Alexandra Tilt

Alliant International University, Los Angeles, California, United States

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Publications (5)15.46 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: "I think that probably convenience is what did in the flexor mechanism allograft," Dr. Leonard Furlow explained in response to why tendon allografts in the 1960s were overshadowed by the Hunter rod, which is still routinely used for flexor tendon reconstruction today. At 83 years old, Dr. Furlow had graciously made the trip from his home in Gainesville, FL up to Charlottesville, VA for a special interview with the Department of Plastic Surgery at the University of Virginia. Furlow is perhaps better known for developing the double-opposing Z-plasty for cleft palate repair, but his interest in hand surgery led to a year in Chapel Hill, NC where he trained with the creator of the flexor mechanism allograft, Dr. Erle E. Peacock, Jr. Through innovative experimental work on flexor tendon reconstruction, Peacock had pioneered the use of fresh composite tendon allografts, which transplant the unscarred synovial space between the tendon and its sheath such that scar formation only occurs outside the sheath. Inspired by our recent research interest in this subject, we asked Dr. Furlow to reflect on his experience with the tendon allograft in the 1960s with the late Dr. Peacock. The picture he painted was of a simple, elegant, and astonishingly successful solution for flexor tendon reconstruction that suffered from a lack of practicality at the time.
    Annals of plastic surgery. 07/2014;
  • David B Drake, Alexandra C Tilt, Brent R Degeorge
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    ABSTRACT: Flexor tendon injuries continue to pose a significant challenge to the hand surgeon. In particular, chronic tendon ruptures with adhesions of the tendons and sheath, damage or loss of the intrasynovial flexor tendons in zone II, and combined soft tissue and bone injuries present especially difficult problems for restoring satisfactory digital function. This challenge in flexor tendon reconstruction has motivated hand surgeons to explore and develop novel solutions for nearly a century. Recent advances and techniques in processing and decellularizing allograft human flexor tendon constructs may prove to be a new horizon for tendon reconstruction.
    The Journal of hand surgery 05/2013; · 1.33 Impact Factor
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    ABSTRACT: : To determine the factors that may predict music-induced relaxation in friends and family of patients in the emergency department. : It remains unclear to date which demographic and experiential factors predict the effectiveness of music-induced relaxation. Furthermore, in-hospital stressors for friends and family of patients rather than patients themselves are underresearched and deserve in-depth investigation to improve this group's experience in health care environments. : A total of 169 relatives and friends of patients in the emergency department-waiting area completed a series of questionnaires, including the Spielberger State-Trait Anxiety Inventory (STAI), the Music Experience Questionnaire (MEQ), and a demographic survey. They were then randomly assigned to either Case Group (1 hour in the waiting area with classical music in the background) or Control Group (1 hour with no music) before completing a second, identical copy of the STAI to measure change from baseline. Data were analyzed for associations between music intervention, change in STAI scores, MEQ scores, and demographic characteristics. : Participants who underwent the music intervention experienced a 9.8% decrease in overall mean State Anxiety, whereas those in the Control Group experienced no change over time (P = 0.001). Higher education significantly inversely correlated with the effectiveness of music intervention: participants with no formal education beyond high school showed a greater overall mean decrease in State Anxiety than those with a college education or beyond in response to classical music (P = 0.006). Furthermore, MEQ scores indicated that the Social Uplift scale (a measure of one's tendency to be uplifted in a group-oriented manner by music) was highly predictive of the effectiveness of music intervention. : Music is an effective and inexpensive means of reducing anxiety in friends and family of patients, who are underresearched in medicine. Moreover, low educational attainment and tendency to respond positively to music in a group setting can predict the effectiveness of music-induced relaxation.
    Annals of surgery 05/2013; 257(5):834-8. · 7.90 Impact Factor
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    ABSTRACT: The study of music and medicine is a rapidly growing field that in the past, has been largely focused on the use of music as a complementary therapy. Increasing interest has been centered on understanding the physiologic mechanisms underlying the effects of music and, more recently, the suggested role of music in modulating metabolic responses. Research has established a role for music in the regulation of the hypothalamic-pituitary axis, the sympathetic nervous system, and the immune system, which have key functions in the regulation of metabolism and energy balance. More recent findings have shown a role for music in the metabolic recovery from stress, the regulation of gastric and intestinal motility, the moderation of cancer-related gastrointestinal symptoms, and the increase of lipid metabolism and lactic acid clearance during exercise and postexercise recovery. The purpose of this article is to summarize the most current understanding of the mechanisms by which music affects the metabolic responses in the context of potential applications.
    Nutrition 08/2012; 28(11-12):1075-80. · 2.86 Impact Factor
  • Alexandra Tilt, Craig Mermel, Claudius Conrad
    Surgery 07/2011; 150(1):5-6. · 3.37 Impact Factor

Publication Stats

9 Citations
15.46 Total Impact Points

Institutions

  • 2013
    • Alliant International University
      Los Angeles, California, United States
  • 2011–2012
    • Massachusetts General Hospital
      • Department of Surgery
      Boston, MA, United States