Q. Xie

Publications (1)2.23 Total impact

• Article: Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity

  Y. Wang, Y. Li, Y. He, Y. Sun, W. Sun, Q. Xie, G. Yin, Y. Du, L. Wang, G. Shi
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  ABSTRACT: Gq, the alpha subunit of Gq, a member of the Gq/11 sub-family, was reported to inhibit phosphatidylinositol-3-Kinase (PI3K) activation and prevent the activation of Akt. Previous studies demonstrated that mice losing Gq in their immune system could spontaneously develop inflammatory arthritis. In this study, we showed that the Gq expressions at mRNA and protein levels in the peripheral blood lymphocytes (PBLs) from patients with rheumatoid arthritis (RA) were significantly decreased in comparison of which in healthy individuals. The expression levels of Gq mRNA in PBLs from patients with RA were correlated with RA disease activity (DAS28), anti-cyclic citrullinated protein antibodies, C-reactive protein and rheumatoid factor. We also demonstrated that Gq controlled the apoptosis of RA PBLs through regulating the activity of Mcl-1 and caspase-3. These data suggested that Gq might be involved in the pathogenesis of RA by regulating PBLs apoptosis.
  Scandinavian Journal of Immunology 01/2012; 75(2):203 - 209. · 2.23 Impact Factor