Lin Lu

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (291)1070.41 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel blue phase-mixed anatase-rutile TiO2 heterogeneous junctions composite, as anode material in lithium ion batteries (LIBs), is built via surface defect induced method. The as-synthesized composites exhibit outstanding rate capability (93 mAh g-1 at 20 C), and good cyclic stability (7.35% capacity loss after 200 cycles at 10 C).
    RSC Advances 09/2014; · 3.71 Impact Factor
  • Source
    Ronghui Qi, Lin Lu
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    ABSTRACT: LDAC (liquid desiccant air-conditioning system) is promising for reducing the energy consumption, and improving the indoor air quality. In this paper, the operation performance of LDAC with internally cooled/heated dehumidifier/regenerator was simulated and optimized. The cooling tower and solar collectors were employed as the cooling/heating source. Four nested iteration loops were developed and solved for system modeling. A typical commercial building in Hong Kong was selected as a case study, which air-conditioning load was obtained by Energy-plus. Results show that with the increase of solar collector area, the electricity consumption of AC (air-conditioning systems) system reduced by 11–35% in original system, but only a part of dehumidification demand was handled with liquid desiccant ventilation, which led to a low chiller COP (coefficient of performance). By adding a cooling coil for the solution entering dehumidifier, the electricity saving effectively increased to 22–47%, while the heat demand for regeneration also increased by 17%. So, a heat exchanger between water leaving regenerator and solution leaving dehumidifier was introduced. With the lower thermal requirement (reduced by 20%) and higher solar fraction (increased from 30 to 40%), the saving further increased to 29–49%, and the required collector area obviously reduced by 50–60% for the similar energy saving purpose.
    Energy 08/2014; 73:801–808. · 4.16 Impact Factor
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    ABSTRACT: Maladaptive memories elicited by exposure to environmental stimuli associated with drugs of abuse are often responsible for relapse among addicts. Interference with the reconsolidation of drug memory can inhibit drug seeking. Previous studies have indicated that the dephosphorylation of the eukaryotic initiation factor 2 α-subunit (eIF2α) plays an important role in synaptic plasticity and long-term memory consolidation, but its role in the reconsolidation of drug memory remains unknown. The amygdala is required for the reconsolidation of a destabilized drug memory after retrieval of drug-paired stimuli. Here, we used conditioned place preference (CPP) and self-administration procedures to determine whether amygdala eIF2α dephosphorylation is required for the reconsolidation of morphine and cocaine memories in rats. We found that the levels of eIF2α phosphorylation (Ser51) and activating transcription factor 4 (ATF4) were decreased after reexposure to a previously morphine- or cocaine-paired context (i.e., a memory retrieval procedure) in the basolateral amygdala (BLA) but not in the central amygdala. Intra-BLA infusions of Sal003, a selective inhibitor of eIF2α dephosphorylation, immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced CPP, leading to a long-lasting suppression of drug-paired stimulus-induced craving. Advanced knockdown of ATF4 expression in the BLA by lentivirus-mediated short-hairpin RNA blocked the disruption of the reconsolidation of morphine-induced CPP induced by Sal003 treatment. Furthermore, inhibition of eIF2α dephosphorylation in the BLA immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. These results demonstrate that eIF2α dephosphorylation in the BLA mediates the memory reconsolidation of drug-paired stimuli.
    The Journal of neuroscience : the official journal of the Society for Neuroscience. 07/2014; 34(30):10010-21.
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    ABSTRACT: The relationship between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. However, the daily rhythm alteration of the functions of the hypothalamus pituitary thyroid axis (HPT) is uncertain. In the present study, we investigated the effects of chronic unpredictable mild stress (CUMS) on the daily rhythm alterations of triiodothyronine (T3), thyroxine (T4), and Thyroid Stimulating Hormone (TSH) in the plasma. We found that CUMS led to depressive-like behavior and the daily rhythm of T3, T4, and TSH in the plasma being disturbed, as well the plasma levels of T3 and T4 decreased compared to control group. Our findings indicate that CUMS not only induce hypofunction of HPT axis but also the disturbance of daily rhythm of PHT axis in rats.
    Endocrine. 06/2014;
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    ABSTRACT: Repeated exposure to nicotine increases psychomotor activity. Long-lasting neural plasticity changes that contribute to the nicotine-induced development of locomotor sensitization have been identified. The mammalian target of rapamycin complex 1 (mTORC1) signalling pathway is involved in regulating the neuroplasticity of the central nervous system. In this study, we examined the role of mTORC1 in the amygdala in nicotine-induced locomotor sensitization. Rapamycin, an inhibitor of mTORC1, was infused into the basolateral amygdala (BLA) and central amygdala (CeA) or systemically administered to investigate the role of the mTORC1 in the development and expression of nicotine-induced locomotor sensitization. We found that locomotor activity progressively increased during the initiation of nicotine-induced locomotor sensitization and the expression of nicotine sensitization was induced by nicotine challenge injection (0.35 mg/kg s.c.) after five days of withdrawal. The initiation of nicotine-induced locomotor sensitization was accompanied by the increased phosphorylated level of mTORC1 downstream target proteins including p-p70s6k and p-4EBP in the BLA, but not CeA. Intra-BLA infusion or systemic administration of rapamycin blocked locomotor activity. Increased p-p70s6k and p-4EBP were also observed in the expression of nicotine sensitization, which was demonstrated to be inhibited by systemic rapamycin administration. Our findings indicated that mTORC1 activity in the BLA, but not the CeA, mediated the initiation and expression of nicotine-induced locomotor sensitization, and may become a potential target for the treatment of nicotine addiction.
    06/2014;
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    ABSTRACT: Drug abuse has resulted in a huge burden on public health and the economy in China. Since the reemergence of drug abuse in China in the 1980s, the number of drug addicts has increased dramatically, especially the proportion of users of synthetic drugs, such as amphetamine-type stimulant (ATS). Further, the proportion of opiate addicts has decreased among the new initiates. This review describes the new pattern of drug abuse and the resultant intervention strategy in China.
    Current opinion in psychiatry 05/2014; · 3.57 Impact Factor
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    ABSTRACT: The persistence of physical dependence and craving in addicts is considered to contribute to relapse. Increasing evidence indicates that neuropeptide systems are associated with several phases of drug addiction, but little is known about whether the neuropeptide trefoil factor affects withdrawal symptoms. This study aims to investigate the potential effects of the neuropeptide trefoil factor 3 (TFF3) on naloxone-precipitated withdrawal symptoms in morphine-dependent mice. Mice received increasing doses of morphine over 3 days. On day 4, the mice were injected with TFF3 (1.0 mg/kg, i.p.) 30 min after the last dose of morphine. Thirty minutes after TFF3 treatment, naloxone (1 mg/kg, i.p.) was injected, and body weight, jumping behavior, wet-dog shakes, and locomotor activity were assessed 30 min later. Naloxone caused significant weight loss and increased jumping behavior and wet-dog shakes in morphine-dependent mice. TFF3 (1.0 mg/kg) reversed these behavioral symptoms caused by morphine withdrawal, suggesting that TFF3 might ameliorate physical dependence associated with opiate addiction. Furthermore, TFF3 pretreatment significantly reduced morphine withdrawal-induced increases in plasma corticosterone and adrenocorticotropic hormone levels. The glucocorticoid receptor agonist RU486 blocked the behavioral effects of TFF3 on morphine withdrawal symptoms. Finally, Fos expression in the medial prefrontal cortex which was decreased during morphine withdrawal was increased by TFF3 pretreatment. These findings indicate that TFF3 might be a potential therapeutic candidate for opiate addiction by regulating glucocorticoid secretion and neuronal activation in the prefrontal cortex.
    Psychopharmacology 05/2014; · 4.06 Impact Factor
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    ABSTRACT: Extinction therapy has been suggested to suppress the conditioned motivational effect of drug cues to prevent relapse. However, extinction forms a new inhibiting memory rather than erasing the original memory trace and drug memories invariably return. Perineuronal nets (PNNs) are a specialized extracellular matrix around interneurons in the brain that have been suggested to be a permissive factor that allows synaptic plasticity in the adolescent brain. The degradation of PNNs caused by chondroitinase ABC (ChABC) may generate induced juvenile-like plasticity (iPlasticity) and promote experience-dependent plasticity in the adult brain. In the present study, we investigated the effect of removing PNNs in the amygdala of rat on the extinction of drug memories. We found that extinction combined with intra-amygdala injections of ChABC (0.01 U/side) prevented the subsequent priming-induced reinstatement of morphine-induced and cocaine-induced, but not food -induced, conditioned place preference (CPP). Intra-amygdala injections of ChABC alone had no effect on the retention, retrieval, or relearning of morphine-induced CPP and storage of acquired food-induced CPP. Moreover, we found that the procedure facilitated the extinction of heroin- and cocaine-seeking behavior and prevented the spontaneous recovery and drug-induced reinstatement of heroin- and cocaine-seeking behavior. We also found that the effect of PNNs degradation combined with extinction may be mediated by the potentiation of several plasticity-related proteins in the amygdala. Altogether, our findings demonstrate that a combination of extinction training with PNNs degradation in the amygdala erases drug memories and suggest that ChABC may be an attractive candidate for the prevention of relapse.
    Journal of Neuroscience 05/2014; 34(19):6647-58. · 6.91 Impact Factor
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    ABSTRACT: Time-dependent increases in cue-induced nicotine and methamphetamine craving during abstinence were recently reported in human drug-dependent individuals. In the present study, we sought to determine whether this ‘incubation of craving’ phenomenon also occurs in alcoholics. Four groups of 80 inpatient adult male alcoholics were assessed in a single session (between-group design) for cue-induced alcohol craving at 7, 14, 30 and 60 days of abstinence. Another group that included 19 patients was repeatedly tested for cue-induced alcohol craving at the same abstinence days as above. Other psychological and physiological measures were assessed at the four abstinence timepoints. Cue-induced alcohol craving measured with visual analogue scales was the highest at 60 days of abstinence both between and within groups. However, heart rate, blood pressure and skin conductance responses did not differ between abstinent groups. These results provide evidence of the incubation of alcohol craving in humans, extending previous reports with smokers and methamphetamine addicts.
    Addiction Biology 05/2014; · 5.91 Impact Factor
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    ABSTRACT: Cardiosphere-derived cells (CDCs) effect therapeutic regeneration after myocardial infarction (MI) both in animal models and in humans. Here we test the hypothesis that cell-cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects. Human CDCs or vehicle were injected into immunodeficient (SCID) mouse hearts during acute MI. CDC transplantation augmented the proportion of cycling (Ki67+) cardiomyocytes and improved ventricular function. CDC-conditioned media only modestly augmented the percentage of Ki67+ cardiomyocytes (>control but <CDCs), but did not improve pump function. When neonatal rat ventricular myocytes (NRVMs) were co-cultured with human CDCs in vitro, the percentage of cycling NRVMs (Ki67+ or BrdU+ nuclei) increased relative to solitary NRVM culture. To further dissect the relative contributions of soluble factors versus contact-dependent mechanisms, we compared CDCs grown with NRVMs in a transwell contact-free system versus admixed co-culture. The percentage of cycling NRVMs was higher in admixed co-culture than in the contact-free system. Pre-treatment with inhibitors of MEK and PI3K, or with β1 integrin neutralizing antibody, blocked the ability of CDCs to promote myocyte cycling. While conditioned media is not inert, direct apposition of CDCs to cardiomyocytes produces greater enhancement of cardiomyocyte proliferation in vitro and in vivo, and improves function post-MI. Intact cardiomyocyte β1 integrin signaling is necessary for the contact-dependent cardioproliferative effects of CDCs. Stem Cells 2014
    Stem Cells 05/2014; · 7.70 Impact Factor
  • International journal of cardiology 04/2014; · 6.18 Impact Factor
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    ABSTRACT: Time-dependent increases in cue-induced nicotine and methamphetamine craving during abstinence were recently reported in human drug-dependent individuals. In the present study, we sought to determine whether this 'incubation of craving' phenomenon also occurs in alcoholics. Four groups of 80 inpatient adult male alcoholics were assessed in a single session (between-group design) for cue-induced alcohol craving at 7, 14, 30 and 60 days of abstinence. Another group that included 19 patients was repeatedly tested for cue-induced alcohol craving at the same abstinence days as above. Other psychological and physiological measures were assessed at the four abstinence timepoints. Cue-induced alcohol craving measured with visual analogue scales was the highest at 60 days of abstinence both between and within groups. However, heart rate, blood pressure and skin conductance responses did not differ between abstinent groups. These results provide evidence of the incubation of alcohol craving in humans, extending previous reports with smokers and methamphetamine addicts.
    Addiction Biology 04/2014; · 5.91 Impact Factor
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    ABSTRACT: The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants. The blood-brain barrier is the most important bottleneck impeding drug transport into the brain. Therefore, development of novel antidepressant medications with rapid onset and sustained activity is urgent. RGD liposomes showed an excellent effect of brain-targeting drug delivery and increased the entering rate to the brain. In the present study, we prepared cyclic RGD liposomes loaded with edaravone (cRGD-ERLs) and evaluated the potential antidepressant-like effects of this drug delivery system in rats. The results showed single injection of cRGD-ERLs produced significant antidepressant-like effects in both forced swim and novelty suppressed feeding test. Moreover, acute cRGD-ERLs increased the expression of c-fos in the medial prefrontal cortex, suggesting that cRGD-ERLs could activate the neuronal function. Furthermore, cRGD-ERLs reversed the increase of lipopolysaccharides (LPS)-induced plasma cytokine IL-1β and IL-6, suggesting that normalization of cytokine level might be involved in the behavioral response of cRGD-ERLs. Finally, cRGD-ERLs prevented the increase of immobility induced by LPS in the forced swim test. Overall, the current data revealed a novel brain-target drug delivery system, which can be used to improve the therapeutic outcomes of antidepressants by increase of crossing rate to the brain.
    European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 04/2014; · 2.61 Impact Factor
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    ABSTRACT: Background: The present study investigated whether serum levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1, -2 and -3 are related to poor coronary collateralization in patients with stable coronary artery disease (CAD). Methods and Results: Serum levels of sVEGFR-1, -2, -3, VEGF, and placental growth factor (PLGF) were determined in 403 consecutive patients with angiographic total or subtotal occlusion of at least 1 major coronary artery. The degree of collateralization was graded according to the Rentrop scoring system. Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralization occurred in 161 and 242 patients, respectively. Serum levels of sVEGFR-1 and -2 were significantly elevated, in contrast, VEGF and PLGF levels were remarkably decreased in patients with low collateralization than in those with high collateralization (all P<0.05). Significant differences in sVEGFR-1, VEGF and PLGF levels was consistently detected between the low and high collateralization subgroups for patients with and without type 2 diabetes mellitus (DM) (for all comparisons, P<0.01). Multivariable regression analysis revealed that DM, dyslipidemia, elevated sVEGFR-1, and reduced VEGF and PLGF in serum were independently associated with a low degree of coronary collateralization. Conclusions: Increased serum sVEGFR-1 level is associated with poor coronary collateralization in patients with stable CAD. Type 2 DM is a predominant factor affecting collateral growth in these patients.
    Circulation Journal 02/2014; · 3.58 Impact Factor
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    ABSTRACT: A conditioned stimulus (CS) is associated with a fearful unconditioned stimulus (US) in the traditional fear conditioning model. After fear conditioning, the CS-US association memory undergoes the consolidation process to become stable. Consolidated memory enters an unstable state after retrieval and requires the reconsolidation process to stabilize again. Evidence indicates the important role of Rac (Ras-related C3 botulinum toxin substrate) in the acquisition and extinction of fear memory. In the present study, we hypothesized that Rac in the amygdala is crucial for the reconsolidation of auditory and contextual Pavlovian fear memory. Auditory and contextual fear conditioning and microinjections of the Rac inhibitor NSC23766 were used to explore the role of Rac in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. A microinjection of NSC23766 into the basolateral amygdala (BLA) but not central amygdala (CeA) or cornu ammonis 1 (CA1) immediately after memory retrieval disrupted the reconsolidation of auditory Pavlovian fear memory. A microinjection of NSC23766 into the CA1 but not BLA or CeA after memory retrieval disrupted the reconsolidation of contextual Pavlovian fear memory. Our experiments demonstrate that Rac in the BLA is crucial for the reconsolidation of auditory Pavlovian fear memory, whereas Rac in the CA1 is critical for the reconsolidation of contextual Pavlovian fear memory.
    Psychopharmacology 02/2014; · 4.06 Impact Factor
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    ABSTRACT: Fear extinction has been extensively studied, but little is known about the molecular processes that underlie the persistence of extinction long-term memory (LTM). We found that microinfusion of norepinephrine (NE) into the CA1 area of the dorsal hippocampus during the early phase (0 h) post-extinction enhanced extinction LTM 2 and 14 days after extinction. Intra-CA1 infusion of NE during the late phase (12 h) post-extinction selectively promoted extinction LTM 14 days after extinction, which was blocked by the β-receptor antagonist propranolol, protein kinase A (PKA) inhibitor Rp-cAMPS, and protein synthesis inhibitors anisomycin and emetine. The phosphorylation levels of PKA, cyclic adenosine monophosphate response element binding protein (CREB) and GluR1, and the membrane GluR1 level was increased by NE during the late phase post-extinction, which was also blocked by propranolol and Rp-cAMPS. These results suggest that the enhancement of extinction LTM persistence induced by NE requires the activation of the β-receptor/PKA/CREB signaling pathway and membrane GluR1 trafficking. Moreover, extinction increased the phosphorylation levels of Erk1/2, CREB, and GluR1, and the membrane GluR1 level during the late phase, and anisomycin/ emetine alone disrupted the persistence of extinction LTM, indicating that the persistence of extinction LTM requires late-phase protein synthesis in the CA1. Propranolol and Rp-cAMPS did not completely disrupt the persistence of extinction LTM, suggesting that another β-receptor/ PKA-independent mechanism underlies the persistence of extinction LTM. Altogether, our results showed that enhancing hippocampal noradrenergic activity during the late phase after extinction selectively promotes the persistence of extinction LTM.Neuropsychopharmacology accepted article preview online, 19 February 2014; doi:10.1038/npp.2014.42.
    Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 02/2014; · 8.68 Impact Factor
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    ABSTRACT: Collaterals to occluded infarct-related coronary arteries (IRA) have been observed after the onset of acute ST-elevation myocardial infarction (STEMI). We sought to investigate the impact of early coronary collateralization, as evidenced by angiography, on myocardial reperfusion and outcomes after primary percutaneous coronary intervention (PCI). Acute procedural results, ST-segment resolution (STR), enzymatic infarct size, echocardiographic left ventricular function, and major adverse cardiac events (MACE) at 6-month follow-up were assessed in 389 patients with STEMI undergoing primary PCI for occluded IRA (TIMI flow grade 0 or 1) within 12 hours of symptom-onset. Angiographic coronary collateralization to the occluded IRA at first contrast injection was graded according to the Rentrop scoring system. Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralization was detected in 329 and 60 patients, respectively. Patients with high collateralization more commonly had prior stable angina and right coronary artery occlusion, but less often had left anterior descending artery occlusion. At baseline, these patients presented with less extent of ST-segment elevation and lower serum levels of creatine kinase myocardial band (CK-MB) and cardiac troponin I (cTnI). Procedural success rate, STR, corrected TIMI flame count, and area under the curve of CK-MB and cTnI measurements after the procedure were similar between patients with high collateralization and those with low collateralization (for all comparisons P > 0.05). There were no differences in left ventricular ejection fraction and rates of MACE at 6 months according to baseline angiographic collaterals to occluded IRA. In patients with acute STEMI undergoing primary PCI within 12 hours of symptom-onset, coronary collateralization to the occluded IRA was influenced by clinical and angiographic features. Early recruitment of collaterals limits infarct size at baseline, but has no significant impact on myocardial reperfusion after the procedure and subsequent left ventricular function and clinical outcomes.
    Chinese medical journal 01/2014; 127(1):66-71. · 0.90 Impact Factor
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    ABSTRACT: This paper presents a mathematical model for describing heat transfer around the pile foundation ground heat exchangers (GHEs) when seepage of groundwater imposes an effect on the heat exchange process. The corresponding analytical solutions on temperature response are acquired based on combined heat transfer case; the model take the spiral coils arrangement and their pitches inside piles into consideration and identify the differences between the new models and those former models which did not treat spiral tube as a series of separate coils along the z-axial direction. The influence exerted on temperature response by every parameter was investigated. Two cases were compared, i.e. pure conduction and combined heat transfer including both conduction and convection. The relevant calculations prove that the heat transfer efficiency between pile foundation GHEs and the surrounding underground medium can be improved especially when some parameters attain a certain extent. The research on new models can help boost the development of energy pile technology.
    Energy and Buildings 01/2014; 71:115–128. · 2.68 Impact Factor
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    ABSTRACT: The selectins play important roles in the inflammatory process of coronary artery disease (CAD) and myocardial infarction (MI). Previous studies have shown ambiguous findings regarding a possible association between the selectin genes and CAD. The E-selectin Ser128Arg polymorphism and the P-selectin Thr715Pro polymorphism have been investigated widely but with inconsistent results. We performed a comprehensive meta-analysis to shed light on this issue. Data were extracted by searches of MEDLINE, Embase, CNKI, Wanfang, Google Scholar, PORTA, GeNii, CiNii, J-STAGE, Nurimedia and Koreanstudies Information Service System [Kiss] up to October 2013, in which 10 studies on the Ser128Arg polymorphism with 3369 cases and 2577 controls and 10 studies on the Thr715Pro polymorphism with 5886 cases and 18345 controls. A random-effects model was used to calculate the combined odds ratios. The between-study heterogeneity and publication bias were addressed. The 128Arg carriers had a significant increased risk of CAD (allele comparison: P = 0.02, OR = 1.33, 95%CI 1.04-1.69, Pheterogeneity = 0.01); The 715Pro conferred a non-significant risk reduction relative to the 715Thr (allele comparison: P = 0.40, OR = 0.94, 95%CI 0.82-1.08, Pheterogeneity = 0.03).Subgroup analyses demonstrated that the 128Arg carriers had a significant increased risk of CAD among Asians (allele comparison: P = 0.001, OR = 2.07, 95%CI 1.33-3.24, Pheterogeneity = 0.77) but not among Caucasians (allele comparison: P = 0.33, OR = 1.13, 95%CI 0.88-1.45, Pheterogeneity = 0.08). Carrier status for the 715Pro was significantly associated with reduced risk of MI (allele comparison: P = 0.04, OR = 0.81, 95%CI 0.67-0.99, Pheterogeneity = 0.14). The asymmetric funnel plot and the Egger's test (P = 0.041) suggested the presence of publication bias for the Ser128Arg polymorphism. Our results suggested there is an increase in the risk of CAD conferred by the Ser128Arg polymorphism and the thr715Pro polymorphism may be a protective factor of MI.
    PLoS ONE 01/2014; 9(2):e88152. · 3.73 Impact Factor
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    ABSTRACT: This paper presents a detailed feasibility study and techno-economic evaluation of a standalone hybrid solar–wind system with battery energy storage for a remote island. The solar radiation and wind data on this island in 2009 was recorded for this study. The HOMER software was employed to do the simulations and perform the techno-economic evaluation. Thousands of cases have been carried out to achieve an optimal autonomous system configuration, in terms of system net present cost (NPC) and cost of energy (COE). A detailed analysis, description and expected performance of the proposed system were presented. Moreover, the effects of the PV panel sizing, wind turbine sizing and battery bank capacity on the system’s reliability and economic performance were examined. Finally, a sensitivity analysis on its load consumption and renewable energy resource was performed to evaluate the robustness of economic analysis and identify which variable has the greatest impact on the results. The results demonstrate the techno-economic feasibility of implementing the solar–wind–battery system to supply power to this island.
    Applied Energy. 01/2014; 121:149–158.

Publication Stats

5k Citations
1,070.41 Total Impact Points

Institutions

  • 2007–2014
    • Shanghai Jiao Tong University
      • • School of Medicine
      • • State Key Laboratory of Medical Genomics
      Shanghai, Shanghai Shi, China
    • Tangshan Gongren Hospital
      Tangshan, Jiangxi Sheng, China
  • 2006–2014
    • Peking University
      • Institute of Mental Health
      Peping, Beijing, China
  • 2003–2014
    • National Institute on Drug Abuse
      • Research Branch Clinical Pharmacology and Therapeutics
      Maryland, United States
  • 2002–2014
    • The Hong Kong Polytechnic University
      • Department of Building Services Engineering
      Hong Kong, Hong Kong
  • 2013
    • Institute for Cardiovascular Diseases
      Socola, Iaşi, Romania
    • Shanghai Ruijin Hospital
      Shanghai, Shanghai Shi, China
  • 2008–2013
    • Baylor College of Medicine
      • Department of Psychiatry & Behavioral Sciences
      Houston, Texas, United States
    • Jilin University
      • School of Public Health
      Jilin, Jilin Sheng, China
    • Sichuan University
      Hua-yang, Sichuan, China
  • 2012
    • Northeast Institute of Geography and Agroecology
      • Institute of Psychology
      Beijing, Beijing Shi, China
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • Keio University
      • Department of Cardiology
      Tokyo, Tokyo-to, Japan
    • Peking University Third Hospital
      Peping, Beijing, China
  • 2011–2012
    • Yale University
      • Department of Psychiatry
      New Haven, CT, United States
    • Fourth Military Medical University
      • Department of Radiology
      Xi’an, Liaoning, China
    • South China Normal University
      • Department of Psychology
      Guangzhou, Guangdong Sheng, China
  • 2010–2012
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Ningbo University
      Ning-po, Zhejiang Sheng, China
    • Capital Medical University
      • School of Public Health and Family Medicine
      Peping, Beijing, China
  • 2008–2012
    • Government of the People's Republic of China
      Peping, Beijing, China
  • 2007–2012
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2005–2012
    • Ruijin Hospital North
      Shanghai, Shanghai Shi, China
  • 2008–2011
    • Hebei Medical University
      Chentow, Hebei, China
  • 2006–2011
    • Guiyang Medical University
      Kuei-yang, Guizhou Sheng, China
  • 2004–2007
    • National Institutes of Health
      • Section on Cellular Neurobiology
      Bethesda, MD, United States