Publications (2)2.93 Total impact
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Article: Synthesis of 3‐substituted‐4‐phenyl‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydrobenzo[4,5]thieno[2,3‐á]pyrimidines
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ABSTRACT: The reactions between 3-benzoyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene and hydrazine or primary amines have been studied. The products obtained were identified as derivatives of 4-phenyl-2-thioxo-2,3,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine. Their easy reduction with sodium borohydride provided a useful method for the synthesis of 3-substituted-4-phenyl-2-thioxo-1,2,3,4,5,6,7,8-octahydrobenzo[4,5]thieno[2,3-d]pyrimidines. Both kind of compounds were evaluated as potential analgesic, anti-inflammatory and anti-arthritic agents.Journal of Heterocyclic Chemistry 03/2009; 27(2):269 - 273. · 1.22 Impact Factor -
Article: Synthesis and Anticonvulsant Activity of New Dibenzo[1,2]thiazepine S,S‐Dioxides
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ABSTRACT: A new series of 11-substituted 6,11-dihydro-6-methyl-dibenzo[c,f]-[1,2]thiazepine S,S-dioxides was synthesized. Some of the components show significant anticonvulsant activity in the MES, pentetrazol and strychnine tests. The more active compounds are devoid of neurotoxic effects.Synthese und antikonvulsive Wirkung neuer Dibenzo[1,2]thiazepin-S,S-DioxideEine neue Reihe 11-substituierter 6,11-Dihydro-6-methyl-dibenzo[c,f]-[1,2]thiazepin-S,S-dioxide wurde synthetisiert. Einige dieser Verbindungen zeigen beträchtliche antikonvulsive Aktivität in MES-Pentetrazol- und Strychnin-Testen. Die aktivsten Derivate zeigen keine neurotoxische Wirkung.Archiv der Pharmazie 09/2006; 327(3):157 - 161. · 1.71 Impact Factor
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Institutions
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2006
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Spanish National Research Council
- Instituto de Química Médica
Madrid, Madrid, Spain
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