Peng Guo

Publications (2)20.86 Total impact

• Article: A Drug-Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast-Cancer Cells with Triggered Drug Release.

  Jin-Oh You, Peng Guo, Debra T Auguste
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  ABSTRACT: Covering all three bases: Drug-delivery vehicles that encapsulate doxorubicin (Dox) within a pH-sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin-poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5-6) and thermal ablation (a photothermal effect).
  Angewandte Chemie International Edition 03/2013; · 13.45 Impact Factor
• Article: Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity.

  Peng Guo, Jin-Oh You, Jiang Yang, Marsha A Moses, Debra T Auguste
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  ABSTRACT: The primary cause of mortality in breast cancer is tumor aggressiveness, characterized by metastases to regional lymph nodes, bone marrow, lung, and liver. C-X-C chemokine receptor type 4 (CXCR4) has been shown to mobilize breast cancer cells along chemokine gradients. Quantification of CXCR4 surface expression may predict the efficacy of anti-CXCR4 labeled liposomal therapeutics to target and kill breast cancer cells. We evaluated gene and surface receptor expression of CXCR4 on breast cancer cell lines distinguished as having low and high invasiveness, MDA-MB-175VII and HCC1500, respectively. CXCR4 surface expression did not correlate with invasiveness. MDA-MB-175VII exhibited more binding to anti-CXCR4 labeled liposomes relative to HCC1500. Increased binding correlated with greater cell death relative to IgG labeled liposomes. Quantitative cell characterization may be used to select targeted therapeutics with enhanced efficacy and minimal side effects.
  Biomaterials 08/2012; 33(32):8104-10. · 7.40 Impact Factor