Manjeet Singh Bhatia

University College of Medical Sciences, Old Delhi, NCT, India

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Publications (25)31.34 Total impact

  • Anubhav Rathi, Manjeet Singh Bhatia, Anurag Jhanjee
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    ABSTRACT: Tuberous sclerosis complex is a multi-system disorder with autosomal dominant inheritance, which can affect the brain, heart, skin, kidneys, lungs, and retina. We hereby report therapeutic challenges faced in a case of an adolescent male suffering from tuberous sclerosis.
    Industrial psychiatry journal 07/2012; 21(2):148-51.
  • Manjeet Singh Bhatia, Anurag Jhanjee
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    ABSTRACT: Tokophobia is a pathological fear of pregnancy and can lead to avoidance of childbirth. It can be classified as primary or secondary. Primary is morbid fear of childbirth in a woman, who has no previous experience of pregnancy. Secondary is morbid fear of childbirth developing after a traumatic obstetric event in a previous pregnancy. A case of tokophobia with depression who responded to fluoxetine is being described.
    Industrial psychiatry journal 07/2012; 21(2):158-9.
  • Manjeet Singh Bhatia, Ravi Gupta
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    ABSTRACT: Migraine is a common disorder which has psychiatric sequelae. The objective of this study was to determine the clinical pattern and psychiatric comorbidity of migraine. 100 cases of migraine seen over a period of one year were analysed to know the sociodemographic characteristics, clinical pattern and psychiatric morbidity. Maximum patients were between 31-40 years of age group (40%), females (78.0%), married (76%) and housewives (56.0%). Family history of migraine was present in 12% cases. Average age of onset was 22 years. Unilateral and throbbing type of headache was most common. The commonest frequency was one to two per week. Migraine without aura was commonest sub-type (80%). Generalized anxiety disorder (F41.1) was the most common psychiatric disorder (34%), followed by mixed anxiety and depressive disorder (F41.2) (18%) and depressive episode (F32) (14%). In 22% cases, no psychiatric disorder could be elicited. The present study confirms that majority patients with migraine had psychiatric disorders. This needs timely detection and appropriate intervention to treat and control the migraine effectively.
    Industrial psychiatry journal 01/2012; 21(1):18-21.
  • Manjeet S Bhatia, Anurag Jhanjee, Anant Oberoi
    The primary care companion to CNS disorders. 01/2012; 14(3).
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    Anurag Jhanjee, Manjeet Singh Bhatia
    The British journal of psychiatry: the journal of mental science 10/2011; 199(4):342; author reply pg 342-3. · 6.62 Impact Factor
  • Ravi Gupta, Manjeet Singh Bhatia
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    ABSTRACT: Migraine and tension type headache (TTH) are two most common types of primary headaches. Though the International Classification of Headache Disorders-2 (ICHD-2) describes the diagnostic criteria, even then in clinical practice, patients may not respect these boundaries resulting in the difficulty in diagnosis of these pains. This cross-sectional study involved 50 subjects in each of the two groups - migraine and TTH - after screening for the inclusion and exclusion criteria. Diagnosis was made according to the ICHD-2 criteria. Their clinical history was taken in detail and noted in a semi-structured performa. They were examined for the presence of a number of factors like pericranial tenderness and muscle parafunction. Statistical analysis was done with the help of SPSS v 11.0. To compare the non-parametric issues, chi-square test was run and continuous variables were analyzed using independent sample t test. In general, migraineurs had progressive illness (χ(2)=9.45; P=0.002) with increasing severity (χ(2)=21.86; P<0.001), frequency (χ(2)=8.5; P=0.04) and duration of each headache episode (χ(2)=4.45; P=0.03) as compared to TTH subjects. Along with the headache, they more commonly suffered orthostatic pre-syncope (χ(2)=19.94; P<0.001), palpitations (42%vs.18% among TTH patients; χ(2)=6.87; P=0.009), nausea and vomiting (68% vs. 6% in TTH; χ(2)=41.22; P<0.001, and 38% vs. none in TTH; χ(2)=23.45, P<0.001, respectively), phonophobia (χ(2)=44.98; P<0.001), photophobia (χ(2)=46.53; P<0.001), and osmophobia (χ(2)=15.94; P<0.001). Their pain tended to be aggravated by head bending (χ(2)=50.17; P<0.001) and exercise (χ(2)=11.41; P<0.001). Analgesics were more likely to relieve pain in migraineurs (χ(2)=21.16; P<0.001). In addition, post-headache lethargy was more frequent among the migraineurs (χ(2)=22.01; P<0.001). On the other hand, stressful situations used to trigger TTH (χ(2)=9.33; P=0.002) and muscle parafunction was more common in TTH patients (46% vs. 20%; χ(2)=7.64; P=0.006). All the cranial autonomic symptoms were more common in migraineurs as compared to TTH subjects (conjunctival injection: χ(2)=10.74, P=0.001; lacrimation: χ(2)=17.82, P<0.001; periorbital swelling: χ(2)=23.45, P<0.001; and nasal symptoms: χ(2)=6.38, P=0.01). A number of symptoms that are presently not included in the ICHD-2 classification may help in differe-ntiating the migraine from the TTH.
    Indian Journal of Psychiatry 04/2011; 53(2):134-9.
  • Manjeet S Bhatia, Anurag Jhanjee, Shruti Srivastava
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    ABSTRACT: Delusional parasitosis is a form of monohypochondriacal psychosis, a condition sometimes encountered in psychiatric or dermatological clinical practice. The exact etiology and outcome of this condition is not well known. A patient with delusional parasitosis of face who responded to aripiprazole is described.
    Industrial psychiatry journal 01/2011; 20(1):64-5.
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    ABSTRACT: Frotteurism is an aberrant behaviour wherein the person tends to rub or bring about physical contact between his genitals and an unrelated female to derive sexual pleasure. Our report describes an atypical case of hypersexual behaviour presenting in the form of masturbation with features of frotteurism and unipolar depression. The paper discusses the differential diagnosis and management of hypersexual behaviour.
    Medicine, science, and the law 10/2010; 50(4):228-9. · 0.48 Impact Factor
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    ABSTRACT: Introduction: The health-care implications of quality of life (QOF) in longstanding disorders such as bipolar disorder (BD) for the patients and their caregivers is significant. Objectives: This study compares QOL among BD patients, their caregivers, and healthy controls and assesses whether the level of depression correlates with the scores of QOF in D patients. Method: We compare BD patients (n = 40), their caregivers (n -40 ), and healthy controls (n = 150) on health-related QOF (HRQOL) which was assessed using the 26-item World Health Organization QOL instrument (WHOQOL-BREF, Hindi version). All BD patients were diagnosed using the Structured Clinical Interview for DSM-IV Within the BD group, we examine the relation between HRQOL using WHOQOL BREF Hindi version and depression assessed on 17-item Hamilton Depression Rating Scale (HDRS). Results: BD patients had lower QOL on all the four domains compared to healthy controls and their caregivers. The four domains of the WHOQOL scale correlated negatively with the HDRS. Conclusions: Our findings suggest thatBD depression and residual symptoms of depression are negatively correlated with QOL in BD patients. The comprehensive treatment should target in improving the QOL of both BD patients and their caregivers.
    International Journal of Mental Health 01/2010; 39(4):3-15.
  • The Journal of Headache and Pain 09/2009; · 2.78 Impact Factor
  • Ravi Gupta, Rahul Pathak, Manjeet Singh Bhatia, Basu Deb Banerjee
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    ABSTRACT: A primary headache, particularly migraine, is associated with oxidative stress during the attack. However, data regarding the interictal state in migraineurs and in those with tension-type headache (TTH) is limited. (1) To assess the oxidative stress in migraineurs and TTH subjects in between the episodes and (2) to see if there is a difference in the degree of oxidative stress in the different subtypes of migraine and TTH. Fifty migraineurs, 50 patients with TTH, and 50 control subjects were included in this study after screening for the exclusion criteria. Diagnosis of headache was made according to the International Classification of Headache Disorders (ICHD)-2 criteria. A venous blood sample was collected from the antecubital vein at least 3 days after the last attack of headache. The sample was centrifuged immediately and the plasma was stored at -70 degrees C. The ferric reducing activity of plasma (FRAP) and the malondialdehyde (MDA) levels were assessed using colorimetric methods. Statistical analysis was done with the help of SPSS for Windows, v 11.0. One way ANOVA with post hoc Tukey test, independent sample t test, univariate regression, and multivariate regression analysis were done as indicated. Migraineurs had higher values of MDA and FRAP than the subjects in the other two groups (P<0.001). No difference was observed between the TTH group and the control group. FRAP levels were significantly higher in subjects who had mixed migraine (migraine with aura and without aura) as compared to those with only migraine without aura (mean difference 196.1; 95% CI = 27.3 to 364.9; P = 0.01). Similarly, oxidative stress was significantly higher in patients with episodic TTH as compared to those with chronic TTH (FRAP t = 3.16; P = 0.003 and MDA t = 2.75; P = 0.008). This study suggests that oxidative stress continues even between headache episodes in migraineurs but not in those with TTH. This could probably be consequent to the different pathophysiological mechanisms of TTH and migraine.
    Annals of Indian Academy of Neurology 07/2009; 12(3):167-72. · 0.93 Impact Factor
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    ABSTRACT: To analyze the epidemiology and characteristics of primary recurrent headaches in Indian adolescents. This cross sectional study was conducted in three urban public schools. Adolescents of 9(th) to 12(th) grades were included and they were given a questionnaire in their classrooms in the presence of at least one of the authors, who assisted them in filling it. They were asked to provide responses based on most severe recurrent headache they had experienced rather than the more frequent one. Diagnosis was based upon the information contained in questionnaire, however, where it was inadequate, those subjects were approached telephonically. Statistical analysis was done with the help of SPSS v. 11.0. Descriptive analysis, Chi-Square test, Fisher's Exact test, and independent sample't' test were run. 2235 adolescents were included in the present study (boys: girls 1.6:1). 57.5% adolescents reported recurrent headaches in past one year. Migraine was the most prevalent (17.2%) headache followed by unspecified (14.9%) and tension type headache (11%). Family history of headache was more common in adolescents with headache (p < 0.001) compared to those without headache. Average age of headache onset was 11.33 yr (10.72 yr in girls vs. 11.75 years in boys; p < 0.001). 37.1% adolescents complained of progression of headache since its onset. A significantly higher proportion of girls suffered headache (p=0.018), particularly migraine, than boys. However, other characteristics of headache were not dependent upon gender. Headache was more prevalent in higher grades. Primary Recurrent headaches are prevalent in Indian adolescents and migraine is comparatively the most prevalent type of headache. Female gender and increasing age is associated with higher chances to have headache, particularly migraine. It progresses in approximately one third of sufferers and aura increases the chances of worsening of headache.
    The Indian Journal of Pediatrics 05/2009; 76(7):733-7. · 0.72 Impact Factor
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    ABSTRACT: Calcitonin gene-related peptide (CGRP) is known to increase during acute attack of migraine and tension type headache (TTH). However, its concentration during inter-ictal period is not known. This may help us to understand the pathophysiology of these headaches. The objectives of this study are to find out the concentration of CGRP in plasma during inter-ictal period among migraineurs and TTH and to compare it with control group through cross-sectional study from headache clinic of a tertiary centre. Study sample comprised of three groups: migraineurs, TTH subjects as well as a healthy control group. Fifty subjects in each group were included after screening for the respective inclusion criteria and exclusion criteria. None of the subjects was blood relatives of other subject. Their venous blood was drawn and plasma was separated to be kept at -70 degrees C. CGRP was analysed with commercially available ELISA kit. Data were analysed with the help of SPSS V 11.0 for Windows. Chi-square, independent sample t test and one-way ANOVA with post hoc Tukey and univariate regression were performed. Plasma CGRP concentration was not different among three diagnostic groups (F = 0.78; P = 0.49). Similarly, plasma CGRP concentration was not different among episodic TTH and chronic TTH groups (t = 0.32; P = 0.97) and comparison of episodic and chronic migraine groups also revealed similar results in this study (1.14 vs. 0.94 ng/ml; P = 0.23). The presence of aura did not affect the inter-ictal CGRP levels among migraineurs (F = 0.16; P = 0.85). In conclusion, this study suggests that migraine and TTH could be episodic disorders and subjects have comparable CGRP levels during inter-ictal period.
    The Journal of Headache and Pain 04/2009; 10(3):161-6. · 2.78 Impact Factor
  • Ravi Gupta, Sushant Dahiya, Manjeet Singh Bhatia
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    ABSTRACT: THE PRESENT STUDY WAS DESIGNED TO ASSESS WHETHER SUBJECTIVE SLEEP PATTERNS DIFFER BETWEEN: (i) depressed patients and controls, and (ii) between subjects with different severity of depression. Based on available literature, it was hypothesized that sleep patterns must be different between the above mentioned groups. This study included 60 subjects with major depressive disorder and 40 subjects in the control group. Subjects with sleep disturbance secondary to any other factor, e.g., medical illness, environmental factors, other psychiatric illness etc, were not included in the study. Depression severity was assessed in the subjects with depression with the help of Beck Depression Inventory II. Subjective sleep complaints were noted in the presence of a reliable informant, preferably bed partner. All the information was recorded in a semistructured performa. Statistical analysis was done with the help of SPSS v 11.0. The Chi square and Fisher exact tests were used for categorical variables; independent t-test and one way ANOVA were applied for numerical variables. Ordinal variables were analyzed using Mann Whitney U and Kruskall-Wallis tests. Depression and control groups were similar in age (P = 0.32) and gender (P = 0.14) distribution. Subjects in the depression group had lesser total sleep time (P = 0.001), longer sleep latency (P = 0.001), frequent awakenings (P = 0.04), greater wake-after-sleep onset and offset times (both P = 0.001), lesser sleep efficiency, and tended to wake up early (Mann Whitney U = 913.5; P = 0.05). Subjects with severe depression were different from the mild and moderate groups with regards to total sleep time (P = 0.002), night-time sleep (P = 0.007), and sleep efficiency (P = 0.001) even when the three groups were comparable in age. Depression is associated with sleep disturbances, not only qualitatively, but also quantitatively. Sleep disturbance arises only after a critical level of depression is reached, and depression of varying severity may selectively affect different sleep parameters.
    Indian Journal of Psychiatry 04/2009; 51(2):117-21.
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    ABSTRACT: Nitric oxide plays an important role in the pathogenesis of migraine as well as tension-type headache. Studies suggest that the expression of molecules involved in the pathogenesis of headache, i.e., nitric oxide and interleukin, is influenced by apolipoprotein E (APOE) and is gene specific. Hence, we hypothesized that APOE polymorphism may be associated with migraine as well as tension-type headache.The study sample comprised of three groups: migraineurs, tension-type headache subjects as well as a healthy control group. A total of 50 subjects in each group were included after screening for the inclusion and exclusion criteria. None of the subjects was a blood relative of any other subject included in the present study. Their venous blood was drawn and stored at -20 degrees C. Genomic DNA extraction was performed with a commercial kit and simple sequence-specific primer PCR was performed to assess the APOE polymorphism. Data were analyzed with the help of SPSS V11.0 for Windows. chi(2) test and logistic regression analysis were run. The results of the study showed that APOE epsilon2 gene increases the risk of migraine as compared to the control group and the tension-type headache group (OR=4.85; 95% CI=1.92-12.72; P<0.001 and OR=2.31; 95% CI=1.08-4.94; P=0.01, respectively). Interestingly, APOE epsilon4 gene was protective against migraine as well as tension-type headache. This study shows that APOE epsilon2 gene increases the risk of migraine, while APOE epsilon4 gene is protective against migraine and tension-type headache. Further research is required to confirm the findings of the present study in a larger sample and to elucidate the role of APOE polymorphism in headache.
    The Journal of Headache and Pain 01/2009; 10(2):115-20. · 2.78 Impact Factor
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    ABSTRACT: Headache patients commonly report sleep disruption and sleep disorders. Available literature suggests that the sleep pattern of headache sufferers is different from the control group. Patients in these studies were recruited from headache clinics; they did not include tension type headache. The aim of this study is to find out whether primary headaches affect sleep patterns. Community based cross sectional study This study was conducted in three high schools. Children in the 12-19 age group were allowed to participate. They were given a questionnaire in the presence of at least one of the authors, who assisted them in filling it. They were asked to provide responses based on most severe recurrent headache that they had experienced rather than the more frequent ones. The questionnaire included questions regarding demographic data and the characteristics of headache according to International Classification of Headache Disorders-2 criteria. Part B of the questionnaire contained questions regarding sleep habits. The children were asked to provide data regarding sleep habits on a normal school day. Diagnosis was based upon the information contained in the questionnaire. A telephonic interview was also done, where the information provided was found inadequate. Analysis was done with the help of SPSS v. 11.0., descriptive analysis, Chi square, and one way ANOVA with post hoc analysis. Kruskall-Wallis tests were run. A total of 1862 subjects were included in the study. Migraineurs and tension type headache sufferers comprised 35.7% and 13.4% of the group respectively. Migraineurs had the highest prevalence of nocturnal awakenings (P < 0.001), abnormal movements (P=0.001) and breathing problems during sleep (P < 0.001). Approximately half the migraineurs felt sleepy during the day (P< 0.001) and spent around 1.17 hours in sleep during the day (P = 0.007). Similarly, values for frequency of nocturnal awakenings per week (P < 0.001), wake time after sleep onset and offset (P < 0.001 and 0.002 respectively) were the maximum in migraineurs. Only 32.8% migraineurs reported refreshing sleep (P< 0.001). Post hoc analysis revealed that migraineurs were different from the other two groups on most of the parameters. Sleep disruption is more common in migraineurs than those in the tension type headache sufferers and the control group.
    Annals of Indian Academy of Neurology 07/2008; 11(3):164-9. · 0.93 Impact Factor
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    ABSTRACT: To analyze the variance in sleep habits of adolescents of different high school Grades in urban India. Cross-sectional questionnaire-based study. Community based school survey in an urban setting. School going adolescents from 9th to 12th Grades. A total of 1,920 adolescents aged 12-18 years were included. The questionnaire contained questions related to sleep habits. Each question was explained to the participants and their responses were noted. Outcome parameters were total sleep time in a day, time to go to bed and wake up-time, sleep latency, nocturnal awakenings (duration, frequency per night and nights per week), wake-time after sleep onset, wake time after sleep offset, sleep efficiency, quality of sleep, daytime napping (duration and frequency), and sleepiness during the day. Mean age of the adolescents included in this study was 15.1 years and mean total sleep time was 7.8 hr/day. Adolescents of higher Grades had lesser total sleep time (9th=8 hours; 10th=7.7 hours; 11th=7.9 hours; 12th=7.6 hours; P=0.001), and more frequent nocturnal awakenings (9th=35.9%; 10th=44.7%; 11th=40.3%; 12th=28.3%; P=0.001). Daytime leg pain ( 9th=14.4%; 10th=18.4%; 11th=6.1%; 12th= 21.8%; P=0.01), daytime napping (9th=47.6%; 10th=50.4%; 11th=61.8%; 12th=69.8%; P=0.001), and daytime sleepiness (9th=37.2%; 10th=39.1%; 11th=39.7%; 12th=54.2%; P=0.001) increased progressively among higher Grades. Adolescents in higher Grades were more prone to not follow their weekly schedule on week-ends (P= 0.001). Sleep debt of approximately one hour per day was seen in all adolescents, and progressed with higher Grades. Adolescents of higher Grades had lesser sleep time, and frequent awakenings; suffered daytime leg pain, and felt sleepy during the day. These factors suggest increasing sleep deprivation among higher Graders.
    Indian pediatrics 04/2008; 45(3):183-9. · 1.04 Impact Factor
  • Manjeet S Bhatia, Ravi Gupta, Jeevanshu Dhawan
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    ABSTRACT: Many reports are available regarding myocarditis induced by clozapine; however, it is an uncommon adverse effect with conventional antipsychotics. We are presenting a case who developed myocarditis after overdose of haloperidol and recovered in a few days after stopping the drug.
    The World Journal of Biological Psychiatry 11/2007; 10(4 Pt 2):606-8. · 3.57 Impact Factor
  • Manjeet Singh Bhatia, Ravi Gupta
    Journal of Neuropsychiatry 02/2006; 18(4):554-6. · 2.40 Impact Factor
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    Ravi Gupta, Manjeet Singh Bhatia
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    ABSTRACT: We describe a case of drug induced Parkinsonism (DIP) that presented with isolated mandibular tremors despite prophylactic anticholinergic therapy. Varied presentations of DIP may be explained by anatomical & functional neuro-circuitry of striatum.
    01/2006;