ABSTRACT: BACKGROUND: The goal of nutrition of the preterm infant is to achieve a postnatal growth approximating normal fetal growth. During the early postnatal period, the protein intake must be sufficient to achieve normal postnatal growth in extremely low birth weight infants. In this study, we tested the hypothesis that higher administration of amino acids and lipids to infants born <34 GWs may improve growth at 40(th) week of gestation and have a positive preventive effect on development of ROP. METHODS: Fifty three neonates born <34GWs and hospitalized in our NICU were included in this prospective study. They were randomly divided into two groups. The Ist-Group received aggressive parenteral nutrition(PN)(amino acids administered 3 g/kg/day and lipids 2 g/kg/day on 1(st) day of life). The 2(nd) -Group received conventional PN(amino acids administered 1.5 g/kg/day and lipids 1 g/kg/day on 1(st) day of life). The anthropometric measurements, clinical outcomes and serum levels of IGF-I, IGFBPs and thyroid hormones were compared between groups. RESULTS: At 40th week of gestation, the measurements of height and head circumference and serum levels of IGF-I and IGFBP3 were statistically higher in the group receiving aggressive PN. Thyroid hormones were not affected by aggressive PN. The lower levels of IGF-I and IGFBP3 in the group receiving conventional PN were negatively correlated with development of ROP. CONCLUSION: Aggressive PN strategy seems to positively affect the neonates' anthropometric measurements at 40(th) gestational week and the development of ROP. Our study showed that these effects may be related to high levels of IGF-I and IGFBP3.
Pediatrics International 08/2012; · 0.63 Impact Factor