Lin Lu

Peking University, Peping, Beijing, China

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Publications (277)1106.82 Total impact

  • Deqi Wang · Lin Lu · Ping Cui ·

    International Journal of Heat and Mass Transfer 02/2016; 93:760-769. DOI:10.1016/j.ijheatmasstransfer.2015.10.055 · 2.38 Impact Factor
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    ABSTRACT: The research on the influence that groundwater exerts on borehole ground heat exchanger has been made progress. However, the investigation on how to obtain the groundwater velocity is a little. According to the line heat source model with groundwater flow, a new methodology is explored to obtain the value and direction of groundwater velocity while it flows through borehole. Some points are distributed around borehole and they have the same distance to the center line of borehole, and the temperature responses of these points are significant parameters which lay firm foundation for reverse-reasoning. The reverse-reasoning calculation can be conducted by establishing objective function. The comparisons of temperature responses between theoretical results and the simulative recorded data are made. The impact degree of groundwater flow can be displayed and then the velocity is estimated. Differences among points' temperature responses are made full use of to respectively indicate the direction and value ranges of velocity. The relativity between the points' location and the velocity intensity is investigated and then some cases are chosen as the trials to verify the rationality of reverse calculation method. To a large extent, the research work of this paper provides theoretical guidance or computing mode for getting velocity of groundwater. The methodology can be employed for obtaining the velocity in actual engineering projects or other cases.
    International Journal of Thermal Sciences 01/2016; 99:52-63. DOI:10.1016/j.ijthermalsci.2015.08.001 · 2.63 Impact Factor
  • Ronghui Qi · Lin Lu · Yu Huang ·

    Energy Conversion and Management 12/2015; 106:1387-1395. DOI:10.1016/j.enconman.2015.10.064 · 4.38 Impact Factor
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    ABSTRACT: Combined pharmacological treatments are the most used approach for neuropathic pain. Carbamazepine, an antiepileptic agent, is generally used as a third-line treatment for neuropathic pain and can be considered an option only when patients have not responded to the first- and second-line medications. In the case presented herein, a patient with neuropathic pain was treated using a combined pharmacological regimen. The patient's pain deteriorated, despite increasing the doses of opioids, when carbamazepine was discontinued, potentially because carbamazepine withdrawal disrupted the balance that was achieved by the multifaceted pharmacological regimen, thus inducing hyperalgesia. Interestingly, when carbamazepine was prescribed again, the patient's pain was successfully managed. Animal research has reported that carbamazepine can potentiate the analgesic effectiveness of morphine in rodent models of neuropathic pain and postoperative pain. This clinical case demonstrates that carbamazepine may have a synergistic effect on the analgesic effectiveness of morphine and may inhibit or postpone opioid-induced hyperalgesia. We postulate that a probable mechanism of action of carbamazepine may involve -aminobutyric acid-ergic potentiation and the interruption of glutamatergic function via N-methyl-D-aspartate receptors. Further research is warranted to clarify the analgesic action of carbamazepine and its potential use for the prevention of opioid-induced hyperalgesia in chronic neuropathic pain patients. Key words: Analgesia, hyperalgesia, carbamazepine, opioids, neuropathic pain, pharmacologic treatment.
    Pain physician 11/2015; 18(6):E1127-E1130. · 3.54 Impact Factor
  • Yan Sun · Yan Zhang · Fan Wang · Yankun Sun · Jie Shi · Lin Lu ·
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    ABSTRACT: Genetic factors contribute to more than 50% of the variation in the vulnerability to alcohol dependence (AD). Although significant advances have been made in medications for AD, these medications do not work for all people. Precise tailoring of medicinal strategies for individual alcoholic patients is needed to achieve optimal outcomes. This review updates the most promising information on genetic variants in AD, which may be useful for improving diagnostic, therapeutic, and monitoring strategies. We describe genetic candidates of various neurotransmitter and enzyme systems. In addition to biological and allelic associations with AD, genetic effects on AD-related phenotypes and treatment responses have also been described. Gene-gene and gene-environment interactions have been considered. Potential applications of genomewide and epigenetic approaches for identifying genetic biomarkers of AD have been discussed. Overall, the application of genetic findings in precision medicine for AD will likely involve an integrated approach that distinguishes effect sizes of specific genetic predictors with regard to sex, pharmacotherapy, ethnicity, and AD-related aspects and considers gene-gene and gene-environment interactions. Our work may pave the way toward more precise treatment for AD that could ultimately improve clinical management and interventions.
    Behavioural pharmacology 11/2015; DOI:10.1097/FBP.0000000000000202 · 2.15 Impact Factor
  • Ronghui Qi · Yan Hu · Yuanhao Wang · Lin Lu ·

    Journal of Cleaner Production 11/2015; DOI:10.1016/j.jclepro.2015.10.115 · 3.84 Impact Factor

  • Hao Lu · Lin Lu ·
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    ABSTRACT: In this study, the influences of rib spacing and height on particle deposition in ribbed duct air flows were numerically investigated. The turbulent air flow was resolved using the Reynolds stresses model (RSM) with turbulent fluctuation correction, while the particle phase was tracked by the discrete particle model (DPM). The ratios of rib spacing to rib height p/e were 2, 4, 6, 8 and 10 while the ratios of rib height to duct diameter e/D were 0.05, 0.1 and 0.2. The air flow velocity profiles for both smooth and ribbed ducts as well as particle deposition velocity in a smooth duct obtained in the simulation agree well with previous related study data. It is found that particle deposition velocity is significantly enhanced by the surface ribs for several orders of magnitude, especially for small particles . Particle deposition enhancement increases with the decreasing rib spacing, while no significant difference is found for different rib heights. The mechanisms of particle deposition enhancement were analyzed and discussed in relation to different rib spacings and heights. Moreover, an efficiency ratio has been defined to evaluate the particle deposition enhancement ratio together with the increase of flow drag. The maximum efficiency ratio can reach about 1000 for small particles and about 100 for large particles when p/e = 2 and e/D = 0.1. Therefore, a reasonable arrangement of surface ribs is an efficient and effective choice for enhancing particle deposition, and could be adopted in air filtration devices.
    Building and Environment 10/2015; 92. DOI:10.1016/j.buildenv.2015.04.035 · 3.34 Impact Factor
  • Hai Wang · Hongxing Yang · Lin Lu ·

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    Tao Ma · Hongxing Yang · Lin Lu ·
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    ABSTRACT: In this study, a hybrid energy storage system (HESS), which combines battery for long-term energy management and supercapacitor for fast dynamic power regulation, is proposed for remote area renewable energy power supply systems. The operation of a passive connected HESS was examined via both theoretical analysis and numerical simulation using Matlab/Simulink. An electric inductor was further introduced to improve the performance of the HESS. An experimental test bench was developed to validate the simulation results. It was demonstrated that the HESS can stabilize energy provision, not only for the intermittent renewable energy (RE), but also for fluctuating load applications.
    Applied Energy 09/2015; 153:56-62. DOI:10.1016/j.apenergy.2014.12.008 · 5.61 Impact Factor
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    Jinqing Peng · Lin Lu · Hongxing Yang · Tao Ma ·
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    ABSTRACT: This paper presents a set of indoor and outdoor measurement methods and procedures to determine the empirical coefficients of the Sandia Array Performance Model (SAPM) for a semi-transparent amorphous silicon (a-Si) PV module. After determining and inputting the total 39 parameters into the SAPM, the dynamic power output of the a-Si PV module was predicted. In order to validate the accuracy of using SAPM for simulating the energy output of the a-Si PV module, a long-term outdoor testing campaign was conducted. The results indicated that the SAPM with indoor and outdoor measured coefficients could accurately simulate the energy output of the a-Si PV module on sunny days, but it didn't work well on overcast days due to the inappropriate spectral correction as well as the equipment measuring error caused by the intense fluctuation of solar irradiance on overcast days. Specifically, all the errors between the simulated daily energy output and the measured one were less than 4% on sunny days. In order to achieve a better prediction performance for a-Si PV technologies, the SAPM was suggested to incorporate a more comprehensive spectral correction function to correct the impact of solar spectrum on overcast days in future.
    Renewable Energy 08/2015; 80. DOI:10.1016/j.renene.2015.02.017 · 3.48 Impact Factor

  • Sleep Medicine 08/2015; DOI:10.1016/j.sleep.2015.06.023 · 3.15 Impact Factor
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    ABSTRACT: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic component. Many lines of evidence indicated that ASD shares common genetic variants with other psychiatric disorders (for example, schizophrenia). Previous studies detected that calcium channels are involved in the etiology of many psychiatric disorders including schizophrenia and autism. Significant association between CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit) and schizophrenia was detected. Furthermore, rare mutation in CACNA1C is suggested to cause Timothy syndrome, a multisystem disorder including autism-associated phenotype. However, there is no evidence for association between CACNA1C and autism in Chinese Han population. To investigate the association between single nucleotide polymorphisms (SNP) in CACNA1C and autism, we first performed a family-based association study between eighteen SNPs in CACNA1C and autism in 239 trios. All SNPs were genotyped by using Sequenom genotyping platform. Two SNPs (rs1006737 and rs4765905) have a trend of association with autism. To further confirm the association between these two SNPs with autism, we expanded the sample size to 553 trios by adding 314 trios. Association analyses for SNPs and haplotype were performed by using family-based association test (FBAT) and Haploview software. Permutation tests were used for multiple testing corrections of the haplotype analyses (n=10,000). The significance level for all statistical tests was two-tailed (p<0.05). The results demonstrated that G allele of rs1006737 and G allele of rs4765905 showed a preferential transmission to affected offspring in 553 trios (p=0.035). Haplotype analyses showed that two haplotypes constructed from rs1006737 and rs4765905 were significantly associated with autism (p=0.030, 0.023, respectively; Global p=0.046). These results were still significant after permutation correction (n=10,000, p=0.027). Our research suggests that CACNA1C might play a role in the genetic etiology of autism in Chinese Han population.
    PLoS ONE 07/2015; 10(7):e0133247. DOI:10.1371/journal.pone.0133247 · 3.23 Impact Factor
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    ABSTRACT: Drug memories that associate drug-paired stimuli with the effects of abused drugs contribute to relapse. Exposure to drug-associated contexts causes consolidated drug memories to be in a labile state, during which manipulations can be given to impair drug memories. Although substantial evidence demonstrates the crucial role of neuronal signaling in addiction, little is known about the contribution of astrocyte-neuron communication. Rats were trained for cocaine-induced conditioned place preference (CPP) or self-administration and microinjected with the glycogen phosphorylation inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol into the basolateral amygdala (BLA) immediately after retrieval. The concentration of lactate was measured immediately after retrieval via microdialysis, and the CPP score and number of nosepokes were recorded 24 hours later. Furthermore, we used antisense oligodeoxynucleotides to disrupt the expression of astrocytic lactate transporters (monocarboxylate transporters 1 and 2) in the BLA after retrieval, tested the expression of CPP 1 day later, and injected L-lactate into the BLA 15 minutes before retrieval to rescue the effects of the oligodeoxynucleotides. Injection of 1,4-dideoxy-1,4-imino-D-arabinitol into the BLA immediately after retrieval prevented the subsequent expression of cocaine-induced CPP, decreased the concentration of lactate in the BLA, and reduced the number of nosepokes for cocaine self-administration. Disrupting the expression of monocarboxylate transporters 1 and 2 in the BLA also caused subsequent deficits in the expression of cocaine-induced CPP, which was rescued by pretreatment with L-lactate. Our results suggest that astrocyte-neuron lactate transport in the BLA is critical for the reconsolidation of cocaine memory. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
    Biological psychiatry 07/2015; DOI:10.1016/j.biopsych.2015.07.007 · 10.26 Impact Factor
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    ABSTRACT: Neurocognitive impairment is one of the factors that put heroin abusers at greater risk for relapse, and deficits in related functional brain connections have been found. However, the alterations in structural brain connections that may underlie these functional and neurocognitive impairments remain largely unknown. In the present study, we investigated topological organization alterations in the structural network of white matter in heroin abusers and examined the relationships between the network changes and clinical measures. We acquired diffusion tensor imaging datasets from 76 heroin abusers and 78 healthy controls. Network-based statistic was applied to identify alterations in interregional white matter connectivity, and graph theory methods were used to analyze the properties of global networks. The participants also completed a battery of neurocognitive measures. One increased subnetwork characterizing widespread abnormalities in structural connectivity was present in heroin users, which mainly composed of default-mode, attentional and visual systems. The connection strength was positively correlated with increases in fractional anisotropy in heroin abusers. Intriguingly, the changes in within-frontal and within-temporal connections in heroin abusers were significantly correlated with daily heroin dosage and impulsivity scores, respectively. These findings suggest that heroin abusers have extensive abnormal white matter connectivity, which may mediate the relationship between heroin dependence and clinical measures. The increase in white matter connectivity may be attributable to the inefficient microstructure integrity of white matter. The present findings extend our understanding of cerebral structural disruptions that underlie neurocognitive and functional deficits in heroin addiction and provide circuit-level markers for this chronic disorder. © 2015 Society for the Study of Addiction.
    Addiction Biology 07/2015; DOI:10.1111/adb.12285 · 5.36 Impact Factor
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    ABSTRACT: We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.
    Nature Communications 07/2015; 6:7675. DOI:10.1038/ncomms8675 · 11.47 Impact Factor
  • Hao Lu · Lin Lu ·
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    ABSTRACT: The effects of surface rib shapes on particle deposition in turbulent duct air flows were numerically studied based on the Reynolds stresses model (RSM) with UDF code correction and the discrete particle model (DPM). The shapes of the rib cross sections were square, triangular and circular. The ratios of rib height to duct diameter e/D were 0.1. The present air velocity distributions for both smooth and ribbed ducts as well as particle deposition velocity in a smooth duct are all in good agreement with previous related study data. An efficiency ratio has been defined to evaluate the particle deposition enhancement ratio together with the increase of flow drag. It is found that the square ribs have the maximum enhancement efficiency on particle deposition, compared with the other rib shapes. The maximum efficiency ratio can reach about 400 for small particles (τp+<1) but only about 2 for large particles (τp+>1) when the rib shape is square. Moreover, the mechanisms of particle deposition enhancement for different rib shapes were investigated and analyzed.
    Building and Environment 07/2015; 94. DOI:10.1016/j.buildenv.2015.07.030 · 3.34 Impact Factor
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    ABSTRACT: Recent research has used context cues (odor or auditory cues) to target memories during sleep and has demonstrated that they can enhance declarative and procedural memories. However, the effects of external cues re-presented during sleep on emotional memory are still not fully understood. In the present study, we conducted a Pavlovian fear conditioning/extinction paradigm and examined the effects of re-exposure to extinction memory associated contextual tones during slow-wave sleep (SWS) and wakefulness on fear expression. The participants underwent fear conditioning on the first day, during which colored squares served as the conditioned stimulus (CS) and a mild shock served as the unconditioned stimulus (US). The next day, they underwent extinction, during which the CSs were presented without the US but accompanied by a contextual tone (pink noise). Immediately after extinction, the participants were required to take a nap or remain awake and randomly assigned to six groups. Four of the groups were separately exposed to the associated tone (i.e. SWS-Tone group and Wake-Tone group) or an irrelevant tone (controltone, CtrT) (i.e. SWS-CtrT group and Wake-CtrT group), while the other two groups were not (i.e. SWS-No Tone group and Wake-No Tone group). Subsequently, the conditioned responses to the CSs were tested to evaluate the fear expression. All of the participants included in the final analysis showed successful levels of fear conditioning and extinction. During the recall test, the fear responses were significantly higher in the SWS-Tone group than that in the SWS-No Tone group or the SWS-CtrT group, while the Wake-Tone group exhibited more attenuated fear responses than either the Wake-No Tone group or Wake-CtrT group. Otherwise, re-exposure to auditory tones during SWS did not affect sleep profiles. These results suggested that distinct conditions during which re-exposure to an extinction memory associated contextual cue contributes to differential effects on fear expression. Copyright © 2015. Published by Elsevier Inc.
    Neurobiology of Learning and Memory 06/2015; 123. DOI:10.1016/j.nlm.2015.06.005 · 3.65 Impact Factor
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    ABSTRACT: The research on heat transfer models of geothermal ground heat exchangers (GHEs) of ground-coupled heat pump (GCHP) system has recently advanced greatly. However, although it is important to optimize the design size of GHEs for reducing the total length of GHEs, the optimization of GHEs by means of models is a little. This paper describes the interior simulation models of borehole in which single U-tube and double U-tubes are each buried. The analytical solutions concerning the borehole's exterior heat transfer are given. All the factors that exert influences on the design size of GHEs are described based on the results of the heat transfer models. These significant parameters consist of the centre to centre distance of the U-tube, thermal conductivity of the backfill material, distance of adjacent boreholes, types of circulating liquid or underground medium, arrangement of boreholes, and the minimum temperature of the circulating liquid which enters the heat pump. Using the simulation models and computer programming, the influence degrees of the above factors are discussed in terms of the adoption of different values or types. Therefore, the initial cost and the economic performance of the system are respectively dropped and improved. The investigation on optimization of GHEs is favourable for the further development of GCHP technology.
    Applied Thermal Engineering 06/2015; 84. DOI:10.1016/j.applthermaleng.2015.03.023 · 2.74 Impact Factor
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    ABSTRACT: This paper presents a new spiral source heat transfer model for simulating the heat transfer performance of pile foundation ground heat exchangers (GHEs) with existence of groundwater transfusion. The model takes heat conduction and convection of groundwater into account and is more accurate than those previously proposed such as solid cylindrical model and ring-coil model to describe the heat transfer behavior. Besides, some shortages and deficiencies are improved and overcome, especially in terms of the configuration of spiral heat transfer tubes. The analytical solutions of the model are obtained to exhibit the temperature response at any point in the underground medium around the pile foundation GHEs. The parameters that exert impacts on the heat transfer process has been investigated and discussed in the paper. The pure conduction case and combined heat transfer case are compared, and the heat exchange efficiency between the pile foundation GHEs and surrounding medium can be improved as a result of the influence of groundwater transfusion. The meliorative effect is becoming increasingly evident with time or velocity of groundwater. The research contributes to more understanding of the potential for pile foundation GHEs and the degrees which the heat transfer efficiency affected by groundwater flow.
    International Journal of Heat and Mass Transfer 05/2015; 84. DOI:10.1016/j.ijheatmasstransfer.2014.12.036 · 2.38 Impact Factor

Publication Stats

8k Citations
1,106.82 Total Impact Points


  • 2006-2015
    • Peking University
      • Institute of Mental Health
      Peping, Beijing, China
  • 2001-2015
    • The Hong Kong Polytechnic University
      • Department of Building Services Engineering
      Hong Kong, Hong Kong
  • 2010-2014
    • The University of Hong Kong
      Hong Kong, Hong Kong
    • Capital Medical University
      • School of Public Health and Family Medicine
      Peping, Beijing, China
  • 2006-2011
    • National Institute on Drug Abuse
      Роквилл, Maryland, United States
  • 2003
    • National Institutes of Health
      베서스다, Maryland, United States