Mehmet Kelles

Publications (2)2.73 Total impact

• Article: Metastatic renal cell carcinoma to the condyle of the mandible.

  Mehmet Kelles, Mustafa Akarcay, Ahmet Kizilay, Emine Samdanci
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  ABSTRACT: A 59-year-old woman who had left nephrectomy because of renal cell carcinoma (RCC) 3 years ago referred with trismus and a mass on her left temporomandibular joint. Computed tomography scan revealed an expanding lytic lesion on the left condyle of the mandible. Incisional biopsy was carried out. Histopathologic diagnosis was metastatic clear cell variant of RCC. Metastasis of RCC to the condyle of the mandible has not been reported yet. In this study, we presented a case of RCC metastasis to the condyle of the mandible.
  The Journal of craniofacial surgery 07/2012; 23(4):e302-3. · 0.81 Impact Factor
• Article: The effect of resveratrol in tracheal tissue of rats exposed to cigarette smoke.

  Meltem Kurus, Yezdan Firat, Asli Cetin, Mehmet Kelles, Ali Otlu
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  ABSTRACT: The aim of this study was to evaluate the effect of resveratrol on the tracheal tissue of rats exposed to cigarette smoke. 40 adult Wistar albino rats were divided into four groups for an experiment of 6 weeks. Animals in group 1 were controls (n = 10). Rats in group 2 were exposed to cigarette smoke only, and rats in group 3 received daily intraperitoneal injections of resveratrol (10 mg/kg/d). Animals in group 4 were exposed to both cigarette smoke and intraperitoneal injections of resveratrol. Rats of all groups were sacrificed using cervical dislocation. The tracheas were removed and embedded in paraffin blocks. Sections of 4-5 mum thickness were prepared from the blocks. These sections were stained with hematoxylin and eosin, periodic acid-Schiff, and Alcian blue and viewed with a Leica DFC 280 light microscope. Tracheal sections showed that, in group 2 (cigarette smoke group), there was desquamation of epithelial cells into the tracheal lumen, loss of cilia in the epithelial layer, an increase of goblet cells, activation of serous glands at the submucosa, and cell infiltration. In group 4 (cigarette smoke + resveratrol group), all these findings also existed but only a few sections were affected. It was observed that cigarette smoking caused morphological changes such as epithelial degeneration in the upper airway. These morphological changes were correlated with the amount of toxic substances in the cigarette smoke. We found that resveratrol had a preventive role in the histopathological changes caused by cigarette smoking in the rat trachea.
  Inhalation Toxicology 04/2009; 21(12):979-84. · 1.92 Impact Factor