H Ogawa

Hyogo College of Medicine, Nishinomiya, Hyōgo, Japan

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Publications (582)1540.56 Total impact

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    ABSTRACT: A search for dark matter was conducted with the XMASS detector by means of the expected annual modulation due to the Earth's rotation around the Sun. The data used for this analysis was 359.2 live days $\times$ 832 kg of exposure accumulated between November 2013 and March 2015. The result of a simple modulation analysis, without assuming any specific dark matter model, showed a slight negative amplitude. As the $p$-values are 6.1 or 17\% in our two independent analyses, these results are consistent with fluctuations. We also set 90\% confidence level (C.L.) upper bounds that can be used to test models. When we assume Weakly Interacting Massive Particle (WIMP) dark matter elastically scattering on the target nuclei, we exclude almost all the DAMA/LIBRA allowed region with the modulation analysis. This is the first extensive search probing this region with redan exposure comparable to theirs.
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    ABSTRACT: Double electron capture is a rare nuclear decay process in which two orbital electrons are captured simultaneously in the same nucleus. Measurement of its two-neutrino mode would provide a new reference for the calculation of nuclear matrix elements whereas observation of its neutrinoless mode would demonstrate lepton number violation. A search for two-neutrino double electron capture on $^{124}$Xe is performed using 165.9 days of data collected with the XMASS-I detector. No significant excess above background was observed and we set a lower limit on the half-life as $4.7 \times 10^{21}$ years at 90% confidence level.
  • K Takano · S Fuji · N Uchida · H Ogawa · K Ohashi · T Eto · H Sakamaki · Y Morishima · K Kato · R Suzuki · T Fukuda ·
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    ABSTRACT: Diabetes mellitus (DM) is a factor in the hematopoietic cell transplantation-comorbidity index. However, the impact of pre-transplant DM on morbidity and cause-specific non-relapse mortality (NRM) remains unclear. We performed a retrospective study with registry data that included a total of 7626 patients who underwent their first allogeneic hematopoietic SCT (HSCT) between 2007 and 2010. The median age was 44 years (range 0-88). Compared with patients without pre-transplant DM (non-DM group, n=7248), patients with pre-transplant DM (DM group, n=378) were older and were more likely to have high-risk disease, a reduced-intensity conditioning regimen and GVHD prophylaxis using tacrolimus. Multivariate analyses showed that pre-transplant DM was associated with increased risks of NRM (hazard ratio (HR)1.46, 95% confidence interval (CI) 1.21-1.76, P<0.01) and infection-related NRM (HR 2.08, 95% CI 1.58-2.73, P<0.01). The presence of pre-transplant DM was associated with an increased risk of overall mortality in a multivariate analysis (HR 1.55, 95% CI 1.35-1.78, P<0.01). In conclusion, pre-transplant DM was a risk factor for NRM, particularly infection-related mortality, after allogeneic HSCT. To improve the clinical outcome in patients with DM, the benefits of strict infection control and appropriate glycemic control should be explored in future trials.Bone Marrow Transplantation advance online publication, 26 January 2015; doi:10.1038/bmt.2014.315.
    Bone Marrow Transplantation 01/2015; 50(4). DOI:10.1038/bmt.2014.315 · 3.57 Impact Factor
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    ABSTRACT: A pulsed slow-positron beam generated by an electron linear accelerator was directly used for positron annihilation lifetime spectroscopy without any positron storage devices. A waveform digitizer was introduced to simultaneously capture multiple gamma-ray signals originating from positron annihilation events during a single accelerator pulse. The positron pulse was chopped and bunched with the chopper signals also sent to the waveform digitizer. Time differences between the annihilation gamma-ray and chopper peaks were calculated and accumulated as lifetime spectra in a computer. The developed technique indicated that positron annihilation lifetime spectroscopy can be performed in a 20 μs time window at a pulse repetition rate synchronous with the linear accelerator. Lifetime spectra of a Kapton sheet and a thermally grown SiO2 layer on Si were successfully measured. Synchronization of positron lifetime measurements with pulsed ion irradiation was demonstrated by this technique.
    The Review of scientific instruments 12/2014; 85(12):123110. DOI:10.1063/1.4903754 · 1.61 Impact Factor
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    ABSTRACT: Bosonic superweakly interacting massive particles (super-WIMPs) are a candidate for warm dark matter. With the absorption of such a boson by a xenon atom, these dark matter candidates would deposit an energy equivalent to their rest mass in the detector. This is the first direct detection experiment exploring the vector super-WIMPs in the mass range between 40 and 120 keV. With the use of 165.9 day of data, no significant excess above background was observed in the fiducial mass of 41 kg. The present limit for the vector super-WIMPs excludes the possibility that such particles constitute all of dark matter. The absence of a signal also provides the most stringent direct constraint on the coupling constant of pseudoscalar super-WIMPs to electrons. The unprecedented sensitivity was achieved exploiting the low background at a level 10^{-4} kg^{-1} keV_{ee}^{-1} day^{-1} in the detector.
    Physical Review Letters 09/2014; 113(12):121301. · 7.51 Impact Factor
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    ABSTRACT: Background Few studies have evaluated the effects of rabeprazole on low-dose aspirin (LDA)-induced gastroduodenal injuries.AimTo conduct a randomised, double-blind, triple-dummy, active-controlled, multicentre trial, named the PLANETARIUM study, to assess the efficacy, dose–response relationship and safety of rabeprazole for peptic ulcer recurrence in Japanese patients on long-term LDA therapy.Methods Eligible patients had a history of endoscopically confirmed peptic ulcers and were receiving long-term LDA (81 or 100 mg/day) therapy for cardiovascular or cerebrovascular protection. Subjects were randomly segregated into three groups receiving rabeprazole 10 mg once daily (standard dose in Japan), rabeprazole 5 mg once daily, or teprenone (geranylgeranylacetone; mucosal protective agent commercially available in Japan) 50 mg three times per day as an active control. The primary endpoint was recurrence of peptic ulcers over 24 weeks.ResultsAmong 472 randomised subjects, 452 subjects (n = 151, 150, 151, respectively) constituted the full analysis set. The cumulative recurrence rates of peptic ulcers over 24 weeks in the 10- and 5-mg rabeprazole groups were 1.4% and 2.8%, respectively, both of which were significantly lower than that in the teprenone group (21.7%). The cumulative occurrence rate of bleeding ulcers over 24 weeks in the teprenone group was 4.6%, while bleeding ulcers were not observed in the 10- or 5-mg rabeprazole groups. Rabeprazole was well tolerated at both doses.Conclusion Rabeprazole prevents the recurrence of peptic ulcers with no evidence of a major dose–response effect in subjects on low-dose aspirin therapy.
    Alimentary Pharmacology & Therapeutics 08/2014; 40(7). DOI:10.1111/apt.12907 · 5.73 Impact Factor
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    ABSTRACT: Bosonic super-WIMP dark matter, in particular its vector boson and pseudoscalar incarnations, were searched for with the large liquid xenon detector at the XMASS-I experiment. With the absorption of such a vector boson by a xenon atom these dark matter candidates would deposit an energy equivalent to their rest mass in the detector. In 165.9 days of data no signal was observed and stringent limits on the electron coupling of bosonic super-WIMPs with a mass in the 40- 120keV range were obtained. For vector bosons in some of this mass range our direct detection limit surpasses existing astrophysical constraints, covering new territory.
    Physical Review Letters 06/2014; 113(12). DOI:10.1103/PhysRevLett.113.121301 · 7.51 Impact Factor
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    ABSTRACT: Autoantibodies to proliferating cell nuclear antigen (PCNA) are specifically, if rarely, present in systemic lupus erythematosus (SLE) patient sera. Even SLE patients lacking PCNA reactivity often show reaction to PCNA-binding protein. Here, immunoreactivity to chromatin assembly factor-1 (CAF-1), an essential molecule for DNA replication and a PCNA-binding protein, was compared for the sera of SLE patients, normal healthy controls (NHCs) and other disease controls, and in autoimmune sera reactive to standard autoantigens, by enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence, and immunoblotting. CAF1 and IRF1 expression in SLE and NHC peripheral mononuclear cells were compared by quantitative real-time polymerase chain reaction. Serum interferon-γ-inducing protein-10 and anti-double-stranded (ds)DNA antibody levels were measured by ELISA. Increased CAF-1 autoimmune reactivity was recognized in SLE or serum anti-dsDNA antibody-positive patients. Significantly greater central nervous system (CNS) involvement (aseptic meningitis) and serum anti-dsDNA antibody titers were present more often in anti-CAF-1 antibody-positive than antibody-negative SLE patients. IFN-γ positively regulated CAF-1 expression in vitro and was associated with anti-CAF-1 antibody production in SLE. Thus, a novel anti-CAF-1 autoantibody is frequently found in patients with SLE and is a useful biomarker for diagnosis, especially in cases with CNS involvement. Aberrant IFN-γ regulation appears to play an important role in anti-CAF-1 antibody production in SLE.
    Lupus 05/2014; 23(10). DOI:10.1177/0961203314536245 · 2.20 Impact Factor
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    ABSTRACT: BackgroundS100A7/psoriasin is a member of the S100 protein family and is encoded in the epidermal differentiation complex, which contains genes for markers of epidermal differentiation. S100A7/psoriasin is overexpressed in hyperproliferative skin diseases, where it is believed not only to exhibit antimicrobial functions, but also to induce immunomodulatory activities, including chemotaxis and cytokine/chemokine production. Objectives To evaluate the effect of S100A7/psoriasin on keratinocyte differentiation and regulation of the tight junction (TJ) barrier. Methods Expression of differentiation markers and TJ proteins in human keratinocytes was determined by real-time polymerase chain reaction and Western blot. The changes in TJ barrier function were assessed by transepithelial electrical resistance and paracellular permeability assays. Glycogen synthase kinase-3 (GSK-3) and mitogen-activated protein kinase (MAPK) activation was analysed by Western blot, whereas -catenin and E-cadherin activation was evaluated by Western blot and immunofluorescence. ResultsS100A7/psoriasin enhanced the expression of several differentiation markers and selectively increased the expression of TJ proteins (e.g. claudins and occludin), which are known to strengthen the TJ barrier. Furthermore, S100A7/psoriasin increased -catenin and E-cadherin accumulation at cell-cell contact, and enhanced transepithelial electrical resistance while reducing the paracellular permeability of keratinocyte layers. The data suggest that S100A7/psoriasin-mediated regulation of the TJ barrier was via both the GSK-3 and MAPK pathways, as evidenced by the inhibitory effects of inhibitors for GSK-3 and MAPKs. Conclusions Our finding that S100A7/psoriasin regulates differentiation and strengthens TJ barrier function provides novel evidence that, in addition to antimicrobial and immunoregulatory activities, S100A7/psoriasin is involved in skin innate immunity.
    British Journal of Dermatology 05/2014; 171(4). DOI:10.1111/bjd.13125 · 4.28 Impact Factor
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    ABSTRACT: A search for the dinucleon decay pp→K+K+ has been performed using 91.6 kton·yr data from Super-Kamiokande-I. This decay provides a sensitive probe of the R-parity-violating parameter λ112''. A boosted decision tree analysis found no signal candidates in the data. The expected background was 0.28±0.19 atmospheric neutrino induced events and the estimated signal detection efficiency was 12.6%±3.2%. A lower limit of 1.7×1032 years has been placed on the partial lifetime of the decay O16→C14K+K+ at 90% C.L. A corresponding upper limit of 7.8×10-9 has been placed on the parameter λ112''.
    Physical Review Letters 04/2014; 112(13):131803. DOI:10.1103/PhysRevLett.112.131803 · 7.51 Impact Factor
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    ABSTRACT: A search for inelastic scattering of weakly interacting massive particles (WIMPs) on the isotope Xe-129 was done in data taken with the single-phase liquid-xenon detector XMASS at the Kamioka Observatory. Using a restricted volume containing 41 kg of liquid xenon at the very center of our detector, we observed no significant excess of events in 165.9 live days of data. Our background reduction allowed us to derive our limits without explicitly subtracting the remaining events that are compatible with background expectations. As an example, we derive for a 50 GeV WIMP an upper limit of 3.2 pb at the 90% confidence level for its inelastic cross section on Xe-129 nuclei.
    Progress of Theoretical and Experimental Physics 01/2014; 2014(6). DOI:10.1093/ptep/ptu064 · 2.49 Impact Factor
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    ABSTRACT: The removal of radioactivity from liquid scintillator has been studied in preparation of a low background phase of KamLAND. This paper describes the methods and techniques developed to measure and efficiently extract radon decay products from liquid scintillator. We report the radio-isotope reduction factors obtained when applying various extraction methods. During this study, distillation was identified as the most efficient method for removing radon daughters from liquid scintillator.
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    ABSTRACT: To determine whether a difference in donor source affects the outcome of transplantation for patients with primary myelofibrosis (PMF), a retrospective study was conducted using the national registry data on patients who received first allogeneic hematopoietic cell transplantation (HCT) with related BM (n=19), related PBSCs (n=25), unrelated BM (n=28) or unrelated umbilical cord blood (UCB; n=11). The 5-year OS rates after related BM, related PBSC and unrelated BM transplantation were 63%, 43% and 41%, respectively, and the 2-year OS rate after UCB transplantation was 36%. On multivariate analysis, the donor source was not a significant factor for predicting the OS rate. Instead, performance status (PS) 2 (vs PS 0-1) predicted a lower OS (P=0.044), and RBC transfusion 20 times before transplantation (vs transfusion 9 times) showed a trend toward a lower OS (P=0.053). No advantage of nonmyeloablative preconditioning regimens in terms of decreasing nonrelapse mortality or increasing OS was found. Allogeneic HCT, and even unrelated BM and UCB transplantation, provides a curative treatment for PMF patients.Bone Marrow Transplantation advance online publication, 25 November 2013; doi:10.1038/bmt.2013.180.
    Bone marrow transplantation 11/2013; 49(3). DOI:10.1038/bmt.2013.180 · 3.57 Impact Factor
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    ABSTRACT: LiteBIRD is a next-generation satellite mission to measure the polarization of the cosmic microwave background (CMB) radiation. On large angular scales the B-mode polarization of the CMB carries the imprint of primordial gravitational waves, and its precise measurement would provide a powerful probe of the epoch of inflation. The goal of LiteBIRD is to achieve a measurement of the characterizing tensor to scalar ratio $r$ to an uncertainty of $\delta r=0.001$. In order to achieve this goal we will employ a kilo-pixel superconducting detector array on a cryogenically cooled sub-Kelvin focal plane with an optical system at a temperature of 4~K. We are currently considering two detector array options; transition edge sensor (TES) bolometers and microwave kinetic inductance detectors (MKID). In this paper we give an overview of LiteBIRD and describe a TES-based polarimeter designed to achieve the target sensitivity of 2~$\mu$K$\cdot$arcmin over the frequency range 50 to 320~GHz.
    Journal of Low Temperature Physics 11/2013; 176(5-6). DOI:10.1007/s10909-013-0996-1 · 1.02 Impact Factor
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    ABSTRACT: In this study, the modification of the helical divertor footprint induced by the net toroidal plasma current was investigated in the Large Helical Device (LHD). The divertor footprint shifted a few centimetres when the net toroidal plasma current, as measured by Rogowski coils, was induced via the neutral-beam injection. The shift direction was related to the plasma current direction, and the shift width showed almost linear dependence on the plasma current divided by the toroidal field strength. Magnetic field line tracing calculation considering the plasma current within a simple model revealed that the modification of the edge field line structure causes the footprint shift. The predicted and experimental shift widths agreed qualitatively.
    Nuclear Fusion 11/2013; 53(11):112001. DOI:10.1088/0029-5515/53/11/112001 · 3.06 Impact Factor

  • International Journal of Cardiology 10/2013; · 4.04 Impact Factor
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    ABSTRACT: Cryptogenic organizing pneumonia (COP), previously known as bronchiolitis obliterans organizing pneumonia (BOOP), is a significant complication after allogeneic hematopoietic SCT (HCT). However, the pathogenesis of this complication has not yet been elucidated. Therefore, we identified the pre-transplant risk factors for the development of COP/BOOP using the Japan transplant registry database between 2005 and 2009. Among 9550 eligible recipients, 193 experienced COP/BOOP (2%). HLA disparity (odds ratio (OR) 1.51, P=0.05), female-to-male HCT (OR 1.53, P=0.023), and PBSC transplant (OR 1.84, P=0.0076) were significantly associated with an increased risk of COP/BOOP. On the other hand, BU-based myeloablative conditioning (OR 0.52, P=0.033), or fludarabine-based reduced-intensity conditioning (OR 0.50, P=0.0011) in comparison with a TBI-based regimen and in vivo T-cell depletion (OR 0.46, P=0.055) were associated with a lower risk. Of the 193 patients with COP/BOOP, 77 died, including non-relapse death in 46 (59%). Pulmonary failure and fatal infection accounted for 41% (n=19) and 26% (n=12) of the non-relapse death. Allogeneic immunity and conditioning toxicity could be associated with COP/BOOP. Prospective studies are required to elucidate the true risk factors for COP/BOOP and to develop a prophylactic approach.
    Bone marrow transplantation 10/2013; 48(10):1368. DOI:10.1038/bmt.2013.153 · 3.57 Impact Factor
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    ABSTRACT: Few studies have evaluated the risk factors for chronic GVHD and organ involvement associated with different graft types, including unrelated cord blood (U-CB). We retrospectively studied 4818 adult patients who received their first allogeneic transplantation and survived for at least 100 days. The incidence of chronic GVHD at 2 years was 37%. The following factors were associated with the development of chronic GVHD: female donor/male recipient, CMV-Ab seropositivity, matched related peripheral blood grafts vs matched related BM grafts, no in vivo T-cell depletion and the occurrence of grade II-IV acute GVHD. Among these factors, the association with acute GVHD occurrence was consistently significant across donor subtypes. The use of U-CB was not associated with chronic GVHD, but was associated with a low incidence of extensive chronic GVHD. Chronic GVHD patients who had received U-CB transplants showed less frequent involvement of the oral cavity (28% vs 55%), eye (12% vs 26%), liver (20% vs 44%), lung (11% vs 25%) and joint (0% vs 6%) than those with matched related BM grafts. In conclusion, we found that U-CB transplants were associated with a low incidence of extensive chronic GVHD and less frequent involvement of the oral cavity, eye, liver, lung and joints.Bone Marrow Transplantation advance online publication, 30 September 2013; doi:10.1038/bmt.2013.151.
    Bone marrow transplantation 09/2013; 49(2). DOI:10.1038/bmt.2013.151 · 3.57 Impact Factor
  • A Kamo · M Tominaga · K Taneda · H Ogawa · K Takamori ·
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    ABSTRACT: Epidermal hyperinnervation is considered one cause of sensitization to itch, and is thought to regulated by keratinocyte-derived axonal guidance molecules, including nerve growth factor (NGF) and semaphorin (Sema)3A. Neurotropin (NTP) shows antipruritic effects in allergic disease and is also used for pain relief. Using cultured rat dorsal root ganglion neurones, we previously found that NTP inhibited NGF-induced neurite outgrowth. However, no such inhibitory effect has been shown in vivo. We therefore assessed the effects of intraperitoneal administration of NTP on nerve density and expression of NGF and Sema3A mRNAs in the epidermis of acetone-treated mice showing epidermal hyperinnervation. We found that NTP significantly reduced intraepidermal nerve growth in these acetone-treated mice. NTP significantly upregulated epidermal Sema3A mRNA, but had no effect on expression of epidermal NGF mRNA. These findings indicate that NTP may reduce intraepidermal nerve density by inducing expression of Sema3A in the epidermis.
    Clinical and Experimental Dermatology 06/2013; 38(6). DOI:10.1111/ced.12100 · 1.09 Impact Factor
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    ABSTRACT: Although recent improvements have been indicated in the outcome after allogeneic hematopoietic cell transplantation (allo-HCT), little information is available on how changes in transplant modalities have affected the outcomes after allo-HCT in non-remission, based on patient age, donor source and disease type. We compared the incidence and causes of non-relapse mortality (NRM) after allo-HCT in non-remission among three consecutive four-year periods using a nationwide transplant outcome registry database. A total of 3308 patients with acute leukemia in non-remission were analyzed. The risk of NRM decreased over the three periods, and the hazard ratios (HRs) in 2001-2004 and 2005-2008 compared with 1997-2000 were 0.86 (95% CI, 0.70-1.06; P=0.16) and 0.65 (95% CI, 0.53-0.80; P<0.01), respectively. A significant decrease in the HR for overall mortality was also observed in 2005-2008 (HR 0.85; 95% CI, 0.75-0.97; P=0.02). We found that a decrease in the incidences of death due to GVHD and infection contributed to the reduction in NRM, to which high-resolution donor-recipient HLA matching and other improvements may have contributed. As none of the subgroups showed improved survival without a reduction in NRM, the effective prevention of transplant-related complications appears to be necessary for improving outcomes after allo-HCT in non-remission.Bone Marrow Transplantation advance online publication, 8 April 2013; doi:10.1038/bmt.2013.42.
    Bone marrow transplantation 04/2013; 48(9). DOI:10.1038/bmt.2013.42 · 3.57 Impact Factor

Publication Stats

9k Citations
1,540.56 Total Impact Points


  • 2008-2015
    • Hyogo College of Medicine
      • Department of Internal Medicine
      Nishinomiya, Hyōgo, Japan
    • National Institutes Of Natural Sciences
      Edo, Tōkyō, Japan
  • 2014
    • Kumamoto University
      Kumamoto, Kumamoto, Japan
  • 2006-2014
    • The University of Tokyo
      • Institute for Cosmic Ray Research
      白山, Tōkyō, Japan
  • 2002-2014
    • National Institute of Advanced Industrial Science and Technology
      • Electronics and Photonics Research Institute
      Tsukuba, Ibaraki, Japan
  • 1979-2014
    • Juntendo University
      • • Atopy (Allergy) Research Center
      • • Graduate School of Medicine
      • • Department of Dermatology
      • • Department of Medicine
      Edo, Tokyo, Japan
  • 2013
    • Osaka Prefecture University
      Sakai, Ōsaka, Japan
  • 2005-2013
    • The Graduate University for Advanced Studies
      • Department of Fusion Science
      Миура, Kanagawa, Japan
    • Sharp Corporation
      Ōsaka, Ōsaka, Japan
  • 1995-2013
    • Tokyo Institute of Technology
      • Department of Physics
      Edo, Tōkyō, Japan
  • 2012
    • Tottori University
      • Faculty of Agriculture
      TTJ, Tottori, Japan
  • 2003-2011
    • Japan Atomic Energy Agency
      • Nuclear Science and Engineering Directorate
      Muramatsu, Niigata, Japan
    • Hiroshima Institute of Technology
      Hirosima, Hiroshima, Japan
  • 2010
    • Tokyo Gakugei University
      Koganei, Tōkyō, Japan
  • 2009
    • Saitama Medical University
      Saitama, Saitama, Japan
  • 1979-2008
    • National Institute of Radiological Sciences
      • Research Center for Charged Particle Therapy
      Tiba, Chiba, Japan
  • 1920-2008
    • Saga University
      • • Synchrotron Light Application Center
      • • Department of Electrical & Electronic Engineering
      Сага Япония, Saga Prefecture, Japan
  • 2007
    • Nagoya University
      Nagoya, Aichi, Japan
  • 1998-2007
    • RIKEN
      • Nishina Center for Accelerator-Based Science (RNC)
      Вако, Saitama, Japan
  • 2002-2006
    • National Institute for Fusion Science
      • Department of Helical Plasma Research
      Tokitsu-chō, Gifu, Japan
  • 1998-2006
    • Tohoku University
      • • Research Center for Neutrino Science
      • • Department of Physics
      Sendai-shi, Miyagi-ken, Japan
  • 1997-2006
    • Osaka City University
      • Department of Neurosurgery
      Ōsaka, Ōsaka, Japan
    • Sophia University
      • Division of Physics
      Edo, Tōkyō, Japan
  • 1999-2003
    • Boston University
      • Department of Physics
      Boston, Massachusetts, United States
  • 2000
    • Chiba University
      Tiba, Chiba, Japan
    • Aichi Medical University
      • Division of Internal Medicine
      Okazaki, Aichi, Japan
    • National Institute of Animal Health
      Ibaragi, Ōsaka, Japan
  • 1975-1994
    • Keio University
      • Department of Dermatology
      Edo, Tōkyō, Japan
  • 1991
    • Tokyo Metropolitan Institute of Medical Science
      Edo, Tōkyō, Japan
  • 1988
    • Nara Medical University
      • Department of Dermatology
      Nara-shi, Nara, Japan