Can Köse

Celal Bayar Üniversitesi, Saruhan, Manisa, Turkey

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Publications (2)1.63 Total impact

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    ABSTRACT: There are no well-defined findings about reasons for first trimester abortion in some pregnancy cases. Selectins are cell adhesion proteins which are important for blastocyst implantation in the decidua. The goal of the study was to investigate the role of selectins in first trimester pregnancy loss by immunohistochemistry.
    Ginekologia polska 04/2014; 85(4):287-93. · 0.79 Impact Factor
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    ABSTRACT: Aim:  The goal of this study was to investigate the combined effects of raloxifene and atorvastatin in aged ovariectomized rats during endothelial dysfunction and atherosclerotic process. Material and Methods:  This study was conducted on 28 Wistar albino female rats randomly divided into four groups. All groups were ovariectomized and one group was kept as the control group (OVX). For four weeks, the remaining three groups were treated with the statin atorvastatin (OVX+AV), the selective estrogen receptor modulator raloxifene (OVX+RL), and both atorvastatin and raloxifene (OVX+RL+AV), respectively. At the end of the treatment period, all rats were sacrificed and thoracic aortas excised, and endothelial cells were immunohistochemically stained for markers in the atherosclerotic process, such as inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-α). Results:  Compared to the ovariectomized group, the iNOS level was significantly increased in the OVX+RL group (P = 0.002), but contrarily decreased in the groups OVX+AV (P = 0.002) and OVX+RL+AV (P = 0.002). eNOS levels in the groups OVX+AV (P = 0.002) and OVX+RL+AV (P = 0.002) were significantly lower than that in the OVX group. When compared to the OVX group, significant reductions in ET-1 and TNF-α levels were found in all treatment groups. A significant decrement in MCP-1 level was found in the OVX+AV group (P = 0.002). Conclusion:  In aged ovariectomized rats, the administration of both raloxifene and atorvastatin significantly decreased the levels of ET-1 and TNF-α on endothelial cells. Combined treatment with these drugs shortly after menopause might play a potential preventive role in the early stages of atherosclerosis development.
    Journal of Obstetrics and Gynaecology Research 07/2012; · 0.84 Impact Factor

Publication Stats

1 Citation
1.63 Total Impact Points


  • 2012
    • Celal Bayar Üniversitesi
      • Department of Histology and Embryology
      Saruhan, Manisa, Turkey
    • Uludag University
      • Faculty of Medicine
      Boursa, Bursa, Turkey