Hong-Suk Suh

Pusan National University, Tsau-liang-hai, Busan, South Korea

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Publications (12)19.08 Total impact

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    ABSTRACT: Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic chemopreventive agent capable of inducing tumor cell death in a variety of cancer types. Several studies were undertaken to obtain synthetic analogues of resveratrol with potent anticancer activity. The aim of the present study was to investigate the effect of HS-1793 as a new resveratrol analog on apoptosis via the mitochondrial pathway in murine breast cancer cells. A pharmacological dose (1.3-20 µM) of HS-1793 exerted a cytotoxic effect on murine breast cancer cells resulting in apoptosis. HS-1793-mediated cytotoxicity in FM3A cells by several apoptotic events including mitochondrial cytochrome c release, activation of caspase-3 and PARP occurred. In addition, HS-1793 induced collapse of ∆Ψm and enhanced AIF and Endo G release from mitochondria while undergoing apoptosis. These results demonstrate that the cytotoxicity by HS-1793 in FM3A cells can mainly be attributed to apoptosis via a mitochondrial pathway by caspase activation or contributions of AIF and Endo G.
    International Journal of Oncology 08/2012; 41(5):1628-34. DOI:10.3892/ijo.2012.1615 · 3.03 Impact Factor
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    ABSTRACT: Two novel conjugated copolymers utilizing 4,7-dithien-2-yl-2,1,3-benzothiadiazole (DTBT) coupled with cyano (-CN) substituted vinylene, as the electron deficient moeity, have been synthesized and evaluated in bulk heterojunction solar cell. The electron deficient moeity was coupled with carbazole and fluorene unit by Knoevenagel condition to provide poly(bis-2,7-((Z)-1-cyano-2-(5-(7-(2-thienyl)-2,1,3-benzothiadiazol-4-yl)-2-thienyl-ethenyl)-alt-9-(1-octylnonyl)-9H-carbazol-2-yl-2-butenenitrile) (PCVCNDTBT) and poly(bis-2,7((Z)-1-cyano-2-(5-(7-(2-thienyl)-2,1,3-benzothiadiazol-4-yl)-2-thienyl)ethenyl)-alt-9,9-dihexyl-9H-fluoren-2-yl) (PFVCNDTBT). The optical band gaps of PCVCNDTBT (1.74 eV) and PFVCNDTBT (1.80 eV) are lower than those of PCDTBT (1.88 eV) and PFVDTBT (2.13 eV), which is advantageous to provide better coverage of the solar spectrum in the longer wavelength region. The high V-oc value of the PSC of PCVCNDTBT (similar to 0.91 V) is attributed to its lower HOMO energy level (-5.6 eV) as compared to PCDTBT (-5.5 eV). Bulk heterojunction solar cells based on the blends of the polymers with [6,6]phenyl-C-61-butyric acid methyl ester (PC61BM) gave power conversion efficiencies of 0.76% for PCVCNDTBT under AM 1.5, 100 mW/cm(2).
    Bulletin- Korean Chemical Society 02/2012; 33(2):629-635. DOI:10.5012/bkcs.2012.33.2.629 · 0.84 Impact Factor
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    ABSTRACT: The synthesis of copolymers containing thiophene and benzimidazole unit by Stille polymerization is reported. The polymers with many unsubstituted thiophene units in the backbone have been reported to show low solubility, which has been a problem for spin-coating for the device fabrication. In dihexyl-2H-benzimidazole, the sulfur at 2-position of BT unit was replaced with dialkyl substituted carbon, while keeping the 1,2-quinoid form, to improve the solubility of the polymers. The PL emission spectra of the PHBIT1, PHBIT2 and PHBIT3 in chloroform solutions show maximum peaks at 500~561 nm. In thin films, maximum peaks of the PHBITs appeared at 529, 562 and 569 nm, respectively. The EL emission maxima of the PHBIT1 and PHBIT2 appear at around 588 and 576 nm, respectively. The current density and maximum luminescence of the LED with the configuration of ITO/PEDOT/ PHBIT2/Ca/Al are 552 mA/ and 46 cd/, respectively.
    Bulletin- Korean Chemical Society 08/2011; 32(spc8). DOI:10.5012/bkcs.2011.32.8.3045 · 0.84 Impact Factor
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    Young-Eup Jin, Hong-Suk Suh
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    ABSTRACT: New electroluminescent polymers with fluoro groups in vinylene units, poly(m-silylphenyl-p-phenylene-difluorovinylene) (m-SiP-PPDFV) have been synthesized by GILCH polymerization. These polymers have been used as the electroluminescent (EL) layers in single layer light-emitting diodes (LEDs) (ITO/PEDOT/polymer/Ca:Al). m-SiP-PPDFV shows PL around = 452 nm and green EL around = 497 nm. The current-voltage-luminance (I-V-L) characteristics of the polymers show turn-on voltages of 4.0 V approximately. Two fluoro groups were introduced on every vinylene units of m-SiP-PPV to give m-SiP-PPDFV in an attempt to increase the electron affinity of the parent polymer, and the devices show an increased color stability even with vinylene units. The color stability is attributed to the electron-withdrawing effect of the fluoro groups, which protect vinylene units from oxidation in PPV derivatives. We believe that fluoro groups can be introduced in vinylene units in order to attain excellent stability of PPV derivatives.
    Journal of the Korean Chemical Society 12/2010; 54(6). DOI:10.5012/jkcs.2010.54.6.711
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    ABSTRACT: New PPV derivatives which contain electron-withdrawing CF3F4phenyl group, poly[2-(2-ethylhexyloxy)-5-(2,3,5,6-tetrafluoro-4-trifluoromethylphenyl)-1,4-phenylenevinylene] (CF3F4P-PPV), and poly[2-(4-(2-etylhexyloxy)-phenyl)-5-(2,3,5,6-tetrafluoro-4-trifluoromethylphenyl)-1,4-phenylenevinylene] (P-CF3F4P-PPV), have been synthesized by GILCH polymerization. As the result of the introduction of the electron-withdrawing CF3F4phenyl group to the phenyl backbone, the LUMO and HOMO energy levels of CF3F4P-PPV (3.14, 5.50 eV) and P-CF3F4P-PPV (3.07, 5.60 eV) were reduced. The PL emission spectra in solid thin film are more red-shifted over 50 nm and increased fwhm (full width at half maximum) than solution conditions by raising aggregation among polymer backbone due to electron withdrawing effect of 2,3,5,6-tetrafluoro-4-trifluoromethylphenyl group. The EL emission maxima of CF3F4P-PPV and P-CF3F4P-PPV appear at around 530-543 nm. The current density-voltage-luminescence (J-V-L) characteristics of ITO/PEDOT/polymer/Al devices of CF3F4P-PPV and P-CF3F4P-PPV show that turn-on voltages are around 12.5 and 7.0 V, and the maximum brightness are about 82 and 598 cd/m2, respectively. The maximum EL efficiency of P-CF3F4P-PPV (0.51 cd/A) was higher than that of CF3F4P-PPV (0.025 cd/A).
    Bulletin- Korean Chemical Society 01/2008; 29(1). DOI:10.5012/bkcs.2008.29.1.139 · 0.84 Impact Factor
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    Bulletin- Korean Chemical Society 01/2008; 29(5). DOI:10.5012/bkcs.2008.29.5.1069 · 0.84 Impact Factor
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    ABSTRACT: The article reports the synthesis of a novel bispyridino-18-crown-6 ether, 7-{[(5S,15S)-5,15-diphenyl- 3,6,14,17-tetraoxa-23,24-diazatricyclo[17.3.1.18,12]tetracosa-1(23),8(24),9,11,19,21-hexaen-10-yl]oxy}heptylferrocenamide 6, bearing the C2-symmetric diphenyl substituents as chiral barriers and the ferrocenyl groups serving as an electrochemical sensor, and its electrochemical study with D- and L-AlaOMe·HCl as the guest by cyclovoltametry.
    Bulletin- Korean Chemical Society 01/2007; 28(11). DOI:10.5012/bkcs.2007.28.11.2015 · 0.84 Impact Factor
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    ABSTRACT: A series of tetra donor substituted [2.2]paracyclophane-based two-photon absorption (TPA) fluorophores were synthesized in neutral and cationic forms. The imaging activity of overall set of fluorophores was studied by the two-photon induced fluorescence (TPIF) method in a range of solvents. We also measured a clear progression toward a longer photoluminescence lifetime with increasing solvent polarity (intrinsic photoluminescence lifetime, τi: ~2 ns in toluene → 12-16 ns in water). The paracyclophane fluorophores with this unique property can be utilized as an optical polarity probe for the biomolecular substrates. The combined measurement of the two-photon fluorescence microscopy (TPM) cell image and TPIF lifetime can give us a better understanding of the biological processes and local environments in the cells.
    Bulletin- Korean Chemical Society 01/2007; 28(12). DOI:10.5012/bkcs.2007.28.12.2253 · 0.84 Impact Factor
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    ABSTRACT: New electroluminescence polymer, poly(5,10-dihexyl-5,10-dihydroindolo[3,2-b]indole-2,7-diyl) (PININO) was synthesized by Yamamoto conditions with Ni(0) catalyst. The full characterization of structures and properties as well as the performances of the electroluminescence devices of the new polymer are presented. The resulting polymer, which exhibits good solubility in common organic solvents, was used as the electroluminescence layer for the light-emitting diodes (LEDs) (ITO/PEDOT/polymer/Al). PININO shows turn-on voltage of 2.5 V, and electroluminescence (EL) with maximum peak at 490 nm, maximum brightness of 40 cd/ at 8 V, and efficiency of 0.002 cd/A at 350 mA/. ??AКK??渠??散???卯?整?k??h??????獨潭????? 祗? ???떭?????A?H??????映???k??h??????楫???牧 ? ??? ???떭???????駭??섃?周???慮???浩?卯?整???潭攄k??h?????歡????爀 堀?? ???떭?볪놰?駭??섄?周???慮???湧???楡瑩潮???h????????湧??歲? ???떭????볪떐?????A?K???潭??潮潭楣????楯渠????楯?k??∀?????????瑩??歲??????? ???떭??誤?駭??섄?周???慮?湳瑩?瑥?映?包k?????????????歲? ? ???떭???????룭???A?K??渠????????敲楯??????????????????? ??? ? ???떭??蚌???????????AЪT????渠???????敷??牧?卯?整?k???????????????爀 ? ??? ???떭?곬鶴????곬??듬??駭??섄?????景??楯渠?獵牡??卯?整?k楡猖h?????????歲? ? ???떭????蓬???뎵?駭??섄?周???????????灰???異敲???瑩癩????特??楣?k楡????????楡???歲 退 ???떭??뎴?뗬???름?駭??섃??????????????瑩潮???敬散潭???瑩潮?慣???????敲楮?k???h??????晥??歲? ?돀で?? ???떭??뎴?냬???麵????駭??섄??????????????瑩潮?散????慮??湯癡瑩潮
    Bulletin- Korean Chemical Society 01/2006; 27(7). DOI:10.5012/bkcs.2006.27.7.1043 · 0.84 Impact Factor
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    ABSTRACT: New PPV based conjugated polymers, containing terphenyl units, were prepared as the electroluminescent (EL) layer in light-emitting diodes (LEDs). The prepared polymers, poly[2,5-bis(4-(2-etylhexyloxy)phenyl)-1,4-phenylenevinylene] (BEHP-PPV), poly[2-(2-ethylhexyloxy)-5-(4-(4-(2-etylhexyloxy)phenyl)phenyl)-1,4-phenylenevinylene] (EEPP-PPV) and poly[2-(2-ethylhexyloxy)-5-(9,9-bis(2-etylhexyl)fluorenyl)-1,4 phenylenevinylene] (EHF-PPV), were soluble in common organic solvents and used as the EL layer in double layer light-emitting diodes (LEDs) (ITO/PEDOT/polymer/Al). The polymers were prepared by the Gilch reaction. The number-average molecular weight , weight-average molecular weight , and the polydispersities (PDI) of these polymers were in the range of 9000-58000, 27000-231000, 2.9-3.9, respectively. These polymers have quite good thermal stability with decomposition starting above 320-350. The polymers show photoluminescence (PL) with maximum peaks at around 526-562 nm (exciting wavelength, 410 nm) and blue EL with maximum peaks at around = 526-552 nm. The current-voltageluminance (I-V-L) characteristics of polymers show turn-on voltages of 5 V. Even though both of EEPP-PPV and BEHP-PPV have the same terphenyl group in the repeating unit, EEPP-PPV with directly substituted alkoxy group in the back bone has longer effective conjugation length than BEHP-PPV, and exhibits red shift in the PL spectra. Both of EEPP-PPV and EHF-PPV have ter-phenyl units and directly substituted alkoxy group in back bone. EHF-PPV with fluorenyl unit attached to the PPV backbone has shorter effective conjugation length than EEPP-PPV with biphenyl unit, and exhibits blue shift in the PL spectra.
    Bulletin- Korean Chemical Society 01/2005; 26(11). DOI:10.5012/bkcs.2005.26.11.1807 · 0.84 Impact Factor
  • Sung-Ho Jin, Mi-Sun Jang, Hong-Suk Suh
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    ABSTRACT: Asymmetric and color tunable poly(p-phenylene vinylene) (PPV) derivatives with a dimethyldodecylsilylphenyl pendant group, poly[2-(3‘-dimethyldodecylsilylphenyl)-1,4-phenylene vinylene] (m-SiPhPPV) and poly[2-(3‘-dimethyldodecylsilylphenyl)-1,4-phenylene vinylene-co-2-methoxy-5-(2‘-ethylhexyl oxy)-1,4-phenylene vinylene] (m-SiPhPPV-co-MEH−PPV), have been synthesized by a dehydrohalogenation method. Newly synthesized, these homo- and copolymers are highly soluble in common organic solvents. The defect-free uniformly thin films easily formed onto the indium tin oxide (ITO) coated glass substrate. The resulting polymers had high molecular weights with narrow polydispersities and high thermal stability up to 400 °C. The copolymers showed better optical and electroluminescent (EL) properties than those of the homopolymer. Single-layer light-emitting devices with an ITO/polymer/Al:Li alloy configuration were fabricated by using the resulting polymers. The maximum EL emissions of m-SiPhPPV and m-SiPhPPV-co-MEHPPV with various monomer feed ratios were observed at 528 and 588−595 nm, respectively. The emission color of the resulting polymers changed from green to orange. The EL properties of the m-SiPhPPV-co-MEH−PPV dramatically improved compared to those of m-SiPhPPV and MEH−PPV. The maximum brightness and the external luminance efficiency of the m-SiPhPPV-co-MEH−PPV were up to 19 180 cd/m2 and 2.9 lm/W. The half lifetime of a single-layer device at 1000 cd/m2 is about 120 h.
    Chemistry of Materials 01/2002; 14(2). DOI:10.1021/cm010593s · 8.54 Impact Factor
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    Bulletin- Korean Chemical Society 01/2002; 23(3). DOI:10.5012/bkcs.2002.23.3.528 · 0.84 Impact Factor