A Yesilkaya

Publications (6)6.38 Total impact

• Article: Exercise-induced oxidative stress leads hemolysis in sedentary but not trained humans

  U. K. Senturk, F. Gunduz, O. Kuru, G. Kocer, Y. G. Ozkaya, A. Yesilkaya, M. Bor-Kucukatay, M. Uyuklu, O. Yalcin, O. K. Baskurt
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  ABSTRACT: Times Cited: 14
  01/2005; 99:1434-1441.
• Article: Serum and skin nitrite levels in patients with Behcet's disease.

  M U Senturk, U K Senturk, P Y Basak, O Kuru, A Yesilkaya
  Journal of the European Academy of Dermatology and Venereology 10/2003; 17(5):614-5. · 2.98 Impact Factor
• Article: Alterations in the erythrocyte antioxidant system of blood stored in blood bags.

  D K Korgun, S Bilmen, A Yesilkaya
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  ABSTRACT: In the present study, we measured the concentrations of reduced glutathione (GSH) and malonyldialdehyde (MDA) and the activities of glutathione peroxidase (GSH-Px), glutathione S-transferase (GSH-S-T), superoxide dismutase (SOD), catalase (CAT) and glucose-6-phosphate dehydrogenase (G-6-PD) in erythrocytes obtained freshly from adult male donors which was preserved with CPDA-1 anticoagulant (citrate,phosphate, dextrose, adenine) on different days of storage. At the end of the study, storage-associated alterations in antioxidant activities were noted and discussed. GSH, GSH-Px, GSH-S-T, SOD, CAT and G-6-PD activities decreased, but erythrocyte MDA levels, as anindex of lipid peroxidation, increased during the storage period. According to our results, glutathione-dependent antioxidant systems in erythrocytes might be depleted during long storage in blood bags.
  Research communications in molecular pathology and pharmacology 02/2001; 109(5-6):357-63.
• Article: The antioxidant effect of free bilirubin on cumene-hydroperoxide treated human leukocytes.

  A Yesilkaya, R Altinayak, D K Korgun
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  ABSTRACT: To examine the antioxidant effect of bilirubin (BR) on leukocyte, we treated leukocytes obtained from healthy subjects with an oxidant and various concentrations of BR. High concentrations of BR decreased thiobarbituric acid reactive substances (TBARS) and catalase activities, increased superoxide dismutase (SOD) activity, but had no effect on glutathione (GSH) concentration. Our results showed that under physiological conditions, BR has an antioxidant effect only in high concentrations.
  General Pharmacology 08/2000; 35(1):17-20.
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  Article: Red blood cell rheological alterations in hypertension induced by chronic inhibition of nitric oxide synthesis in rats.

  M Bor-Küçükatay, O Yalçin, O Gökalp, D Kipmen-Korgun, A Yesilkaya, A Baykal, M Ispir, U K Senturk, I Kaputlu, O K Başkurt
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  ABSTRACT: Nitric oxide (NO) plays a major role in vascular regulation. Modulation of NO synthesis is known to influence blood pressure. Inhibition of NO synthesis by NG-nitro-L-arginine methyl ester (L-NAME; 72 mg/kg/day, p.o., 21 days) resulted in 60% increase in blood pressure in rats. Red blood cell (RBC) transit time measured by the cell transit analyzer increased significantly in the L-NAME treated group, in comparison to normotensive rats. RBC aggregation measured in autologous plasma, by a photometric rheoscope also increased significantly in the hypertensive rats. RBC cytosolic free calcium concentration was also significantly higher in the hypertensive animals. Incubation of RBC from hypertensive and control animals with NO donor, sodium nitroprusside (SNP; 10-1000 microM) for 60 minutes resulted in a dose-dependent decrease in RBC aggregation, however aggregation index was significantly higher in hypertensive group at each SNP concentration. Incubation with SNP had no effect on RBC deformability in the control group, while a slight decrease in RBC transit time was observed only at 10 microM SNP in the hypertensive group. These results imply that NO may play a role in the regulation of rheological properties of RBC and the alterations in these properties may at least in part be involved in the development of L-NAME induced hypertension.
  Clinical hemorheology and microcirculation 02/2000; 22(4):267-75. · 3.40 Impact Factor
• Article: Deformability and oxidant stress in red blood cells under the influence of halothane and isoflurane anesthesia.

  A Yesilkaya, Z Ertug, A Yegin, M Melikoglu, O K Baskurt
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  ABSTRACT: 1. The effects of halothane and isoflurane anesthesia on red blood cell (RBC) deformability, lipid peroxidation and antioxidant enzymes were tested in rabbits. 2. RBC transit time was significantly increased to 2.12 +/- 0.07 msec after 1-hr halothane anesthesia preceded by 6 mg/kg pentobarbital injections from 1.98 +/- 0.07 msec preanesthesia value (p < 0.05). Thiobarbituric acid-reactive substances also were increased significantly, being 23.35 +/- 2.75 nmol/gHb and 33.11 +/- 5.34 nmol/gHb before and after anesthesia, respectively (p < 0.05). 3. Under halothane anesthesia without prior pentobarbital injection or under isoflurane anesthesia with or without pentobarbital injection, no significant alterations were observed in these parameters. 4. RBC superoxide dismutase activity was decreased in the group anesthetized with the pentobarbital-halothane combination. The impaired RBC deformability and increased oxidant damage might be related to the free radical formation during the metabolism of halothane. Pentobarbital can potentiate this effect either by inducing cytochrome P-450 or by altering antioxidant defense. 5. Alterations in RBC mechanical properties may contribute to the tissue perfusion problems that develop after surgery under general anesthesia.
  General Pharmacology 07/1998; 31(1):33-6.