Zhi Zheng

Tongji Hospital, Wu-han-shih, Hubei, China

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Publications (14)8.47 Total impact

  • The American Journal of the Medical Sciences 12/2012; · 1.33 Impact Factor
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    ABSTRACT: Focal organizing pneumonia is a unique form of organizing pneumonia. Little is known regarding its clinical and radiological feature, diagnosis, management, and outcome. Twenty patients with focal organizing pneumonia were investigated and compared with 40 patients with bronchogenic carcinoma. There were 38 men (63.3%) and 22 women (36.7%). The mean age was 55 ± 9.9 years. No specific feature in clinical and radiological manifestation was found to distinguish between focal organizing pneumonia and bronchogenic carcinoma. In patients with focal organizing pneumonia, wedge resection was performed in 12 cases and lobectomy in eight cases. Follow-up was complete with a median period of 26 months (range, 6 to 104 months). All patients were free from recurrence of organizing pneumonia. Clinical and radiologic findings of focal organizing pneumonia are nonspecific, and this unique form of organizing pneumonia is difficult to differentiate from lung cancer. Surgical resection allows both diagnosis and cure. However, considering the benign nature of this disease, major pulmonary resections should be avoided.
    The American surgeon 01/2012; 78(1):133-7. · 0.92 Impact Factor
  • Zhi Zheng, Fengwei Guo, Youmin Pan
    The American surgeon 11/2011; 77(11):E222-3. · 0.92 Impact Factor
  • The American surgeon 08/2011; 77(8):1098-100. · 0.92 Impact Factor
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    ABSTRACT: Differentiation between pulmonary tuberculoma and malignancy by preoperative diagnostic imaging sometimes proves difficult. The purpose of this study is to investigate variable manifestations of pulmonary tuberculoma mimicking lung cancer on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) image and pathologic correlation. Twenty-five patients with a high suspicion of malignancy and histopathologically diagnosed as pulmonary tuberculoma were included. Their FDG PET/CT images, clinical data, and pathologic findings were investigated. There were 18 men and seven women. The mean age was 52 ± 8.8 years. The maximal diameter of pulmonary tuberculoma ranged from 1.7 to 4.2 cm. CT scan revealed that abnormal signs associated with malignancy such as spicular radiation, notching, and pleural indentation also frequently manifested in tuberculoma. During early imaging, positive FDG uptake was identified in 21 patients (84%), intermediate uptake in 3 patients (12%) and negative uptake in 1 patient (4%). During delayed imaging, 16 patients (64%) showed persistent elevated FDG accumulation and 8 patients (32%) experienced a slight drop of FDG accumulation. Pathologically active tuberculoma showed significantly higher FDG radioactivity during both early and delayed imaging than inactive lesion (P < 0.05). Lymphadenopathy with positive FDG uptake was identified in nine patients (36%). Pulmonary tuberculomas mimicking lung cancer, most of which were pathologically active lesions, commonly displayed abnormal appearances in CT scan and an increase in FDG uptake, similar to changes seen on malignancy. Coexistent lymphadenopathy made differential diagnosis even more complicated. These results suggested that positive FDG PET/CT findings should be interpreted with caution in tuberculosis-endemic regions.
    Southern medical journal 06/2011; 104(6):440-5. · 0.92 Impact Factor
  • The Annals of thoracic surgery 03/2011; 91(3):e43. · 3.45 Impact Factor
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    ABSTRACT: It has been known that facilitative glucose transporter (GLUT) is the main carrier which intervenes the glucose uptake of cell. The expression of Glut-1, Glut-3 has close relationship with the uptake of (18)Fluoro-2-deoxyglucose (FDG). The aim of this study is to discuss the relationship between expression of glucose transporter-1, 3 (Glut-1, Glut-3) and FDG uptake in NSCLC and benign pulmonary lesion. Eighty-four NSCLC patients and twenty-four benign pulmonary lesion patients received PET/CT scan before operation. The expression of Glut-1, Glut-3 was detected by immunohistochemistry. The relationship among these factors was investigated. The range of average SUV (SUVave) of the eighty-four patients was 3.6-13.2, and the average value was 7.8+/-3.0. The range of average SUV (SUVave) of the twenty-four patients was 1.2-9.2, and the average value was 3.2+/-1.9. In NSCLC tissues, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 4.4+/-1.3 and 2.6+/-1.9, respectively. In benign pulmonary lesion, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 0.9+/-0.9 and 1.2+/-1.4, respectively. Both of the Glut-1 and the Glut-3 expression levels were significantly higher in NSCLC than those in benign pulmonary lesion (P <0.01). Glut-1 expression was positively correlated to SUVave (r =0.78, P <0.01) in NSCLC patients. Glut-3 expression was positively correlated to SUVave (r =0.45, P =0.03) in benign pulmonary lesion patients. The results show Glut-1 and Glut-3 express not only in NSCLC but also in benign pulmonary lesion. Glut-1 play an important role in FDG uptake in NSCLC. Glut-3 play an important role in FDG uptake in benign pulmonary lesion.
    Zhongguo fei ai za zhi = Chinese journal of lung cancer 08/2008; 11(4):555-8.
  • Bo Ai, Tiecheng Pan, Zhi Zheng, Tao Chen
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    ABSTRACT: It has been known that facilitative glucose transporter(GLUT) is the main carrier which intervenes the glucose uptake of cell,and there is a significant correlation between GLUT1 and cancer.The expression of GLUT1 in lung cancer has close relationship with the uptake of 18fluoro-2-deoxyglucose(FDG) of lung cancer,and the expression of GLUT1 is regulated by hypoxia inducible factor-1(HIF-1).The aim of this study is to investigate the relationship among expression of GLUT1,HIF-1α and the uptake of FDG in non-small cell lung cancer(NSCLC). Eighty-four patients with NSCLC were evaluated with FDG PET/CT before operation.The expression of GLUT1 and HIF-1α was detected immunohistochemically in lung cancer,and their expression level was assessed by the intensity of immunohistochemical staining.Correlation analysis was carried out among the expression level of GLUT1,HIF-1α and the value of standard uptake value(SUV) obtained from preoperative FDG PET/CT examination. The range of average SUV(SUVave) of the eighty-four patients was 3.6-13.2,and the average value was 7.8±3.0.There was no significant correlation between the SUVave and the maximum diameter of the tumors,the TNM stage,pathological classification and the degree of differentiation.The positive rate of GLUT1 in the eighty-four patients was 95.2%(80/84).The average intensity of immunohistochemical staining was 4.4±1.3.The positive rate of HIF-1α in the eighty-four patients was 96.4%(81/84).The average intensity of immunohistochemical staining was 4.4±1.4.A highly significant positive correlation was found between GLUT1 expression and the SUVave(r=0.78,P < 0.01),and also between HIF-1α expression and the SUVave(r=0.73,P < 0.01).There was also a highly significant positive correlation between GLUT1 expression and HIF-1α expression(r=0.93,P < 0.01). GLUT1 protein and HIF-1α expressions are general in NSCLC tissues.GLUT1 may paly an important role in the glucose and FDG uptake of lung cancer cell,and HIF-1α might be one of the most important regulative factors of GLUT1 expression,which up-regulates the expression of GLUT1.
    Zhongguo fei ai za zhi = Chinese journal of lung cancer 12/2007; 10(6):508-12.
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    ABSTRACT: There is no agreement on the appropriate extent of lymph node dissection for lung cancer, especially for early non-small cell lung cancer (NSCLC). This study was to explore the appropriate extent of lymph node dissection for early NSCLC by investigating the metastasis regulations of hilar and mediastinal lymph nodes. Forty-one clinical Ia stage NSCLC patients received lobectomy and systematic mediastinal lymphadenectomy in Tongji Hospital from Jan. 2002 to Dec. 2004. The removed lymph nodes were subjected for pathologic examination. The metastasis regulations of hilar and mediastinal lymph nodes were investigated. A total of 295 groups of lymph nodes were removed. Among them, 42 (14.2%) groups had metastasis, including 33 groups of hilar lymph nodes and 9 of mediastinal lymph nodes. Four patients had mediastinal lymph node metastasis in the 7th station, 2 in the 5th station, 2 in the 9th station, and 1 in the 4th station. The patients with tumors in the upper lobe had metastasis in the 5th or 7th station lymph nodes; the patients with tumors in the middle or lower lobe had metastasis in the 4th, 7th, or 9th station. The metastasis regulations of hilar and mediastinal lymph nodes in Ia stage NSCLC is accordant to regional lymph node drainage regulations. Selective regional lymph node dissection might be applied in these patients, that is, upper mediastinal lymph node, not lower mediastinal lymph node, should be removed when the tumor is in the upper lobe without hilar or subcarinal lymph node metastasis, while all mediastinal lymph nodes should be removed when the tumor is in the middle or lower lobe.
    Ai zheng = Aizheng = Chinese journal of cancer 03/2007; 26(3):303-6.
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    ABSTRACT: By now there are a few reports describing a case of pulmonary inflammatory pseudotumor, presenting multiple nodules in bilateral lungs and a pseudotumor caused by fungus infection is also a very rare disease. Here we report a rare case of pulmonary inflammatory pseudotumor with confirmed cause by Cryptococcus infection presenting multiple nodules in bilateral lungs.
    The Chinese-German Journal of Clinical Oncology 11/2006; 5(6):460-462.
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    ABSTRACT: Lymphatic dissemination is the main approach of metastasis in lung cancer, and it is also an important prognostic factor. The aim of this study is to explore the relationship between tumor size and lymph node metastasis in squamous cell carcinoma and adenocarcinoma of the lung. A total of 240 patients diagnosed as squamous cell carcinoma and adenocarcinoma were studied. The relationship between tumor size and lymph node metastasis was analyzed. Lymph node metastasis rate in maximum diameter (d)≤2cm, 2cm < d≤3cm, 3cm < d≤6cm, 6cm < d≤10cm, and d > 10cm groups was 50.0%, 35.1%, 52.8%, 52.1% and 71.4%, respectively. There was no correlation between tumor size and lymph node metastasis (r=0.10, P > 0.05). Lymph node metastasis occurred more frequently in adenocarcinoma (58.8%) than that in squamous cell carcinoma (42.9%) (P < 0.05). Mediastinal lymph node metastasis was found in 7 patients (16.3%) with d≤3cm, who were all diagnosed as moderate or poor differentiation. Lymph node metastasis is not related to tumor size. Lymph node metastasis occurs more frequently in adenocarcinoma than it does in squamous cell carcinoma. Mediastinal lymph node metastasis can be found in tumor with d≤3cm, and differentiation grade may play an important role in lymph node metastasis.
    Zhongguo fei ai za zhi = Chinese journal of lung cancer 06/2006; 9(3):267-9.
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    ABSTRACT: Lung cancer is one of the most common malignant tumors in China. Surgical resection is still the first choice of treatment for most lung cancer patients. The prognosis of lung cancer after surgical treatment is correlated to many factors. One of them is nosocomial infection. This study is to investigate the distribution of the pathogens causing nosocomial infection and its correlative factors in patients with lung cancer. One hundred and thirteen cases that had hospital-acquired infection out of 1227 surgically treated patients with lung cancer were analyzed statistically. Of all the pathogenic species, the most prevalent species were Gram-negative bacteria with average positive detection of 64.03% (299/467). The second were Gram-positive bacteria (145/467, 31.05%) and the third were fungi (23/467, 4.92%). The results of drug sensitivity tests showed that all of strains had higher resistance rate. The rate of extended spectrum β-lactamases (ESBLs) and meticillin-resistant Staphylococcus (MRS) was very high. The incidence of nosocomial infection was seriously correlated with age, fatness, long smoking history, complicated diseases such as diabetes, damaged renal function and using time of mechanical ventilation over 24 hours. The nosocomial infection of lung cancer patients after surgical treatment is seriously correlated with patient's age, fatness, long smoking history, complicated diseases such as diabetes, damaged renal function and using time of mechanical ventilation over 24 hours. More attentions should be paid to the pathogenic species and its correlative factors of nosocomial infection in lung cancer patients. The resistance of bacteria to the commonly used antibiotics is produced in various degrees. During clinical therapy with antibiotics, antibiotics should be selected according to the results of drug sensitivity tests. In order to reduce the production of drug-resistance, the appropriate use of antibiotics must be strengthened.
    Zhongguo fei ai za zhi = Chinese journal of lung cancer 10/2005; 8(5):468-71.
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    ABSTRACT: Recent researches have manifested that down-regulation of KAI1 relates to metastasis in various tumors, but its association with non-small cell lung cancer (NSCLC) and the mechanism for its down-regulation are not clear. The aim of this study is to investigate the expression of KAI1 in NSCLC and its relationship with clinicopathological characteristics and mutant P53 protein. The expression of KAI1/CD82 and mutant P53 protein was detected in 48 cases of NSCLC tissues by Western blot, and KAI1 mRNA was detected by RT-PCR method, with 20 cases of pulmonary benign disease tissues and normal lung tissues as control.. The positive rate of KAI1 mRNA was 52% in lung cancer group and 90% in control group, respectively (P < 0.01), KAI1/CD82 was 48% and 85% respectively (P < 0.01), and mutant P53 protein was 65% and 5% respectively (P < 0.01). The positive rate of KAI1 mRNA, KAI1/CD82 and mutant P53 protein closely related to the tumor stages, cell differentiation and lymph node metastasis status (P < 0.05 or P < 0.01). The expression of KAI1/CD82 highly related to KAI1 mRNA (P < 0.01) and mutant P53 protein (P < 0.05), while expression of KAI1 mRNA did not relate to mutant P53 protein expression (P > 0.05). The down-regulation of KAI1 may relate to carcinogenesis, development and metastasis of NSCLC. Its reduction may occur mainly at transcriptional level and correlate with p53 in NSCLC. KAI1 and p53 might be helpful to predict the potential metastasis of NSCLC.
    Zhongguo fei ai za zhi = Chinese journal of lung cancer 06/2005; 8(3):190-4.
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    ABSTRACT: Lymph node metastasis is an important factor for prognosis of non-small cell lung cancer (NSCLC). There were different opinions about what effect does lymph node micrometastasis have on prognosis. This study was designed to collect literatures of lymph node micrometastasis and prognosis in stage I NSCLC patients, in order to investigate their relationship. The results from eight literatures on lymph node micrometastasis and prognosis from 1980 to 2002 were analyzed synthetically by meta-analysis. The cumulative cases were 536 NSCLC patients with stage I disease. The detection rate of lymph node micrometastasis ranged from 3.4% to 28.9%, and the rate of positive cases ranged from 20% to 70%. The 3-, 5-year over-survival rate for positive lymph node micrometastasis patients was worse than those of negative lymph node micrometastasis patients: odd ratios (ORs) were 4.16 (95%CI:2.32-7.46) and 3.57 (95%CI:2.30-5.53), respectively (P< 0.01). Positive lymph node micrometastasis may be an adverse factor for post-operative prognosis of NSCLC stage I patients.
    Ai zheng = Aizheng = Chinese journal of cancer 03/2004; 23(2):185-8.

Publication Stats

16 Citations
8.47 Total Impact Points

Institutions

  • 2004–2012
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2005
    • Huazhong University of Science and Technology
      • Department of Cardio Thoracic Surgery
      Wuhan, Hubei, China