H Ogawa

Hyogo College of Medicine, Nishinomiya, Hyōgo, Japan

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Publications (536)1319.69 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Diabetes mellitus (DM) is a factor in the hematopoietic cell transplantation-comorbidity index. However, the impact of pre-transplant DM on morbidity and cause-specific non-relapse mortality (NRM) remains unclear. We performed a retrospective study with registry data that included a total of 7626 patients who underwent their first allogeneic hematopoietic SCT (HSCT) between 2007 and 2010. The median age was 44 years (range 0-88). Compared with patients without pre-transplant DM (non-DM group, n=7248), patients with pre-transplant DM (DM group, n=378) were older and were more likely to have high-risk disease, a reduced-intensity conditioning regimen and GVHD prophylaxis using tacrolimus. Multivariate analyses showed that pre-transplant DM was associated with increased risks of NRM (hazard ratio (HR)1.46, 95% confidence interval (CI) 1.21-1.76, P<0.01) and infection-related NRM (HR 2.08, 95% CI 1.58-2.73, P<0.01). The presence of pre-transplant DM was associated with an increased risk of overall mortality in a multivariate analysis (HR 1.55, 95% CI 1.35-1.78, P<0.01). In conclusion, pre-transplant DM was a risk factor for NRM, particularly infection-related mortality, after allogeneic HSCT. To improve the clinical outcome in patients with DM, the benefits of strict infection control and appropriate glycemic control should be explored in future trials.Bone Marrow Transplantation advance online publication, 26 January 2015; doi:10.1038/bmt.2014.315.
    Bone Marrow Transplantation 01/2015; 50(4). DOI:10.1038/bmt.2014.315 · 3.47 Impact Factor
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    ABSTRACT: A pulsed slow-positron beam generated by an electron linear accelerator was directly used for positron annihilation lifetime spectroscopy without any positron storage devices. A waveform digitizer was introduced to simultaneously capture multiple gamma-ray signals originating from positron annihilation events during a single accelerator pulse. The positron pulse was chopped and bunched with the chopper signals also sent to the waveform digitizer. Time differences between the annihilation gamma-ray and chopper peaks were calculated and accumulated as lifetime spectra in a computer. The developed technique indicated that positron annihilation lifetime spectroscopy can be performed in a 20 μs time window at a pulse repetition rate synchronous with the linear accelerator. Lifetime spectra of a Kapton sheet and a thermally grown SiO2 layer on Si were successfully measured. Synchronization of positron lifetime measurements with pulsed ion irradiation was demonstrated by this technique.
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    ABSTRACT: Background Few studies have evaluated the effects of rabeprazole on low-dose aspirin (LDA)-induced gastroduodenal injuries.AimTo conduct a randomised, double-blind, triple-dummy, active-controlled, multicentre trial, named the PLANETARIUM study, to assess the efficacy, dose–response relationship and safety of rabeprazole for peptic ulcer recurrence in Japanese patients on long-term LDA therapy.Methods Eligible patients had a history of endoscopically confirmed peptic ulcers and were receiving long-term LDA (81 or 100 mg/day) therapy for cardiovascular or cerebrovascular protection. Subjects were randomly segregated into three groups receiving rabeprazole 10 mg once daily (standard dose in Japan), rabeprazole 5 mg once daily, or teprenone (geranylgeranylacetone; mucosal protective agent commercially available in Japan) 50 mg three times per day as an active control. The primary endpoint was recurrence of peptic ulcers over 24 weeks.ResultsAmong 472 randomised subjects, 452 subjects (n = 151, 150, 151, respectively) constituted the full analysis set. The cumulative recurrence rates of peptic ulcers over 24 weeks in the 10- and 5-mg rabeprazole groups were 1.4% and 2.8%, respectively, both of which were significantly lower than that in the teprenone group (21.7%). The cumulative occurrence rate of bleeding ulcers over 24 weeks in the teprenone group was 4.6%, while bleeding ulcers were not observed in the 10- or 5-mg rabeprazole groups. Rabeprazole was well tolerated at both doses.Conclusion Rabeprazole prevents the recurrence of peptic ulcers with no evidence of a major dose–response effect in subjects on low-dose aspirin therapy.
    Alimentary Pharmacology & Therapeutics 08/2014; 40(7). DOI:10.1111/apt.12907 · 4.55 Impact Factor
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    ABSTRACT: Autoantibodies to proliferating cell nuclear antigen (PCNA) are specifically, if rarely, present in systemic lupus erythematosus (SLE) patient sera. Even SLE patients lacking PCNA reactivity often show reaction to PCNA-binding protein. Here, immunoreactivity to chromatin assembly factor-1 (CAF-1), an essential molecule for DNA replication and a PCNA-binding protein, was compared for the sera of SLE patients, normal healthy controls (NHCs) and other disease controls, and in autoimmune sera reactive to standard autoantigens, by enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence, and immunoblotting. CAF1 and IRF1 expression in SLE and NHC peripheral mononuclear cells were compared by quantitative real-time polymerase chain reaction. Serum interferon-γ-inducing protein-10 and anti-double-stranded (ds)DNA antibody levels were measured by ELISA. Increased CAF-1 autoimmune reactivity was recognized in SLE or serum anti-dsDNA antibody-positive patients. Significantly greater central nervous system (CNS) involvement (aseptic meningitis) and serum anti-dsDNA antibody titers were present more often in anti-CAF-1 antibody-positive than antibody-negative SLE patients. IFN-γ positively regulated CAF-1 expression in vitro and was associated with anti-CAF-1 antibody production in SLE. Thus, a novel anti-CAF-1 autoantibody is frequently found in patients with SLE and is a useful biomarker for diagnosis, especially in cases with CNS involvement. Aberrant IFN-γ regulation appears to play an important role in anti-CAF-1 antibody production in SLE.
    Lupus 05/2014; 23(10). DOI:10.1177/0961203314536245 · 2.48 Impact Factor
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    ABSTRACT: BackgroundS100A7/psoriasin is a member of the S100 protein family and is encoded in the epidermal differentiation complex, which contains genes for markers of epidermal differentiation. S100A7/psoriasin is overexpressed in hyperproliferative skin diseases, where it is believed not only to exhibit antimicrobial functions, but also to induce immunomodulatory activities, including chemotaxis and cytokine/chemokine production. Objectives To evaluate the effect of S100A7/psoriasin on keratinocyte differentiation and regulation of the tight junction (TJ) barrier. Methods Expression of differentiation markers and TJ proteins in human keratinocytes was determined by real-time polymerase chain reaction and Western blot. The changes in TJ barrier function were assessed by transepithelial electrical resistance and paracellular permeability assays. Glycogen synthase kinase-3 (GSK-3) and mitogen-activated protein kinase (MAPK) activation was analysed by Western blot, whereas -catenin and E-cadherin activation was evaluated by Western blot and immunofluorescence. ResultsS100A7/psoriasin enhanced the expression of several differentiation markers and selectively increased the expression of TJ proteins (e.g. claudins and occludin), which are known to strengthen the TJ barrier. Furthermore, S100A7/psoriasin increased -catenin and E-cadherin accumulation at cell-cell contact, and enhanced transepithelial electrical resistance while reducing the paracellular permeability of keratinocyte layers. The data suggest that S100A7/psoriasin-mediated regulation of the TJ barrier was via both the GSK-3 and MAPK pathways, as evidenced by the inhibitory effects of inhibitors for GSK-3 and MAPKs. Conclusions Our finding that S100A7/psoriasin regulates differentiation and strengthens TJ barrier function provides novel evidence that, in addition to antimicrobial and immunoregulatory activities, S100A7/psoriasin is involved in skin innate immunity.
    British Journal of Dermatology 05/2014; 171(4). DOI:10.1111/bjd.13125 · 4.10 Impact Factor
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    ABSTRACT: To determine whether a difference in donor source affects the outcome of transplantation for patients with primary myelofibrosis (PMF), a retrospective study was conducted using the national registry data on patients who received first allogeneic hematopoietic cell transplantation (HCT) with related BM (n=19), related PBSCs (n=25), unrelated BM (n=28) or unrelated umbilical cord blood (UCB; n=11). The 5-year OS rates after related BM, related PBSC and unrelated BM transplantation were 63%, 43% and 41%, respectively, and the 2-year OS rate after UCB transplantation was 36%. On multivariate analysis, the donor source was not a significant factor for predicting the OS rate. Instead, performance status (PS) 2 (vs PS 0-1) predicted a lower OS (P=0.044), and RBC transfusion 20 times before transplantation (vs transfusion 9 times) showed a trend toward a lower OS (P=0.053). No advantage of nonmyeloablative preconditioning regimens in terms of decreasing nonrelapse mortality or increasing OS was found. Allogeneic HCT, and even unrelated BM and UCB transplantation, provides a curative treatment for PMF patients.Bone Marrow Transplantation advance online publication, 25 November 2013; doi:10.1038/bmt.2013.180.
    Bone marrow transplantation 11/2013; 49(3). DOI:10.1038/bmt.2013.180 · 3.47 Impact Factor
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    ABSTRACT: In this study, the modification of the helical divertor footprint induced by the net toroidal plasma current was investigated in the Large Helical Device (LHD). The divertor footprint shifted a few centimetres when the net toroidal plasma current, as measured by Rogowski coils, was induced via the neutral-beam injection. The shift direction was related to the plasma current direction, and the shift width showed almost linear dependence on the plasma current divided by the toroidal field strength. Magnetic field line tracing calculation considering the plasma current within a simple model revealed that the modification of the edge field line structure causes the footprint shift. The predicted and experimental shift widths agreed qualitatively.
    Nuclear Fusion 11/2013; 53(11):112001. DOI:10.1088/0029-5515/53/11/112001 · 3.24 Impact Factor
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    ABSTRACT: Cryptogenic organizing pneumonia (COP), previously known as bronchiolitis obliterans organizing pneumonia (BOOP), is a significant complication after allogeneic hematopoietic SCT (HCT). However, the pathogenesis of this complication has not yet been elucidated. Therefore, we identified the pre-transplant risk factors for the development of COP/BOOP using the Japan transplant registry database between 2005 and 2009. Among 9550 eligible recipients, 193 experienced COP/BOOP (2%). HLA disparity (odds ratio (OR) 1.51, P=0.05), female-to-male HCT (OR 1.53, P=0.023), and PBSC transplant (OR 1.84, P=0.0076) were significantly associated with an increased risk of COP/BOOP. On the other hand, BU-based myeloablative conditioning (OR 0.52, P=0.033), or fludarabine-based reduced-intensity conditioning (OR 0.50, P=0.0011) in comparison with a TBI-based regimen and in vivo T-cell depletion (OR 0.46, P=0.055) were associated with a lower risk. Of the 193 patients with COP/BOOP, 77 died, including non-relapse death in 46 (59%). Pulmonary failure and fatal infection accounted for 41% (n=19) and 26% (n=12) of the non-relapse death. Allogeneic immunity and conditioning toxicity could be associated with COP/BOOP. Prospective studies are required to elucidate the true risk factors for COP/BOOP and to develop a prophylactic approach.
    Bone marrow transplantation 10/2013; 48(10):1368. DOI:10.1038/bmt.2013.153 · 3.47 Impact Factor
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    ABSTRACT: Few studies have evaluated the risk factors for chronic GVHD and organ involvement associated with different graft types, including unrelated cord blood (U-CB). We retrospectively studied 4818 adult patients who received their first allogeneic transplantation and survived for at least 100 days. The incidence of chronic GVHD at 2 years was 37%. The following factors were associated with the development of chronic GVHD: female donor/male recipient, CMV-Ab seropositivity, matched related peripheral blood grafts vs matched related BM grafts, no in vivo T-cell depletion and the occurrence of grade II-IV acute GVHD. Among these factors, the association with acute GVHD occurrence was consistently significant across donor subtypes. The use of U-CB was not associated with chronic GVHD, but was associated with a low incidence of extensive chronic GVHD. Chronic GVHD patients who had received U-CB transplants showed less frequent involvement of the oral cavity (28% vs 55%), eye (12% vs 26%), liver (20% vs 44%), lung (11% vs 25%) and joint (0% vs 6%) than those with matched related BM grafts. In conclusion, we found that U-CB transplants were associated with a low incidence of extensive chronic GVHD and less frequent involvement of the oral cavity, eye, liver, lung and joints.Bone Marrow Transplantation advance online publication, 30 September 2013; doi:10.1038/bmt.2013.151.
    Bone marrow transplantation 09/2013; 49(2). DOI:10.1038/bmt.2013.151 · 3.47 Impact Factor
  • A Kamo · M Tominaga · K Taneda · H Ogawa · K Takamori
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    ABSTRACT: Epidermal hyperinnervation is considered one cause of sensitization to itch, and is thought to regulated by keratinocyte-derived axonal guidance molecules, including nerve growth factor (NGF) and semaphorin (Sema)3A. Neurotropin (NTP) shows antipruritic effects in allergic disease and is also used for pain relief. Using cultured rat dorsal root ganglion neurones, we previously found that NTP inhibited NGF-induced neurite outgrowth. However, no such inhibitory effect has been shown in vivo. We therefore assessed the effects of intraperitoneal administration of NTP on nerve density and expression of NGF and Sema3A mRNAs in the epidermis of acetone-treated mice showing epidermal hyperinnervation. We found that NTP significantly reduced intraepidermal nerve growth in these acetone-treated mice. NTP significantly upregulated epidermal Sema3A mRNA, but had no effect on expression of epidermal NGF mRNA. These findings indicate that NTP may reduce intraepidermal nerve density by inducing expression of Sema3A in the epidermis.
    Clinical and Experimental Dermatology 06/2013; 38(6). DOI:10.1111/ced.12100 · 1.23 Impact Factor
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    ABSTRACT: Although recent improvements have been indicated in the outcome after allogeneic hematopoietic cell transplantation (allo-HCT), little information is available on how changes in transplant modalities have affected the outcomes after allo-HCT in non-remission, based on patient age, donor source and disease type. We compared the incidence and causes of non-relapse mortality (NRM) after allo-HCT in non-remission among three consecutive four-year periods using a nationwide transplant outcome registry database. A total of 3308 patients with acute leukemia in non-remission were analyzed. The risk of NRM decreased over the three periods, and the hazard ratios (HRs) in 2001-2004 and 2005-2008 compared with 1997-2000 were 0.86 (95% CI, 0.70-1.06; P=0.16) and 0.65 (95% CI, 0.53-0.80; P<0.01), respectively. A significant decrease in the HR for overall mortality was also observed in 2005-2008 (HR 0.85; 95% CI, 0.75-0.97; P=0.02). We found that a decrease in the incidences of death due to GVHD and infection contributed to the reduction in NRM, to which high-resolution donor-recipient HLA matching and other improvements may have contributed. As none of the subgroups showed improved survival without a reduction in NRM, the effective prevention of transplant-related complications appears to be necessary for improving outcomes after allo-HCT in non-remission.Bone Marrow Transplantation advance online publication, 8 April 2013; doi:10.1038/bmt.2013.42.
    Bone marrow transplantation 04/2013; 48(9). DOI:10.1038/bmt.2013.42 · 3.47 Impact Factor
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    ABSTRACT: Excited states in 17C were investigated through the measurement of beta?-delayed neutrons and gamma rays emitted in the ? decay of 17B. In the measurement, three negative-parity states and two inconclusive states, were identified in 17C above the neutron threshold energy, and seven gamma-lines were identified in a beta?-delayed multiple neutron emission of the 17B ? decay. From these transitions, the beta?-decay scheme of 17B was determined. In the present work, the ?beta-NMR technique is combined with the ?-delayed particle measurements using a fragmentation-induced spin-polarized 17B beam. This new scheme allows us to determine the spin parity of beta?-decay feeding excited states based on the difference in the discrete ?beta-decay asymmetry parameters, provided the states are connected through the Gamow-Teller transition. In this work, 1/2-, 3/2-, and (5/2-) are assigned to the observed states at Ex = 2.71(2), 3.93(2), and 4.05(2) MeV in 17C, respectively.
    Physical Review C 01/2013; 87(3). DOI:10.1103/PhysRevC.87.034316 · 3.88 Impact Factor
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    ABSTRACT: This study aimed to investigate the safety and feasibility of physical therapy in cytopenic patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT), and to investigate the effect of physical therapy on physiological functions and quality of life (QOL) in allo-HSCT patients. The study cohort included 321 patients who underwent allo-HSCT. To investigate the safety and feasibility of physical therapy during cytopenia, patients were assigned to the physical therapy group (n = 227) or the control group (n = 94). To determine the effects of physical therapy, patients were divided according to the frequency with which they underwent physical therapy (n = 51 per group). Handgrip strength, knee extensor strength and a 6-min walk test were used as measures of physiological function. Short-Form 36 was used to assess QOL. The physical therapy group had higher rate of achieving engraftment and lower death rate than the control group (P < 0.05). After HSCT, the high-frequency physical therapy group showed significantly less decline than the low-frequency physical therapy group with respect to physical functioning of QOL (P < 0.01). Physical therapy is quite beneficial and can be performed safely and feasibly in cytopenic patients during allo-HSCT.
    European Journal of Cancer Care 12/2012; 22(3). DOI:10.1111/ecc.12027 · 1.76 Impact Factor
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    ABSTRACT: Acute GVHD (aGVHD) is a major obstacle to allogeneic hematopoietic SCT (alloHSCT). Although it is thought that aGVHD is initiated in secondary lymphoid organs at a very early stage of alloHSCT, whether CD4(+)FOXP3(+) regulatory T-cells (Tregs) have an impact on aGVHD development during this period remains unclear. Here, we measured Tregs in peripheral blood as early as possible after HLA-mismatched alloHSCT, and assessed the incidence of aGVHD. Flow cytometric analyses revealed that at the second week after HSCT, patients with aGVHD had significantly (P=0.018) lower Treg:CD4(+)T-cell ratios than those without aGVHD. As these differences were seen before the development of aGVHD, these ratios can predict the incidence of aGVHD. The cumulative incidence of aGVHD in patients with ratios of <9% was significantly higher than that in patients with ratios of 9% (P=0.0082, log-rank test). Additionally, the specific ratio of Tregs:CD4(+)T-cells was the most significant value among all other possible lymphocyte-associated ratios and absolute cell counts. These findings suggest that the ratio of Tregs:CD4(+)T-cells at the second week post HLA-mismatched alloHSCT might be a potent predictor of aGVHD in these patients. The practical efficacy of this finding should be verified in further interventional studies.Bone Marrow Transplantation advance online publication, 19 November 2012; doi:10.1038/bmt.2012.232.
    Bone marrow transplantation 11/2012; 48(6). DOI:10.1038/bmt.2012.232 · 3.47 Impact Factor
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    ABSTRACT: The outcomes for allogeneic hematopoietic cell transplantation (allo-HCT) are heavily influenced by non-relapse mortality (NRM). We retrospectively assessed the changes in the incidence and causes of NRM after allo-HCT over the past 12 years. NRM, relapse rate and OS were analyzed using the Japan transplant outcome database of 6501 adult patients with acute leukemia or myelodysplastic syndrome who received their first allo-HCT in remission from 1997 through 2008. In multivariate analysis in patients aged 16-49 years, the adjusted hazard ratios (HRs) for NRM for 2001-2004 and 2005-2008 were 0.78 (95% confidence interval, 0.65-0.93) and 0.64 (0.54-0.78), respectively, compared with 1997-2000. The HR for overall mortality in 2005-2008 was 0.81 (0.70-0.93) compared with 1997-2000. In patients aged 50-70 years, the HRs for NRM and overall mortality in 2005-2008 were 0.56 (0.46-0.68) and 0.66 (0.47-0.93), respectively, compared with those in 2001-2004. We found that causes of death that contributed to the changes in NRM varied among subgroups. In conclusion, our study indicated that the incidence of NRM after allo-HCT has significantly decreased over the past 12 years, which has led to an improvement of OS, and also showed reductions in NRM in subgroups consisting of older patients and those who received unrelated cord blood transplantation.Bone Marrow Transplantation advance online publication, 10 September 2012; doi:10.1038/bmt.2012.172.
    Bone marrow transplantation 09/2012; 48(4). DOI:10.1038/bmt.2012.172 · 3.47 Impact Factor
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    ABSTRACT: Hydrogen sulfide (H(2)S), an endogenous gasotransmitter, modulates various biological functions, including nociception. It is known that H(2)S causes neurogenic inflammation and elicits hyperalgesia. Here we show that H(2)S activates mouse transient receptor potential ankyrin 1 (TRPA1) channels and elicits acute pain, using TRPA1-gene deficient mice (TRPA1(-/-)) and heterologous expression system. In wild-type mouse sensory neurons, H(2)S increased the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by ruthenium red (a nonselective TRP channel blocker) and HC-030031 (a TRPA1 blocker). H(2)S-responsive neurons highly corresponded to TRPA1 agonist-sensitive ones. [Ca(2+)](i) responses to H(2)S were observed in neurons from transient receptor potential vanilloid 1 (TRPV1(-/-)) mice but not from TRPA1(-/-) mice. Heterologously expressed mouse TRPA1, but not mouse TRPV1, was activated by H(2)S. H(2)S-induced [Ca(2+)](i) responses were inhibited by dithiothreitol, a reducing agent. Analyses of the TRPA1 mutant channel revealed that two cysteine residues located in the N-terminal internal domain were responsible for the activation by H(2)S. Intraplantar injection of H(2)S into the mouse hind paw caused acute pain which was significantly less in TRPA1(-/-) mice. The [Ca(2+)](i) responses to H(2)S in sensory neurons and in heterologously expressed channels, and pain-related behavior induced by H(2)S were enhanced under acidic conditions. These results suggest that H(2)S functions as a nociceptive messenger through the activation of TRPA1 channels. TRPA1 may be a therapeutic target for H(2)S-related algesic action, especially under inflammatory conditions.
    Neuroscience 05/2012; 218:335-43. DOI:10.1016/j.neuroscience.2012.05.044 · 3.33 Impact Factor
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    ABSTRACT:   ATP2A2 encoding the sarcoplasmic/endoplasmic reticulum Ca(2+) -ATPase2 (SERCA2) is a Darier disease (DD)-related gene. Ultraviolet (UV) B irradiation downregulates ATP2A2/SERCA2 expression in keratinocytes, whereas cyclooxygenase-2 (COX-2) expression is dramatically upregulated by UVB.  To analyse the involvement of COX-2 in ATP2A2/SERCA2 expression.   Keratinocytes were transfected with COX-2 siRNA or treated with COX-2 inhibitor, celecoxib, to evaluate the effect of COX-2 on ATP2A2/SERCA2 expression. Quantitative real-time polymerase chain reaction, Western blotting analysis and reporter assay were used to determine the amount of mRNA, protein level and transcription activity, respectively.   COX-2 knockdown by siRNA resulted in upregulation of ATP2A2 transcription. Treatment by celecoxib rescued UVB-mediated suppression of the ATP2A2 transcription and SERCA2 protein expression. Simple addition of prostaglandin (PG) E(2) , which is a product of COX-2 enzyme, reduced the amounts of ATP2A2 mRNA and SERCA2 protein in keratinocytes.   UVB downregulates ATP2A2/SERCA2 expression via induction of COX-2 expression and subsequent increase of PGE(2) production in keratinocytes. Considering that DD is caused by the decreased function of SERCA2 due to the reduced expression of the ATP2A2 gene, this finding shows the possibility that COX-2 inhibition may be useful to prevent and/or treat DD.
    British Journal of Dermatology 03/2012; 166(5):1017-22. DOI:10.1111/j.1365-2133.2011.10789.x · 4.10 Impact Factor
  • H. Ogawa · N. Sei · K. Yamada
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    ABSTRACT: Yield enhancement of high-energy photon pulses, which were generated via inverse Compton scattering of free-electron laser (FEL) pulses with electron pulses in relativistic motion, was achieved by an asymmetric two-bunch method. This method involves the use of two electron bunches recirculating in an electron storage ring for FEL oscillation with asymmetric bunch filling, and the generation of inverse Compton photon pulses at two collision points. The effects of the magnetic field of an undulator for FEL oscillation on the photon energy spectrum and photon yield were analyzed by Monte Carlo simulations and experiments.
    Physics Letters A 02/2012; 376(s 12–13):1171–1175. DOI:10.1016/j.physleta.2012.02.023 · 1.63 Impact Factor
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    ABSTRACT: Pre-existing donor-specific HLA antibodies in patients undergoing HLA-mismatched SCT have increasingly been recognized as a risk factor for primary graft failure. However, the clinical implications of the presence of HLA antibodies in donors remain unknown. We prospectively examined 123 related donors for the presence of HLA antibodies by using a Luminex-based single antigen assay. Of these, 1/57 (1.8%) male, 6/27 (22%) parous female and 0/39 (0%) nonparous female donors were HLA antibody-positive. Then, we determined the presence of HLA antibodies in seven patients who received SCT from antibody-positive donors. Of these, four became HLA antibody-positive after SCT. The specificities of the antibodies that emerged in the patients closely resembled those of the antibodies found in the donors, indicating their production by donor-derived plasma cells. Moreover, the kinetics of the HLA antibody levels were similar in all four patients: levels started increasing within 1 week after SCT and peaked at days 10-21, followed by a gradual decrease. These results suggest that donor-derived HLA antibody production frequently occurs in patients undergoing SCT from antibody-positive donors. Further studies are warranted for clarifying the clinical significance of donor-derived HLA antibodies, including the role of these antibodies in post transplant platelet transfusion refractoriness.
    Bone marrow transplantation 02/2012; 47(10):1338-42. DOI:10.1038/bmt.2012.28 · 3.47 Impact Factor
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    Biology of Blood and Marrow Transplantation 02/2012; 18(2):S328-S329. DOI:10.1016/j.bbmt.2011.12.326 · 3.35 Impact Factor

Publication Stats

7k Citations
1,319.69 Total Impact Points

Institutions

  • 2008–2015
    • Hyogo College of Medicine
      • Department of Internal Medicine
      Nishinomiya, Hyōgo, Japan
    • National Institutes Of Natural Sciences
      Edo, Tōkyō, Japan
  • 2014
    • Kumamoto University
      Kumamoto, Kumamoto, Japan
  • 2002–2014
    • National Institute of Advanced Industrial Science and Technology
      • Electronics and Photonics Research Institute
      Tsukuba, Ibaraki, Japan
  • 1983–2014
    • Juntendo University
      • • Graduate School of Medicine
      • • Department of Internal Medicine
      • • Department of Dermatology
      • • Atopy (Allergy) Research Center
      • • Department of Medicine
      Edo, Tōkyō, Japan
  • 2007–2013
    • The Graduate University for Advanced Studies
      • Department of Fusion Science
      Миура, Kanagawa, Japan
    • Tokyo Medical University
      • Division of Dermatology
      Edo, Tōkyō, Japan
  • 1995–2013
    • Tokyo Institute of Technology
      • Department of Physics
      Edo, Tōkyō, Japan
  • 2012
    • Tottori University
      • Faculty of Agriculture
      TTJ, Tottori, Japan
  • 2003–2011
    • Japan Atomic Energy Agency
      • Nuclear Science and Engineering Directorate
      Muramatsu, Niigata, Japan
    • Hiroshima Institute of Technology
      Hirosima, Hiroshima, Japan
  • 2010
    • Tokyo Gakugei University
      Koganei, Tōkyō, Japan
  • 2009
    • Saitama Medical University
      Saitama, Saitama, Japan
  • 1979–2008
    • National Institute of Radiological Sciences
      • Research Center for Charged Particle Therapy
      Tiba, Chiba, Japan
  • 1920–2008
    • Saga University
      • • Synchrotron Light Application Center
      • • Department of Electrical & Electronic Engineering
      Сага Япония, Saga Prefecture, Japan
  • 1998–2007
    • RIKEN
      • Nishina Center for Accelerator-Based Science (RNC)
      Вако, Saitama, Japan
  • 2002–2006
    • National Institute for Fusion Science
      • Department of Helical Plasma Research
      Tokitsu-chō, Gifu, Japan
  • 1997–2006
    • Osaka City University
      • Department of Neurosurgery
      Ōsaka, Ōsaka, Japan
    • Sophia University
      • Division of Physics
      Edo, Tōkyō, Japan
  • 2004
    • Shanghai Jiao Tong University
      • State Key Laboratory of Metal Matrix Composites
      Shanghai, Shanghai Shi, China
  • 2001
    • Kinki University
      • Faculty of Agriculture
      Ōsaka-shi, Osaka-fu, Japan
  • 2000
    • Aichi Medical University
      • Division of Internal Medicine
      Okazaki, Aichi, Japan
    • National Institute of Animal Health
      Ibaragi, Ōsaka, Japan
    • Chiba University
      Tiba, Chiba, Japan
  • 1994
    • Keio University
      • Department of Dermatology
      Edo, Tōkyō, Japan
  • 1991
    • Tokyo Metropolitan Institute of Medical Science
      Edo, Tōkyō, Japan
  • 1988
    • Nara Medical University
      • Department of Dermatology
      Nara-shi, Nara, Japan
  • 1987
    • Osaka University
      Suika, Ōsaka, Japan