Mitsuhiro Arisawa,
Yayoi Kasaya,
Tohru Obata,
Takuma Sasaki,
Tomonori Nakamura,
Takuya Araki,
Koujirou Yamamoto, Akito Sasaki,
Akihito Yamano,
Mika Ito,
Hiroshi Abe,
Yoshihiro Ito,
Satoshi Shuto
[show abstract]
[hide abstract]
ABSTRACT: We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.
Journal of Medicinal Chemistry 08/2012; 55(18):8152-63. · 4.80 Impact Factor
