, H S Son,
M J Choi,
K J Baek,
J S Kim,
G J Suh,
Y S Won,
K Sun,
B G Min
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ABSTRACT: T-PLS (Twin-Pulse Life Support) is the first commercial pulsatile ECLS (Extra Corporeal Life Support) device (1). The dual sac structure of T-PLS can effectively reduce high membrane oxygenator inlet pressure and hemolysis. To verify both the use of T-PLS for ECLS and the advantages of T-PLS, we tested various models.
In the partial CPB (cardio pulmonary bypass) model (swine), T-PLS (N = 6), and Biopump (N = 2), a single pulsatile pump (N = 2), were compared. In the case of single pulsatile flow, during pump systole, pressure increased to 700 - 800 mmHg at the inlet port of the membrane oxygenator. fHb, a hemolysis measurement value, was about 80 mg/dL at 3 hours. On the contrary, because of T-PLS's dual sac system, the pressure of T-PLS had a maximum value of about 250 mmHg and fHb was similar to that of the commercial centrifugal pumps. In the total CPB model (bovine, N = 6), the heart was stopped via cardioplegia (Kcl). T-PLS flow was maintained at 3.0-4.5 L/min. T-PLS functioned like a natural heart, having a pulse pressure of 26-43 mmHg and a pulse rate of 40-60 bpm (beats per minute). In the emergency case model (canine, N = 6), T-PLS was started 10 minutes after cardiac arrest from electronic shock. In spite of cardiac arrest for a period of 40 minutes, the heart was recovered after defibrillation. In the ARDS (Acute Respiratory Distress Syndrome) model (canine, N = 6), minimal ventilator parameters were set: tidal volume 130 ml, respiration rate = bpm, FiO2 = 10%. Three hours after starting T-PLS, PO2 of the carotid artery blood (after 2 hours: 195 +/- 89.4; after 3 hours: 258 +/- 99.3 mmHg) was above half the value of the femoral artery but was within normal range.
It is suggested that a portable pulsatile ECLS like T-PLS may be used as a CPB device and as an alternative CPR (cardiopulmonary resuscitation) device in the case of cardiac arrest. Due to the pulsatile flow, oxygenated blood is delivered to the patient without overloading the ARDS patients heart.
The International journal of artificial organs 06/2003; 26(5):428-35. · 1.86 Impact Factor
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H. S. Lee,
Y. R Rho,
C. M. Hwang,
S. W. Choi,
J. C. Lee,
H. Choi,
S. S. Ahn,
K. Sun, H. S. Son,
K. J. Baek,
Y. S. Won,
B. G. Min
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ABSTRACT: Extracorporeal life support (ECLS) systems have been increasingly applied to groups of patients with cardiorespiratory failure,
including pediatric and adult patients with respiratory failure. Current pulsatile ECLS systems use a single pulsatile blood
pump that generates a high inlet pressure in the membrane oxygenator. To minimize this high inlet pressure, we have developed
a new and improved ECLS system, twin pulse life support (T-PLS). To analyze the advantages of T-PLS, we have compared T-PLS
with a single pulsatile ECLS system. An acute heart failure model was constructed by using a pulmonary artery banding technique.
Fourteen pigs (22–31 kg) were used, with cardiac outputs of 2.0 l/min and a V/Q ratio set at 1. Cannulae of 28 Fr and 18 Fr
were used in the right atrium and aorta, respectively. A polypropylene hollow-fiber membrane oxygenator and four polymer valves
30 mm in diameter were used in the T-PLS system. In the single pulsatile ECLS system, Medtronic Hall monostrut valves were
used. To evaluate blood cell trauma in both pulsatile ECLS systems, plasma free hemoglobin (fHb) was measured while the systems
were in use. The results show that fHb levels in T-PLS are lower than fHb levels in the single pulsatile ECLS system. There
is a possibility that T-PLS could be used as an ECLS system for emergency situations.
Journal of Artificial Organs 01/2003; 6(1):0025-0029. · 1.59 Impact Factor
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ABSTRACT: This study was undertaken to examine the degradation of TNT, RDX and HMX in a circular photocatalytic reactor with TiO2 as a photocatalyst. We examined the impact of parameters such as the initial concentration, initial pH of solution on rates of photocatalized transformation, and the mineralization. The results showed that photocatalysis is an effective process for the degradation of TNT, RDX and HMX. They could be comoletely degraded in 150 min with 1.0 g/L TiO2 at pH 7. An increase in the photocatalytic degradation of HMX was noticed with decreasing initial HMX. The rates of RDX and HMX degradation were greater in neutral pH than in acidic and alkaline conditions. In case of TNT degradation, the rate of degradation was the fastest at pH 11. Approximately 82% TOC decrease in the TNT degradation was achieved after 150 min, whereas TOC decrease in RDX and HMX was 24% and 59%, respectively. Nitrate, nitrite, and ammonium ions were detected as the nitrogen byproducts from the photocatalysis, and more than 50% of the total nitrogen was recovered as nitrate ion in every explosives.
Water Science & Technology 02/2002; 46(11-12):139-45. · 1.12 Impact Factor
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S A Chang,
B Y Cha,
S J Yoo,
Y B Ahn,
K H Song,
J H Han,
J M Lee, H S Son,
K H Yoon,
M I Kang,
K W Lee,
H Y Son,
S K Kang
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ABSTRACT: It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined.
About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats.
In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats.
These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
The Korean Journal of Internal Medicine 07/2001; 16(2):87-92.
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ABSTRACT: This study was designed to investigate the relationship between adipokines in metabolic syndrome and insulin resistance. Sixty male and female subjects with or without metabolic syndrome and type 2 diabetes were included. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Compared with lean control subjects, patients with metabolic syndrome and type 2 diabetes had lower circulating levels of total adiponectin and high molecular weight (HMW) adiponectin, and higher levels of leptin and interleukin-6 (IL-6). Total and HMW adiponectin and the adiponectin/leptin (A/L) ratio were negatively correlated with HOMA-IR. After adjusting for age and sex, leptin, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were positively correlated with HOMA-IR. After also adjusting for body mass index, HOMA-IR was found to be independently associated with leptin, A/L ratio and TNF-alpha levels. In conclusion, decreased total adiponectin and HMW adiponectin and increased leptin and IL-6 levels are characteristic of patients with metabolic syndrome and type 2 diabetes.
The Journal of international medical research 37(6):1803-12. · 0.90 Impact Factor
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ABSTRACT: Evaluating increasing circulating adiponectin levels is becoming an important strategy in the prevention of diabetes mellitus and cardiovascular events. This study was designed to investigate the effect of the angiotensin II receptor blocker valsartan on blood adiponectin levels and insulin sensitivity in patients with type 2 diabetes and mild-to-moderate hypertension. A total of 91 Korean patients were treated with 80 mg/day valsartan for 4 weeks followed by 160 mg/day for a further 8 weeks. Blood pressure, adiponectin levels and metabolic parameters were measured before and after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an insulin sensitivity index. Valsartan significantly decreased mean blood pressure and increased circulating adiponectin levels. There were no differences in metabolic parameters, including HOMA-IR, glycosylated haemoglobin and lipid levels before and after treatment. These results indicated that valsartan increases circulating adiponectin levels, but does not change insulin sensitivity in patients with type 2 diabetes and mild-to-moderate hypertension.
The Journal of international medical research 38(1):234-41. · 0.90 Impact Factor
