Joey Scafidi

Publications (1)0 Total impact

• Source

  Available from: nih.gov

  Article: Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP

  Uwe Konietzko, Gunther Kauselmann, Joey Scafidi, Ursula Staubli, Harald Mikkers, Anton Berns, Michaela Schweizer, Robert Waltereit
  [show abstract] [hide abstract]
  ABSTRACT: > Keywords: gene induction/knockout/LTP/Pim kinase/ synaptic plasticity Introduction Neurons have the capacity to undergo activity-dependent changes in their molecular composition and structure in order to adjust their synaptic strength. Such synaptic plasticity appears to contribute to a variety of physiological and pathological processes in the adult brain, including learning and memory, epileptogenesis, drug abuse and neurological diseases (Nestler and Aghajanian, 1997; Kuhl and Skehel, 1998; Milner et al., 1998). The cellular and molecular mechanisms underlying synaptic plasticity have been studied intensively in the context of memory storage. Long-term potentiation (LTP) is an activity-dependent and persistent enhancement of synaptic efficacy that may underlie certain forms of long-term memory (Bliss and Collingridge, 1993). Like memory, LTP can exist in both short- and long-term forms. Short-term forms of LTP (early LTP) appear to rely on the c
  10/1999;