H B Coimbra

Publications (2)1 Total impact

• Source

  Available from: min-saude.pt

  Article: Peripheral blood lymphocyte phenotype can predict rejection episodes after orthotopic liver transplantation.

  R Perdigoto, A Paiva, A Freitas, H B Coimbra, O Mota, J Ferrão, L Tomé, E Furtado, M A Cipriano, B Geraldes, F J Oliveira, A L Furtado
  Transplantation Proceedings 10/1999; 31(6):2418-20. · 1.00 Impact Factor
• Article: [Primary immunodeficiency secondary to ZAP-70 deficiency].

  L T Barata, R Henriques, C Hivroz, E Jouanguy, A Paiva, A M Freitas, H B Coimbra, A Fischer, H C da Mota
  [show abstract] [hide abstract]
  ABSTRACT: The authors present the case of a child with recurrent infections since the age of 4 months, including bilateral pneumonia by Pneumocystis carinii and protracted varicella. Serum immunoglobulin values (when 10 months old), and B cell values were normal. There was persistent lymphocytic leucocytosis, near absence of CD8+ cells, and an increased CD4/CD8 ratio. The percentage of activated T cells and the expression of HLA class I were normal. Proliferation, activation and IL-2 synthesis studies in T cells showed a TCR/CD3-associated signal transduction deficit. ZAP-70 cDNA sequencing showed a mutation, and no ZAP-70 protein was detected in T cells. ZAP-70 deficiency is associated with a rare immune deficiency with absence of CD8+ T cells as well as a functional deficiency in T cells. Seven months after bone marrow transplantation the child is clinically well and immunologically recovered.
  Acta médica portuguesa 14(4):413-7.