Dong-Soo Shin

Changwon National University, Changnyeong, Gyeongsangnam-do, South Korea

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Publications (92)158.37 Total impact

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    ABSTRACT: Novel series of ( )-catechin derivatives 1a-l were synthesized, characterized and assayed for their cytotoxicity against four selected human cancer cell lines by standard MTT assay method. Most of the compounds significantly active among which 1d exhibited promising activity with IC50 values of 2.5, 4.8 and 5.4 μM specifically against hepatocellular liver carcinoma (HepG2), lung adenocarcinoma (A549) and prostate (DU-145) cell lines, while compound 1j showed promising cytotoxicity against human breast adenocarcinoma MDA-MB-231 (IC50 value of 6.6 μM). Compounds 1a, 1d, 1e, 1f and 1j exhibited broad spectrum cytotoxicity against all the cell lines screened. Molecular docking studies of compound 1d established the good binding affinity and are in favor of the observed biological activity. These data collectively suggest that compound 1d could serve as a new template for further optimization as anticancer agent.
    Bulletin of the Korean Chemical Society 01/2015; 36(2):564-570. DOI:10.1002/bkcs.10108 · 0.84 Impact Factor
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    ABSTRACT: High-quality and monodisperse CaMoO4:Eu3+, M+(M =Li,Na,K)microspheres have been synthesized with the assistance of poly-(diallyldimethylammonium chloride) (PDDA) via a facile copre-cipitation hydrothermal route. X-Ray diffraction (XRD), scanning elec-tron microscopy (SEM), energy dispersive X-ray spectrum (EDS), trans-mission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectra (XPS), as well as photoluminescence (PL) spectra are used to characterize the resulting samples. The results show that the CaMoO4: Eu3+, M+(M =Li,Na,K)can be directly indexed to tetragonal CaMoO4 phase with high purity. A series of controlled ex-periments indicate that PDDA as a shape modifier introduced into the re-action system plays a critical role in the morphology of the final products. Furthermore, the shape and size of the products can be further manipu-lated by adjusting the concentration of PDDA and pH values in the initial solution. The prepared microspheres morphology is stable at a suitable annealing temperature. The possible formation mechanism for these mi-crospheres has been presented. Additionally, the PL properties of CaMoO4 :Eu3+, M+(M =Li,Na,K) were investigated in detail. The results revealed that the red emission peak intensity of CaMoO4: Eu3+, Li+ and CaMoO4: Eu3+, Na+ is higher than that of CaMoO4: Eu3+, K+. The particle size and shape have a remarkably effect on the photolumines-cence properties of the phosphor. The luminescence intensity is observa-bly enhanced with the increase of annealing temperature due to eliminate PDDA and/or H2O present in the samples and to the improved crystal quality.
    RSC Advances 01/2015; 5(13). DOI:10.1039/C4RA12183J · 3.71 Impact Factor
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    ABSTRACT: To meet the challenges and additional requirements towards the development of white LED׳s with utmost efficacy, a sol–gel approach is adopted wherein a water soluble silicon compound is used as a silica source. The phosphor material obtained is subjected to detailed structural, morphological and luminescent studies. The results obtained show that the XRD patterns of Eu2+ doped CaSrSiO4 phosphors are in good agreement with the CaSrSiO4 (ICSD no. 49660) whose structure is orthorhombic. The output of the luminescence studies clearly portrays a broad yellow emission between 450 and 750 nm with a peak at ~600 nm under the broad excitation range. This confirms its efficient emission towards the development of a warm white light using blue LEDs. A red shift in the peak emission wavelength was observed for the prepared samples. This longer shift in wavelength can be credited to the sol–gel method adopted and is not offered by the conventional solid state reaction method. A warm white emitting LED was fabricated by combining near ultraviolet LED (400 nm) chip with our sol–gel synthesized CaSrSiO4:Eu2+ phosphor. The CIE chromaticity coordinates (0.44 and 0.41), color correlated temperature (CCT) <4000 K, color rendering index (CRI) >80 provide their emission potentiality in the warm white light region.
    Ceramics International 12/2014; 7. DOI:10.1016/j.ceramint.2014.12.131 · 2.09 Impact Factor
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    ABSTRACT: A series of benzofuran-2-carboxamides of biological and medicinal significance were synthesized by a microwave-assisted one-pot parallel approach via O-alkylation/Knoevenagel condensation. All the compounds were characterized and assayed for their in vivo anti-inflammatory, analgesic and antipyretic activities. The activity data of all compounds were listed and discussed in detail, among which some derivatives exhibited potent activities of particular interest.
    Tetrahedron Letters 10/2014; 55(17):2796–2800. DOI:10.1002/chin.201441114 · 2.39 Impact Factor
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    ABSTRACT: This study outlines a novel approach to the synthesis of an efficient yellow-emitting Sr0.975Ca0.975Eu0.05SiO4 phosphor with the adequate red spectral components. This was achieved by the use of a well-known silicate source, mesoporous silica. The findings showed that the synthesized phosphor gave a broad emission from blue to red, along with a stable emission color till 450 K and an emission decay time of 1 μs. When the phosphor was fabricated using UV (400 nm) and blue LED (450 nm) chips, it promisingly generated warm white light at a color temperature < 4000 K and a color rendering index > 80.
    07/2014; 2(32). DOI:10.1039/C4TC00711E
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    ABSTRACT: Perfluorobutyl substituted disodium alkanesulfonates derivatives were synthesized and characterized as alternative substances to perfluorooctanesulfonic acid (PFOS, 1), a well known surfactant. 1H,1H,2H,2H-nonafluorohexyl iodide, diethyl malonate and sultones were used to prepare disodium sulfonates 2 and 3 in three synthetic steps. The surface tension behavior of 2 and 3 were studied and critical micelle concentration values were noted to be 2025 mg/L and 2052 mg/L respectively at room temperature.
    Journal of Fluorine Chemistry 07/2014; 163. DOI:10.1016/j.jfluchem.2014.04.003 · 1.95 Impact Factor
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    ABSTRACT: A successful method has been demonstrated for the synthesis of mesoporous organic-inorganic nanohybrid using amine functionalized polyhedral oligomericsilsesquioxane (POSS) and pluronic polymer as silica precursor and structure directing agent, respectively. The results confirmed the presence of porous structure, along with the high surface area and uniform pore size distribution which can be utilized for various applications namely catalysis, drug-delivery etc.
    New Journal of Chemistry 03/2014; 38(7). DOI:10.1039/C4NJ00292J · 3.16 Impact Factor
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    ABSTRACT: The Er3+-doped novel oxyfluoride glasses of composition (43 - x)SiO2-10Al(2)O(3)-24LiF-23SrF(2)-xEr(2)O(3), where x = 1.0, 2.0, 4.0 and 6.0 mol%, have been prepared by conventional melt quenching technique and are characterized through X-ray diffraction (XRD), differential thermal analysis (DTA), Raman, Fourier transform infrared (FT-IR) analysis, optical absorption spectra, visible (vis) and near-infrared (NIR) emission spectra measurements. Judd-Ofelt (JO) intensity parameters (Omega(lambda), lambda = 2, 4 and 6) have been derived from the absorption spectrum of 1.0 mol% Er2O3 doped glass and are in turn used to calculate radiative properties for the important luminescent levels of Er3+ ions. The studied glasses show intense green and weak red visible emissions under 365 nm excitation. The decrease in visible emission intensities with concentration of Er3+ ions has been explained due to energy transfer processes between Er3+ ions. Upon excitation at 980 nm laser diode, an intense 1.53 mu m NIR emission has been observed with the maximum full width at half maximum (FWHM) for Er3+-doped oxyfluoride glasses. The higher Er3+ ion doping capability and relatively high gain and broad emission at 1.5 mu m are the most notable features of these glasses to realize efficient short-length optical amplifiers.
    Materials Research Bulletin 03/2014; 51:336-344. DOI:10.1016/j.materresbull.2013.12.023 · 1.97 Impact Factor
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    ABSTRACT: Perfluorooctanesulfonate (PFOS) is a compound of global concern because of its persistence and bioaccumulation in the environment. Nevertheless, little is known of the potential for PFOS biodegradation, even though the importance of characterizing the function and activity of microbial populations detected in the environment has been discussed. This study focused on the biodegradation of PFOS by a specific microorganism. Through this study, we have identified the aerobic microorganism for the specific decomposition of PFOS from wastewater treatment sludge, as a well-known sink for environmental PFOS. This species was Pseudomonas aeruginosa strain HJ4 with a 99% similarity, a mesophilic rod type bacteria (30-37°C). A pH range of 7-9 was determined to be optimal for the growth of strain HJ4. In this study approximately 67% over a range of concentrations (1400-1800μgL(-)(1)) for PFOS was biologically decomposed by P. aeruginosa after 48h incubation. This result is reported here for the first time, which strongly pertains to the efficient biodegradation of PFOS. Therefore, our study is considered a major advancement in sustainable PFOS treatment.
    Chemosphere 02/2014; 109. DOI:10.1016/j.chemosphere.2014.01.072 · 3.50 Impact Factor
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    ABSTRACT: The optical properties and the carrier dynamics of CaSrSiO4:Eu3+ phosphors synthesized by using a solid-state reaction method have been studied by means of scanning electron microscopy, X-ray diffraction, photoluminescence (PL), PL excitation, time-resolved PL, and PL quantum-yield measurements. The phosphor synthesized with a Eu concentration of 5% and sintered at 1380 °C for 2 h in air showed a high quantum yield of 88.53% and good CIE chromaticity coordinate values. The strong excitation bands observed at 395 nm (7F0-5L6) and 466 nm (7F0-5D2) lead to an intense 5D0-7F2 transition (614 nm). The forbidden transitions (5D0-7F0 and 5D0-7F2) were observed and showed lifetimes shorter than that of the magnetic dipole transition (5D0-7F1).
    Journal- Korean Physical Society 02/2014; 64(11):1721. DOI:10.3938/jkps.64.1721 · 0.43 Impact Factor
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    ABSTRACT: Design and synthesis of hemi fluorinated perfluorooctanesulfonic acid (PFOS) alternatives was described using a Zn/CuI mediated Michael-type addition 10 reaction in ionic liquids considering environmentally benign reaction conditions as well as products. One of the new potassium sulfonates showed promising surface tension activities when compared to that of PFOS potassium salt.
    Green Chemistry 01/2014; 16(5). DOI:10.1039/C3GC42642D · 6.85 Impact Factor
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    ABSTRACT: Aminoquinolines and their derivatives are important chemical entities that are widely used as pro-drugs and drugs due to their antimicrobial, cytotoxic and anti-malarial activities etc. 1 Among which, N-alkyl/aryl-6-aminoquino-lines attracted the interest of medicinal chemists because of their exceptional significance as potential nootropics. 2 Bio-chemical studies have shown that these compounds possess good acetyl-cholinesterase inhibitor (AChEI) activity. N-Substituted-6-aminoquinoline has been considered as new lead compound for the discovery of memory and cognition facilitating drugs. Synthetic efforts to attain the 6-amino quinoline (I) based biologically active structures have been studied including the parent compound which itself is a fluorophore (acts as a probe in metabolite identification). 3 Generally, N-substituted-6-aminoquinolines can be obtained by using sodium borohydride to reduce the Schiff's base prepared by condensation of 6-aminoquinoline with differ-ent aldehydes. 4-7 Another method is the palladium-catalyzed C-N coupling between amines and 6-halogenated (or 6-sulfonyl) quinolines. 8-10 However, all of them have some limitation with respect to expensive starting materials and long reaction times. For example, aldehydes are highly reactive, not stable for air and absent in diversity. Although phenols are diverse to be used in laboratory for amine synthesis, palladium-catalyzed method has serious problems with respect to cost and presence of residual palladium. The lack of an efficient method to facile synthesis of N-sub-stituted-6-aminoquinoline derivatives attracted us to take up their preparation. In order to study the specific AChEI agents, one needs to synthesize a series of N-substituted-6-aminoquinolines by following convenient strategies that also cover economical aspects. In continuation of our efforts to develop simple and cost-effective methodologies in investigating C-N bond formation from various phenols to anilines via Smiles rear-rangement, 11 we herein wish to report a practical one-pot synthesis of N-substituted-6-aminoquinolines from 6-hydr-oxylquinolines. The amine counterparts would be N-alkyl/ aryl-2-chloroacetamide and the bases used for this reaction include Cs 2 CO 3 and/or K 2 CO 3 in DMF . 6-Hydroxylquinoline (1) is a commercial starting material to start with and very cheaper than 6-aminoquinoline. N-alkyl/aryl 2-chloroacetamides (2) can be easily prepared by acylation of amines with chloroacetylchloride and triethyl-amine in dichloromethane. The C-N coupling between com-pound 1 and 2 undergoes a tandem O-alkylation/Smiles rearrangement/hydrolysis sequence. The proposed three-step process has been illustrated in Scheme 1. The compound 1 was etherified with excess base and compound 2 to afford N-alkyl/aryl-2-(quinoline-6-yloxy)acetamide (3). This further underwent Smiles rearrangement to give the intermediate 4. Finally, hydrolysis of compound 4 yielded us the N-alkyl/ aryl-6-aminoquinolines (5). To explore the optimized conditions for this reaction we chose compound 1 and N-benzyl-2-chloroacetamide (2a) as phenol and amine counterparts and the results are repre-sented in Table 1. It was found that the compound 1 reacted with 1.2 equiv of 2a in the presence of Cs 2 CO 3 in DMF, afforded 5a after 2 h at 150 o C in 68% yield. Changing base from Cs 2 CO 3 to K 2 CO 3 or Na 2 CO 3 sharply decreased the reaction yields (Table 1, Entry 2 & 3). We have recently established our refurbish results for obtaining arylamines using Smiles rearrangement in presence of K 2 CO 3 and cata-lytic KI as a better regent system, from phenols (which have Scheme 1. The three-step one-pot process.
    Bulletin of the Korean Chemical Society 12/2013; 34(12):3881. DOI:10.5012/bkcs.2013.34.12.3881 · 0.84 Impact Factor
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    ABSTRACT: A simple post-co-precipitation strategy is adopted for the construction of mesoporous silica frame work in which the rare earth gadolinium oxide (Gd2O3:Eu3+& Gd2O3:Sm3+,Eu3+) is incorporated as an emissive probe for optical and bio-medical applications. The samples show good emission along with the required theranostic properties. Under blue region, a better red emissive behavior is observed in the case of Eu3+ doped sample while the Sm3+ and Eu3+ co-doped sample exhibit the same under the near ultra-violet region. Moreover, the structural and textural properties of mesoporous silica are preserved even in the presence of rare earth groups doped of Gd2O3 and this can very well be utilized for theranostic applications. A clear confocal microscopy image shows a red spot, and thus its potential towards trackability is confirmed. In addition to this, other admirable properties are also associated with it namely, an excellent drug loading ability, bio-compatibility, easy surface modification by the targeting moiety and excellent longitudinal relaxivity (T1) under magnetic resonance imaging (MRI), which stands par for it to be utilized in the field of theranostics too. This material shows a good luminescence property along with the desired internal-external morphology& a narrowly ordered porosity can validate the application of these materials in multi-faceted fields such as phosphors for LEDs, bio-imaging, theranostics etc.,
    RSC Advances 12/2013; 4(12). DOI:10.1039/C3RA47414C · 3.71 Impact Factor
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    ABSTRACT: Single crystalline pure and rare-earth metal ions (Eu3 + and Ce3 +) doped TiO2 nanowire arrays were prepared on conductive fluorine doped indium tin oxide substrates by a facile hydrothermal method. Initially the conditions and parameters were optimized to prepare the high quality TiO2 nanowire arrays in the absence of organic additives. The average diameter and length of the TiO2 nanowire were found to be ~ 30–50 nm and ~ 0.5–1.5 μm, respectively. The formations of rutile phase structure in all the samples were confirmed by x-ray diffractometric analysis while the transmission electron microscopy confirms the single crystallinity and the maximum orientation of growth direction along [001] for the as-grown TiO2 nanowire. The optical properties of all the samples were analyzed using photoluminescence spectroscopy. The photocatalytic properties of the pure and doped TiO2 were investigated for the decomposition of organic toludine blue-O dye under ultraviolet irradiation. The result demonstrates that the Ce3 +: TiO2 decomposed almost 90% of the organic dye within 80 min.
    Thin Solid Films 11/2013; DOI:10.1016/j.tsf.2013.03.039 · 1.87 Impact Factor
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    ABSTRACT: A rare-earth metal ion (Eu3+) doped ZnO nanocomposites have been successfully synthesized by employing wet chemical procedure using multi-wall carbon nanotubes (MWCNT's) as removable template. The preparation was carried out by immersing empty and dried MWCNT's in a stoichiometric composition of zinc nitrate and europium nitrate solution followed by filtration and sintering. The synthesized Eu3+ doped ZnO nanocomposites were characterized by means of different characterization techniques namely XRD, SEM, EDS, FT-IR and Raman spectroscopy. The XRD profile of the Eu3+ doped ZnO nanocomposites indicated its hexagonal nature while the photoluminescent analysis reveals that the prepared nanocomposite exhibits a strong red emission peak at 619 nm due to 5D0 --> 7F2 forced electric dipole transition of Eu3+ ions. Such luminescent materials are expected to find potential applications in display devices.
    Journal of Nanoscience and Nanotechnology 11/2013; 13(11):7680-4. DOI:10.1166/jnn.2013.7842 · 1.34 Impact Factor
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    ABSTRACT: Porphyrin-POSS hybrid: Porphyrin-POSS molecular hybrid composites (see scheme; POSS = polyhedral oligomeric silsesquioxanes) were synthesized and structurally characterized, allowing the realization of truly homogenous dispersion of basic functional building blocks between organic and inorganic components at the molecular level. These materials allow the optimization of aggregation/association behavior and thus the functional optical properties of the porphyrinato zinc compounds.
    Chemistry - A European Journal 09/2013; 19(38):12613-8. DOI:10.1002/chem.201301875 · 5.93 Impact Factor
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    ABSTRACT: Eu3+ activated NaSr(P,V)O4 phosphors have been synthesized using solid state reaction method and further characterized for their structure and optical properties using different techniques such as X-ray diffraction, scanning electron microscopy, photolumniscenec excitation, emission, and chromaticity coorrdinate analysis, etc. Material shows a broad excitation peak (monitored for lambda(ems) = 613 nm) lying in the 300-360 nm region and gives intense transitions (lambda(exc) = 320 nm) namely 5D0 --> 7F1 at 590 nm, 5D0 --> 7F2 at 613 nm, 5D0 --> 7F3 at 650 nm, and 5D0 --> 7F4 at 700 nm due to Eu3+ ion. Our results show that replacement of the PO4(3-) ions with isomorphic VO4(3-) ions improves the structural stability and the overall intensity of the emission. The maxium emission intensity is achieved for the NaSr(P0.4, V0.6)O4:Eu3+ phosphor. An estimated increase of an order is attained for the NaSr(P0.4, V0.6)O4:Eu3+ phosphor as compared to NaSrPO4:Eu3+ or NaSrVO4:Eu3+ phosphor. The chromaticity coordinate of the phosphor (0.68, 0.31) lies well within the red region and suggest that the material could be an alternative red phosphor for lighting and display applications.
    Journal of Nanoscience and Nanotechnology 08/2013; 13(8):5552-5. DOI:10.1166/jnn.2013.7068 · 1.34 Impact Factor
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    ABSTRACT: Al contents have been doped as a sensitizer to improve the luminescent brightness, and the conventional solid state reaction method has been used to synthesize the phosphors. Al doping effects on the microstructures of YVO4:Eu3+ phosphors were measured by X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The luminescent characteristics were characterized by photoluminescence excitation (PLE) and emission (PL) measurements. Incorporation of Al3+ ions into the YVO4:Eu phosphors has greatly enhanced the crystallinity, particle size and hence the luminescence properties and the optimum concentration in Al dopants are found to be 0.05 mol. The photoluminescence intensity of 0.05 mol Al(3+)-doped YVO4:Eu3+ phosphors was improved by a factor of 1.41, in comparison with undoped Y0.95Eu0.05VO4 phosphor. The improvement in photoluminescence properties with Al doping may result from the improved crystallinity and from the enlarged grain sizes inducing lower scattering loss.
    Journal of Nanoscience and Nanotechnology 08/2013; 13(8):5636-9. DOI:10.1166/jnn.2013.7059 · 1.34 Impact Factor
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    ABSTRACT: In this present work, we have developed a novel POSS type monomer ligand “2,6-pyridinediamine-bis-(propanylheptaisobutyl POSS)” (PDC-POSS) and utilized in the preparation of potential luminescent hybrid complex Eu-PDC-POSS with an inner transition metal ion Eu3+. The solubility and photo-emitting properties of new Eu-PDC-POSS hybrid material were studied. The precursor PDC-POSS was synthesized by treating (3-aminopropyl)heptaisobutyl POSS with PDC (2,6-pyridinedicarboxylic acid chloride), and then coordinated with Eu3+ using europium nitrate to afford Eu-PDC-POSS hybrid material. The europium-doped hybrid material was characterized using fourier transform infrared spectroscopy, and scanning electron microscopy along with energy dispersive X-ray analysis. The photo emitting properties were studied using a fluorescence spectrophotometer in which, the results showed enhancement in red emission peak at 618 nm for Eu-PDC-POSS, when compared to that of a known solgel-based material Eu-PDC-solgel.
    Journal of Materials Science 07/2013; 48(21). DOI:10.1007/s10853-013-7568-2 · 2.31 Impact Factor
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    ABSTRACT: The present investigation aims to demonstrate the potentiality of Eu3+/Sm3+ single-doped and co-doped Ca4YO(BO3)3 phosphors, which were prepared by a sol–gel method. The X-ray diffraction (XRD) profiles showed that all the observed peaks could be attributed to the monoclinic phase of Ca4YO(BO3)3. From the measured emission profiles, we have noticed that both the single-doped Eu3+/Sm3+ phosphors shows four emission transitions of 5D0 → 7F0,1,2,3 and 4G5/2 → 6H5/2,7/2,9/2,11/2 respectively. Among them, the 5D0 → 7F2 of Eu3+ and 4G5/2 → 6H7/2 of Sm3+ are intense emission transitions, leading to an intense red color emission from the prepared phosphors. The excitation spectra showed that Eu3+/Sm3+ doped samples can be excited efficiently by 394 nm and 402 nm respectively, incidentally which matches well with the characteristic emission from UVLED. The co-doping of Sm3+ ions can broaden and strengthen the absorption of near UV region and to be efficient to sensitize the emission of the Ca4YO(BO3)3:Eu3+ phosphor. The mechanism involved in the energy transfer between Eu3+ and Sm3+ has been explained and elucidated by an energy level diagram.
    Materials Chemistry and Physics 07/2013; 140(s 2–3):453–457. DOI:10.1016/j.matchemphys.2013.03.023 · 2.13 Impact Factor

Publication Stats

631 Citations
158.37 Total Impact Points


  • 1999–2014
    • Changwon National University
      • Department of Chemistry
      Changnyeong, Gyeongsangnam-do, South Korea
  • 2010
    • Southwest University in Chongqing
      Pehpei, Chongqing Shi, China
  • 2004–2010
    • Shandong University
      • Department of Chemical Engineering
      Chi-nan-shih, Shandong Sheng, China
  • 2002–2003
    • University of Texas at Dallas
      • Biochemistry
      Richardson, Texas, United States
  • 1994
    • University of North Texas at Dallas
      Dallas, Texas, United States
  • 1993–1994
    • University of Texas Southwestern Medical Center
      • • Department of Molecular Genetics
      • • Department of Biochemistry
      Dallas, Texas, United States