Samer Karamohamed PhD,
L.I. Golbe MD, M.H. Mark MD,
A.M. Lazzarini PhD,
O. Suchowersky MD,
N. Labelle BN,
Mark Guttman MD,
L.J. Currie PhD,
G.F. Wooten MD,
M. Stacy MD, [......],
C. Klein MD,
B.A. Racette MD,
J.S. Perlmutter MD,
A. Parsian PhD,
Carlos Singer MD,
E. Montgomery MD,
K. Baker PhD,
J.F. Gusella PhD,
PhD A. Herbert MD,
R.H. Myers PhD
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ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study. © 2005 Movement Disorder Society
Movement Disorders 06/2005; 20(9):1188 - 1191. · 4.51 Impact Factor
